Neck, Cervical Metastases, Detection: Overview, Anatomy of the Cervical Lymphatics, Classification of Cervical Node Groups
Cervical metastasis by a tumor is firm statement of its aggressive malignant nature. Nothing is more controversial than the ... In such cases, rerouting is possible, with metastases arising in unusual sites. Metastases have also been shown to skip first- ... encoded search term (Neck%2C Cervical Metastases%2C Detection) and Neck, Cervical Metastases, Detection What to Read Next on ... Evaluation of the Neck for Cervical Metastases: Physical Examination. Evaluating neck metastases based on physical examination ...
Loop | Publication Impact | Dissecting the Lymphatic System to Predict Melanoma Metastasis
Changes in the tumor microenvironment during lymphatic metastasis of lung squamous cell carcinoma<...
Changes in the tumor microenvironment during lymphatic metastasis of lung squamous cell carcinoma. Cancer science. 2017 Jan 1; ... Changes in the tumor microenvironment during lymphatic metastasis of lung squamous cell carcinoma. In: Cancer science. 2017 ; ... We aimed to elucidate the microenvironmental changes in the process of lymphatic metastasis of lung squamous cell carcinoma. We ... We aimed to elucidate the microenvironmental changes in the process of lymphatic metastasis of lung squamous cell carcinoma. We ...
Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer
Lymphangiogenesis - Wikipedia
... excessive lymphatic vessel formation has been implicated in a number of pathological conditions including neoplasm metastasis, ... The role of the lymphatic system in these diseases has received renewed interest largely due to the discovery of lymphatic ... Lymphangiogenesis is the formation of lymphatic vessels from pre-existing lymphatic vessels in a method believed to be similar ... Ji, Rui-Cheng (2006). "Lymphatic Endothelial Cells, Lymphangiogenesis, and Extracellular Matrix". Lymphatic Research and ...
Lymphatics and the breast - Health Video: MedlinePlus Medical Encyclopedia
The process is called metastasis. It can lead to the formation of a secondary cancer mass in another part of the body. ... Lymphatic circulation in breast tissue helps regulate the local fluid balance as well as filter out harmful substances. But the ... Lymphatic vessels provide a highway along which invasive cancerous cells move to other parts of the body. ... That system is the lymphatic system. It runs parallel to the veins and empties into them. Lymph forms at the microscopic level ...
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis. | Trends Immunol;44(9): 724...
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis. ... Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic meta ... widespread tumor dissemination is preceded by regional metastases involving tumor-draining lymph nodes [sentinel lymph nodes ( ...
Occult metastases in the sentinel lymph nodes of patients with early stage breast carcinoma: A preliminary study
... in cases of breast carcinoma significantly underestimates lymph node metastases. This deficiency may be overcome by SS of the ... Occult metastases in the sentinel lymph nodes of patients with early stage breast carcinoma: A preliminary study Cancer. 1999 ... Results: Tumor metastases were found in 6 patients (12%) when the sentinel lymph nodes were sectioned at 2 mm intervals and ... These occult metastases have been shown to have an adverse effect on survival. Serial sectioning (SS) is impractical for all ...
Well-Differentiated villoglandular adenocarcinoma of the uterine cervix: a report of 15 cases including two with lymph node...
However, lymph node metastases of this tumor have been described in few reports. Fifte … ... Presence of lymphatic invasion and deep stromal involvement appeared to be the risk factors for lymph node metastasis of well- ... Lymphatic invasion was observed in 3 cases, two of them had pelvic lymph node metastasis. Both patients had tumors involving ... However, lymph node metastases of this tumor have been described in few reports. Fifteen cases of well-differentiated ...
JCI - Emerging roles of lymphatic endothelium in regulating adaptive immunity
A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis. Cancer Res. 2008;68(18):7293- ... Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med. ... Transport and trafficking functions of the lymphatic system. The lymphatic vessels and secondary lymphoid organs (SLOs) are ... which lack dermal lymphatic capillaries but possess intact LNs and otherwise normal lymphatic vasculature, it was shown that ...
Lymphatic metastasis is predicted by gene expression signature of the primary tumor in squamous cell carcinoma of the oral...
Prognostic value of biomarkers EpCAM and αB-crystallin associated with lymphatic metastasis in breast cancer by iTRAQ analysis ...
We have identified that EpCAM plays a role in the metastasis of breast cancer cells to the lymph node. αB-crystallin, a stress- ... Obviously, EpCAM plays a role in the metastasis of breast cancer cells to the lymph node. We further identified αB-crystallin ... Quantitative iTRAQ proteomics analysis was used to detect differentially expressed proteins between lymph node metastases and ... We identified 637 differentially regulated proteins (397 upregulated and 240 downregulated) in lymph node metastases compared ...
DataSheet 1 Near-infrared upconversion multimodal nanoparticles for targeted radionuclide therapy of breast cancer lymphatic...
Near-infrared upconversion multimodal nanoparticles for targeted radionuclide therapy of breast cancer lymphatic metastases. ... the delivery of NP-mAb through the lymphatic system allows for effective targeting and accumulation in lymphatic metastasis. ... Near-infrared upconversion multimodal nanoparticles for targeted radionuclide therapy of breast cancer lymphatic metastases. . ... Near-infrared upconversion multimodal nanoparticles for targeted radionuclide therapy of breast cancer lymphatic metastases. ...
A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis. - Radcliffe Department of...
... plasticity in cancer lymphatics and provide new insight into the processes of lymphatic invasion and lymph node metastasis. ... it is unclear whether this is a consequence of increased lymphatic vessel number, altered lymphatic vessel properties, or both ... Moreover, we show similar induction of ESAM, Endoglin, and leptin receptor within tumor lymphatics in a series of human head ... Here we have addressed the question by comparing the RNA profiles of primary lymphatic endothelial cells (LEC) isolated from ...
MicroRNA miR-107 | Cancer Genetics Web
CONCLUSIONS: These findings suggest that miR-26 and miR-125b may be associated with the progression and metastasis of HNSCC and ... MATERIALS AND METHODS: The expression of microRNAs in primary HNSCC with lymph node metastasis (n = 16) and their matched lymph ... Conclusion: MiR-107 suppresses the metastasis of colorectal cancer and could be a potential therapy target in colorectal cancer ... The influences of ESC on growth and metastasis inhibition were evaluated with xenograft tumor model of HCC. Protein expressions ...
LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C | Nature...
Here the authors profile lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs ... We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells ( ... have been associated with lymphangiogenesis and lymphatic metastasis29,30, lymphatic endothelial-specific lncRNAs have not been ... LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment. Nat. Commun. 9, 3826-18 (2018 ...
ENDOU | Cancer Genetics Web
RESULTS: Metastases acquire a higher frequency of copy number alterations with the highest in distant metastasis (median = 42, ... lymph node metastases: median = 23, primary tumors: median = 17). In lymph node metastases, gains were prevalent on chromosome ... Genes on amplified regions are involved in cancer-related pathways such as WNT-signaling, also involved in metastasis.. ... BACKGROUND: Mortality rates of pancreatic cancer remain high, which is mainly due to advanced disease and metastasis. We ...
A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis. - MRC Weatherall Institute of...
... plasticity in cancer lymphatics and provide new insight into the processes of lymphatic invasion and lymph node metastasis. ... it is unclear whether this is a consequence of increased lymphatic vessel number, altered lymphatic vessel properties, or both ... Moreover, we show similar induction of ESAM, Endoglin, and leptin receptor within tumor lymphatics in a series of human head ... Here we have addressed the question by comparing the RNA profiles of primary lymphatic endothelial cells (LEC) isolated from ...
Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting...
Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting ... Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting ... Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting ...
Metastasis-associated lung adenocarcinoma transcript 1 molecular mechanisms in gastric cancer progression
Metastasis. Zhu et al[33]. 30 GC, 30 NTAT. Tissue. Vascular invasion, Lymphatic invasion. Esfandi et al[30]. ... gastric cancer patients with distant metastasis; CG/NDM: gastric cancer patients withoutmetastasis; LNM: lymph node metastasis ... Dysregulation of MALAT1 improves the expression of β-catenin and other EMT markers, promoting metastasis. Lee et al[56]. ... MALAT1 increases cell stemness via the SOX2 protein, and promotes metastasis. Xiao et al[60]. ...
Gerald L. Wolf, M.D., Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
Stereotactic Body Radiotherapy for Localized Ureter Transitional Cell Carcinoma: Three Case Reports
Two out of the three patients did not develop local recurrence or distant metastasis during the observation period. However, ... There was no evidence of lymphatic or distant metastasis. Therefore, the patient was diagnosed with ureter cancer T2N0M0. The ... A CT scan showed the tumor at the distal ends of the left ureter with no lymphatic or distant metastasis (Figure 3(a)). ... A CT scan revealed the mass at the distal ends of the left ureter with no lymphatic or distant metastasis. Therefore, this ...
The implementation of NILS : A web-based artificial neural network decision support tool for noninvasive lymph node staging in...
artificial intelligence, breast cancer, clinical decision support, disease diagnosis, lymphatic metastasis, neural networks, ... lymphatic metastasis; neural networks; programmable calculator; sentinel lymph node}}, language = {{eng}}, publisher = {{ ... tool and facilitate the option to omit surgical axillary staging in breast cancer patients with low-risk of nodal metastasis. ... tool and facilitate the option to omit surgical axillary staging in breast cancer patients with low-risk of nodal metastasis. ...
The value of trefoil factor 3 expression in predicting the long‑term outcome and early recurrence of colorectal cancer
i] T, depth of cancer invasion; N, lymph node metastasis; ly, lymphatic invasion; v, vascular invasion. Bold P-values are ... including liver metastasis, lung metastasis, para-aortic lymph node metastasis and peritoneal dissemination (Table I), thus, ... i] T, depth of cancer invasion; N, lymph node metastasis; ly, lymphatic invasion; v, vascular. Bold P-values are statistically ... Lymph node metastasis was found in 73 patients (47.4%), and distant metastasis was observed in 20 patients (13.0%). ...
Thieme E-Books & E-Journals - Laryngo-Rhino-Otologie / Issue
Netzer, C; Witte Paz, H; Weigert, A; Beutner, D: Examination of lymphatic metastasis of oropharyngeal carcinomas by Phenoptics ... Jakobi, Paul Joseph; Hackenberg, S; Ehrmann-Müller, Désirée; Hagen, R: Cervical metastasis of male breast cancer * Abstract ... Seelig, C; Hackenberg, S; Hagen, R; Gehrke, T: Intraorbital metastasis from adenocarcinoma of unknown primary of the upper ... A Case Report about Prostate Cancer Metastasis in the Thyroid Gland * Abstract ...
Sister Mary Joseph Nodules: A Case Report about a Rare Location of Skin Metastasis | Case Reports in Oncology | Karger...
The umbilical region is also drained by a lymphatic system that follows the venous system. It comprises a deep network ( ... Sister Mary Joseph Nodules: A Case Report about a Rare Location of Skin Metastasis Subject Area: Oncology ... These metastases can be present at diagnosis or appear at disease recurrence, and are associated with a very poor prognosis ... Umbilical skin metastases, also known as Sister Mary Joseph nodules, are rare. They are described in 1-3% of patients with ...
KAKEN - Research Projects | Roles of prostanoids in facilitation of lymphangiogenesis and lymph node metastasis (KAKENHI...
Lymphangiogesis, the formation of lymphatic vessels from preexisting lymphatic vessels, plays an important role in homeostasis ... Journal Article] Aspirin reduces lung cancer metastasis to regional lymph nodes.2014. *. Author(s). Ogawa F., Amano H., Ito H ... Lymphatic vasculature forms a network of vessels that drain interstitial fluid from tissues and return this fluid to the blood ... Presentation] Roles of prostanoid receptor signaling in enhancement of tumor metastasis2013. *. Author(s). Ogawa F. Amano H. ...
Melanoma & Skin Cancer Surgery Program
Evaluation of an Umbilical Lesion | AAFP
Sister Josephs nodule is a lymphatic metastasis to the umbilical region. The differential diagnosis of an umbilical nodule ... Marys Hospital, was credited with making the observation of lymphatic metastases to the umbilical region in metastatic tumors ... Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol. 1993;29 ... Dubreuil A, Dompmartin A, Barjot P, Louvet S, Leroy D. Umbilical metastasis or Sister Mary Josephs nodule. Int J Dermatol. ...
Pediatric Lymph Node Disorders: Background, Anatomy, Pathophysiology
It includes lymphatic fluid, lymphatic vessels, lymph nodes, spleen, tonsils, adenoids, Peyer patches, and the thymus. ... The lymphatic system is an important component of the immune system. ... Infiltration of neoplastic cells carried to the node by lymphatic or blood circulation (metastasis) ... The lymphatic system is an important component of the immune system. It includes lymphatic fluid, lymphatic vessels, lymph ...