Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. - Radcliffe Department of Medicine
... and the presence of intratumoral lymphatic vessels have been controversial. Using a novel marker for lymphatic endothelium, ... The degree of tumor lymphangiogenesis was highly correlated with the extent of lymph node and lung metastases. These results ... the ability of tumor cells to induce the growth of lymphatic vessels (lymphangiogenesis) ... resulting in significantly enhanced metastasis to regional lymph nodes and to lungs. ...https://www.rdm.ox.ac.uk/publications/102763
High lymphatic vessel density and presence of lymphovascular invasion both predict poor prognosis in breast cancer | BMC Cancer...
The metastasis routes of breast cancer consist of local invasion, hematogenous metastasis, and lymphatic metastasis. New blood ... Lymphatic endothelial cells, tumor lymphangiogenesis and metastasis: new insights into intratumoral and peritumoral lymphatics ... were used to label the lymphatic vessels. Lymphatic vessel density was determined by counting the number of lymphatic vessels ... Lymphatic vessel was formerly considered as a passive participant in tumor metastasis and regarded mainly as a transportation ...https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3338-x
Increased Sentinel Lymph Node Lymphangiogenesis is Associated with Nonsentinel Axillary Lymph Node Involvement in Breast Cancer...
... and lymphatic ECP fraction (LECP%)-were assessed in sentinel LN metastases of 65 T1/T2 patients with breast cancer using CD34/ ... Proliferating lymphatic endothelial cells (. ) are seen lining a lymphatic vessel that is also invaded by tumor cells. C and D, ... and metastasis size in patients with metastasis in nonsentinel axillary LNs compared with patients without metastasis in ... If more than one sentinel LN was involved, the largest metastasis was selected. If the metastasis was no longer present on the ...http://clincancerres.aacrjournals.org/content/13/18/5391.long
Integrin Alpha-9 Mediates Lymphatic Valve Formation in Corneal Lymphangiogenesis | IOVS | ARVO Journals
A broad spectrum of diseases and conditions are associated with lymphatic dysfunction including inflammation, cancer metastasis ... With the discovery of several lymphatic-specific markers, such as lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) ... lymphatic vessels were identified as valves. The number of lymphatic valves per cornea was quantified and the percentage scores ... the formation of new lymphatic vessels).12-15 More recently, we have reported that corneal lymphatic vessels develop luminal ...http://iovs.arvojournals.org/article.aspx?articleid=2451423
Lymphangiogenesis, inflammation and metastasis Lymphatic endothelial cells, lymphangiogenesis, cell matrix Influence of IFN- ... The formation of lymphatic vessels from pre-existing lymphatic vessels, in a method believed to be similar to blood vessel ... The Formation of Lymphatic Vessels and Its Importance in the Setting of Malignancy ...http://www.lymphedemapeople.com/wiki/doku.php?id=glossary:lymphangiogenesis
Lymph node stromal cell - Wikipedia
Lymphatic endothelial cells (LECs) line lymphatic vessels. They express adhesion molecules, chemokine CCL21, and lymphatic ... In addition, lymph node stromal cells may produce growth factors which actively contribute to tumour cell metastasis. Malhotra ... Lymph nodes are found between lymphatic ducts and blood vessels. Afferent lymphatic vessels bring lymph fluid from the ... This is the place where blood vessels enter and leave the lymph node and lymphatic vessels leave the lymph node. Lymph vessels ...https://en.wikipedia.org/wiki/Lymph_node_stromal_cell
Tumor-associated Lymphatic Endothelial Cells Promote Lymphatic Metastasis By Highly Expressing and Secreting SEMA4C | Clinical...
... thereby promoting lymphatic metastasis. Therefore, tumor-associated lymphatic vessels can actively participate in lymphatic ... Tumor-associated Lymphatic Endothelial Cells Promote Lymphatic Metastasis By Highly Expressing and Secreting SEMA4C. Jun-Cheng ... Lymphatic vessels are classically viewed as passive conduits for metastasis. A higher lymphatic vessel density (LVD) is thought ... 3D). Because lymphatic metastasis positively correlates with tumor size (30), metastasis was analyzed when primary tumors ...http://clincancerres.aacrjournals.org/content/23/1/214
Lymphatic metastasis of breast cancer cells is associated with differential gene expression profiles that predict cancer stem...
Although lymphatic dissemination is a major route for breast cancer metastasis, there has been little work to determine what ... Lymphatic metastasis of breast cancer cells is associated with differential gene expression profiles that predict cancer stem ... Pandit, T.S., Kennette, W., MacKenzie, L., Zhang, G., Al-Katib, W., Andrews, J. ... Tuck, A.B. (2009). Lymphatic metastasis of ... low (468GFP) lymphatic metastatic ability, and related these to clinical literature on genes associated with lymphatic ...https://www.spandidos-publications.com/ijo/35/2/297
KAKEN - Research Projects | Analysis of micro and molecular mechanism of lymphatic metastasis, and development of new strategy...
In immunohistochemistry of lymphatic vessels, LS174T-NEO showed marked lymphatic invasion, in contrast to minimal lymphatic ... Analysis of micro and molecular mechanism of lymphatic metastasis, and development of new strategy targeting for tumor ... In 90% of nude mice, lymph node metastasis was established by alloic transplantation of LS174T and LS174T-NEO, which expressed ... We evaluated the ability of colorectal cancer cell lines on metastasis to lymph nodes, and metastatic (or anti-metastatic) ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390370/
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. - Radcliffe Department of Medicine
These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF- ... induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis. ... In vitro, PDGF-BB stimulated MAP kinase activity and cell motility of isolated lymphatic endothelial cells. In vivo, PDGF-BB ... Expression of PDGF-BB in murine fibrosarcoma cells induced tumor lymphangiogenesis, leading to enhanced metastasis in lymph ...https://www.rdm.ox.ac.uk/publications/102739
Analysis of risk factors for skip lymphatic metastasis and the...
Analysis of risk factors for skip lymphatic metastasis and their prognostic value in operated N2 non-small-cell lung carcinoma ... Analysis of risk factors for skip lymphatic metastasis and their prognostic value in operated N2 non-small-cell lung carcinoma. ... Skip metastasis are frequent in non-small-cell lung cancer and complete dissection of hilar and mediastinal lymph nodes should ...https://www.mysciencework.com/publication/show/analysis-risk-factors-skip-lymphatic-metastasis-prognostic-value-operated-n2-non-small-cell-lung-carcinoma-9720a14e
Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer. ...
We further addressed the biological function of VEGF-D for induction of lymphatic metastasis in a nude mouse xenograft model ... Our results suggest that VEGF-D plays a pivotal role in stimulating lymphangiogenesis and lymphatic metastasis in human ductal ... In order to better understand the mechanisms controlling lymphatic growth and lymph node metastasis in human ductal pancreatic ... with a significant increase in lymphatic vessel invasion by tumor cells and an increased rate of lymphatic metastases, as ...https://www.imm.ox.ac.uk/publications/102731
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis (vol 6, pg 333, 2004) - Radcliffe Department...
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis (vol 6, pg 333, 2004) ... PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis (vol 6, pg 333, 2004) ... PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis (vol 6, pg 333, 2004) ...https://www.rdm.ox.ac.uk/publications/102727
Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients |...
The upregulation of Hsp90-beta and annexin A1 were associated with poor post-surgical survival time and lymphatic metastasis of ... and the expression levels of the markers were significantly associated with the pathological grade and lymphatic invasion of ... The upregulation of Hsp90-beta and annexin A1 were associated with poor post-surgical survival time and lymphatic metastasis of ... Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients. ...https://jeccr.biomedcentral.com/articles/10.1186/1756-9966-31-70
Circulating Lymphatic Progenitor Cell and Lymph Node Metastasis - No Study Results Posted - ClinicalTrials.gov
Circulating Lymphatic Progenitor Cell and Lymph Node Metastasis. The safety and scientific validity of this study is the ...https://clinicaltrials.gov/ct2/show/results/NCT01268956
Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis | Cancer Discovery
Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis. Brett L Ecker, ... Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis ... Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis ... Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis ...http://cancerdiscovery.aacrjournals.org/content/early/2018/09/28/2159-8290.CD-18-0168
Liver metastasis in gastric cancer with particular reference to lymphatic advancement | Springer for Research & Development
Key words Gastric cancer Liver metastasis Lymphatic advancement Extranodal invasion Received: May 10, 2001 / Accepted: August ... Conclusion. We consider that the lymphatic system is closely related to the establishment of liver metastasis; in particular, ... In the present study, we investigated the relationship between liver metastasis and lymphatic involvement in gastric carcinoma ... Metastasis to the lymph nodes was the next most significant risk for liver metastasis. ...https://rd.springer.com/article/10.1007/PL00011738
Significance of lymphatic invasion and cancer invasion-related proteins on lymph node metastasis in gastric cancer. - PubMed -...
Significance of lymphatic invasion and cancer invasion-related proteins on lymph node metastasis in gastric cancer.. Kamata I1 ... Tumor size, lymphatic invasion and MMP-1 expression level at the invasive front were the predictive factors of LN metastasis of ... These consisted of 105 cases with regional LN metastasis (LN[+] group) and 105 cases without LN metastasis (LN[-] group). Both ... stromal invasion and lymphatic invasion on regional LN metastasis in gastric cancer was investigated by comprehensive ...https://www.ncbi.nlm.nih.gov/pubmed/19383080
Endoscopic ultrasound: diagnostic and the... & related info | Mendeley
Lymphatic Metastasis. *cancer staging. *endoscopic ultrasound. *fine-needle aspiration biopsy. Get free article suggestions ...https://www.mendeley.com/research-papers/endoscopic-ultrasound-diagnostic-therapeutic-applications/
Prophylactic Selective Lateral Neck Dissection in Patients With Papillary Thyroid Carcinoma - Full Text View - ClinicalTrials...
Neoplasm Metastasis. Thyroid Diseases. Thyroid Neoplasms. Lymphatic Metastasis. Neoplasms, Glandular and Epithelial. Neoplasms ... Papillary thyroid carcinoma with central neck metastasis. *No evidence of lateral neck metastasis as determined by high- ... Initial nodal metastasis in PTC usually occurs in the paratracheal and pretracheal nodes in level VI of the central compartment ... Macroscopic skip metastases to the lateral compartment of the neck in the absence of central disease are uncommon. ...https://clinicaltrials.gov/ct2/show/NCT01103557
Evolving notions on immune response in colorectal cancer and their implications for biomarker development | SpringerLink
Molecular control of lymphatic metastasis. Ann N Y Acad Sci. 2008;1131:225-34.Google Scholar ... Microenvironmental regulation of metastasis. Nat Rev Cancer. 2009;9:239-52.PubMedGoogle Scholar ... Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med. 2005;353:2654-66.PubMedGoogle ... Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer. 2004;4:71-8.PubMedGoogle Scholar ...https://link.springer.com/article/10.1007/s00011-017-1128-1
Search of: Recruiting, Not yet recruiting, Available Studies | 'Oropharyngeal Neoplasms' - List Results - ClinicalTrials.gov
Time to lymphatic metastasis. *(and 2 more...). 560. All. 18 Years and older (Adult, Senior). NCT00964977. DOESAK-pN1-108399. ... The number of lymph node metastases that can be identified by means of uPAR PET / CT compared with the histological findings. ... Effectiveness of Adjuvant Radiotherapy in Small Oropharyngeal Squamous Cell Cancer and Single Lymph Node Metastasis.. * ...https://clinicaltrials.gov/search/open/condition=%22Oropharyngeal+Neoplasms%22
Translation of Pelvic Lipomas
pelvic lymphatic metastases. - vascular disorders such as the pelvic varixes of hollow thromboses ... 2) Lubricating degeneration of lymphatic (hypoplastic pelvic lymphadenopathy). It is about a very rare affection (2 cases in ... 1975 less than 10 cases in 1983). The lymphatic ganglia are invaded gradually by mature fatty tissue, without any sign of ...http://members.tripod.com/dercums_data/Other_websites/lipo_trans.html
Treatment of breast cancer during pregnancy: an observational study.
Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Organ Preservation. Pregnancy. Pregnancy ...http://www.biomedsearch.com/nih/Treatment-breast-cancer-during-pregnancy/22902483.html
Analytical aspects of symptoms of nasopharyngeal malignancies.
Lymphatic Metastasis. Lymphoma / complications, diagnosis*. Nasopharyngeal Neoplasms / complications, diagnosis*. Nose Diseases ...http://www.biomedsearch.com/nih/Analytical-aspects-symptoms-nasopharyngeal-malignancies/215513.html