BithionolThymolMetabolic Detoxication, DrugMetabolic Detoxication, Phase IMetabolic Detoxication, Phase IIMicrosomes, LiverBiotransformationDealkylationGlucuronidesMetabolic Networks and PathwaysCytochrome P-450 Enzyme SystemChromatography, High Pressure LiquidHydroxylationCytochrome P-450 CYP3AMass SpectrometryGlutathione TransferaseClinical Trials, Phase I as TopicRats, Sprague-DawleyPsychoses, AlcoholicAristolochic AcidsAdrenochromeCytochrome P-450 CYP1A1Aflatoxin B1Aminopyrine N-DemethylaseCarcinogensNAD(P)H Dehydrogenase (Quinone)GlutathioneBenzo(a)pyreneLiverDNA AdductsGlucosinolatesAnticarcinogenic AgentsCytochrome P-450 CYP1A2ThiocyanatesCarboxylesteraseMaximum Tolerated DoseEnzyme InductionIsothiocyanatesOxidation-ReductionDose-Response Relationship, DrugPyrazinesMetabolismCarboxylic Ester HydrolasesNeoplasmsIsoenzymesSubstrate SpecificityDrug EvaluationKineticsDrug Administration ScheduleRats, Inbred F344MetabolomeMetabolomicsEnzymesMolecular Sequence DataInfusions, IntravenousAntineoplastic AgentsMetabolic EngineeringCoxiellaGlycolysisModels, BiologicalAntineoplastic Combined Chemotherapy ProtocolsArea Under CurveGene Expression ProfilingTreatment OutcomeCitric Acid CycleBiosynthetic PathwaysAdministration, OralPentose Phosphate PathwayNauseaCarbonCarbohydrate MetabolismComputational BiologyMetabolic Clearance RateGlucoseNeutropenia