Clinical Trial of a Therapeutic Vaccine With NY-ESO-1 in Combination With the Adjuvant Monophosphoryl Lipid A (MPLA) - Full...
Clinical Trial of a Therapeutic Vaccine With NY-ESO-1 in Combination With the Adjuvant Monophosphoryl Lipid A (MPLA). The ...https://clinicaltrials.gov/ct2/show/NCT01584115?recr=Open&cond=%22Whooping+Cough%22&rank=19
The Effect of Monophosphoryl Lipid A on Maturation of DCs from Patients with Acute Myeloid Leukaemia
Objective: To compare effects of traditional cytokine cocktail (TNF-α + IL-1β) versus TLR4-agonist monophosphoryl lipid A on ... Objective: To compare effects of traditional cytokine cocktail (TNF-α + IL-1β) versus TLR4-agonist monophosphoryl lipid A on ... "The Effect of Monophosphoryl Lipid A on Maturation of DCs from Patients with Acute Myeloid Leukaemia". Iranian Journal of ... The Effect of Monophosphoryl Lipid A on Maturation of DCs from Patients with Acute Myeloid Leukaemia. ...http://iji.sums.ac.ir/article_39284.html
Relative Contributions of Genes, Environment, and Interactions to Blood Lipid Concentrations in a General Adult Population :...
The authors evaluated the contributions of nine genetic (G) variants (selected from 275 single nucleotide polymorphisms in 11 reverse cholesterol transport pathway genes), five environmental (E) factors (selected from 10), and G × G, E × E, and G × E interactions in explaining population variance of blood lipid concentrations. Total cholesterol, triglycerides, and high density lipoprotein (HDL) cholesterol were measured, and low density lipoprotein (LDL) cholesterol and HDL cholesterol/LDL cholesterol ratio were calculated in a population-based random sample of 1,543 men and women in Geneva, Switzerland, aged 35-74 years in 1999-2001. Explained variances (R2) for HDL cholesterol/LDL cholesterol ratio, HDL cholesterol, and LDL cholesterol, respectively, were 34%, 33%, and 19%, decomposed into main effects of G (6%, 4%, and 5%) and E (25%, 28%, and 11%), with just 3%, 2%, and 3% due to G × G, E × E, and G × E interactions, respectively. Risk factor clustering was only moderate: 70% of study ...http://oxfordindex.oup.com/view/10.1093/aje/kwi103
Lipidomics: quest for molecular lipid biomarkers in cardiovascular disease. - Semantic Scholar
Lipidomics is the comprehensive analysis of molecular lipid species, including their quantitation and metabolic pathways. The huge diversity of native lipids and their modifications make lipidomic analyses challenging. The method of choice for sensitive detection and quantitation of molecular lipid species is mass spectrometry, either by direct infusion (shotgun lipidomics) or coupled with liquid chromatography. Although shotgun lipidomics allows for high-throughput analysis, low-abundant lipid species are not detected. Previous separation of lipid species by liquid chromatography increases ionization efficiency and is better suited for quantifying low abundant and isomeric lipid species. In this review, we will discuss the potential of lipidomics for cardiovascular research. To date, cardiovascular research predominantly ...https://www.semanticscholar.org/paper/Lipidomics-quest-for-molecular-lipid-biomarkers-in-Hinterwirth-Stegemann/02324a61f86ff7681f5b8164dc54e6dc2e41666d
Identification of Plasma Lipid Biomarkers for Prostate Cancer by Lipidomics and Bioinformatics
Background Lipids have critical functions in cellular energy storage, structure and signaling. Many individual lipid molecules have been associated with the evolution of prostate cancer; however, none of them has been approved to be used as a biomarker. The aim of this study is to identify lipid molecules from hundreds plasma apparent lipid species as biomarkers for diagnosis of prostate cancer. Methodology/Principal Findings Using lipidomics, lipid profiling of 390 individual apparent lipid species was performed on 141 plasma samples from 105 patients with prostate cancer and 36 male controls. High throughput data generated from lipidomics were analyzed using bioinformatic and statistical methods. From 390 apparent lipid species, 35 species were demonstrated to have potential in differentiation of prostate cancer. Within the 35 species, 12 were identified ...http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048889&imageURI=info:doi/10.1371/journal.pone.0048889.g002
Lipid profile - Wikipedia
Lipid profile or lipid panel is a panel of blood tests that serves as an initial broad medical screening tool for abnormalities in lipids, such as cholesterol and triglycerides. The results of this test can identify certain genetic diseases and can determine approximate risks for cardiovascular disease, certain forms of pancreatitis, and other diseases. Lipid panels are commonly ordered as part of a physical exam, along with other panels such as the complete blood count (CBC) and basic metabolic panel (BMP). The lipid profile typically includes: Low-density lipoprotein (LDL) High-density lipoprotein (HDL) Triglycerides Total cholesterol Using these values, a laboratory may also calculate: Very low-density lipoprotein (VLDL) Cholesterol:HDL ratio The lipid profile tests are of 7 types: Total lipids Serum total cholesterol serum HDL cholesterol Total cholesterol/HDL cholesterol ratio Serum ...https://en.wikipedia.org/wiki/Lipid_profile
Prevalence of Abnormal Lipid Levels Among Youths --- United States, 1999--2006
Cardiovascular disease (CVD) is the leading cause of death among adults in the United States (1). CVD risk factors, including abnormal lipid levels and elevated body mass index (BMI), often emerge during childhood and adolescence (2). In 2008, the American Academy of Pediatrics (AAP) established recommendations for targeted screening of youths aged ≥2 years for abnormal blood lipid levels (2). To provide prevalence data on abnormal lipid levels among youths, eligibility for lipid screening based on BMI, and eligibility for therapeutic lifestyle counseling among overweight youths, CDC analyzed results from the National Health and Nutrition Examination Survey (NHANES) for 1999--2006. This report describes the results of that analysis, which found that the prevalence of abnormal lipid levels among youths aged 12--19 years was 20.3%. This prevalence varied by BMI; 14.2% of normal weight youths, 22.3% of overweight and 42.9% of ...https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5902a1.htm
中国科学院大连化学物理研究所机构知识库(DICP OpenIR): Analytical strategies in lipidomics and applications in disease biomarker discovery
Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes, obesity, atherosclerosis and Alzheimer's disease. Investigating lipid biochemistry using a lipidomics approach will not only provide insights into the specific roles of lipid molecular species in health and disease, but will also assist in identifying potential biomarkers for establishing preventive or therapeutic approaches for human health. Recent technological advancements in mass spectrometry and rapid improvements in chromatographic techniques have led to the rapid expansion of the ...http://cas-ir.dicp.ac.cn/handle/321008/102165
1joc » Early endosome antigen 1 (EEA1), model of dimer with lipids - Orientations of Proteins in Membranes (OPM) database
This is calculation with bound lipids. Acyl chains of two lipids were modelled. Calculated hydrocarbon boundary of the lipid bilayer corresponds to the carbonyl groups of the bound lipid. Depending on conformations of bound lipids, the protein can penetrate deeper by ~2 A. Results for the dimer without bound lipids are exactly the same as for lipid-free EEA1 monomer (1hyi). Transfer energy was calculated without contribution from the bound lipid ...http://opm.phar.umich.edu/protein.php?pdbid=1joc
Stress, Fat and Lipid Wikis
The presentations reflected the early development of LipidomicNet, the European Union Framework VII project focused on the structure of lipid droplets and their function in human health and disease that kicked off just last year. Lipid droplet formation is a hallmark of "energy-overload" metabolic diseases that are a major heath concern. One goal of LipidomicNet is to integrate lipid structure profiles with proteome and transcriptome analysis to reveal the interrelationship between gene expression and lipid droplet formation.. The project also manages the LipidomicNetWiki (www.lipidomicnet.org), in close collaboration with LIPID Metabolites and Pathways Strategy (LIPID MAPS) and Lipid Bank-Japan. One hope is that those investigators who "bump" into lipid metabolism in their work will take advantage of the ...http://www.asbmb.org/asbmbtoday/asbmbtoday_article.aspx?id=4782&ekfxmen_noscript=1&ekfxmensel=e51b41e94_366_376
In Situ Preparation and Modification of Supported Lipid Layers by Lipid Transfer from Vesicles Studied by QCM-D and TOF-SIMS
The study of lipid transfer between lipid membranes is of great interest for the fundamental understanding of this complex and important process and, furthermore, for providing a new avenue for the in situ modification of supported lipid bilayers (SLBs). SLBs are conveniently formed by vesicle spreading onto a solid support, but this method is limited to conditions (i.e., combination of vesicle lipid composition, surface chemical properties, and buffer) such that the vesicles break spontaneously upon adsorption to the surface. Many SLB compositions are not accessible by this approach. In the present study, we give an example of how lipid transfer can be made use of to form lipid layers with striking new features, notably with respect to stability. After lipid transfer between negatively charged POPS small unilamellar vesicles and a positively charged POEPC SLB on TiO2, an SLB is obtained, ...http://publications.lib.chalmers.se/publication/108672-in-situ-preparation-and-modification-of-supported-lipid-layers-by-lipid-transfer-from-vesicles-studi
Lipid Metabolism - BioFiles Volume 5, Number 7 | Sigma-Aldrich
Lipid-based diseases are a growing and expensive challenge to health care systems. As a population ages, chronic conditions associated with aging such as cardiovascular disease, neurodegenerative disorders, and metabolic disorders take increasing tolls in terms of morbidity and mortality. Oxidation of lipids and lipid metabolites has been linked to disorders of aging like osteoporosis and vascular calcification. Additionally, research is now trying to explain how dysregulations in lipid metabolism may underlie diseases such as Alzheimer's, cancer, and asthma. Lipid synthesis pathways, such as the methyl-Derythritol 4-phosphate (MEP) pathway of isoprenoid synthesis, are being investigated as potential targets for antibacterial therapies and drug targets. As changes in lipid profiles can mark developmental stages or more ominously, pathological states, there is great potential for the use of ...https://www.sigmaaldrich.com/life-science/learning-center/biofiles/biofiles-v5-n7/introduction.html
Lipids: Biochemistry, Biotechnology and Health 6th Edition - SkuDra.Net
For the 6th Edition of this highly regarded textbook devoted to lipids, the title has been modified from Lipid Biochemistry to Lipids to acknowledge the coming together of biological and medical sciences, the increasingly blurred boundaries between them and the growing importance of lipids in diverse aspects of science and technology. The principal aims of this new edition - to inform students and researchers about lipids, to assist teachers and encourage further research - have not changed since previous editions.. Significant advances in lipid science have demanded yet another extensive rewriting for this edition, with the addition of two new authors, to cover new knowledge of genes coding for proteins involved in lipid metabolism, the many lipids involved in cell signalling, the roles of lipids in health and disease and new developments in biotechnology ...https://www.skudra.net/2016/12/26/lipids-biochemistry-biotechnology-and-health-6th-edition.html
Describe the role of lipids in living organisms. - A-Level Science - Marked by Teachers.com
Introduction. Describe the role of lipids in living organisms Lipids can be defined as 'a group of substances that contain carbon, hydrogen and oxygen.'(1) The proportion of oxygen in lipids is less than in carbohydrates. Lipids are non polar and therefore they are insoluble in polar solvents such as water. Lipids are however soluble in non polar solvents such as alcohols and ethers. The chemistry of lipids are also very varied but they are all esters of fatty acids (can be saturated or unsaturated) and an alcohol. Lipids are a large and varied group of organic compounds. They have an intensive role in biological systems. They can be classified as: * Fats and oil (Triglycerides) * Phospholipids * Steroids * Waxes * Fatty acids (The nature of the fatty acid determines the characteristic of any particular fat.) All triglycerides molecules are formed when a molecule of glycerol ...http://www.markedbyteachers.com/as-and-a-level/science/describe-the-role-of-lipids-in-living-organisms.html
Serum Lipid Levels in Normal Persons | Circulation
Measurements of Sf 12-20, Sf 20-100, and total serum cholesterol made on 10,690 men and 3,404 women are reported and the relation of lipid level to race, source, age, sex, blood pressure, and weight is described. Distributions for men 40 to 59 are reported in detail.. The groups studied, while not selected as representative of the population at large, were remarkably similar in their lipid levels. The lipid levels of only 2 of the 33 groups-Los Angeles and the prisoners-differed significantly from the average. No convincing explanation for either of these exceptions was discovered.. The data in this study were mainly from a white population. Data for nonwhites came primarily from 2 aberrant groups and were too meager to allow a clear characterization of lipid levels. The levels for nonwhites from these 2 sources were closer to those of the white members of these groups than to the levels of the general population.. Cholesterol levels for men ...http://circ.ahajournals.org/content/16/2/227
"Lipid deposition and intimal stress and strain. A study in rats with a" by Thomas Zand, G. Majno et al.
These experiments were designed to study the topography of lipid deposition in the stenotic aorta of hypercholesterolemic rats, and to correlate it with flow conditions and intimal stresses and strains studied in a scale biophysical model and in a computer model. A 69% +/- 5% stenosis was produced with a U-shaped metal clip. One month to 8 months later, the aorta was studied en face by light microscopy after fixation and lipid staining. The intima in the throat of the stenosis was almost completely free of lipid, whereas symmetric lipid deposits occurred as bands just above and especially just below the stenosis; elsewhere lipid deposits appeared to be random. The flow data obtained from the scale model showed that the intima in the throat of the stenosis was subjected to an increase of as much as 20 times in shear stress, whereas the lipid deposits just above and just below the stenosis were associated with ...http://escholarship.umassmed.edu/oapubs/98/
Lipid Panel with Total Cholesterol:HDL Ratio Test - Request A Test
Use the Lipid Panel with Total Cholesterol:HDL Ration to monitor your cholesterol. With Request A Test, ordering your own lab testing couldn't be easier or more convenient. Order your lab tests, give your sample, get results. Call or go online to order today.http://requestatest.com/lipid-panel-with-total-cholesterolhdl-ratio-testing
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. - MRCPHRU
To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprising 6,068 individuals specific to our study (1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables) and 2,758 individuals from the Diabetes Genetics Initiative, reported in a companion study in this issue. We subsequently examined promising signals in 11,569 additional individuals. Overall, we identify strongly associated variants in eleven loci previously implicated in lipid metabolism (ABCA1, the APOA5-APOA4-APOC3-APOA1 and APOE-APOC clusters, APOB, CETP, GCKR, LDLR, LPL, LIPC, LIPG and PCSK9) and also in several newly identified loci (near MVK-MMAB and GALNT2, with variants primarily associated with high-density lipoprotein (HDL) cholesterol; near SORT1, with variants primarily associated with ...https://www.mrc-phru.ox.ac.uk/publications/40612
Tests for High Cholesterol (Lipid Panel)
WebMD explains the tests used to diagnose high cholesterol, including a total cholesterol test, lipoprotein analysis, lipid panel, and LDL test.https://www.webmd.com/cholesterol-management/guide/tests-for-high-cholesterol-lipid-panel
Serum lipid responses to phytosterol-enriched milk in a moderate hypercholesterolemic population is not affected by...
Background/Objectives:The importance of both low-density lipoprotein cholesterol (LDLc) size and the apolipoprotein E (Apo E) in the atherogenic process is known, but there is little information with regard to the effect of phytosterols (PS) on thesehttp://www.biomedsearch.com/nih/Serum-lipid-responses-to-phytosterol/21048770.html
JAIRO | Primitive Extracellular Lipid Components on the Surface of the Charophytic Alga Klebsormidium flaccidum and Their...
Primitive Extracellular Lipid Components on the Surface of the Charophytic Alga Klebsormidium flaccidum and Their Possible Biosynthetic Pathways as Deduced from the Genome Sequence.Primitive Extracellular Lipid Components on the Surface of the Charophytic Alga Klebsormidium flaccidum and Their Possible Biosynthetic Pathways as Deduced from the Genome Sequence. ...http://jairo.nii.ac.jp/0083/00244270
Lipids in Health and Disease | Home page
|p|Lipids in Health and Disease publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.|/p|http://www.lipidworld.com
What are Lipids?
Lipids are utilized or synthesized from the dietary fats. There are in addition numerous biosynthetic pathways to both break down and synthesize lipids in the body. There are, however, some essential lipids that need to be obtained from the diet. The main biological functions of lipids include storing energy as lipids may be broken down to yield large amounts of energy. Lipids also form the structural components of cell membranes and form various messengers and signalling molecules within the body ...https://www.news-medical.net/life-sciences/What-are-Lipids.aspx
How do you maintain normal lipid profile values? | Reference.com
Eating a healthy diet, getting enough exercise, losing weight and consuming enough omega-3 fatty acids are some recommended ways to maintain normal lipid profile values, states WebMD. A lipid...https://www.reference.com/health/maintain-normal-lipid-profile-values-8d1eee40f97a2afc
Lipid Panel Help - Pharma - Forums - T Nation
Got a lipid panel done the other day and it seems some of my numbers are off. Specifically My HDL or good cholesterol. I don't know a lot about this stuff since my results are always fine, but this is the first time i Have had one done on cycle. I am on test 500mg a week dbol 30mg ed Just stopped 4 days before the test adex .5 eod Here is my panel from the other day Cholesterol Total 139 HDL 25 LDL 104 Non HDL 114 Triglyceride 52 Chol risk ratio 5.6 Here is my panel from last year not juici...https://forums.t-nation.com/t/lipid-panel-help/209901
ApoB-100 Secretion by HepG2 Cells Is Regulated by the Rate of Triglyceride Biosynthesis but Not by Intracellular Lipid Pools |...
The various cellular models and multiple experimental conditions that have been used to study the role of lipids in the regulation of apoB-100 secretion have generated conflicting results.22 23 24 25 26 27 28 29 30 31 32 We reinvestigated this question in HepG2 cells by using several modulators of lipid synthesis. The size of the CE and TG pools was upregulated or downregulated by a 3-day treatment with oleic acid and/or 58-035 (an ACAT inhibitor), simvastatin (a hydroxymethylglutaryl coenzyme A reductase inhibitor), or TOFA (an inhibitor of fatty acid synthesis). These modulators of lipid synthesis were eliminated by washing the HepG2 cells and incubating them overnight in fresh medium. Such treatment was sufficient to restore lipid synthesis rates equivalent to the control condition. Either through inhibition by 58-035 or stimulation by oleic acid, the cellular content of CE could be modulated over a ninefold range between the two ...http://atvb.ahajournals.org/content/16/10/1229
Marine Drugs | Free Full-Text | The Lipid A from the Haloalkaliphilic Bacterium Salinivibrio sharmensis Strain BAGT | HTML
Lipid A is a major constituent of the lipopolysaccharides (or endotoxins), which are complex amphiphilic macromolecules anchored in the outer membrane of Gram-negative bacteria. The glycolipid lipid A is known to possess the minimal chemical structure for LPSs endotoxic activity, able to cause septic shock. Lipid A isolated from extremophiles is interesting, since very few cases of pathogenic bacteria have been found among these microorganisms. In some cases their lipid A has shown to have an antagonist activity, i.e., it is able to interact with the immune system of the host without triggering a proinflammatory response by blocking binding of substances that could elicit such a response. However, the relationship between the structure and the activity of these molecules is far from being completely clear. A deeper knowledge of the lipid A chemical structure can help the understanding of these mechanisms. ...http://www.mdpi.com/1660-3397/11/1/184/htm