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*  CCR7: Unifying Disparate Journeys to the Lymph Node | The Journal of Immunology
Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. J. ... was selected in 1992 as international research mounted to recognize the existence of a structurally related, highly potent ... with recognition in 1998 that these ligands attracted T cells by binding to CCR7 (12, 13). These ligands are now called CCL19 ... As data on chemokine biology emerged, it became clear that some chemokines were homeostatic (4), produced constitutively, ...
  http://www.jimmunol.org/content/196/1/3
*  Regulation of the bioavailability of CCR7 ligands - Enlighten: Theses
CCRL1, a member of the atypical chemokine receptor family, binds to CCL19, CCL21 and CCL25 and is proposed to be a scavenger of ... chemokines can be controlled by proteases and interactions with atypical chemokine receptors that structurally resemble ... The reason this phenotype is restricted to the mesenteric lymph node is unclear, but it might be related to the fact the ... The coordinated migration of cells into and within tissues is mediated by chemokines, a family of small chemotactic cytokines ...
  http://theses.gla.ac.uk/5904/
*  angiogenesis | High-Throughput Screen for the Chemical Inhibitors
Chemokines belong to the small molecule chemo-attractive cytokine family and are grouped into CXC chemokines and CC chemokines ... and it could induce the homing of dendritic and T cells to the lymph node by binding with its specific ligands CCL19 WZ8040 and ... As a member of chemokine receptor family, C-C chemokine receptor type 7 (CCR7) is usually mainly located on the membrane of ... family and inhibitors of angiogenesis, including endostatin, angiostatin and other related molecules [6]. VEGF family comprises ...
  http://acancerjourney.info/index.php/tag/angiogenesis/
*  Chemokines in Atherosclerosis | Arteriosclerosis, Thrombosis, and Vascular Biology
Chemokine-Like Functions of Macrophage Migration Inhibitory Factor. *Immune-Regulatory Chemokines CCL19 and CCL21 in Vascular ... Chemokines belong to a large group of structurally related and secretable, largely basic, chemotactic cytokines, which can be ... CXCR2 Ligands in Atherosclerosis. The CXC chemokine receptor CXCR252 has several ligands defined by an N-terminal ELR motif, ... atherosclerotic plaques and in monocyte/macrophages is regulated by the Rel proteins p50 and p65 belonging to the NF-κB family ...
  http://atvb.ahajournals.org/content/28/11/1897.long
*  Chemokine‐guided cell migration and motility in zebrafish development | The EMBO Journal
Chemokines are vertebrate‐specific, structurally related proteins that function primarily in controlling cell movements by ... secreted protein ligands that bind to their cognate chemokine receptors to elicit cellular responses. The chemokine family is ... In humans, CCR7 has 3 ligands, CCL19, CCL21, and CCL25, while in zebrafish, 4 homologous proteins were identified and named ... The recent sequence analysis of the zebrafish genome provided a comprehensive list of chemokine and chemokine receptor family ...
  http://emboj.embopress.org/content/early/2015/03/11/embj.201490105
*  Maturing Dendritic Cells Depend on RAGE for In Vivo Homing to Lymph Nodes | The Journal of Immunology
Structurally heterogeneous ligands, including advanced glycation end products, members of the S100 calgranulin family, the β2 ... and controls the expression and function of receptors for lymph node chemokines, such as CXCL12 and CCL19 (21 ,22 ). As a ... and acquiring the ability to respond in vitro to chemokine receptor ligands (21). All events abate in the presence of ... Related Articles. Cited By.... More in this TOC Section. *. Innate Immunity Together with Duration of Antigen Persistence ...
  http://www.jimmunol.org/content/180/4/2270
*  Chemokine C Receptor 7 Expression and Protection of Circulating CD8+ T Lymphocytes from Apoptosis | Clinical Cancer Research
chemokines. Chemokines are a group of small (8-14 kDa) structurally related molecules. They regulate trafficking of various ... There are two ligands for CCR7: chemokine C ligands (CCL) 19 and CCL21 (4). The two ligands are expressed on high endothelial ... CXCR4, a member of CXCR family, is involved in survival of CD4+ T cells. CXCR4 activation in CD4+ T cells by its ligand, ... To study CCR7 signaling, CD8+ T cells were stimulated with CCR7 ligands, chemokine C ligands 19 or 21. Ligand binding to CCR7 ...
  http://clincancerres.aacrjournals.org/content/11/21/7901
*  Protocols and Video Articles Authored by Michael Dustin (Translated to Dutch)
Silencing of either CCR7 or its chemokine ligand CCL19 (ref. 6) in an animal model of T-ALL specifically inhibits CNS ... Rap1, a Ras-related GTPase, appears to be central to LFA-1 function. Rap1 is regulated by receptor signaling [e.g. T-cell ... Chemokines stimulated an increase in the percentage of naïve cells that adhered to ICAM-1, but did not increase the average ... Src and Syk family kinases are activated early in immunological synapse formation, but this signaling process returns to the ...
  https://www.jove.com/author/Michael_Dustin?language=Dutch
*  Immunopathogenesis of psoriasis - Sabat - 2007 - Experimental Dermatology - Wiley Online Library
Metalloproteinases constitute a family of structurally related zinc-dependent neutral endopeptidases, which degrade the ... CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to ... 4). This is achieved by integrins expressed on immune cells and their ligands expressed on endothelial cells. Chemokines induce ... migrate into the T-cell area of the regional lymph nodes via afferent lymphatic vessels following a gradient of CCL21 and CCL19 ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2007.00629.x/full
*  Additive Roles for MCP-1 and MCP-3 in CCR2-Mediated Recruitment of Inflammatory Monocytes during Listeria monocytogenes...
... a number of chemokine receptors bind multiple chemokine ligands, as demonstrated by the association of CCR7 with CCL19 and ... Some chemokine-chemokine receptor pairs are monogamous, such as CXCL12-CXCR4 and CCL20-CCR6. Other chemokines, however, bind to ... belonging to the chemokine family. J. Exp. Med. 176: 59-65. ... MCP-3 is structurally and functionally similar to MCP-1 and is ... Related Articles. Cited By.... More in this TOC Section. *. Early Self-Regulatory Mechanisms Control the Magnitude of CD8+ T ...
  http://www.jimmunol.org/content/180/10/6846?ijkey=883a336c583bda1321493b2394501deb77b894a3&keytype2=tf_ipsecsha
*  Protocols and Video Articles Authored by Nina Bhardwaj (Translated to Chinese)
CCL19, CCR7, VCAM1) while genes negatively associated with survival were cell proliferation related (e.g., PDE4D, CDK2, GREF1, ... DCs generated in a medium with HCV-negative plasma and treated with a defined cocktail of cytokines or a CD40 ligand trimer ... Previous analyses have failed to identify phenotypic properties other than chemokine receptor 5 (CCR5) and CD4+ T-cell tropism ... Jun, 2004 , Pubmed ID: 15130499 Myeloid and plasmacytoid dendritic cells, a family of professional antigen presenting cells, ...
  https://www.jove.com/author/Nina_Bhardwaj?language=Chinese
*  Protocols and Video Articles Authored by Raymond A. Sobel
We also show that the effect of PPAR-delta in inhibiting the production of IFN-gamma and IL-12 family cytokines is ligand ... and altered expression of the structurally related protein CD58 (LFA-3) is associated with disease remission in MS. We examined ... IFN-inducible Protein 10/CXC Chemokine Ligand 10-independent Induction of Experimental Autoimmune Encephalomyelitis Journal of ... of transferred BDC and BDC-Idd9 T cells at least partly depends on their differential chemotaxis toward the CCR7 ligand CCL19. ...
  https://www.jove.com/author/Raymond++A._Sobel
*  William Robinson | Stanford Medicine Profiles
CCL19 as a Chemokine Risk Factor for Posttreatment Lyme Disease Syndrome: a Prospective Clinical Cohort Study. Clinical and ... Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives ... Suppression of autoimmunity via microbial mimics of altered peptide ligands MOLECULAR MIMICRY: INFECTION-INDUCING AUTOIMMUNE ... CD81 is a tetraspanin family member involved in diverse cellular interactions in the immune and nervous systems and in cell ...
  https://med.stanford.edu/profiles/william-robinson
*  Organs of the immune system
HEVs express a similar non-signaling chemokine receptor - the Duffy antigen-related receptor for chemokines (DARC)ref, which ... but not lymphoid chemokines such as CCL21. , CCL19. , CXCL12. and CXCL13. that are normally expressed in HEVref ... which binds the majority of pro-inflammatory b-chemokine family members. , including CCL2. ref. After ligation, D6 triggers ... and its ligand CXCL13 / BLC. are concentrated in the light zone and contribute to recruitment of centrocytes to this zoneref. ...
  http://www.ufrgs.br/imunovet/molecular_immunology/organsimmune.html
*  Multivalent Immunoglobulin-Based Bioactive Assemblies - Patent application
0138] Chemokines generally act as chemoattractants to recruit immune effector cells to the site of chemokine expression. ... Proinflammatory effector chemokines include, but are not restricted to, CCL19, CCL21, IL-8, MCP-1 (monocyte chemotactic protein ... a chemokine, a growth factor, a drug, a prodrug, an enzyme, a binding molecule, a ligand for a cell surface receptor, a ... Other Related Methods Example 6 Generation of Di-AD1 [0359] In this example, a small polypeptide (AD1-C) having the amino acid ...
  http://www.patentsencyclopedia.com/app/20120276608
*  Purification and mass spectrometric characterization of human CXCR4 - UBC Library Open Collections
... an important group of rhodopsin family GPCRs and their cognate chemokine ligands Chemokines are small structurally related ... Cki1 CCL19 SCYA19 CCR7 MIP-3a, LARC, Exodus-I, Mexikine, 5T38, Ckf34 CCL2O SCYA2O CCR6 6-Ckine, Exodus-2, SLC, TCA4, Ckj39 ... an important group of rhodopsin family GPCRs and their cognate chemokine ligands 1.2.1 Chemokine nomenclature and ... Matrix metalloproteinases (MMPs) have been implicated in clipping the N-terminus of the CC chemokine family of chemokines. ...
  https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0067000