*  Notes from Dr. RW: Macrolides and mortality in critically ill patients with community acquired pneumonia
These results suggest that macrolides be considered first-line combination treatment in critically ill patients with community- ... Conclusions:In observational studies of almost 10,000 critically ill patients with community-acquired pneumonia, macrolide use ...
  http://doctorrw.blogspot.com/2014/08/macrolides-and-mortality-in-critically.html
*  Macrolide 2'-kinase: Definition with Macrolide 2'-kinase Pictures and Photos
Definition of Macrolide 2'-kinase with photos and pictures, translations, sample usage, and additional links for more ... macrolide. macrolide 2'-kinase. macrolide glycosyltransferase. macrolides. macrolike. macrolinguistic. macrology. macromanage. ... Medical Definition of Macrolide 2'-kinase. 1. Inducible intracellular enzyme which inactivates 14-member ring macrolides at the ... macrolide 2'-phosphotransferase, macrolide 2'-phosphotransferase I, mph(2')i (26 Jun 1999) ...
  http://www.lexic.us/definition-of/macrolide_2
*  Overview: Macrolides possess diverse natural activities and an capability to modulate - How NF-B is activated: the role of the...
183 325 In this review macrolide antibiotics are called "macrolides." The nonantimicrobial properties of macrolides were ... Erythromycin A a 14-membered macrolide was isolated more than 50 years ago from cultures of and was the first macrolide ... low-dose macrolide therapy) are effective; (iii) the effect is seen even when patients are infected with macrolide-resistant ... Overview: Macrolides possess diverse natural activities and an capability to modulate. April 24, 2017. By cancercurehere with ...
  http://cancercurehere.com/?p=2115
*  Macrolide Antibiotics - Health tips, Health care, Diseases treatment, Cancer, Blood Pressure
The Topic in which i am going to write today is a Topic on which you would have listen and read almost thousand of times because it is a ver ...
  http://health38.blogspot.com/2012/08/macrolide-antibiotics.html
*  Improving Glycosyltransferase by RACHITT Gene Shuffling | SBIR.gov
... macrolides. Moreover, we expect to generate a recombinant DesVII that has a higher enzymatic activity toward the 14-membered ... biosynthesis of novel macrolide anti-infective agents. In this proposal, a new gene shuffling technology, RACHITT, is applied ...
  https://www.sbir.gov/sbirsearch/detail/69495
*  Macrolides - MP Biomedicals
Erythromycin is a macrolide antibiotic that bind to the 50S ribosomal subunit and inhibit protein synthesis. This is an ... Erythromycin is a macrolide antibiotic that bind to the 50S ribosomal subunit and inhibit protein synthesis. This is an ... Kitasamycin is a macrolide antibiotic produced by Streptomyces kitasatoensis. The drug has antimicrobial activity against a ...
  http://www.mpbio.com/index.php?cPath=1_6_30_206&country=223
*  Macrolides Blunt Aldosterone BiosynthesisNovelty and Significance | Hypertension
Macrolides Blunt Aldosterone BiosynthesisNovelty and Significance. A Proof-of-Concept Study in KCNJ5 Mutated Adenoma Cells Ex ... Macrolides Blunt Aldosterone BiosynthesisNovelty and Significance. Brasilina Caroccia, Selene Prisco, Teresa Maria Seccia, ... Macrolides Blunt Aldosterone BiosynthesisNovelty and Significance. Brasilina Caroccia, Selene Prisco, Teresa Maria Seccia, ... Because KCNJ5 mutated channels were reported to be specifically sensitive to inhibition by macrolide antibiotics, which ...
  http://hyper.ahajournals.org/content/70/6/1238
*  Erythromycin and related macrolides for gastroparesis | Cochrane
Erythromycin and related macrolides for gastroparesis. To assess the effects of erythromycin (including derivatives) for ... To compare erythromycin (or other macrolide or its derivatives) versus control (no treatment, placebo, prokinetic, antiemetic ... Erythromycin and related macrolides for gastroparesis. Cochrane Database of Systematic Reviews 2016, Issue 4. Art. No.: ... Treatment with macrolide antibiotics for people with cystic fibrosis and chronic chest infection ...
  http://www.cochrane.org/CD012154/UPPERGI_erythromycin-and-related-macrolides-gastroparesis
*  Study raises concerns over macrolides in CHD patients | News Article | Pulse Today
It follows research first reported by Pulse in September last year finding macrolides were associated with an increased risk of ... We need to exercise some care on prescribing macrolides.'. The Medicines and Healthcare Products Regulatory Agency said: 'These ... A new study raises concerns over use of macrolide antibiotics in patients with coronary heart disease - after finding ... It does create a question-mark over our use of macrolides in patients with CVD. ...
  http://www.pulsetoday.co.uk/study-raises-concerns-over-macrolides-in-chd-patients/10921830.article
*  Pathogen- and Host-Directed Anti-Inflammatory Activities of Macrolide Antibiotics
to a range of macrolides and macrolide-like agents resulted in significant attenuation of the production of pneumolysin, while ... This includes a number of in vitro studies which have demonstrated the inhibitory effects of macrolides and macrolide-like ... M. J. Schultz, "Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and crystic ... Y. Fukuda, K. Yanagihara, Y. Higashiyama et al., "Effects of macrolides on pneumolysin of macrolide-resistant Streptococcus ...
  https://www.hindawi.com/journals/mi/2012/584262/
*  JCI - Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma
Macrolides are potent inhibitors of KCNJ5MUT, but not KCNJ5WT. Macrolides feature a many-membered lactone ring with one or more ... Eight macrolides or macrolide derivatives tested had no significant effect on KCNJ5WT channels; several of these, including ... Further exploration of macrolides showed that KCNJ5MUT was similarly selectively inhibited by idremcinal, a macrolide motilin ... Synthesis of macrolide derivatives without antibiotic or motilide activity. The use of macrolide antibiotics is associated with ...
  https://www.jci.org/articles/view/91733
*  Statin-macrolide combination 'doubles risk of kidney injury' | News Article | Pulse Today
GPs should avoid prescribing macrolide antibiotics with statins 'where possible' as the combination doubles the risk of acute ... The risk of all-cause mortality was also one and a half times higher in the statin/macrolide patients, compard with those ... The Canadian researchers found the risk of all-cause mortality was one and a half times higher in patients taking macrolides ... They also found a greater risk of acute kidney injury, with 0.46% of patients taking statins and macrolides diagnosed with the ...
  http://www.pulsetoday.co.uk/clinical/prescribing/statin-macrolide-combination-doubles-risk-of-kidney-injury/20003333.article
*  macA - Macrolide export protein MacA - Escherichia coli (strain K12) - macA gene & protein
When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak ... increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC. ... Macrolide export protein MacAAdd BLAST. 371. Proteomic databases. PaxDb, a database of protein abundance averages across all ... "Novel macrolide-specific ABC-type efflux transporter in Escherichia coli.". Kobayashi N., Nishino K., Yamaguchi A.. J. ...
  http://www.uniprot.org/uniprot/P75830
*  Repetitive use of antibiotic macrolide increases long-lasting obesity and asthma - WUR
The use of the antibiotic macrolide in two to seven years old Finnish children is associated with a long-lasting shift in their ... Repetitive use of antibiotic macrolide increases long-lasting obesity and asthma. Gepubliceerd op. 26 januari 2016 The use of ... Finally, the researchers found that the use of macrolides was associated with a decreased level of bile salt hydrolase, en ... Remarkably, a similar strong effect of macrolide but not the other antibiotics, was detected on the intestinal microbiota. In ...
  https://www.wur.nl/nl/nieuws/Repetitive-use-of-antibiotic-macrolide-increases-long-lasting-obesity-and-asthma.htm
*  A Case of Macrolide-Refractory Mycoplasma pneumoniae Pneumonia in Pregnancy Treated with Garenoxacin
... Yoko Matsuda,1 Yoshitsugu ... Yoko Matsuda, Yoshitsugu Chigusa, Eiji Kondoh, Isao Ito, Yusuke Ueda, and Masaki Mandai, "A Case of Macrolide-Refractory ...
  https://www.hindawi.com/journals/criog/2017/3520192/cta/
*  Macrolides, quinolones and amoxicillin/clavulanate for chronic bronchitis: a meta-analysis | European Respiratory Society
A/C versus macrolides (1.70 (0.72-4.03)), 0.01-1.00 favours macrolides and 1.00-75.66 favours A/C. d) Macrolides versus ... In both trials macrolides were compared with quinolones. In one RCT 25 a total of 48% (122 out of 254) of macrolide-treated ... Thus, 19 RCTs that compared macrolides with quinolones (n = 8) 24-31 and A/C with quinolones (n = 4) 24, 32-34 or macrolides (n ... study the role of macrolides in comparison with quinolones or the role of A/C in comparison with macrolides or quinolones for ...
  http://erj.ersjournals.com/content/29/6/1127
*  Clinical Application of Development of Nonantibiotic Macrolides That Correct Inflammation-Driven Immune Dysfunction in...
3.2.4. New Macrolides and Their Applications. A new synthetic azythromycin-derivative-macrolide, called CSY0073 [92], has anti- ... The activity of these compounds stems from the presence of a macrolide ring. Macrolide rings are comprised of a large ... These newer macrolides arrest the G1 to S transition, an important early event in the control of mammalian cell growth and ... Another widely used macrolide is rapamycin, also known as sirolimus (Figure 8) [9]. Rapamycin acts through the inhibition of ...
  https://www.hindawi.com/journals/mi/2012/563709/
*  Clinical Application of Development of Nonantibiotic Macrolides That Correct Inflammation-Driven Immune Dysfunction in...
Nonantibiotic macrolides have anti-inflammatory and/or immunomodulatory activity that suggests the exploitation of these in the ... We also reviewed new macrolides, like rapamycin, everolimus, and temsirolimus. In addition to the literature review, we report ... We performed an extensive review of the nonantibiotic macrolide literature published between 2005 and 2012, including cross- ... Clinical Application of Development of Nonantibiotic Macrolides That Correct Inflammation-Driven Immune Dysfunction in ...
  https://www.hindawi.com/journals/mi/2012/563709/abs/
*  New insights into polyene macrolide biosynthesis in Couchioplanes caeruleus - Molecular BioSystems (RSC Publishing)
... an aromatic heptaene macrolide that contains a mannosyl-mycosaminyl disaccharide. An improved draft genome sequence was used to ... New insights into polyene macrolide biosynthesis in Couchioplanes caeruleus J. Sheehan, C. D. Murphy and P. Caffrey, Mol. ... Couchioplanes caeruleus DSM43634 synthesises 67-121C, an aromatic heptaene macrolide that contains a mannosyl-mycosaminyl ...
  http://pubs.rsc.org/en/content/articlelanding/2017/mb/c7mb00112f
*  CiNii 論文 - Synthesis and In Vitro antimicrobial Activity of 3-Keto 16-Membered Macrolides...
Synthesis and In Vitro antimicrobial Activity of 3-Keto 16-Membered Macrolides Derived From Tylosin * * CREEMER Lawrence C. ... Mycinamicins, new macrolide antibiotics. VII. Structures of minor components, mycinamicin VI and VII HAYASHI M. ... Mycinamicins, new macrolide antibiotics. XI. Isolation and structure elucidation of a key intermediate in the biosynthesis of ... Syntheses of recyclized macrolide antibiotics and related derivatives from mycaminosyltylonolide. Tanaka Akihiro , Watanabe ...
  https://ci.nii.ac.jp/naid/10008472629
*  CiNii 論文 - Genetic Analysis of Biosynthesis of Polyketide Anthelmintic Macrolide Avermectin...
Genetic Analysis of Biosynthesis of Polyketide Anthelmintic Macrolide Avermectin in Streptomyces avermitilis * * Ikeda Haruo ... A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae : architecture of metabolic diversity XUE Y. ... Milbemycins, a new family of macrolide antibiotics : Fermentation, isolation and physico-chemical properties TAKIGUCHI Y. ... Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin Streptomyces avermitils., ...
  http://ci.nii.ac.jp/naid/10008263532
*  Macrolide - Wikipedia
Some macrolides are also known to cause cholestasis. Macrolides should not be taken with colchicine as it may lead to ... Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or antifungal activity and are ... Macrolides are protein synthesis inhibitors. The mechanism of action of macrolides is inhibition of bacterial protein ... Cruentaren is another example of an antifungal macrolide. A variety of toxic macrolides produced by bacteria have been isolated ...
  https://en.wikipedia.org/wiki/Macrolide