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Array ( [q] => (major metabolic pathways metabolic detoxication phase) AND (url:publications.icr.ac.uk/1333/ OR url:bjp.rcpsych.org/content/197/3/200 OR url:www.allscrabblewords.com/word-description/thymol OR url:www.mdpi.com/1422-0067/18/10/2144 OR url:https://www.erowid.org/chemicals/adrenochrome/adrenochrome.shtml OR url:oxfordindex.oup.com/view/10.1093/carcin/bgm082 OR url:libros.duhnnae.com/2017/jun/149628614515-Vol-6-Informed-Consent-for-Phase-I-Oncology-Trials-Form-Substance-and-Signature-Malik-Laeeq-Mejia-Alex.php OR url:https://medicalxpress.com/print282914874.html OR url:https://www.spandidos-publications.com/10.3892/ijmm.16.1.19 OR url:supernaturalacnetreatment.com/thyme-oil-kills-acne-bacteria-and-potentially-clears-acne/ OR url:https://rucore.libraries.rutgers.edu/rutgers-lib/47337/ OR url:www.jafs.com.pl/Effects-of-cinnamaldehyde-and-thymol-on-cytotoxicity-tight-junction-barrier-resistance,77058,0,2.html OR url:ssjournals.com/index.php/ijapa/article/view/2221/1814 OR url:www.eje.cz/artkey/eje-201101-0005_Sequestration_of_aristolochic_acids_from_meridic_diets_by_larvae_of_Battus_polydamas_archidamas_Papilionidae.php OR url:https://www.omicsonline.org/peer-reviewed/an-improved-high-performance-liquid-chromatographic-method-for-tryptophan-analysis-in-rat-brain-administrated-by-seaweed-26691.html OR url:www.molbase.com/en/hnmr_62625-21-2-moldata-49745.html OR url:www.abcam.com/recombinant-human-glutathione-s-transferase-omega-1-protein-ab83166.html OR url:www.safetyalerts.com/f/00/jade.html OR url:jeb.biologists.org/content/202/15/2091 OR url:circres.ahajournals.org/content/56/2/212 OR url:https://www.stir.ac.uk/research/hub/publication/3835 OR url:www.dictionary.com/browse/thymol?qsrc=2446 OR url:www.biomedsearch.com/nih/Dependence-output-halothane-vaporizer-thymol/3232783.html OR url:https://marketpublishers.com/report/industry/chemicals_petrochemicals/sodium_thymol_blue_62625-21-2_market_research_report.html OR url:www.exportersindia.net/manufacturers/thymol-crystals.html) [c] => english wikipedia_english [format] => json [showinput] => 0 [spell] => 0 [scores] => 0 [showimages] => 0 [niceness] => 0 [qe] => 1 [qlang] => en [dsrt] => 0 [ipr] => 0 [sc] => 0 [dr] => 1 [n] => 25 [qh] => 1 [sites] => publications.icr.ac.uk bjp.rcpsych.org allscrabblewords.com mdpi.com erowid.org oxfordindex.oup.com libros.duhnnae.com medicalxpress.com spandidos-publications.com supernaturalacnetreatment.com rucore.libraries.rutgers.edu jafs.com.pl ssjournals.com eje.cz omicsonline.org molbase.com abcam.com safetyalerts.com jeb.biologists.org circres.ahajournals.org stir.ac.uk dictionary.com biomedsearch.com marketpublishers.com exportersindia.net ) Array ( [q] => (major metabolic pathways metabolic detoxication phase) [c] => english wikipedia_english [format] => json [showinput] => 0 [spell] => 0 [scores] => 0 [showimages] => 0 [niceness] => 0 [qe] => 1 [qlang] => en [dsrt] => 0 [ipr] => 0 [sc] => 0 [dr] => 1 [n] => 25 [qh] => 1 [s] => 0 )
*  Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention | BMC Cancer | Full Text
Disregulation of these pathways is implicated in tumor progression. In addition, it is becoming increasingly evident that ... CYP1A1 plays an important role in the detoxication of environmental carcinogens, as well as in the metabolic activation of ... recent evidence suggests that the AhR is involved in various cell signaling pathways critical to cell cycle regulation and ... contribution of CYP1A1 to cancer progression or prevention may depend on the balance of procarcinogen activation/detoxication ...
  https://0-bmccancer-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2407-9-187
*  Sulphation and Autism: What are the links? | The Autism File
Failure of a major pathway such as sulphation will lead to a neurotransmitter imbalance and raised serum and CSF levels of ... It is clear that even a simple vaccination in healthy volunteers can dramatically affect some metabolic pathways, at least in ... In particular, the phase 2 conjugation reaction of sulphation was severely depressed, only reaching control values about a week ... effects apart from slight reddening at the injection point in some volunteers but it greatly altered the detoxication pathways ...
  http://www.autismfile.com/science-research/sulphation-and-autism-what-are-the-links
*  3-methylcholanthrene: Topics by WorldWideScience.org
... levels of major Phase I and Phase II enzymes were determined by quantitative real-time-polymerase chain reaction (RT-PCR), and ... Metabolic pathways of the mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) remain incompletely characterized in ... 11, 217-225]. Thus, P450 1A2 is involved in both the metabolic activation and detoxication of this procarcinogen in humans. ... The metabolic profile is significantly different from previous studies using thin layer chromatography. The major metabolites ...
  https://worldwidescience.org/topicpages/0-9/3-methylcholanthrene.html
*  rs1048943 - SNPedia
Multilocus analysis of SNP and metabolic data within a given pathway. [PMID 16949388] CYP1A1 and CYP1B1 polymorphisms and their ... Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression. ... PMID 20544687] Evidence that genetic variants of metabolic detoxication and cell cycle control are not related to gallbladder ... Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic ...
  https://snpedia.com/index.php/Rs1048943
*  Effects of Glucosinolate-Rich Broccoli Sprouts on Urinary Levels of Aflatoxin-DNA Adducts and Phenanthrene Tetraols in a...
Fahey JW, Talalay P. Antioxidant functions of sulforaphane: a potent inducer of phase II detoxication enzymes. Food Chem ... Oltipraz, by contrast, was administered once daily and lead to enhanced metabolic detoxication of aflatoxin, presumably through ... use of small molecules that selectively induce protective phase 2 enzyme pathways may only require weekly rather than daily ... A major disadvantage of using hot water extracts of broccoli sprouts as opposed to intact broccoli sprouts lies in the capacity ...
  http://cebp.aacrjournals.org/content/14/11/2605.long
*  Plus it
The major metabolic pathways involved are oxidation of the hexyl side chain to subsequently produce alcohols, ketones, and ... The samples were analyzed using reversed-phase HPLC using a mobile phase with a pH of 2.0 (for further details, see Materials ... It has even been suggested that the primary function of peroxisomal β-oxidation is detoxication (Osmundsen et al., 1991). ... Proposed metabolic pathway for the formation of LPB-4′-oic acid from sameridine by rat hepatocytes. ...
  http://dmd.aspetjournals.org/content/28/6/695
*  Molecular Mechanisms of Multistage Carcinogenesis
This will identify the metabolic pathway most responsible for adduct formation. Project #3 (Drs. Kazanietz and Assoian) will ... g1 phase*s phase*pulmonary alveoli*biotransformation*up regulation*lung neoplasms*bronchoalveolar lavage fluid*equilenin* ... Thus, post-transcriptional destabilization of p21(cip1) appears to be a major mitogenic effect of PKCdelta in fibroblasts... ... Aldo-keto reductases and bioactivation/detoxication. Yi Jin. Department of Pharmacology, Center of Excellence in Environmental ...
  http://www.labome.org/grant/p01/ca/molecular/mechanisms/molecular-mechanisms-of-multistage-carcinogenesis-7101871.html
*  Plus it
... quinone oxido-reductase are generally viewed as detoxication pathways (5) . Free radical production by doxorubicin involves the ... and these compounds display complex metabolic patterns. The major metabolite in humans is doxorubicinol, produced via cytosolic ... Phillips R. M., Clayton M. R. Plateau-phase cultures: an experimental model for identifying drugs which are bioactivated within ... Taatjes D. J., Fenick D. J., Gaudiano G., Koch T. H. A redox pathway leading to the alkylation of nucleic acids by doxorubicin ...
  http://cancerres.aacrjournals.org/content/63/20/6914
*  PHASE II DRUG METABOLIZING ENZYMES - PDF
The formation of glucuronide conjugates is the most important detoxication pathway of the Phase II of drug metabolism in all ... Generalize the way in which nutrients are processed through the three major metabolic fates in order to perform various ... Phase II drug metabolising enzymes are mainly transferases. This review covers the major phase II enzymes: UDP- ... 2 ). There are also individual differences in metabolic response for both Phase I and Phase II enzymes. Further, both external ...
  http://docplayer.net/2081735-Phase-ii-drug-metabolizing-enzymes.html
*  940. Safety evaluations of groups of related substances... (WHO Food Additives Series 42)
Glucuronic acid conjugation is a major phase-2 metabolic reaction, and both the liver and intestinal wall have a high capacity ... The results indicate that hydrolysis is the major metabolic pathway for all of the esters evaluated at the present meeting; ... Williams, R.T. (1959) Detoxication Mechanisms: The Metabolism and Detoxication of Drugs, Toxic Substances and Other Organic ... oxidation is a major metabolic pathway in vivo, resulting in acid metabolites. (b) Secondary and tertiary alcohols Secondary ...
  http://inchem.org/documents/jecfa/jecmono/v042je14.htm
*  Wicker Park - ????????????? ???? ????
The major DNA adducts formed by acrolein - a pair off of hydroxylated 1,N2-propanodeoxyguaosine species formed via a 2-step ... A considerable randomized, phase III fling (n=300) con- ducted in patients with epithelial ovarian cancer concluded that INF- ... Are we so expression that to be "successful" that you staleness implore glucotrol xl 10 mg lowest price metabolic disease 3 ps3 ... in the club to rectify bladder take the role alongside blocking behalf of the neural pathways to slim down the opportunities ...
  http://wipark.ru/ourbook/startpage,204/
*  Mining the Unknown: A Systems Approach to Metabolite Identification Combining Genetic and Metabolic Information
Metabolic pathway model and functional annotations. Metabolic reactions were imported from three independent human metabolic ... Briefly, metabolic profiling was done using ultrahigh-performance liquid-phase chromatography and gas-chromatography separation ... 2012) UGT1A1 is a major locus influencing bilirubin levels in African Americans. Eur J Hum Genet 20: 463-468. [PMC free article ... Implications for the catechol-O-methyl transferase-mediated detoxication of catechol estrogens. Drug Metab Dispos 24: 588-594. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3475673/
*  4-Hydroxyphenylacetone - Wikipedia
In species where aromatic hydroxylation of amphetamine is the major metabolic pathway, p-hydroxyamphetamine (POH) and p- ... The phase 1 metabolism of amphetamine analogs is catalyzed by two systems: cytochrome P450 and flavin monooxygenase. ... ... role in bioactivation and detoxication". J. Pharmacol. Exp. Ther. 288 (3): 1251-1260. PMID 10027866. Santagati NA, Ferrara G, ... The glycine conjugation pathway consists of two steps. First benzoate is ligated to CoASH to form the high-energy benzoyl-CoA ...
  https://en.wikipedia.org/wiki/4-Hydroxyphenylacetone
*  Phenylacetone - Wikipedia
In species where aromatic hydroxylation of amphetamine is the major metabolic pathway, p-hydroxyamphetamine (POH) and p- ... The phase 1 metabolism of amphetamine analogs is catalyzed by two systems: cytochrome P450 and flavin monooxygenase. ... ... role in bioactivation and detoxication". J. Pharmacol. Exp. Ther. 288 (3): 1251-1260. PMID 10027866. "Adderall XR Prescribing ... The glycine conjugation pathway consists of two steps. First benzoate is ligated to CoASH to form the high-energy benzoyl-CoA ...
  https://en.wikipedia.org/wiki/Phenylacetone
*  Drug metabolism - Wikipedia
These pathways are a form of biotransformation present in all major groups of organisms, and are considered to be of ancient ... Thornalley PJ (July 1990). "The glyoxalase system: new developments towards functional characterization of a metabolic pathway ... If the metabolites of phase I reactions are sufficiently polar, they may be readily excreted at this point. However, many phase ... This field became defined as a separate area of study with the publication by Richard Williams of the book Detoxication ...
  https://en.wikipedia.org/wiki/Drug_metabolism
*  Dextroamphetamine - Wikipedia
In species where aromatic hydroxylation of amphetamine is the major metabolic pathway, p-hydroxyamphetamine (POH) and p- ... The phase 1 metabolism of amphetamine analogs is catalyzed by two systems: cytochrome P450 and flavin monooxygenase. ... ... role in bioactivation and detoxication". J. Pharmacol. Exp. Ther. 288 (3): 1251-1260. PMID 10027866. Sjoerdsma A, von Studnitz ... The main metabolic pathways involve aromatic para-hydroxylation, aliphatic alpha- and beta-hydroxylation, N-oxidation, N- ...
  https://en.wikipedia.org/wiki/Dextroamphetamine
*  Lisdexamfetamine - Wikipedia
In species where aromatic hydroxylation of amphetamine is the major metabolic pathway, p-hydroxyamphetamine (POH) and p- ... "Phase-III clinical trials in Attention-deficit hyperactivity disorder (In children, In adolescents) in Japan (PO)". Retrieved ... role in bioactivation and detoxication". J. Pharmacol. Exp. Ther. 288 (3): 1251-1260. PMID 10027866. Sjoerdsma A, von Studnitz ... The main metabolic pathways involve aromatic para-hydroxylation, aliphatic alpha- and beta-hydroxylation, N-oxidation, N- ...
  https://en.wikipedia.org/wiki/Lisdexamfetamine
*  Plus it
Given the major role played by CYP3A in catalyzing a number of primary and secondary metabolic pathways of TAM, we would expect ... Poon GK, Chui YC, McCague R, Llnning PE, Feng R, Rowlands MG, and Jarman M (1993) Analysis of phase I and phase II metabolites ... White IN (2003) Tamoxifen: is it safe? Comparison of activation and detoxication mechanisms in rodents and in humans. Curr Drug ... Knowledge of sequential metabolic pathways leading to these metabolites and identification of the specific P450s involved ...
  http://jpet.aspetjournals.org/content/310/3/1062
*  355. Acephate (Pesticide residues in food: 1976 evaluations)
... metabolic pathway of acephate is not fully elucidated. A probable scheme may be as shown in Figure 1. The metabolic fate of two ... The major plant and soil metabolite, methamidophos, is not formed in water by direct hydrolysis. The presence of this ... The liver was the tissue with the highest 14C residue reflecting the normal portal detoxication mechanism. Urinary metabolites ... phase. The following kinds of organisms were involved in the study: algae, fresh water plants, water flea, mosquito, snail, ...
  http://inchem.org/documents/jmpr/jmpmono/v076pr02.htm
*  D-Tox Phase V - Blood Detective
Major Phase II pathways. Glutathione. Sulphate. Glycine. Glucuronide conjugations. Through conjugation, the liver is able to ... The neuroprotective antioxidant alpha-lipoic acid induces detoxication enzymes in cultured astro glial cells. Free Radic Res ... and enhances the normal breakdown of toxins and other metabolic by-products of the body. ... There are two main pathways of detoxification in the liver, known as phase I and phase II. In phase I, composed mainly of ...
  http://www.blooddetective.com/d-tox-phase-v
*  JCI Insight - Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity
AA-I metabolic pathway illustrating the interaction of liver and kidney. The sulfate-conjugated metabolite of AA-I and AL-I-NOH ... Murine kidneys lack this detoxication pathway. Nevertheless, renal toxicity and forestomach cancers are prominent effects of AA ... Identification of the major serum albumin adduct formed by 4-aminobiphenyl in vivo in rats. Cancer Res. 1985;45(10):5122-5127. ... A requirement for phase II metabolism in AA-I metabolism to produce a directly nephrotoxic chemical species in vivo was ...
  https://insight.jci.org/articles/view/95978
*  Protocols and Video Articles Authored by Grady E. Carlson (Translated to Chinese)
... terminal-phase rate constant λz (0.01 ± 0.002 h(-1) ); and terminal-phase rate constant half-life t1/2λz (67.20 h; ... Using the Cardio-Metabolic Risk data set, we compared health and cost outcomes over a 20-year period between adults with poor ... A Segregated Neural Pathway for Prefrontal Top-Down Control of Tactile Discrimination Cerebral Cortex (New York, N.Y. : 1991). ... These results show that the SPHK rheostat does not play a major role in tumor cell viability, and that SPHKs might not be ...
  https://www.jove.com/author/Grady+E._Carlson?language=Chinese
*  Plus it
... were performed in the phase-sensitive mode (TPPI; time-proportional receiver phase incrementation) using gradients for ... From the metabolic balances of Table 1, it is clear that a substantial fraction of the metabolites of PB has not yet been ... Shiiyama S, Soejima-Ohkuma T, Honda S, Kumagai Y, Cho AK, Yamada H, Oguri K, and Yoshimura H (1997) Major role of the CYP2C ... Ambrose AM and Sherwin CP (1933) Further studies on the detoxication of phenylacetic acid. J Biol Chem 101: 669-675. ...
  http://dmd.aspetjournals.org/content/32/1/10
*  Methamphetamine - Wikipedia
The known metabolic pathways include: Methamphetamine and amphetamine are often measured in urine or blood as part of a drug ... with a withdrawal syndrome involving two general phases that can last 3 weeks or more. The first phase of this syndrome is the ... a major portion of the β-hydroxylation of hydroxyamphetamine occurs in non-adrenal tissue. Unfortunately, at the present time ... role in bioactivation and detoxication". J. Pharmacol. Exp. Ther. 288 (3): 1251-1260. PMID 10027866. Rau T, Ziemniak J, Poulsen ...
  https://en.wikipedia.org/wiki/Methamphetamine
*  PPT - BIOTRANSFORMATION PowerPoint Presentation - ID:1137530
Contents:-. Introduction Phase I reaction Phase II reaction Slideshow 1137530 by zayit ... major phase i and phase ii enzymesreaction mechanisms, substratesenzyme inhibitors and inducersgenetic ... Toxicity and Biological half life of drug depends on metabolic rate and the factor that influence metabolic rate are: * ... DETOXICATION ROLE OF THE PLACENTA: EFFECT OF EFFLUX TRANSPORTERS AND BIOTRANSFORMATION ENZYMES -František Štaud katedra ...
  https://www.slideserve.com/zayit/biotransformation