*  Suicide gene - Wikipedia
A suicide gene, in genetics, will cause a cell to kill itself through apoptosis. Activation of these genes can be due to many ... The cell shrinks and sends out distress signals, which are answered by macrophages. The macrophages clean away the shrunken ... Main mechanisms inducing cancer cells' deaths include: transgenic expression of thymidine kinases, cytosine deaminases, ... Suicide genes are often utilized in biotechnology to assist in molecular cloning. Vectors incorporate suicide genes for an ...
  https://en.wikipedia.org/wiki/Suicide_gene
*  Butyrate induces apoptosis in murine macrophages via caspase-3, but independent of autocrine synthesis of tumor necrosis factor...
Bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell, 57: 79-88 ... 1. Steller H (1995). Mechanisms and genes of cellular suicide. Science, 267: 1445-1449. [ Links ]. 2. Alnermi ES, Livingston DJ ... Cell, 87: 171. [ Links ]. 3. Nathan CF, Murray HW & Cohn ZA (1980). The macrophage as an effector cell. New England Journal of ... macrophages and natural killer cells or with FITC-labeled Mac-3 (Pharmingen), a cell marker specific for activated macrophages ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200004&lng=pt&nrm=iso&tlng=en
*  Genetic manipulation of drug sensitivity in haematopoietic cells. - The Christie Research Publications Repository
Genes, Transgenic, Suicide. -. dc.subject.mesh. Hematopoietic Stem Cell Transplantation. -. dc.subject.mesh. Hematopoietic Stem ... Macrophages. -. dc.subject.mesh. Models, Biological. -. dc.subject.mesh. Protein Engineering. -. dc.subject.mesh. Tumor ... Suicide gene therapy: possible applications in haematopoietic disorders.Authors: Dilber MS, Gahrton G. Issue date: 2001 Apr ... Gene therapy with drug resistance genes.Authors: Zaboikin M, Srinivasakumar N, Schuening F. Issue date: 2006 Apr ...
  http://christie.openrepository.com/christie/handle/10541/78371
*  Development of Vaccines against Visceral Leishmaniasis
Drug-sensitive Leishmania mutants containing suicide genes [139-141] are also being developed for use during leishmanization, ... L. Beattie, K. J. Evans, P. M. Kaye, and D. F. Smith, "Transgenic Leishmania and the immune response to infection," Parasite ... Y. F. Vanloubbeeck, A. E. Ramer, F. Jie, and D. E. Jones, "CD4+ Th1 cells induced by dendritic cell-based immunotherapy in mice ... Host resistance to Leishmania infection is mediated by cellular immune responses leading to macrophage activation and parasite ...
  https://www.hindawi.com/journals/jtm/2012/892817/
*  Ending aging
Death-resistant cells ,- Suicide genes, immune stimulation. Routinely performed with mice in the lab but too dangerous for ... by encouraging phagocytosis is the engulfing of a solid particle, such as a bacteria, by a eucaryotic cell such as a macrophage ... Intracellular junk ,- transgenic microbial hydrolases,. *Extracellular junk ,- Phagocytosis by immune stimulation. Amyloid can ... Cell loss ,- Stem cell therapy (Parkinson's disease corresponds to the breakdown of certain interneurons in the brain. It is ...
  http://robsstrategystudio.org/awfcpisea.htm
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell ... Cellular Biology, Issue 96, Anastasis, apoptosis, apoptotic bodies, caspase, cell death, cell shrinkage, cell suicide, ... It effectively transduces naive mouse T cells if they express a transgenic Coxsackie adenovirus receptor (CAR). Importantly, ... A human hepatoma cell line (Huh-7 based) was used for transfection of in vitro transcribed HCV genomic RNAs. Cell-free culture ...
  https://www.jove.com/visualize/abstract/25993287/hepatitis-b-virus-x-protein-sensitizes-trail-induced-hepatocyte
*  Overview of gene therapy clinical progress including cancer treatment with gene-modified T cells
Transfer of specificity by murine alpha and beta T-cell receptor genes. Nature. 1986;320:232-238. [PubMed] ... administration of GCV to treat CMV would produce cell suicide irrespective of need. Finally, Tk/GCV may have limited ability to ... Preclinical studies have shown that infusion of αβ TCR transgenic T cells can eradicate tumors in vivo.20,21 Recently, Morgan ... granulocyte-macrophage colony stimulating factor [GM-CSF] or IL125: or (3) to express transgenes which directly or indirectly ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2929387/
*  Table of Contents | Blood Journal
Autocrine cell suicide in a Burkitt lymphoma cell line (Daudi) induced by interferon α: involvement of tumor necrosis factor as ... Identical mutations in RAG1 or RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B-severe combined ... Down-regulation of interleukin-3/granulocyte-macrophage colony-stimulating factor receptor β-chain in BCR-ABL+human leukemic ... in vivo studies in human glycophorin A transgenic mice Isabelle Auffray, Shirin Marfatia, Kitty de Jong, Gloria Lee, Cheng-Han ...
  http://www.bloodjournal.org/content/97/9?sso-checked=true
*  Shu-Hsia Chen, PhD | Houston Methodist
Program 2. Identify novel immune checkpoints, reprogram of myeloid cell/macrophage function and stress signaling to develop ... Using our newly developed immune checkpoints, nanotechnology, and T cell therapy, we can improve tumor targeting and reduce ... Program 4. The MDSC and macrophage mediated immune regulation in human health Program 5. Synergist effect of innate and ... T cell therapy, and antibody-based novel immune checkpoint therapies. This will help researchers and clinicians integrate ...
  http://www.houstonmethodist.org/faculty/shuhsia-chen/
*  Oncolytic virus - Wikipedia
Freeman, SM; Whartenby, KA; Freeman, JL; Abboud, CN; Marrogi, AJ (1996). "In situ use of suicide genes for cancer therapy". ... a type of white blood cell). Macrophages automatically migrate to areas of tissue destruction, especially where oxygen levels ... With Transgenic MAGE-A3 Insertion in Patients With Incurable MAGE-A3-Expressing Solid Tumours (I214) Kuhn I, Harden P, Bauzon M ... Viruses can be used as vectors for delivery of suicide genes, encoding enzymes that can metabolise a separately administered ...
  https://en.wikipedia.org/wiki/Oncolytic_virus
*  Patent US6783977 - Internal ribosome entry site and vector containing same - Google Patents
The invention also concerns a vector comprising said nucleotide sequence, a viral particle generated from this vector, a cell ... It may be a primary or tumor cell of hematopoietic origin (totipotent stem cell, leucocyte, lymphocyte, monocyte, macrophage ... the production of transgenic animals which have integrated into their genome a cassette for the expression of one or more genes ... a product of expression of a suicide gene such as thymidine kinase of the HSV virus (herpesvirus) type I, that of the fur1 and/ ...
  http://www.google.ca/patents/US6783977
*  Type I Interferons: Key Players in Normal Skin and Select Cutaneous Malignancies
Further, tissue samples from neither human nor transgenic mouse squamous cell carcinomas expressed significant levels of IFN-β ... This concomitant expression of CD95L and CD95 eventually led to cell death by suicide and fratricide, with the majority of ... α in all cell lines. The genes for IFN-α and IFN-β are localized to chromosome 9p, and the antiproliferative effect of IFN-α ... In the presence of IFN-α and granulocyte/macrophage colony-stimulating factor (GM-CSF), monocytes differentiate into dendritic ...
  https://www.hindawi.com/journals/drp/2014/847545/
*  October 2014 - Fight Aging!
The approach allows scientists to activate genes in specific cells, by giving a dose of a drug that triggers the cell to "read ... "When we did that, we found that the macrophages from the bone marrow did not come in. And the macrophages native to the heart ... All wild-type and GH transgenic mice lived longer when fed 0.16% methionine but not when fed higher levels. In contrast, ... Senescent cells also develop resistance to signals for apoptosis (cellular suicide) and secrete inflammatory signaling ...
  https://www.fightaging.org/archives/2014/10/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
T cells from the FVBN202 transgenic mouse model of HER-2/neu positive breast carcinoma for use in adoptive T cell therapy of ... Both human and mouse TCR genes can be used. Retroviruses carrying specific TCR genes are generated and used to infect mouse T- ... Intra-vital two-photon microscopy enables the study of macrophages and microglia in the spinal cord lesion in the living animal ... piggyBac to be efficient in genetic modification of human T cells with a reporter gene and a non-immunogenic inducible suicide ...
  https://www.jove.com/visualize/abstract/23441216/co-introduced-functional-ccr2-potentiates-vivo-anti-lung-cancer
*  IJMS | Free Full-Text | Oxidative Stress in Malaria | HTML
... platelet endothelial cell adhesion molecule (PECAM), vascular cell adhesion molecule (VECAM), hyaluronic acid, heparin sulfate ... ROS generated by macrophages are known as non-specific effectors molecules in the host's defense arsenal, which can contribute ... Other studies have correlated the incidence of malaria to changes in the promoters of genes encoding the enzymes iNOS and G6PD ... Pino, P.; Taoufiq, Z.; Nitcheu, J.; Vouldoukis, I.; Mazier, D. Blood-brain barrier breakdown during cerebral malaria: Suicide ...
  http://www.mdpi.com/1422-0067/13/12/16346/htm
*  Frontiers | Impact of Enriched Environment on Murine T Cell Differentiation and Gene Expression Profile | Immunology
Our study shows that exposure to two weeks in an enriched environment does not impact the T cell repertoire in vivo and causes ... Together our results provide first evidence for a specific effect of enriched environment on T cell differentiation and its ... Together our results provide first evidence for a specific effect of enriched environment on T cell differentiation and its ... Surprisingly, however, T cells from enriched mice showed a unique T helper effector-cell phenotype upon differentiation in ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00381/full
*  Protocols and Video Articles Authored by Stephen H. Tsang
The functions of these genes were highly related to cell proliferation, nervous system development and cell adhesion. HESC can ... This transgenic line was crossed with Pde6g(tm1)/Pde6g(tm1) mice to generate animals able to synthesize only the transgenic ... By crossing rd7 mice (a model for hereditary retinal degeneration owing to Nr2e3 mutation) with mice carrying the macrophage ... Microglial cells in these double-mutant mice express enhanced green fluorescent protein (EGFP) and a suicide gene that can ...
  https://www.jove.com/author/Stephen++H._Tsang
*  Patent US7910370 - Methods of using BCL-2 for the therapeutic treatment and prevention of diseases - Google Patents
Methods to identify compounds that alter apoptotic cell death and to enhance monoclonal antibody production are also provided ... The invention provides a method of treating a disease or pathological condition resulting in apoptotic cell death. The method ... with the idea of simultaneously providing genes for enhancement of cell survival (Bcl-2) and cell function (dopamine-β- ... In vivo cell lysis never occurs because the apoptotic cells are usually phagocytosed by macrophages and related cells before ...
  http://www.google.com/patents/US7910370?dq=6650327
*  Presentation History
Cell 136, 1044-1055.. *10/11/11 - Bridget Lins presented Duplantis, B.N.et al. (2010) Essential genes from Artic bacteria used ... Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages. Cell ... 11/13/12 - Lin-Ya Huang presented Wather, W. et al. (2012) Novel Clostridium perfringens enterotoxin suicide gene therapy for ... 1/31/12 - Fran Tondnevis presented Stöhr, J.et al. (2011) Spontaneous generation of anchorless prions in transgenic mice. PNAS ...
  http://biochem.med.ufl.edu/events/biochemistry-and-molecular-biology-journal-club/presentation-history/
*  FENS Forum 2004 - Abstracts
1) Dept Anat & Cell Biology, Coll Med, NTU, Taipei, Taiwan; (2) Dept Biol & Anat, NDMC, Taipei, Taiwan. - RESPONSES OF ... IMPAIRED DECISION-MAKING IN SUICIDE ATTEMPTERS.. A049.7. Poster 218 - Sun 11/07, 16:00 - Hall I. Jones D. M., Dobrossy M. D. & ... BRAIN ACETYLCHOLINESTERASE ACTIVITY IN TRANSGENIC MICE EXPRESSING THE PS1-A246E MUTATION.. A011.9. Poster 137 - Sun 11/07, 12: ... ANALYSING THE TEMPORAL CHANGES IN THE EXPRESSION OF DEVELOPMENTALLY REGULATED GENES IN STRIATAL PRECURSORS.. A149.3. Poster 84 ...
  http://fens2004.neurosciences.asso.fr/posters/Let/LetJ.html
*  Protocols and Video Articles Authored by Brian Peterson (Translated to Korean)
This live cell-based automated microscopy assay is very robust and allows simultaneous detection of cell permeable, non-toxic ... Expression of the seven candidate reference genes varied across all tissue types tested, indicating that none of the genes ... Two Cases of Firearm Grip Impressions on the Hands of Suicide Victims The American Journal of Forensic Medicine and Pathology. ... and in transgenic carrot cells (prGCD) have been previously solved. We now describe the structure and characteristics of a ...
  https://www.jove.com/author/Brian_Peterson?language=Korean
*  Neuroimmune Biomarkers in Mental Illness | Springer for Research & Development
Tsai S-Y, Chen K-P, Yang Y-Y, Chen C-C, Lee J-C, Singh VK, Leu S-JC (1999) Activation of indices of cell-mediated immunity in ... Smith RS (1991) The macrophage theory of depression. Med Hypotheses 35:298-306PubMedCrossRefGoogle Scholar ... Arion D, Unger T, Lewis DA, Levitt P, Mirnics K (2007) Molecular evidence for increased expression of genes related to immune ... Sockalingam S, Links P, Abbey S (2011) Suicide risk in hepatitis C and during interferon-alpha therapy: a review and clinical ...
  https://rd.springer.com/chapter/10.1007/7854_2018_45
*  Protein Kinase C ε Is an Endogenous Photosensitizer That Enhances Ultraviolet Radiation-Induced Cutaneous Damage and...
Analysis of Proliferating Cell Nuclear Antigen-Positive Cells and Epidermal Thickness.. PKCε transgenic mice and their wild- ... UVR has been reported to alter the expression of genes regulating inflammation, cell growth and differentiation, and ... a suicide inhibitor of ODC, completely prevented the UVR-induced development of skin tumors in SKH mice (42) . Also, TNFα ... and granulocyte macrophage colony-stimulating factor. The role of TNFα in UVR-induced cutaneous damage was evaluated using PKCε ...
  http://cancerres.aacrjournals.org/content/64/21/7756
*  Table of Contents | Blood Journal
Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes Ivan ... Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid ... Enhanced tumorigenesis in HTLV-1 Tax-transgenic mice deficient in interferon-gamma Shibani Mitra-Kaushik, John Harding, Jay ... Evidence for increased risk of secondary graft failure after in vivo depletion of suicide gene-modified T lymphocytes ...
  http://www.bloodjournal.org/content/104/10?sso-checked=true
*  Vasopressin Receptors - Inhibitors of Protein Methyltransferases as Chemical Tools
... using viral delivery methods including immune modulators cell cycle regulators suicide genes anti-angiogenic genes and genes ... A) Crosses performed to produce the required transgenic mice represented by dotted rectangles. Male mice are represented by ... macrophage inflammatory protein (MIP)-1β and granulocyte monocyte colony revitalizing element (GM-CSF). This inflammatory ... The application of electric pulses to tissues causes cell membrane destabilization. Posted on May 13, 2017 10:42 pm by Alice ...
  http://bio-naturlan.com/category/vasopressin-receptors/