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*  Neuronal human BACE1 knockin induces systemic diabetes in mice | SpringerLink
... is a key enzyme in Alzheimer's disease pathogenesis that catalyses the amyloidogenic cleavage of amyloid precursor protein (APP ... Sc-6384), mouse monoclonal protein tyrosine phosphatase 1B (PTP1B; no. Sc-14021), C/EBP homologous protein (CHOP; also known as ... Insulin receptor β. mTOR. Mammalian target of rapamycin. GS. Glycogen synthase. GSK3β. Glycogen synthase kinase-3 β ... peptide tyrosine tyrosine (PYY), IL-6 and resistin following the manufacturer's instructions. Triacylglycerol and glycogen ...
  https://link.springer.com/article/10.1007/s00125-016-3960-1
*  WO2001061053A9 - Protein and peptide sensors using electrical detection methods - Google Patents
... for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or ... provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein ... INF-γ receptor alpha chain, MHC Class I, MHC Class II , T Cell Receptor, Insulin receptor, insulin receptor tyrosine kinase and ... and mammalian proteins (or libraries thereof), with the latter being preferred, and human proteins being especially preferred. ...
  https://patents.google.com/patent/WO2001061053A9/en
*  Inositol-trisphosphate 3-kinase - Wikipedia
In this pathway, either a G-protein coupled receptor (GPCR) or receptor tyrosine kinase (RTK) is activated by an extracellular ... Inositol 5-phosphatase existed before ITP3K evolved in the mammalian cell. Like other phosphatases, inositol 5-phosphatase is ... In further detail, the larger domain of the protein structure has an α/β-class structure. The domain has an N-terminal and a C- ... The pipeline includes 186 drug targets; the goal is activation of non-receptor tyrosine kinases such as Src, Tek, and Syc ...
  https://en.wikipedia.org/wiki/Inositol-trisphosphate_3-kinase
*  Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the...
Three proteins are lyases (EC 4.-.-.-) and two of these contain the Protein tyrosine phosphatase-like protein domain (PF04387) ... Receptors, or Dual Functions were grouped into the Miscellaneous class. To further describe the miscellaneous proteins, GO ( ... Fukata Y, Iwanaga T, Fukata M. Systematic screening for palmitoyl transferase activity of the DHHC protein family in mammalian ... Receptors. The two proteins identified solely as receptors each belong to different receptor types. The first receptor is the ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2592-7
*  MAPK7 - Wikipedia
Kamakura S, Moriguchi T, Nishida E (1999). "Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. ... Lee JD, Ulevitch RJ, Han J (1995). "Primary structure of BMK1: a new mammalian map kinase". Biochem. Biophys. Res. Commun. 213 ... Buschbeck M, Eickhoff J, Sommer MN, Ullrich A (Aug 2002). "Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 ... lessons from knockout mice". J. Mol. Med. 82 (12): 800-8. doi:10.1007/s00109-004-0602-8. PMID 15517128. Roberts OL, Holmes K, ...
  https://en.wikipedia.org/wiki/MAPK7
*  NAVBO Newsletter - Announcing New Councilors
In this study, the authors investigated how tyrosine-protein kinase receptor (TEK or Tie2) promoter-dependent deletion of Lpp3 ... Aim: Lipid phosphate phosphatase (LPP)3 is expressed at high levels in endothelial cells (ECs). Although LPP3 is known to ... "D uring the spring of 2015," writes McKenzie Wood in The Chronicle of Higher Education, "I had the momentous experience of ... The mammalian circulatory system comprises both the cardiovascular system and the lymphatic system. In contrast to the blood ...
  https://myemail.constantcontact.com/NAVBO-Newsletter---Announcing-New-Councilors.html?soid=1123122143395&aid=noL-fgsRgeA
*  Genomics, Circuits, and Pathways in Clinical Neuropsychiatry - 1st Edition
Sortilin-Related Receptor, LDLR Class A Repeats Containing. *Inositol Polyphosphate-5-Phosphatase ... Protein Tyrosine Kinase 2β. *Ras and Rab Interactor 3 (RIN3) and Solute Carrier Family 24 Sodium/Potassium/Calcium Exchanger, ... Optogenetic Approaches to Neural Circuit Analysis in the Mammalian Brain*Introduction. *Tools for Functional Neural Circuit ... RNA, Protein, and Epigenetic Molecular Levels in Neurobiology. *The Challenge of Spatial and Temporal Heterogeneity in the ...
  https://www.elsevier.com/books/genomics-circuits-and-pathways-in-clinical-neuropsychiatry/lehner/978-0-12-800105-9
*  Kellie S[au] - PubMed - NCBI
Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast ... The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer. ... Implementing a patient education intervention about Methicillin-resistant Staphylococcus aureus prevention and effect on ... Functional and structural properties of mammalian acyl-coenzyme A thioesterases.. Kirkby B, Roman N, Kobe B, Kellie S, Forwood ...
  https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Kellie+S%5Bau%5D&dispmax=50
*  Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis
Eyes absent represents a class of protein tyrosine phosphatases. Nature. 2003;426(6964):295-298. [PubMed] ... Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003;426( ... Eyes absent mediates cross-talk between retinal determination genes and the receptor tyrosine kinase signaling pathway. Dev ... EYA proteins are both transcriptional activators (Xu et al. 1996) and tyrosine phosphatases (Rayapureddi et al. 2003; Tootle et ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2809821/
*  G protein-coupled receptor - Mashpedia Free Video Encyclopedia
... the bradykinin receptor B2 has been shown to interact directly with a protein tyrosine phosphatase. The presence of a tyrosine- ... Class A (Rhodopsin-like), Class B (Secretin-like), Class C (Glutamate Receptor-like), Others (Adhesion (33), Frizzled (11), ... They constitute a family of seven mammalian serine-threonine protein kinases that phosphorylate agonist-bound receptor. GRKs- ... 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLR), constitute a large protein ...
  http://www.mashpedia.com/G-protein_coupled_receptor
*  PTP4A3 - Wikipedia
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell ... 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome ... Receptors & signal transduction. 7 (4): 241-56. PMID 9633825. Zeng Q, Si X, Horstmann H, et al. (2000). "Prenylation-dependent ... 2006). "Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3". Biochem. Biophys. ...
  https://en.wikipedia.org/wiki/PTP4A3
*  RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells | Molecular Systems Biology
Some of the lipid and protein kinases and phosphatases present in these two subnetworks are known to respond to extracellular ... Bard F, Mazelin L, Péchoux‐Longin C, Malhotra V, Jurdic P (2003) Src regulates Golgi structure and KDEL receptor‐dependent ... Egea G, Lázaro‐Diéguez F, Vilella M (2006) Actin dynamics at the Golgi complex in mammalian cells. Curr Opin Cell Biol 18: 168- ... This relocation event is stimulated by growth factors such as EGF and mediated by Src tyrosine kinase (Gill et al, 2010, 2011). ...
  http://msb.embopress.org/content/8/1/629
*  Mitogen-activated protein kinase - Wikipedia
Similarly, both dual-specificity MAP kinase phosphatases and MAP-specific tyrosine phosphatases bind to MAP kinases through the ... receptor tyrosine kinases, Ras or Raf proteins. Although no MKK1/2 or ERK1/2 inhibitors were developed for clinical use, kinase ... D-motifs can even be found in certain MAPK pathway regulators and scaffolds (e.g. in the mammalian JIP proteins). Other, less ... Hayashi M, Lee JD (Dec 2004). "Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice". Journal of Molecular ...
  https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase
*  Kate Carroll | Scripps Research
An immunochemical approach to detect oxidized protein tyrosine phosphatases using a selective C-nucleophile tag. Garcia, F. J ... We are also exploring the therapeutic potential of redox-regulated protein function by developing an entirely new class of ... Cell culture: Mammalian cell lines, bacteria, and primary cultures Proteomics: Solid-phase capture, fractionation, LC-MS/MS, ... Molecular basis for redox activation of epidermal growth factor receptor kinase. Truong, T. H.; Ung, P. M.; Paulsen, C. E.; ...
  https://www.scripps.edu/faculty/carroll/
*  Protocols and Video Articles Authored by Balamurali K. Ambati (Translated to Arabic)
... tyrosine phosphatase-1 (SHP-1). The VEGFR-1-specific ligand placental growth factor-1 (PlGF-1), but not VEGF-E, which ... We show instead that CNV inhibition is a siRNA-class effect: 21-nucleotide or longer siRNAs targeting non-mammalian genes, non- ... These provide a detailed prediction of key amino acid side-chain interactions at the protein-protein interface. To validate the ... Here we show that the cornea expresses soluble VEGF receptor-1 (sVEGFR-1; also known as sflt-1) and that suppression of this ...
  https://www.jove.com/author/Balamurali+K._Ambati?language=Arabic
*  Genome-wide review of transcriptional complexity in mouse protein kinases and phosphatases | Genome Biology | Full Text
We also report on the existence of likely dominant negative forms for many of the receptor kinases and phosphatases, including ... We undertook a systematic study to catalog the variant transcripts of every protein kinase-like and phosphatase-like locus of ... These findings suggest that alternative transcripts of protein kinases and phosphatases are produced that encode different ... of kinase and phosphatase loci in mouse generate alternative splice forms, and that 44% of these loci have well supported ...
  https://genomebiology.biomedcentral.com/articles/10.1186/gb-2006-7-1-r5
*  Modulation of Glucose Transporter Protein by Dietary Flavonoids in Type 2 Diabetes Mellitus
... liver X receptor; G6Pase: glucose 6-phosphatase; IKK: IκB kinase; FoXO1: Forkhead box protein O1; G6Pase: Glucose-6-phosphatase ... The defect in translocation of GLUT-4 protein takes place due to the inhibition of tyrosine phosphorylation of insulin receptor ... Among other GLUT proteins present in class I, GLUT-3 has the highest apparent affinity and highest maximum turnover number of ... mammalian target of rapamycin; Bad: bcl-2-associated death promoter; SREBP-1C: sterol regulatory element binding protein-1c; ...
  http://www.ijbs.com/v11p0508.htm
*  HMGB1 - Wikipedia
"High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with ... interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells ... Ge H, Roeder RG (1994). "The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction ... High mobility group box 1 protein, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in ...
  https://en.wikipedia.org/wiki/HMGB1
*  IJMS | Free Full-Text | βArrestins in Cardiac G Protein-Coupled Receptor Signaling and Function: Partners in Crime or "Good...
... are universal G protein-coupled receptor (GPCR) adapter proteins expressed abundantly in extra-retinal tissues, including the ... They are now known to switch GPCR signaling from G protein-dependent to G protein-independent, which, in the case of βARs and ... roles in the G protein-independent signaling pathways they initiate in the cardiovascular system, including in the myocardium. ... initially as terminators of signaling from the β-adrenergic receptor (βAR), a process known as functional desensitization. ...
  http://www.mdpi.com/1422-0067/14/12/24726/htm
*  STX6 - Wikipedia
Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6". The Journal of ... "Control of vesicle fusion by a tyrosine phosphatase". Nature Cell Biology. 6 (9): 831-9. doi:10.1038/ncb1164. PMID 15322554. ... "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex". Biochemical and Biophysical ... Syntaxin-6 is a protein that in humans is encoded by the STX6 gene. STX6 has been shown to interact with SNAP23, VAMP3 and ...
  https://en.wikipedia.org/wiki/STX6
*  Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression | Journal of Neuroscience
1993) Increased production of the TrkB protein tyrosine kinase receptor after brain insults. Neuron 10:151-164. ... However, K252a also inhibits other classes of tyrosine kinase receptors, as well as Ser/Thr kinases, including those in the MAP ... 1994) Inhibitors of protein kinases and phosphatases. Trends Biochem Sci 19:444-448. ... 2001) Mammalian MAP kinase signalling cascades. Nature 410:37-40.. OpenUrlCrossRefPubMed ...
  http://www.jneurosci.org/content/22/8/3251.long
*  Plus it
... a protein tyrosine phosphatase inhibitor, can up-regulate tyrosine kinase-linked growth factor receptor signaling via the ... Lendahl U, Zimmerman LB, and McKay RD (1990) CNS stem cells express a new class of intermediate filament protein. Cell 60: 585- ... Proliferating Cells in SVZ in the Adult Mammalian Brain. Cells in the SVZ give rise to most neurons and glial cells in the ... Elberg G, Li J, and Shechter Y (1994) Vanadium activates or inhibits receptor and non-receptor protein tyrosine kinases in cell ...
  http://jpet.aspetjournals.org/content/318/3/982
*  The immunoglobulin superfamily in Caenorhabditis elegans and Drosophila melanogaster | Development
The family of Caenorhabditis elegans tyrosine kinase receptors: similarities and differences with mammalian receptors. Genome ... For example, most members of the `Cell Surface I protein' class, classified as `cell adhesion proteins' by Vogel et al., can ... kinases and phosphatases' section of table 3. Although its extracellular domain is similar to VER receptor tyrosine kinases, ... Treating these structural classes as being equivalent to functional classes is incorrect as members from each class have been ...
  http://dev.biologists.org/content/131/10/2237
*  Transcriptome profiling of antiviral immune and dietary fatty acid dependent responses of Atlantic salmon macrophage-like cells...
Fatty acid-binding protein adipocyte (fabp4) and proteasome subunit beta type-8 (psmb8) were significantly up- and down- ... Shen W-J, Hu J, Hu Z, Kraemer FB, Azhar S. Scavenger receptor class B type I (SR-BI): a versatile receptor with multiple ... Mammalian OPTN is a virus- and pIC-induced protein that can inhibit the virus-induced IFNB production [128]. We revealed herein ... IFNB/G (interferon beta/gamma), IFNAR (IFN alpha receptor), IL (interleukin), IFNGR (IFN-gamma receptor), TYK2 (tyrosine kinase ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-4099-2
*  Joseph (Joe) Lipsick | Stanford Medicine Profiles
Conversely, CRYP-alpha, encoding a transmembrane tyrosine phosphatase, was expressed in the presence but not the absence of ... including a number of proteins that do not bind directly to DNA. We performed a phylogenetic analysis of diverse classes of Myb ... we utilized primary cells transformed by a retrovirus encoding a v-Myb-estrogen receptor (ER) fusion protein. The Ets-2 gene ... unfused protein in both mammalian cells and in budding yeast. To identify the critical residues for transcriptional activation ...
  https://med.stanford.edu/profiles/joseph-lipsick