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*  Anaplastic large-cell lymphoma - Wikipedia
The cells are also typically positive for a subset of markers of T-cell lineage. However, as with other T-cell lymphomas, they ... Anaplastic large-cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma involving aberrant T cells or null lymphocytes. It is ... It has been suggested that ALK-negative anaplastic large-cell lymphomas derive from other T-cell lymphomas that are morphologic ... European T-Cell Lymphoma Study Group (2012). "ALK Signaling and Target Therapy in Anaplastic Large Cell Lymphoma". Front Oncol ...
  https://en.wikipedia.org/wiki/Anaplastic_large-cell_lymphoma
*  ALK− anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell...
Subsequent immunophenotypic and genetic studies resulted in restriction of the diagnosis to cases of T-cell or null lineage, ... Molecular biology of anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma. J Clin Oncol 2002;20:3691-3702. ... Anaplastic large cell lymphomas lack the expression of T-cell receptor molecules or molecules of proximal T-cell receptor ... Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma. ...
  http://www.bloodjournal.org/content/111/12/5496.long?sso-checked=true
*  Case of the Week #36
Anaplastic large cell lymphoma (ALCL) causes 10-15% of childhood non-Hodgkin lymphomas versus 3% in adults. T-cell origin and T ... cell lineage can usually be proven by molecular studies, even if no T-cell antigen expression is present by ... Anaplastic large cell lymphoma is associated with t(2;5)(p23;q35), with a translocation of the anaplastic lymphoma kinase gene ... Immunohistochemistry is necessary to confirm the diagnosis of anaplastic large cell lymphoma. Tumor cells have characteristic ...
  http://www.pathologyoutlines.com/caseofweek/case200636.htm
*  Primary Cutaneous Anaplastic Large Cell Lymphoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Primary Cutaneous Anaplastic Large Cell Lymphoma, also known as lymphoma, primary cutaneous anaplastic large cell, is related ... Dendritic Cells Developmental Lineage Pathway 65 11.33. IRF4 PTPRC 5. Interferon type I signaling pathways 1 ... MalaCards integrated aliases for Primary Cutaneous Anaplastic Large Cell Lymphoma:. Name: Primary Cutaneous Anaplastic Large ... Primary cutaneous anaplastic large cell lymphoma simulating an aggressive angiocentric T-cell lymphoma. ( 22458926 ) ...
  https://www.malacards.org/card/primary_cutaneous_anaplastic_large_cell_lymphoma
*  Primary rare anaplastic large cell lymphoma, ALK positive in small intestine: case report and review of the literature |...
Here, we report a case of 32-year-old male with ALK positive anaplastic large cell lymphoma at the junction of jejunum and ... The neoplastic cells were mainly medium to large size with moderate basophilic cytoplasm. Most of them had hyperchromatic ... Microscopically, almost all layers of the intestinal wall were infiltrated by pleomorphic tumor cells with diffuse and cohesive ... Primary anaplastic large cell lymphoma, ALK positive in small intestine is clinically rare and the clinical, radiological and ...
  https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-016-0539-6
*  Human herpesvirus 8-associated solid lymphomas that occur in AIDS patients take anaplastic large cell morphology. - Herpes...
HHV-8-positive plasmablasts visualized in the mantle zone of pathologic lymph nodes as large cells of a B lineage that express ... Human herpesvirus 8-associated solid lymphomas that occur in AIDS patients take anaplastic large cell morphology.. Thus, we ... as they could restore activation and survival of tumoricidal NK cells. Thus, at least in the southeast Texas region, large- ... Comparison of early-passage cells (5 passages after initial isolation) with those after long-term culture of 2 KSHV-infected ...
  http://www.bestmovinginfo.com/human-herpesvirus-8-associated-solid-lymphomas-that-occur-in-aids-patients-take-anaplastic-large-cell-morphology/
*  Orange County Medical Association > News > OCMA Blog |...
4. Anaplastic Large Cell Lymphoma Associated With Breast Implants: A Report of 13 Cases. Aladily, Tariq N.; Medeiros, L. ... 2 Breast implant-associated ALCL is a rare type of lymphoma of T-cell lineage with clinical signs and symptoms of swelling, ... Anaplastic large cell lymphoma (ALCL) in women with breast implants: preliminary FDA findings and analyses. 2011. Available at ... Discussion: anaplastic large cell lymphoma and breast implants: a systematic review. Plast Reconstr Surg. 2011;127:2151-2153. ...
  http://www.ocma.org/news/ocma-blog.aspx?BlogPage=21
*  BEB Conditioning Regimen for Autologous Stem-cell Transplantation(ASCT) in Non-Hodgkin's Lymphoma
CUTANEOUS T-CELL LYMPHOMA; or ANAPLASTIC LARGE-CELL LYMPHOMA. ... being more heterogeneous with respect to malignant cell lineage ... The atypical cells resemble REED-STERNBERG CELLS of HODGKIN DISEASE or the malignant cells of CUTANEOUS T-CELL LYMPHOMA. In ... It may contain different types of non-Hodgkin lymphoma cells or both Hodgkin and non-Hodgkin lymphoma cells. ... Lymphoma, Mantle-cell. A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes ...
  https://www.bioportfolio.com/resources/trial/162212/BEB-Conditioning-Regimen-for-Autologous-Stem-cell-Transplantation-ASCT-in-Non-Hodgkins.html
*  TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS - Patent application
... anaplastic large-cell lymphoma (ALCL), prolymphocytic leukemia (PML), juvenile myelomonocyctic leukemia (JMML), adult T-cell ... ALL, AML with trilineage myelodysplasia (AML/TMDS), mixed lineage leukemia (MLL), myelodysplastic syndromes (MDSs), ... hematopoietically-derived primary cells including cells of the immune system such as B cells, T cells, monocytes, macrophages, ... B Cell In Vivo Functional Assay [0126] The effect of a compound of Formula I on B cell responses can be determined with the ...
  http://www.patentsencyclopedia.com/app/20110144100
*  Initial cutaneous manifestation of lymphomas in children
Prognostic factors in childhood anaplastic large cell lymphoma: results of a large European intergroup study. Blood. 2008;111: ... Unlike systemic NHL in which the most com-mon cell lineage is B, cases of PCL are generally T-cell related. Cutaneous T-cell ... Anaplastic large cell lymphomas (ALCL) may be primary to the skin (patient #5) or may be systemic (patient #2). In children, ... Primary cutaneous anaplastic large cell lymphoma in a young child. Eur J Pediatr. 2008;167:111-3. [ Links ]. ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962011000400031&lng=en&nrm=iso&tlng=en
*  Pyridyl-Triazine Inhibitors of Hedgehog Signaling - Patent application
... mantle cell lymphoma, B-lineage large cell lymphoma, Burkitt's lymphoma, and T-cell anaplastic large cell lymphoma). [0123] The ... and lymphomas (including Hodgkin's lymphoma, lymphoplasmacytoid lymphoma, follicular lymphoma, mucosa-associated lymphoid ... C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 h). Media ... Zhang and Kalderon have shown that Hh acts specifically on stem cells in Drosophila ovaries and that these cells cannot ...
  http://www.patentsencyclopedia.com/app/20120277233
*  Malignant Lymphomas Involving Lung and Pleura | SpringerLink
By contrast, secondary involvement of the lung in patients with systemic lymphoma is common. Most of... ... Primary malignant lymphomas represent approximately 0.5 % of all primary neoplasms of the lung. ... Mantle Cell Lymphoma Anaplastic Lymphoma Kinase Malt Lymphoma Anaplastic Large Cell Lymphoma Primary Effusion Lymphoma ... Most of the primary malignant lymphomas are non-Hodgkin's lymphomas of B-cell lineage and, overall, extranodal marginal zone ...
  https://link.springer.com/chapter/10.1007/978-1-4419-0787-5_11
*  Non-Hodgkin Lymphoma Workup: Approach Considerations, CBC Count, Serum Chemistry Studies
In general, lymphomas are divided into 2 large groups of neoplasms, namely non-Hodgkin lymphoma (NHL) and Hodgkin disease. ... The term lymphoma describes a heterogeneous group of malignancies with different biology and prognosis. ... CD30 expression is important for the recognition of anaplastic large cell lymphoma, and it can also be found in the majority of ... This analysis provides information about lineage and clonality, which are complementary to the histology of a given case. ...
  https://emedicine.medscape.com/article/203399-workup
*  A Mutant Collagen XIII Alters Intestinal Expression of Immune Response Genes and Predisposes Transgenic Mice to Develop B-Cell...
... and subsets of mouse B lineage tumors, including most plasmacytomas ( 3) and some diffuse large B-cell lymphomas (DLBCL; ref. 4 ... Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage ... The B-cell lineage tumors were primarily of GC or post-GC origin with three follicular lymphomas, three centroblastic lymphomas ... For example, a subset of human follicular B-cell lymphomas is characterized by a large number of genes encoding T-cell markers ...
  http://cancerres.aacrjournals.org/content/68/24/10324
*  Childhood Non-Hodgkin Lymphoma Treatment (PDQ®) (Health professionals) | OncoLink
All anaplastic large cell lymphoma cases are CD30-positive. More than 90% of pediatric anaplastic large cell lymphoma cases ... Phenotype (i.e., B-lineage, T-lineage, or natural killer [NK] cell lineage). ... Evidence (treatment of anaplastic large cell lymphoma):. CNS involvement in anaplastic large cell lymphoma is rare at diagnosis ... Anaplastic large cell lymphoma: In a retrospective subset analysis of children with anaplastic large cell lymphoma, MDD ...
  https://www.oncolink.org/healthcare-professionals/nci/pqid-cdr0000062808
*  CD20-positive NK/T-cell lymphoma with indolent clinical course: report of case and review of literature | SpringerLink
CD20-positive T-cell lymphoma is extremely rare and only two cases of CD20-positive NK/T-cell lymphoma with aggressive clinical ... anaplastic large cell lymphoma (2/39, 5.1%), T-cell lymphoma with features of angioimmunoblastic T-cell lymphoma (1/39, 2.6%) ... we found that the tumor cells exhibited co-expression of CD20 and markers for T-cell lineage and NK cell lineage, but were ... Primary mediastinal anaplastic alk-1-positive large-cell lymphoma of T/NK-cell type expressing CD20. Virchows Arch. 2007, 450: ...
  https://link.springer.com/article/10.1186%2F1746-1596-7-133
*  Rare Occurrence of Classical Hodgkin's Disease as a T Cell Lymphoma | JEM
... assignment of T cell genotype to H/RS cells of the Hodgkin's lymphoma was not conclusive: anaplastic large cell lymphoma versus ... Thus, H/RS cells can mimic cells of various hematopoietic lineages in terms of cell surface marker expression. ... 1996) Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules. Blood. 88:4005-4011, pmid: ... 1997) Cytotoxic cell antigen expression in anaplastic large-cell lymphomas of T- and null-cell type and Hodgkin's ...
  http://jem.rupress.org/content/191/2/387
*  Intravascular large B-cell lymphoma - Wikipedia
ISBN 1-4160-2999-0. Wang L, Li C, Gao T (March 2010). "Cutaneous intravascular anaplastic large cell lymphoma". J Cutan Pathol ... Most intravascular lymphomas are of the B-cell lineage. Most cases of intravascular lymphoma are caused by the infiltration of ... Intravascular large B-cell lymphoma (ILBCL), also referred to as angiotropic large-cell lymphoma, angiotropic large-cell ... Intravascular lymphomas have a large cell morphology, i.e. the malignant cells are two or more times the size of a normal ...
  https://en.wikipedia.org/wiki/Intravascular_large_B-cell_lymphoma
*  Lineage-Specific Biomarkers Predict Response to FGFR Inhibition | Cancer Discovery
... several groups have established larger and more diverse cancer cell line libraries to better capture the lineage and genomic ... include the anaplastic lymphoma kinase (ALK) inhibitor crizotinib in patients with EML4-ALK fusions and the BRAF inhibitor ... Guagnano and colleagues use a large and diverse annotated collection of cancer cell lines, the Cancer Cell Line Encyclopedia, ... This cancer cell line screen also draws attention to one of the known bottlenecks originally associated with large-scale ...
  http://cancerdiscovery.aacrjournals.org/content/2/12/1081
*  TCF7L1 | Cancer Genetics Web
Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.. Cancer Cell. ... How embryonic stem cells (ESCs) commit to specific cell lineages and yield all cell types of a fully formed organism remains a ... cells were detected in the ALDHpos FA‑HNSCC cells and not in the ALDHneg cells. FA‑HNSCC cell lines revealed enhanced in vitro ... PCA decreased cell viability in a dose-dependent manner in HCT116 and SW480 cells. In addition, PCA reduced cell viability in ...
  http://www.cancerindex.org/geneweb/TCF7L1.htm
*  John Higgins | Stanford Medicine Profiles
T-cell anaplastic large cell lymphoma (one case), and precursor T-lymphoblastic lymphoma (one case). Six tumors were of B-cell ... lineage, and two tumors were of T-cell lineage. All three diffuse large B-cell lymphomas were positive for BCL-6, two were ... of large B cells and compared it with angioimmunoblastic T-cell lymphoma and angioimmunoblastic T-cell lymphoma with a large B- ... neoplastic T cells in contrast to angioimmunoblastic T-cell lymphoma and angioimmunoblastic T-cell lymphoma with a large B-cell ...
  https://med.stanford.edu/profiles/john-higgins
*  Chae SY[au] - PubMed - NCBI
18)F-FDG PET in Patients with Primary Systemic Anaplastic Large Cell Lymphoma: Differential Features According to Expression of ... Combined injection of three different lineages of early-differentiating human amniotic fluid-derived cells restores urethral ... Highly stable tandem solar cell monolithically integrating dye-sensitized and CIGS solar cells. ... Gold-conjugated resveratrol nanoparticles attenuate the invasion and MMP-9 and COX-2 expression in breast cancer cells. ...
  https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Chae+SY%5Bau%5D&dispmax=50
*  MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia - Full Text View - ClinicalTrials.gov
Large Granular Lymphocyte Leukemia Aggressive NK Cell Leukemia Hodgkin Lymphoma, Childhood Anaplastic Large Cell Lymphoma ... Large-cell Chronic Myeloproliferative Disorders Lymphoblastic Lymphoma Acute Leukemia of Ambiguous Lineage Mantle Cell Lymphoma ... Lymphoma, B-Cell, Marginal Zone. Lymphoma, Large B-Cell, Diffuse. Burkitt Lymphoma. Lymphoma, T-Cell. Lymphoma, Large-Cell, ... Diffuse Large B-Cell Lymphoma Marginal Zone Lymphoma Waldenstrom Macroglobulinemia Extranodal Nasal NK/T Cell Lymphoma Chronic ...
  https://clinicaltrials.gov/ct2/show/NCT01231919?recr=Open&cond=%22Ileal+Diseases%22&rank=4
*  MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia - Full Text View - ClinicalTrials.gov
Large Granular Lymphocyte Leukemia Aggressive NK Cell Leukemia Hodgkin Lymphoma, Childhood Anaplastic Large Cell Lymphoma ... Large-cell Chronic Myeloproliferative Disorders Lymphoblastic Lymphoma Acute Leukemia of Ambiguous Lineage Mantle Cell Lymphoma ... Lymphoma, Mantle-Cell. Lymphoma, B-Cell, Marginal Zone. Lymphoma, Large B-Cell, Diffuse. Burkitt Lymphoma. Lymphoma, T-Cell. ... Leukemia, Mast-Cell. Leukemia, Large Granular Lymphocytic. Leukemia, B-Cell. Leukemia, T-Cell. Lymphoma. Disease. Lymphoma, ...
  https://clinicaltrials.gov/ct2/show/NCT01231919?cond=%22Leukemia%22&rank=12
*  Printable - Extrarenal Rhabdoid Tumor - Surgical Pathology Criteria - Stanford University School of Medicine
Anaplastic Large Cell Lymphoma Extrarenal Rhabdoid Tumor LCA and or T lineage markers positive. LCA and T lineage markers ... Large polygonal or spindled cells *Abundant glassy eosinophilic cytoplasm *Paranuclear eosinophilic inclusions *May be focal or ... Neoplasm composed of large noncohesive cells with keratin positive paranuclear inclusions * Other recognized types of neoplasms ... May have strap cells. Strap cells rare. No consistent abnormalities of 22q Various deletions, translocations involving 22q11 ...
  http://surgpathcriteria.stanford.edu/softmisc/extrarenal_rhabdoid_tumor/printable.html