*  Loss of Heterozygosity at Tumor Suppressor Genes Detectable on Fractionated Circulating Cell-Free Tumor DNA as Indicator of...
Mapping loss of heterozygosity at chromosome 13q: loss at 13q12-q13 is associated with breast tumour progression and poor ... Loss of heterozygosity in serial plasma DNA samples during follow-up of women with breast cancer. Int J Cancer 2003;106:923-9. ... Loss of Heterozygosity at Tumor Suppressor Genes Detectable on Fractionated Circulating Cell-Free Tumor DNA as Indicator of ... Loss of Heterozygosity at Tumor Suppressor Genes Detectable on Fractionated Circulating Cell-Free Tumor DNA as Indicator of ...
  http://clincancerres.aacrjournals.org/content/18/20/5719
*  LOH11CR2A Pre-design Chimera RNAi - (H00004013-R02) - Products - Abnova
Homo sapiens loss of heterozygosity, 11, chromosomal region 2, gene A (LOH11CR2A), transcript variant 2, mRNA. (H00004013-R02 ... Homo sapiens loss of heterozygosity, 11, chromosomal region 2, gene A (LOH11CR2A), transcript variant 2, mRNA. ... BCSC-1,loss of heterozygosity, 11, chromosomal region 2, gene A,ortholog of mouse AW551984 ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=H00004013-R02
*  Hepatocellular Carcinoma Caused by Loss of Heterozygosity in Lkb1 Gene Knockout Mice | Cancer Research
Hepatocellular Carcinoma Caused by Loss of Heterozygosity in Lkb1 Gene Knockout Mice Masayuki Nakau, Hiroyuki Miyoshi, Michael ... Western blotting and PCR analyses showed loss of Lkb1 heterozygosity in all of the HCC tissues examined, indicating a tumor ... 3 The abbreviations used are: PJS, Peutz-Jeghers syndrome; LOH, loss of heterozygosity; RT-PCR, reverse transcription-PCR; TGF ... Hepatocellular Carcinoma Caused by Loss of Heterozygosity in Lkb1 Gene Knockout Mice ...
  http://cancerres.aacrjournals.org/content/62/16/4549
*  Analysis of losses of heterozygosity of the candidate tumour suppressor gene DMBT1 in melanoma resection specimens.
Loss of Heterozygosity*. Melanocytes / metabolism, pathology. Melanoma / genetics*, pathology, surgery. Microsatellite Repeats ... hence we screened primary melanoma samples for losses of heterozygosity (LOH), and acquired melanocytic naevi and melanomas for ... In melanomas, the chromosomal region 10q22-qter is commonly affected by losses, ... suggesting loss of 1 DMBT1 allele. Three further melanomas showed LOH at 1 informative locus but were heterozygous for the ...
  http://www.biomedsearch.com/nih/Analysis-losses-heterozygosity-candidate-tumour/12239452.html
*  Mosaicism due to myeloid lineage-restricted loss of heterozygosity as cause of spontaneous Rh phenotype splitting | Blood...
Chromosome loss with concomitant duplication and recombination both contribute most to loss of heterozygosity in vitro. Genes ... Loss of heterozygosity on chromosome 1 in RHD−/RHCE*C− (only RHCE*c+/RHCE*e+) erythropoietic blast-forming units as determined ... Frequent loss of heterozygosity in the region of D1S450 at 1p36. 2 in myelodysplastic syndromes. Leuk Res 2001;25:855-858. ... Loss of heterozygosity on chromosome 1 in RHD-negative but not RHD-positive erythropoietic blast-forming units. DNA samples ...
  http://www.bloodjournal.org/content/110/6/2148?sso-checked=true
*  p57KIP2 Expression and Loss of Heterozygosity during Immortal Conversion of Cultured Human Mammary Epithelial Cells | Cancer...
p57KIP2 Expression and Loss of Heterozygosity during Immortal Conversion of Cultured Human Mammary Epithelial Cells Tarlochan ... p57KIP2 Expression and Loss of Heterozygosity during Immortal Conversion of Cultured Human Mammary Epithelial Cells ... 3 The abbreviations used are: CDK, cyclin-dependent kinase; CKI, CDK inhibitor; LOH, loss of heterozygosity; EL, extended life ... p57KIP2 Expression and Loss of Heterozygosity during Immortal Conversion of Cultured Human Mammary Epithelial Cells ...
  http://cancerres.aacrjournals.org/content/59/20/5112
*  Loss of Heterozygosity Analysis Defines a Critical Region in Chromosome 1p22 Commonly Deleted in Human Malignant Mesothelioma |...
Loss of Heterozygosity Analysis Defines a Critical Region in Chromosome 1p22 Commonly Deleted in Human Malignant Mesothelioma. ... Loss of Heterozygosity Analysis Defines a Critical Region in Chromosome 1p22 Commonly Deleted in Human Malignant Mesothelioma ... Loss of Heterozygosity Analysis Defines a Critical Region in Chromosome 1p22 Commonly Deleted in Human Malignant Mesothelioma ... Loss of Heterozygosity Analysis Defines a Critical Region in Chromosome 1p22 Commonly Deleted in Human Malignant Mesothelioma ...
  http://cancerres.aacrjournals.org/content/56/19/4297
*  Stress-Induced Loss of Heterozygosity in Candida: a Possible Missing Link in the Ability to Evolve
Stress alters rates and types of loss of heterozygosity in Candida albicans. mBio 2(4):e00129-11 [PMC free article] [PubMed] ... Stress-Induced Loss of Heterozygosity in Candida: a Possible Missing Link in the Ability to Evolve. Susan M. Rosenberg ... Stress-induced loss of heterozygosity in Candida: a possible missing link in the ability to evolve. mBio 2(5):e00200-11. doi: ... They show that in the pathogenic yeast Candida albicans, loss of heterozygosity (LOH) is also induced by stress. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3175628/?lang=en-ca
*  Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions | Clinical...
Semiautomated assessment of loss of heterozygosity and replication error in tumors. Cancer Res 1996;56:3331-7. ... Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions. Brian S. ... Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions ... Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions ...
  http://clincancerres.aacrjournals.org/content/14/8/2421
*  Loss of Heterozygosity of Chromosome 3 Detected with Single Nucleotide Polymorphisms Is Superior to Monosomy 3 for Predicting...
Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays. PLoS Comput Biol 2006;2: ... High-throughput loss-of-heterozygosity study of chromosome 3p in lung cancer using single-nucleotide polymorphism markers. ... Loss of Heterozygosity of Chromosome 3 Detected with Single Nucleotide Polymorphisms Is Superior to Monosomy 3 for Predicting ... Loss of Heterozygosity of Chromosome 3 Detected with Single Nucleotide Polymorphisms Is Superior to Monosomy 3 for Predicting ...
  http://clincancerres.aacrjournals.org/content/13/10/2923?ijkey=9272e7b4baf892f049508fa4fe43fc3e8b7cf8f6&keytype2=tf_ipsecsha
*  Genome-wide loss of heterozygosity and copy number alteration in esophageal squamous cell carcinoma using the Affymetrix...
... including loss of heterozygosity (LOH) and copy number alterations (CNA), either gain or loss, are the focus of substantial ... Genome-wide loss of heterozygosity and copy number alteration in esophageal squamous cell carcinoma using the Affymetrix ... Zhou X, Mok SC, Chen Z, Li Y, Wong DT: Concurrent analysis of loss of heterozygosity (LOH) and copy number abnormality (CNA) ... The Affymetrix 10 K SNP chip is a valid platform to integrate analyses of loss of heterozygosity and copy number alterations. ...
  https://rd.springer.com/article/10.1186/1471-2164-7-299
*  Atypical ductal hyperplasia of the breast: clonal proliferation with loss of heterozygosity on chromosomes 16q and 17p. |...
Atypical ductal hyperplasia of the breast: clonal proliferation with loss of heterozygosity on chromosomes 16q and 17p. ... Atypical ductal hyperplasia of the breast: clonal proliferation with loss of heterozygosity on chromosomes 16q and 17p. ... Loss of heterozygosity (LOH) was detected in five of nine informative cases on chromosome 16q at the microsatellite D16S413 and ... AIMS--To determine if allelic loss on chromosomes 16q and 17p, commonly encountered in in situ and invasive ductal carcinomas, ...
  http://jcp.bmj.com/content/48/7/611
*  Scientific Protocols - Loss of Heterozygosity
For a more detailed discussion of applying this approach to microdissected samples, see Allelic Loss Studies in Prostate MP at ... Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia. Cancer Res 55: 2959-62, 1995. ... including artifactual allelic loss and poor amplification of large products. If this technique is to be utilized for analysis ... including artifactual allelic loss and poor amplification of large products. Therefore, when this technique is used to analyze ...
  https://protocols.scienceexchange.com/protocols/loss-of-heterozygosity
*  Analysis of loss of heterozygosity on chromosome 11q13 in atyp...
Analysis of loss of heterozygosity on chromosome 11q13 in atypical ductal hyperplasia and in situ carcinoma of the breast.: ... Analysis of loss of heterozygosity on chromosome 11q13 in atypical ductal hyperplasia and in situ carcinoma of the breast.. ... In this study we analyzed loss of heterozygosity (LOH) on 11q13 (PYGM, INT-2) in atypical ductal hyperplasia (ADH) and various ... Identical allelic loss in invasive and adjacent in situ ductal breast carcinoma (DCIS) on chromosome 11q13 has been previously ...
  https://www.mysciencework.com/publication/show/analysis-of-loss-of-heterozygosity-on-chromosome-11q13-in-atypical-ductal-hyperplasia-and-in-situ-carcinoma-of-the-breast
*  CLImAT-HET: detecting subclonal copy number alterations and loss of heterozygosity in heterogeneous tumor samples from whole...
... and loss of heterozygosity (LOH) represent a large proportion of genetic structural variations of cancer genomes. These ... Yu Z, Liu Y, Shen Y, Wang M, Li A. CLImAT: accurate detection of copy number alteration and loss of heterozygosity in impure ... Copy number alterations (CNA) and loss of heterozygosity (LOH) represent a large proportion of genetic structural variations of ... CLImAT-HET: detecting subclonal copy number alterations and loss of heterozygosity in heterogeneous tumor samples from whole- ...
  https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-017-0255-4
*  Distinction of low grade from high grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3, 6,...
Losses of heterozygosity on chromosomes 3 or 11 were not seen in low grade lesions, although they were present in most of the ... Losses of heterozygosity on chromosome 6 as well as HER-2/neu amplification, in contrast, were present in several low grade ... The results confirmed earlier findings that losses of heterozygosity occurred at nonrandom frequencies on chromosomes 3, 6, and ... We examined the frequencies of loss of heterozygosity at 13 different loci distributed on 9 chromosomes in 30 human ovarian ...
  https://www.semanticscholar.org/paper/Distinction-of-low-grade-from-high-grade-human-ova-Zheng-Robinson/eefaecb0d05d11785bba82cdbe8257936cf858ef
*  High incidence of loss of heterozygosity in breast tumors from carriers of the BRCA2 999del5 mutation
Loss of heterozygosity mapping suggests that the same chromosome regions are involved in both tumor groups but at elevated ... High incidence of loss of heterozygosity at chromosome 17p13 in breast tumours from BRCA2 mutation carriers. ... High incidence of loss of heterozygosity in breast tumors from carriers of the BRCA2 999del5 mutation. ... We found that the frequency of loss of heterozygosity was similar at some chromosomal regions in the BRCA2 999del5 and sporadic ...
  https://www.hirsla.lsh.is/handle/2336/47994
*  What Makes a Cancer Cell a Cancer Cell? - Holland-Frei Cancer Medicine - NCBI Bookshelf
Loss of Heterozygosity. Deletion of genetic material is a very common event in human cancer. Indeed, it is the most frequently ... These deletion events often involve loss of heterozygosity (LOH) of the expression of either the maternal or paternal alleles ... Frequently involved allelic loss occurs in cancer cells on chromosomes 3p, 5q, 7q, 8q, 9p, 13q, 17p, and 18q. These losses ... the loss of density-dependent inhibition of growth, decreased adhesiveness, loss of anchorage dependence, and invasiveness ...
  https://www.ncbi.nlm.nih.gov/books/NBK12516/
*  Cancers | Free Full-Text | Emerging Biomarkers in Glioblastoma | HTML
... loss of heterozygosity 10q, isocitrate dehydrogenase (IDH) mutations, epidermal growth factor receptor (EGFR), epidermal growth ... loss of heterozygosity (LOH) of chromosomes 1p and 19q, ... loss of heterozygosity (LOH) of chromosomes 1p and 19q, loss of ... Lower losses on chromosome 10 are seen in anaplastic astrocytoma indicating that loss of heterozygosity on chromosome 10 is a ... Loss of Heterozygosity (LOH) of Chromosomes 1p and 19q. In GBM, deletions involving 1p and 19q are uncommon but have been ...
  http://www.mdpi.com/2072-6694/5/3/1103/htm
*  IJMS | Free Full-Text | The Clinical Utilization of Circulating Cell Free DNA (CCFDNA) in Blood of Cancer Patients | HTML
Loss of Heterozygosity (LOH). Loss of Heterozygosity (LOH) analysis of alleles at specific chromosomes of cell free plasma or ... Pang, J.Z.; Qin, L.X.; Wang, Q.Q.; Ren, N.; Sun, B.S.; Lin, G.L.; Ye, Q.H.; Liu, Y.K.; Tang, Z.Y. Loss of heterozygosity of ... Nakamura, T.; Sunami, E.; Nguyen, T.; Hoon, D.S. Analysis of loss of heterozygosity in circulating DNA. Methods Mol. Biol 2009 ... Thus, point mutations, copy number variations, loss of heterozygosity or aneuploidy can be detected. Also, digital PCR can ...
  http://mdpi.com/1422-0067/14/9/18925/htm
*  IJMS | Free Full-Text | Brain Metastases from Lung Cancer Show Increased Expression of DVL1, DVL3 and Beta-Catenin and Down...
Genetic alterations of E-cadherin were tested by polymerase chain reaction (PCR)/loss of heterozygosity (LOH). Heteroduplex was ... gene was used to test loss of heterozygosity (LOH) in brain metastases. Allelic loss at the CDH1 locus was assessed using 3 ... Cooper, C.A.; Bubb, V.J.; Smithson, N.; Carter, R.L.; Gledhill, S.; Lamb, D.; Wyllie, A.H.; Carey, F.A. Loss of heterozygosity ... 4.3.2. Loss of Heterozygosity, Microsatellite Instability (MSI). Absence or significant decrease in the intensity of one ...
  http://mdpi.com/1422-0067/15/6/10635/htm
*  Investigation of Second Genetic Hits at the BMPR2 Locus as a Modulator of Disease Progression in Familial Pulmonary Arterial...
MSI and Loss of Heterozygosity Analysis. MSI analysis was performed with 5 microsatellite markers: BAT-25, a thymine repeat in ... DNA was analyzed for loss of heterozygosity at BMPR2 and for microsatellite instability (MSI) at 5 loci. MSI was detected in 1 ... Three polymorphic markers were used to detect loss of heterozygosity (LOH) at the BMPR2 locus: a previously undescribed marker ... Heterozygosity was retained in all informative cases for 3 markers that encompass the BMPR2 gene. These results suggest that ...
  http://circ.ahajournals.org/content/111/5/607
*  STRAD in Peutz-Jeghers syndrome and sporadic cancers | Journal of Clinical Pathology
Abujiang P, Mori TJ, Takahashi T, et al. Loss of heterozygosity (LOH) at 17q and 14q in human lung cancers. Oncogene 1998;17: ... Loss of heterozygosity. Eight markers were used for LOH analysis, two on chromosome 17p13.1 around the TP53 locus (markers TP53 ... Garcia-Patino E, Gomendio B, Lleonart M, et al. Loss of heterozygosity in the region including the BRCA1 gene on 17q in colon ... Loss of heterozygosity (LOH) results for eight microsatellite markers on chromosome 17, including those near the STRAD, BRCA1, ...
  http://jcp.bmj.com/content/58/10/1091
*  A Drosophila Model of Multiple Endocrine Neoplasia Type 2 | Genetics
Khosla, S., V. M. Patel, I. D. Hay, D. J. Schaid, C. S. Grant et al., 1991 Loss of heterozygosity suggests multiple genetic ... Loss-of-heterozygosity studies in human tumor tissue:. One goal in this study was to assess the role human orthologs of GMR- ... Loss-of-heterozygosity and sequencing studies on human tumors:. Human orthologs for GMR-dRet modifiers were identified by ... Loss-of-heterozygosity (LOH) analysis was performed using microsatellite repeat markers, essentially as previously described (P ...
  http://www.genetics.org/content/171/3/1057
*  Dienekes' Anthropology Blog: Greek horse breeds
Nevertheless, comparisons between DNA-based and pedigree-based results revealed that a loss of genetic diversity had probably ... Nonetheless, relatively high levels of heterozygosity and Polymorphism Information Content indicated sufficient residual ...
  http://dienekes.blogspot.com/2011/06/greek-horse-breeds.html?m=0