Studies on the role of lymphocyte function-associated antigen 1 (LFA-1) in T cell activation. - Semantic Scholar
... antibodies against lymphocyte function-associated antigen 1 (LFA-1) on T cell activation was studied. When added at the ... The results suggest that the LFA-1 antibodies block an early step in the reactions necessary for IL-2 production, and that the ... Addition of external IL-2 at the beginning of the anti-LFA-1 containing culture prevented the inhibition of IL-2 receptor ... The polyclonal and monoclonal anti-LFA-1 antibodies also inhibited phorbol ester (PMA)-dependent OKT3 activation of highly ...https://www.semanticscholar.org/paper/Studies-on-the-role-of-lymphocyte-function-associa-Berzins-Axelsson/b8017b5ec1ebdfc792aafe7b250f6750c7e85fbf
The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)...
To study the adhesive properties of the LFA-1 I domain, we stably expressed a GPI-anchored form of this I domain (I-GPI) on the ... I-GPI cells bound soluble ICAM-1 (sICAM-1) with a low avidity and affinity. Flow cell experiments demonstrated a specific ... The I domain of lymphocyte function-associated antigen (LFA)-1 contains an intercellular adhesion molecule (ICAM)-1 and ICAM-3 ... The LFA-1 activating antibody MEM-83, or its Fab fragment, decreased the rolling velocity of I-GPI cells on ICAM-1-containing ...https://www.ndorms.ox.ac.uk/publications/482676
Lifitegrast | CAS 1025967-78-5 | AbMole BioScience | Lifitegrast Price
Lifitegrast is an integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist; inhibits Jurkat T cell attachment to ... ICAM-1 with an IC50 of 2.98 nM. Buy Integrin inhibitor Lifitegrast from AbMole BioScience. ... lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses ... Lifitegrast strongly inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. In vivo: Lifitegrast, has potent anti ...http://www.abmole.com/products/lifitegrast.html
Intercellular adhesion molecule-1 dimerization and its consequences for adhesion mediated by lymphocyte function associated-1. ...
... is a ligand for the integrins lymphocyte function associated-1 (LFA-1, CD11a/CD18) and complement receptor-3 (Mac-1, CD11b/CD18 ... Soluble ICAM-1 dimers bind to solid-phase purified LFA-1 with high avidity (dissociation constant [Kd] = 8 nM) in contrast to ... Cell surface ICAM-1 was found to be dimeric based on two distinct criteria. First, a monoclonal antibody specific for monomeric ... Cell surface ICAM-1 dimers are more potent ligands for LFA-1-dependent adhesion than ICAM-1 monomers. While many extracellular ...https://www.kennedy.ox.ac.uk/publications/482684
CD11a - Wikipedia
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is ... antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)". Lu C, Takagi J, Springer TA (May 2001). " ... CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1. Efalizumab acts as an ... to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a ...https://en.wikipedia.org/wiki/CD11a
Lymphocyte function-associated antigen 1 - Wikipedia
Lymphocyte function-associated antigen 1 (LFA-1) is found on all T-cells and also on B-cells, macrophages, neutrophils and NK ... "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte- ... LFA-1 is part of the family of leukocyte integrins that are recognised by their common β-chains (β2, CD18). LFA-1 also has a ... LFA-1 is the first to bind T-cells to antigen-presenting cells and initially binds weakly. A signal from the T-cell receptor ...https://en.wikipedia.org/wiki/Lymphocyte_function-associated_antigen_1
Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin...
lymphocyte function-associated antigen;. VCAM,. vascular cell adhesion molecule;. IgSF,. Ig superfamily;. MAdCAM,. mucosal ... Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin ... Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin ... Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin ...http://www.pnas.org/content/96/6/3017
A monoclonal antibody against lymphocyte function-associated antigen-1 decreases HIV-1 replication by inducing the secretion of...
Background: Lymphocyte Function-Associated Antigen-1 (LFA-1) likely plays a role in the pathogenesis of against HIV-1 and is ... A monoclonal antibody against lymphocyte function-associated antigen-1 decreases HIV-1 replication by inducing the secretion of ... A monoclonal antibody against lymphocyte function-associated antigen-1 decreases HIV-1 replication by inducing the secretion of ... A monoclonal antibody against lymphocyte function-associated antigen-1 decreases HIV-1 replication by inducing the secretion of ...https://dash.harvard.edu/handle/1/11177952
Shedding of lymphocyte function-associated antigen-1 (LFA-1) in a human inflammatory response. - Oxford Clinical Trials...
Here, we describe shedding of the integrin lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18) from human leukocytes ... but expression on lymphocytes remained unchanged. A capture enzyme-linked immunosorbent assay (ELISA) indicated that LFA-1 was ... However, LFA-1 was shed in a ligand-binding conformation, since it expressed KIM-127 and 24 activation epitopes and bound to ... Expression of LFA-1 was significantly diminished on blister-infiltrated neutrophils (P , .001) and monocytes (P = .02) compared ...https://www.octru.ox.ac.uk/publications/226496
Analysis of the Binding Site on Intercellular Adhesion Molecule 3 for the Leukocyte Integrin Lymphocyte Function-associated...
... of the Binding Site on Intercellular Adhesion Molecule 3 for the Leukocyte Integrin Lymphocyte Function-associated Antigen 1 ... of the Binding Site on Intercellular Adhesion Molecule 3 for the Leukocyte Integrin Lymphocyte Function-associated Antigen 1 ...https://www.ndorms.ox.ac.uk/publications/728154
Expression of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-3 on human thyroid epithelial cells...
... and lymphocyte function-associated antigen-3 (LFA-3) with CD2, it was of interest to determine whether TEC can express the ... such as lymphocyte function-associated antigen-1 (LFA-1) with intercellular adhesion molecule-1 (ICAM-1) ... Since the initiation of a specific immune response also involves antigen-receptor independent interactions between accessory ... which augment the efficiency of antigen presentation. Cultured TEC were studied for their expression of ICAM-1 and LFA-3 by ...https://www.kennedy.ox.ac.uk/publications/481745
CiteSeerX - Citation Query A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the...
The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol by Michael L ... The corresponding endosomal fractions were immunoisolated using the cytoplasmic domain of the G protein as antigen. These ... Abstract - Cited by 94 (1 self) - Add to MetaCart In the studies reported here we have examined the role of the medial ... Endothelial cell ICAM-1 was a single band of 90 kD in SDS-PAGE. Purified endothelial cell ICAM-1 reconstituted into liposomes ...http://citeseerx.ist.psu.edu/showciting?cid=239401
Immune physiologic D/C Flashcards by Lorne Runge | Brainscape
Lymphocyte function-associated antigen 1 is a heterodimer integrin CD11a (integrin alpha L, p189) and CD18 (integrin beta-2). ... Lymphocyte function-associated antigen 1 is a heterodimer integrin CD11a (integrin alpha L, p189) and CD18 (integrin beta-2). ... 2.The beta chain of the T cell receptor must recognize the antigen in the MHC class 2 groove and CD4 must associate with the T ... Citrulline modified auto antigens include filaggrin, fibrin, vimentin, collagen, and alpha enolase. Filaggrin is a protein in ...https://www.brainscape.com/flashcards/immune-physiologic-d-c-2484247/packs/4392200
Category:Immunology - Wikimedia Commons
Lymphocyte function-associated antigen-1 (28 t.t.). M. *. ► Media from BMC Immunology (18 t.t.) ... Schematic diagram depicting polyclonal response by B lymphocytes.JPG 600×750; 57 kB. ... antigen; 2 - IgE; 3 - FcεRI receptor; 4 - medijatori (histamin, proteaze, hemokini, heparin); 5 - granule; 6 - mastocit; 7 - ... Table showing mortality of smallpox from 1721-9 Wellcome M0010784.jpg 2.492×4.226; 1,18 MB. ...https://commons.wikimedia.org/wiki/Category:Immunology?uselang=vi
Vaccine Therapy Plus QS21 in Treating Patients With Progressive Prostate Cancer
CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. Lymphocyte function-associated ... Lymphocyte Function-associated Antigen-1. An integrin heterodimer widely expressed on cells of hematopoietic origin. ... Thomsen-Friedenreich antigen (TA) is present on erythrocytes, platelets and glomeruli, and it can be activated du... ... Immune response to the hepatitis B antigen in the RTS,S/AS01 malaria vaccine, and co-administration with pneumococcal conjugate ...https://www.bioportfolio.com/resources/trial/125921/Vaccine-Therapy-Plus-QS21-in-Treating-Patients-With-Progressive-Prostate-Cancer.html
Anti-CD18 antibody (PerCP) [GRF1] | Abcam
Lymphocyte function associated antigen 1 (LFA1) antibody. *Lymphocyte function associated antigen 1 antibody ... Function. Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 ... patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions ... Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:116920]. LAD1 ...http://www.abcam.com/cd18-antibody-grf1-percp-ab91154.html
Anti-CD18 antibody [MEM-48] (Biotin) (ab28093) | Abcam
Cited in 1 publication(s). Immunogen corresponding to tissue, cells or virus. ... Lymphocyte function associated antigen 1 (LFA1) antibody. *Lymphocyte function associated antigen 1 antibody ... Function. Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 ... Ab28093 reacts with an epitope located in the region encoded by aa 534-546 in cysteine rich repeat 3 of the CD18 antigen. ...https://www.abcam.com/cd18-antibody-mem-48-biotin-ab28093.html
Immunopathogenesis of psoriasis - Sabat - 2007 - Experimental Dermatology - Wiley Online Library
Dependence on lymphocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. J Immunol 1993: 150: 2148 ... and lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18; αL:β2) (T cells) and (ii) the interactions between lymphocyte ... Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 1997: 389: 978-981. * ... Baker B S, Bokth S, Powles A et al. Group A streptococcal antigen-specific T lymphocytes in guttate psoriatic lesions. Br J ...http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2007.00629.x/full
Monoclonal antibody therapy for non-malignant disease | Australian Prescriber
Advances in technology have enabled monoclonal antibodies to be produced which bind to specific antigens associated with ... Efalizumab is a monoclonal antibody that targets part of the lymphocyte function-associated antigen-1 (LFA-1) on T cells. This ... By targeting these antigens the antibodies can destroy or alter the function of cells which express the target. They may also ... These activated lymphocytes have antigens called integrins on their surface. Natalizumab, a humanised monoclonal antibody ...https://www.nps.org.au/australian-prescriber/articles/monoclonal-antibody-therapy-for-non-malignant-disease
Molecular regulation of T-cell anergy. - Semantic Scholar
... and the E3 ubiquitin ligases known as gene related to anergy in lymphocytes (GRAIL) and Casitas B-cell lymphoma-b (Cbl-b). A ... which is a hyporesponsive state that occurs when T cells are activated through the T-cell antigen receptor in the absence of ... which phosphorylate diacylglycerol and restrict Ras guanyl releasing protein 1 (RasGRP1)-dependent activation of Ras. Increased ... The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. *Adam Mor, ...https://www.semanticscholar.org/paper/Molecular-regulation-of-T-cell-anergy.-Zheng-Zha/01409cb5019396d83a8f81a4c4c72c1897a5f172
TCA-4 is presented on the luminal surface of wild-type, | Open-i
... triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high ... triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high ... firm adhesion of T cells requires rapid upregulation of lymphocyte function-associated antigen 1 (LFA-1) adhesiveness by a ... firm adhesion of T cells requires rapid upregulation of lymphocyte function-associated antigen 1 (LFA-1) adhesiveness by a ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195804_JEM990903.f2c&req=4
November 2017 - LIFITEGRAST generic entry, pharmaceutical patent expiry and freedom to operate
Lymphocyte Function-Associated Antigen-1 Antagonist Mechanism of Action. Lymphocyte Function-Associated Antigen-1 Antagonists ...https://www.drugpatentwatch.com/p/generic-api/LIFITEGRAST
Xiidra / lifitegrast FDA New drug application 208073 international drug patent coverage, generic alternatives and manufacturers
Lymphocyte Function-Associated Antigen-1 Antagonists Suppliers and Packaging for NDA: 208073. ...https://www.drugpatentwatch.com/p/NDA/208073