Leicester Research Archive: Localized breakdown in linkage disequilibrium does not always predict sperm crossover hot spots in...
Localized breakdown in linkage disequilibrium does not always predict sperm crossover hot spots in the human MHC class II ... To investigate the relationship between meiotic crossover hot spots and block-like linkage disequilibrium (LD), we have ...https://lra.le.ac.uk/handle/2381/15426
Leicester Research Archive: High levels of sequence polymorphism and linkage disequilibrium at the telomere of 12q:...
High levels of sequence polymorphism and linkage disequilibrium at the telomere of 12q: implications for telomere biology and ... The human Xp/Yp telomere-junction region exhibits high levels of sequence polymorphism and linkage disequilibrium. To determine ... Twenty polymorphic positions were in almost complete linkage disequilibrium, creating three common diverged haplotypes ...https://lra.le.ac.uk/handle/2381/25319
Leicester Research Archive: Molecular evolution of a pervasive natural amino-acid substitution in Drosophila cryptochrome
The SNP frequency spectra and the excessive linkage disequilibrium in this locus suggested that this variation is maintained by ...https://lra.le.ac.uk/handle/2381/28694
Seminars archive - Mathematics - School of Mathematics, Statistics & Actuarial Science - University of Kent
Statistical models for DNA sequence segmentation: linkage disequilibrium and haplotype blocks. 7 December ... John Hunton (Leicester) The shape of attractive space. 19 October. Constanze Roitzheim. Model Categories- the Joy of Abstract ... Narrative and the rationality of mathematical research programmes. 20 October. John McKay (Montreal). The finite simple groups ... Alexander Gorban (Leicester). Dynamics of large systems with inheritance (selection theorems and finite-dimensional asymptotics ...https://www.kent.ac.uk/smsas/seminars/pastmaths.html
Human recombination hot spots hidden in regions of strong marker association. - PubMed - NCBI
Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. ... 2005 Jun;37(6):601-6. Epub 2005 May 8. Research Support, N.I.H., Extramural; ... which identified localized regions of linkage disequilibrium breakdown that mark the locations of sperm crossover hot spots. ... Department of Genetics, University of Leicester, Leicester LE1 7RH, UK. firstname.lastname@example.org. ...https://www.ncbi.nlm.nih.gov/pubmed/15880103?access_num=15880103&link_type=MED&dopt=Abstract
Genome-wide association of functional traits linked with Campylobacter jejuni survival from farm to fork [PeerJ Preprints]
Distribution of squared correlation coefficient (linkage disequilibrium r2) values between SNPs across C. jejuni genomic ... 12 Department of Genetics, University of Leicester, Leicester, United Kingdom 13 Department of Infectious Disease Epidemiology ... KY was supported by a JSPS Research Fellowship for Young Scientists. GM was supported by a NISCHR Health Research Fellowship ( ... Raw reads are available on the European Nucleotide Archive (ENA) and the Short Read Archive (SRA) (see Table S1 for accession ...https://peerj.com/preprints/2300/
A second generation human haplotype map of over 3.1 million SNPs
It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life ... peer-reviewed health and life sciences research publications. ... free access to a stable and permanent online digital archive of ... New insights into linkage disequilibrium structure. The paradigm underlying association studies is that linkage disequilibrium ... 30University of Leicester, Department of Genetics, Leicester LE1 7RH, UK.. 31Johns Hopkins University School of Medicine, ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2689609/
Genealogical DNA test - Wikipedia
The field of linkage disequilibrium, unequal association of genetic disorders with a certain mitochondrial lineage, is in its ... how genetic testing can advance your genealogical research. Dundurn Press Ltd. ISBN 978-1-55002-536-1. Foundations and research ... Archived from the original on 27 July 2011. Retrieved 2011-06-15. Bettinger (2016, p. 50) "DNA Tests prove that the body found ... mtDNA testing was used by University of Leicester archaeologists to verify the skeletal remains of King Richard III, found in ...https://en.wikipedia.org/wiki/Genealogical_DNA_test
Common variants near MC4R are associated with fat mass, weight and risk of obesity
It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life ... peer-reviewed health and life sciences research publications. ... free access to a stable and permanent online digital archive of ... with low pair-wise linkage disequilibrium (LD; r2 = 0.08, D′ = 0.33 in CEU HapMap) mapping 109-188 kb from the coding sequence ... 33Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK. ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2669167/?lang=en-ca
A Meta-analysis of the Association of the Deletion Allele of the Angiotensin-Converting Enzyme Gene With Myocardial Infarction ...
3 The I/D polymorphism was found to be in strong linkage disequilibrium with the major gene locus controlling plasma ACE with ... An important purpose of a meta-analysis is to help direct future research. Our findings certainly suggest that further research ... In addition, our study27 carried out in Leicester and Sheffield was included. Table 1⇓ shows the details of the individual ... Podcast Archive. *→ Subscribe to Circulation on the Run. *→ Circulation on the Run, FIT Edition ...http://circ.ahajournals.org/content/94/4/708
Dienekes' Anthropology Blog: 08/2010
Bray and his colleagues did find evidence of elevated linkage disequilibrium in the Ashkenazi Jewish population, but were able ... To investigate the role of the Y chromosome further, a team from the University of Leicester carried out research to determine ... Old Blog Archive. 02/2003 03/2003 04/2003 05/2003 06/2003 07/2003 08/2003 09/2003 10/2003 11/2003 12/2003 01/2004 02/2004 03/ ... High linkage disequilibrium can come either from an isolated population (for example, an island whose residents are all ...http://dienekes.blogspot.com/2010/08/
Microsatellite - Wikipedia
... thus microsatellites can differentiate alleles within a SNP-defined linkage disequilibrium block of interest. Thus, ... "DNA Profiling". Archived from the original on 2001-09-27. Retrieved 2010-09-20. Lászik, A; Brinkmann, B; Sótonyi, P; Palus, A ( ... Although the first microsatellite was characterised in 1984 at the University of Leicester by Weller, Jeffreys and colleagues ... Genome Research. 26 (1): 12-23. doi:10.1101/gr.181008.114. ISSN 1549-5469. PMC 4691745 . PMID 26566657. Scherer S. (2008). A ...https://en.wikipedia.org/wiki/Microsatellite
Vitamin D Receptor Polymorphisms Are Associated with Altered Prognosis in Patients with Malignant Melanoma | Clinical Cancer...
... are in mutual tight linkage disequilibrium and a representative, Bsm, is known to be in linkage disequilibrium with the poly(A ... 2 To whom requests for reprints should be addressed, at Department of Dermatology, Leicester Royal Infirmary, Leicester LE1 5WW ... Copyright © 2017 by the American Association for Cancer Research.. Clinical Cancer Research. eISSN: 1557-3265. ISSN: 1078-0432 ... Because the TaqI restriction site is in strong linkage disequilibrium with the poly(A) polymorphism (T demonstrates linkage ...http://clincancerres.aacrjournals.org/content/6/2/498
Genetic polymorphisms of cytochrome p4502E1 and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a...
... the two polymorphisms show complete linkage disequilibrium in white populations.6,7,22 Therefore, for the purposes of our study ... two research groups have demonstrated the frequency of the C allele to be higher among patients with alcoholic liver disease ... were obtained from the archives of the department of pathology, University of Edinburgh. The hepatocellular carcinoma group did ... held at the University of Leicester, 1-3 July 1998, UK. ... but it might be in linkage disequilibrium with as yet ...http://mp.bmj.com/content/53/2/88
Cystatin C and Cardiovascular Disease | JACC: Journal of the American College of Cardiology
mmNational Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, ... When this SNP was not available, we used suitable proxies in linkage disequilibrium with rs911119 (r2 ≥0.90) (Online Table 4, ... archiving, and monograph (MORGAM) biomarker project. Circulation 121:2388-2397. ... ggNational Institute for Health Research Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Queen Mary ...http://www.onlinejacc.org/content/68/9/934
JCI Insight - LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients
... with color indicating the level of linkage disequilibrium (R2) with lead SNP. (B, D, and F) Corresponding normal Paneth cells- ... Annual reports of the research group of intractable inflammatory bowel disease subsidized by the Ministry of Health, Labour, ... and second-generation South Asians in Leicester (1991-1994). Am J Gastroenterol. 1999;94(10):2918-2922.. View this article via ... resection samples previously collected as part of standard diagnostic procedures and stored in Pathology Department archives at ...https://insight.jci.org/articles/view/91917
Dienekes' Anthropology Blog: 2014
Crucial to these findings has been an approach to analysis that accounts for linkage disequilibrium.. ... Recent research (R. Sebro et al., ASHG 2013) has shed light on the U.S. demography by studying the self-reported ethnicity from ... In 2012, a skeleton was excavated at the presumed site of the Grey Friars friary in Leicester, the last-known resting place of ... The majority of haplotypes will also be deposited in the European Genotype Archive.. ...https://dienekes.blogspot.com/2014/
... in strong linkage disequilibrium with rs445114 was positively associated with PSA level (P = 4.8 × 10−8). While rs11199874-A ... Kote-Jarai are supported by Cancer Research UK Grant (C5047/A7357) and support from the NIHR to the Biomedical Research Centre ... Leicester, Newcastle, and Sheffield). All men were invited to a prostate check clinic and were offered a PSA test: ... it is in strong linkage disequilibrium with rs10788160-A (r2 = 0.94; FGFR2), which has been shown to be associated with ...http://cebp.aacrjournals.org/content/23/7/1356
Exploring the Relationship Between Autistic-Like Traits and ADHD Behaviors in Early Childhood: Findings from a Community Twin...
The more general limitations of the twin design can be resolved by using other research designs to address the same research ... Archives of Pediatrics & Adolescent Medicine, 161, Hoekstra, R. A., Happé, F., Baron-Cohen, S., & Ronald, A. (2009). The ... Professor Terry Brugha University of Leicester with Staufenberg E., U. Challenging behaviour in Asperger Syndrome in early ... 2002). Genetic linkage of attentiondeficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism. ...http://docplayer.net/213139-Exploring-the-relationship-between-autistic-like-traits-and-adhd-behaviors-in-early-childhood-findings-from-a-community-twin-study-of-2-year-olds.html
Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci. ... Autism - International Journal of Research and Practice, 2, 4, 427 - 429. 100. Fitzgerald M. (1996). Current research on autism ... Submitted to Archives of General Psychiatry, February 2007. 235. Mulligan A., Anney R., O'Regan M., Chen W., Butler L., ... British Psychological Society, Occasional Paper 2, Leicester. 496. McDermott M., Brennan A., Fitzgerald M., Hoey H. (1998). ...http://new.professormichaelfitzgerald.eu/publications-2/
Microsatellite - Wikipedia
... thus microsatellites can differentiate alleles within a SNP-defined linkage disequilibrium block of interest. Thus, ... "Genome Research. 26 (1): 12-23. doi:10.1101/gr.181008.114. ISSN 1549-5469. PMC 4691745. PMID 26566657.. ... Although the first microsatellite was characterised in 1984 at the University of Leicester by Weller, Jeffreys and colleagues ... "Archived from the original on 2001-09-27. Retrieved 2010-09-20.. ... Genetic linkage analysis. During the 1990s and the first ...https://en.wikipedia.org/wiki/Short_tandem_repeats
International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and...
... linkage disequilibrium plots (LOD scores), and Manhattan plots (-log10 (P values)). Green boxed areas on Manhattan plots ... Women and Infants Research Foundation, and Curtin University. ALSPAC: The UK Medical Research Council and the Wellcome Trust ( ... University of Leicester, Leicestershire, UK (M.D.T.); Department of Clinical Physiology & Nuclear Medicine, Turku University ... Regional association plots and linkage disequilibrium plots for significant SNP clusters for SBP and DBP are presented by epoch ...http://circgenetics.ahajournals.org/content/9/3/266
High-Resolution Mapping of Complex Traits with a Four-Parent Advanced Intercross Yeast Population | Genetics
C) Inferred scaled linkage disequilibrium measure D′ for chromosome II, evaluated in 5-kb windows in the WA × NA cross, SGRP-4X ... University of Leicester, Leicester LE1 7RH, United Kingdom ... Research in model systems has led the way in this effort and ... The large decrease in linkage disequilibrium (LD) in the region (Figure 4C) strongly supports the latter explanation, showing ... Linkage analysis in 179 SGRP-4X segregants. (A) Strength of linkage to arsenite resistance for a QTL region mapped on ...http://www.genetics.org/content/195/3/1141
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals | Circulation:...
NIHR Leicester Cardiovascular Biomedical Research Unit (L.M.H., C.P.N.) and NIHR Leicester Respiratory Biomedical Research Unit ... For GMPR, the coding variant is in almost perfect linkage disequilibrium with the noncoding QT-IGC variant (r2=0.99 in ARIC), ... Cardiovascular Research Center (P.L.H., P.T.E., S.A.L.), and Center for Human Genetic Research and Cardiovascular Research ... GWiS was run on European-only summary statistics from 22 cohorts (QT, n=83 884; JT, n=80 330), with linkage disequilibrium (LD ...http://circgenetics.ahajournals.org/content/11/1/e001758
September 2017 - Page 2 - Polo-Like Kinases and Aurora Kinases in Cancer Therapy
Indeed, Linkage Disequilibrium (LD) across breeds was shown to only persist over few kb ,  which is still below the ... Research that are contained in the meta-analyses are shown in Desk 1. Other research that met all of the addition criteria but ... Leicester, UK). The analysis of asthma was confirmed by a physician based on medical history and one or more of the following ... 56 reviews of case-control research, 41 reviews of cohort research, and 4 reviews of randomized studies with data on the ...http://technumber.com/2017/09/page/2/