*  Loss of Heterozygosity at Tumor Suppressor Genes Detectable on Fractionated Circulating Cell-Free Tumor DNA as Indicator of...
Mapping loss of heterozygosity at chromosome 13q: loss at 13q12-q13 is associated with breast tumour progression and poor ... Loss of heterozygosity in serial plasma DNA samples during follow-up of women with breast cancer. Int J Cancer 2003;106:923-9. ... Loss of Heterozygosity at Tumor Suppressor Genes Detectable on Fractionated Circulating Cell-Free Tumor DNA as Indicator of ... Loss of Heterozygosity at Tumor Suppressor Genes Detectable on Fractionated Circulating Cell-Free Tumor DNA as Indicator of ...
  http://clincancerres.aacrjournals.org/content/18/20/5719
*  loss of heterozygosity....
... Bert Gold bgold at itsa.ucsf.edu Sat Nov 18 19:04:49 EST 1995 *Previous message: loss of ... Loss of heterozygosity is the observation that malignant tissues present in an individual bearing a tumor supressor gene ...
  http://www.bio.net/bionet/mm/biochrom/1995-November/000905.html
*  Loss of heterozygosity - Wikipedia
Loss of heterozygosity due to loss of one parental copy in a region is also called hemizygosity in that region. The loss of ... "Mapping loss of heterozygosity in normal human breast cells from BRCA1/2 carriers" - BJC "Loss of Heterozygosity Studies on ... Loss of heterozygosity (LOH) is a cross chromosomal event that results in loss of the entire gene and the surrounding ... Loss of heterozygosity can be identified in cancers by noting the presence of heterozygosity at a genetic locus in an ...
  https://en.wikipedia.org/wiki/Loss_of_heterozygosity
*  Hepatocellular Carcinoma Caused by Loss of Heterozygosity in Lkb1 Gene Knockout Mice | Cancer Research
Hepatocellular Carcinoma Caused by Loss of Heterozygosity in Lkb1 Gene Knockout Mice Masayuki Nakau, Hiroyuki Miyoshi, Michael ... Western blotting and PCR analyses showed loss of Lkb1 heterozygosity in all of the HCC tissues examined, indicating a tumor ... 3 The abbreviations used are: PJS, Peutz-Jeghers syndrome; LOH, loss of heterozygosity; RT-PCR, reverse transcription-PCR; TGF ... Hepatocellular Carcinoma Caused by Loss of Heterozygosity in Lkb1 Gene Knockout Mice ...
  http://cancerres.aacrjournals.org/content/62/16/4549
*  Analysis of losses of heterozygosity of the candidate tumour suppressor gene DMBT1 in melanoma resection specimens.
Loss of Heterozygosity*. Melanocytes / metabolism, pathology. Melanoma / genetics*, pathology, surgery. Microsatellite Repeats ... hence we screened primary melanoma samples for losses of heterozygosity (LOH), and acquired melanocytic naevi and melanomas for ... In melanomas, the chromosomal region 10q22-qter is commonly affected by losses, ... suggesting loss of 1 DMBT1 allele. Three further melanomas showed LOH at 1 informative locus but were heterozygous for the ...
  http://www.biomedsearch.com/nih/Analysis-losses-heterozygosity-candidate-tumour/12239452.html
*  Mosaicism due to myeloid lineage-restricted loss of heterozygosity as cause of spontaneous Rh phenotype splitting | Blood...
Chromosome loss with concomitant duplication and recombination both contribute most to loss of heterozygosity in vitro. Genes ... Loss of heterozygosity on chromosome 1 in RHD−/RHCE*C− (only RHCE*c+/RHCE*e+) erythropoietic blast-forming units as determined ... Frequent loss of heterozygosity in the region of D1S450 at 1p36. 2 in myelodysplastic syndromes. Leuk Res 2001;25:855-858. ... Loss of heterozygosity on chromosome 1 in RHD-negative but not RHD-positive erythropoietic blast-forming units. DNA samples ...
  http://www.bloodjournal.org/content/110/6/2148?sso-checked=true
*  p57KIP2 Expression and Loss of Heterozygosity during Immortal Conversion of Cultured Human Mammary Epithelial Cells | Cancer...
p57KIP2 Expression and Loss of Heterozygosity during Immortal Conversion of Cultured Human Mammary Epithelial Cells Tarlochan ... p57KIP2 Expression and Loss of Heterozygosity during Immortal Conversion of Cultured Human Mammary Epithelial Cells ... 3 The abbreviations used are: CDK, cyclin-dependent kinase; CKI, CDK inhibitor; LOH, loss of heterozygosity; EL, extended life ... p57KIP2 Expression and Loss of Heterozygosity during Immortal Conversion of Cultured Human Mammary Epithelial Cells ...
  http://cancerres.aacrjournals.org/content/59/20/5112
*  Stress-Induced Loss of Heterozygosity in Candida: a Possible Missing Link in the Ability to Evolve
Stress alters rates and types of loss of heterozygosity in Candida albicans. mBio 2(4):e00129-11 [PMC free article] [PubMed] ... Stress-Induced Loss of Heterozygosity in Candida: a Possible Missing Link in the Ability to Evolve. Susan M. Rosenberg ... Stress-induced loss of heterozygosity in Candida: a possible missing link in the ability to evolve. mBio 2(5):e00200-11. doi: ... They show that in the pathogenic yeast Candida albicans, loss of heterozygosity (LOH) is also induced by stress. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3175628/?lang=en-ca
*  Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions | Clinical...
Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions. Brian S. ... Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions ... Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions ... Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions ...
  http://clincancerres.aacrjournals.org/content/14/8/2421.figures-only
*  Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions | Clinical...
Semiautomated assessment of loss of heterozygosity and replication error in tumors. Cancer Res 1996;56:3331-7. ... Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions. Brian S. ... Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions ... Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions ...
  http://clincancerres.aacrjournals.org/content/14/8/2421
*  Loss of Heterozygosity of Chromosome 3 Detected with Single Nucleotide Polymorphisms Is Superior to Monosomy 3 for Predicting...
Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays. PLoS Comput Biol 2006;2: ... High-throughput loss-of-heterozygosity study of chromosome 3p in lung cancer using single-nucleotide polymorphism markers. ... Loss of Heterozygosity of Chromosome 3 Detected with Single Nucleotide Polymorphisms Is Superior to Monosomy 3 for Predicting ... Loss of Heterozygosity of Chromosome 3 Detected with Single Nucleotide Polymorphisms Is Superior to Monosomy 3 for Predicting ...
  http://clincancerres.aacrjournals.org/content/13/10/2923?ijkey=9272e7b4baf892f049508fa4fe43fc3e8b7cf8f6&keytype2=tf_ipsecsha
*  Atypical ductal hyperplasia of the breast: clonal proliferation with loss of heterozygosity on chromosomes 16q and 17p. |...
Atypical ductal hyperplasia of the breast: clonal proliferation with loss of heterozygosity on chromosomes 16q and 17p. ... Atypical ductal hyperplasia of the breast: clonal proliferation with loss of heterozygosity on chromosomes 16q and 17p. ... Loss of heterozygosity (LOH) was detected in five of nine informative cases on chromosome 16q at the microsatellite D16S413 and ... AIMS--To determine if allelic loss on chromosomes 16q and 17p, commonly encountered in in situ and invasive ductal carcinomas, ...
  http://jcp.bmj.com/content/48/7/611
*  Scientific Protocols - Loss of Heterozygosity
For a more detailed discussion of applying this approach to microdissected samples, see Allelic Loss Studies in Prostate MP at ... Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia. Cancer Res 55: 2959-62, 1995. ... including artifactual allelic loss and poor amplification of large products. If this technique is to be utilized for analysis ... including artifactual allelic loss and poor amplification of large products. Therefore, when this technique is used to analyze ...
  https://protocols.scienceexchange.com/protocols/loss-of-heterozygosity
*  Distinction of low grade from high grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3, 6,...
Losses of heterozygosity on chromosomes 3 or 11 were not seen in low grade lesions, although they were present in most of the ... Losses of heterozygosity on chromosome 6 as well as HER-2/neu amplification, in contrast, were present in several low grade ... The results confirmed earlier findings that losses of heterozygosity occurred at nonrandom frequencies on chromosomes 3, 6, and ... We examined the frequencies of loss of heterozygosity at 13 different loci distributed on 9 chromosomes in 30 human ovarian ...
  https://www.semanticscholar.org/paper/Distinction-of-low-grade-from-high-grade-human-ova-Zheng-Robinson/eefaecb0d05d11785bba82cdbe8257936cf858ef
*  Cancers | Free Full-Text | Emerging Biomarkers in Glioblastoma | HTML
... loss of heterozygosity 10q, isocitrate dehydrogenase (IDH) mutations, epidermal growth factor receptor (EGFR), epidermal growth ... loss of heterozygosity (LOH) of chromosomes 1p and 19q, ... loss of heterozygosity (LOH) of chromosomes 1p and 19q, loss of ... Lower losses on chromosome 10 are seen in anaplastic astrocytoma indicating that loss of heterozygosity on chromosome 10 is a ... Loss of Heterozygosity (LOH) of Chromosomes 1p and 19q. In GBM, deletions involving 1p and 19q are uncommon but have been ...
  http://www.mdpi.com/2072-6694/5/3/1103/htm
*  IJMS | Free Full-Text | The Clinical Utilization of Circulating Cell Free DNA (CCFDNA) in Blood of Cancer Patients | HTML
Loss of Heterozygosity (LOH). Loss of Heterozygosity (LOH) analysis of alleles at specific chromosomes of cell free plasma or ... Pang, J.Z.; Qin, L.X.; Wang, Q.Q.; Ren, N.; Sun, B.S.; Lin, G.L.; Ye, Q.H.; Liu, Y.K.; Tang, Z.Y. Loss of heterozygosity of ... Nakamura, T.; Sunami, E.; Nguyen, T.; Hoon, D.S. Analysis of loss of heterozygosity in circulating DNA. Methods Mol. Biol 2009 ... Thus, point mutations, copy number variations, loss of heterozygosity or aneuploidy can be detected. Also, digital PCR can ...
  http://mdpi.com/1422-0067/14/9/18925/htm
*  Plus it
... loss of heterozygosity, mutations, and CpG island methylation), p53 (TP53) lesions (loss of heterozygosity, mutation) and ... Loss of Heterozygosity.. LOH analysis was performed on the flow-purified fractions, as described previously (32 , 34) yielding ... A Cox proportional hazards regression indicates that the sizes of clones with p53 loss of heterozygosity (relative risk = 1.27x ... Galipeau PC, Prevo LJ, Sanchez CA, Longton GM, Reid BJ Clonal expansion and loss of heterozygosity at chromosomes 9p and 17p in ...
  http://cancerres.aacrjournals.org/content/64/20/7629
*  Investigation of Second Genetic Hits at the BMPR2 Locus as a Modulator of Disease Progression in Familial Pulmonary Arterial...
MSI and Loss of Heterozygosity Analysis. MSI analysis was performed with 5 microsatellite markers: BAT-25, a thymine repeat in ... DNA was analyzed for loss of heterozygosity at BMPR2 and for microsatellite instability (MSI) at 5 loci. MSI was detected in 1 ... Three polymorphic markers were used to detect loss of heterozygosity (LOH) at the BMPR2 locus: a previously undescribed marker ... Heterozygosity was retained in all informative cases for 3 markers that encompass the BMPR2 gene. These results suggest that ...
  http://circ.ahajournals.org/content/111/5/607
*  STRAD in Peutz-Jeghers syndrome and sporadic cancers | Journal of Clinical Pathology
Abujiang P, Mori TJ, Takahashi T, et al. Loss of heterozygosity (LOH) at 17q and 14q in human lung cancers. Oncogene 1998;17: ... Loss of heterozygosity. Eight markers were used for LOH analysis, two on chromosome 17p13.1 around the TP53 locus (markers TP53 ... Garcia-Patino E, Gomendio B, Lleonart M, et al. Loss of heterozygosity in the region including the BRCA1 gene on 17q in colon ... Loss of heterozygosity (LOH) results for eight microsatellite markers on chromosome 17, including those near the STRAD, BRCA1, ...
  http://jcp.bmj.com/content/58/10/1091
*  Plus it
Loss of Heterozygosity (LOH) Analysis.. Allelic losses were analyzed using a PCR approach, with primers amplifying polymorphic ... Results: Loss of heterozygosity at the WWOX locus was observed in 4 primary tumors (27%). Methylation analysis showed that site ... Arrow indicates loss of heterozygosity at D16S518. B, direct sequencing chromatogram of PCR products from Hs766T. The CpG sites ... A, representative loss of heterozygosity analysis of case 3 at the D16S518 locus. The microsatellite locus is identified below ...
  http://clincancerres.aacrjournals.org/content/10/7/2459
*  PRKAR1A, one of the Carney complex genes, and its locus (17q22-24) are rarely altered in pituitary tumours outside the Carney...
Loss of heterozygosity analysis for the 17q22-24 PRKAR1A locus. The location of the tested markers on 17q22-24 and ... Microsatellite and loss of heterozygosity analysis. The polymorphic markers from 17q22-24 surrounding the PRKAR1A gene are ... Loss of heterozygosity at 11q13: analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects ... Twenty paired blood-tumour samples of sporadic cases were studied for loss of heterozygosity (LOH) of the 17q22-24 PRKAR1A ...
  http://jmg.bmj.com/content/39/12/e78
*  Ploidy dynamics and evolvability | Philosophical Transactions of the Royal Society B: Biological Sciences
4. Loss of heterozygosity as a long-term mechanism of rapid genome change. LOH is a common feature of C. albicans clinical ... 2011 Loss of heterozygosity at an unlinked genomic locus is responsible for the phenotype of a Candida albicans sap4Δ sap5Δ ... Aneuploidy and loss of heterozygosity (LOH), which are large-scale genome shifts involving whole chromosomes or chromosome arms ... These often result in a high level of aneuploidy and loss of heterozygosity (LOH) [3], which can lead to clinical consequences ...
  http://rstb.royalsocietypublishing.org/content/371/1709/20150461
*  Study of Skin Tumors in Tuberous Sclerosis - Full Text View - ClinicalTrials.gov
To accomplish this, we plan to obtain samples of these cutaneous tumors, to test tumor DNA for loss of heterozygosity, and to ...
  https://clinicaltrials.gov/ct2/show/NCT00001975?recr=Open&cond=%22Tuberous+Sclerosis%22&rank=1
*  Dienekes' Anthropology Blog: Greek horse breeds
Nevertheless, comparisons between DNA-based and pedigree-based results revealed that a loss of genetic diversity had probably ... Nonetheless, relatively high levels of heterozygosity and Polymorphism Information Content indicated sufficient residual ...
  http://dienekes.blogspot.com/2011/06/greek-horse-breeds.html?m=0