*  Abstract 15820: Early and Pre-clinical Transcriptome Analysis by RNA Sequencing Identifies Mitochondrial Dysfunction and...
Introduction: Mutations in the LMNA gene, encoding Lamin A/C, cause several distinct phenotypes collectively referred to as ... Methods: Lmna-/- and control wild type (WT) mice were characterized for cardiac function (echocardiography) and cardiac ... Analysis by RNA Sequencing Identifies Mitochondrial Dysfunction and Inflammation as Early Phenotypic Consequences of Lamin A/C ... Analysis by RNA Sequencing Identifies Mitochondrial Dysfunction and Inflammation as Early Phenotypic Consequences of Lamin A/C ...
  http://circ.ahajournals.org/content/134/Suppl_1/A15820
*  Effects of mechanical stress and carvedilol in lamin A/C-deficient dilated cardiomyopathy | Garvan Institute of Medical Research
Sustained pressure overload generated by thoracic aortic constriction depressed ventricular contraction in young wild-type and ... Sustained pressure overload generated by thoracic aortic constriction depressed ventricular contraction in young wild-type and ... Mechanical stress-induced apoptosis has been proposed as the mechanism underpinning DCM in lamin A/C-deficient hearts, but ... Mechanical stress-induced apoptosis has been proposed as the mechanism underpinning DCM in lamin A/C-deficient hearts, but ...
  https://www.garvan.org.au/research/publications/10809
*  LAP2α-binding protein LINT-25 is a novel chromatin-associated protein involved in cell cycle exit | Journal of Cell Science
... together with A-type lamins and LAP2 proteins (Fig. 3A). However, unlike the majority of A/C-type lamins, LAP2α and LAP2β, LINT ... Whereas B-type lamins are essential for cell viability, A-type lamins are predominantly expressed in terminally differentiated ... Hutchison, C. J. and Worman, H. J. (2004). A-type lamins: guardians of the soma? Nat. Cell Biol. 6, 1062-1067. ... Lamina-associated polypeptide (LAP)2α interacts with the nucleoplasmic pool of A-type lamins (Dechat et al., 2000a). It is one ...
  http://jcs.biologists.org/content/120/5/737
*  CMR-Verified Interstitial Myocardial Fibrosis as a Marker of Subclinical Cardiac Involvement in LMNA Mutation Carriers | JACC:...
2007) Severe myocardial fibrosis caused by a deletion of the 5′ end of lamin A/C gene. J Am Coll Cardiol 49:2430-2439. ... 39 ± 14 years) and had a higher pro-B-type natriuretic peptide level (median 333 ng/l [25th to 75th percentiles: 62 to 1,943] ... Lamin A/C (LMNA) gene mutation, identified in 10% of familial dilated cardiomyopathy (DCM) patients, is associated with an ... 2007) Mid-myocardial fibrosis by cardiac magnetic resonance in patients with lamin A/C cardiomyopathy. J Cardiovasc Magn Reson ...
  http://imaging.onlinejacc.org/content/6/1/124
*  What does lamin type a mean?
Meaning of lamin type a. What does lamin type a mean? Information and translations of lamin type a in the most comprehensive ... Definition of lamin type a in the Definitions.net dictionary. ... Search for lamin type a on Amazon. *Search for lamin type a on ... What does lamin type a mean?. Definitions for lamin type a. Here are all the possible meanings and translations of the word ... Alternative searches for lamin type a:. *Search for Synonyms for lamin type a ...
  https://www.definitions.net/definition/lamin%20type%20a
*  Universiteit Antwerpen - Molecular dissection of A-type lamin-regulated pathways
... known as lamins. Mutations in the LMNA gene, which encodes A-type lamins, or in the ZMPSTE24 gene, which encodes a zinc ... Molecular dissection of A-type lamin-regulated pathways. Datum: 2 oktober 2017 Locatie: Universiteit Gent, Campus Coupure, ... In summary, we show that redox balance, focal adhesion and cytoskeletal tension are affected by loss of A-type lamins. We ... Interestingly, functional validation showed that loss of A- type lamins perturbed the coordination between focal adhesion ...
  https://www.uantwerpen.be/popup/kalenderonderdeel.aspx?calitem_id=5742&c=LANDP56&n=219948
*  The p.R482W substitution in A-type lamins deregulates SREBP1 activity in Dunnigan-type familial partial lipodystrophy. | Sigma...
Dunnigan type familial partial lipodystrophy (FPLD2; OMIM#151660) is caused in most cases by the A-type lamin R482W mutation. ... The p.R482W substitution in A-type lamins deregulates SREBP1 activity in Dunnigan-type familial partial lipodystrophy.. [ ... These interactions involve the Ig-fold of A-type lamins and are favored upon SREBP1 binding to its DNA target sequences. We ... In contrast, both overexpression of LMNA R482W in primary human preadipocytes and endogenous expression of A-type lamins R482W ...
  https://www.sigmaaldrich.com/catalog/papers/25524705
*  Specific phosphorylation of Ser458 of A-type lamins in LMNA-associated myopathy patients | Journal of Cell Science
... a portion of the Ig-fold domain of A-type lamins (amino acids 450−469) in vertebrates and invertebrates. Homo sapiens lamin A ( ... S2. C2 myoblasts were transfected with Akt−HA constructs (wtAkt−HA or myrAkt−HA) and FLAG−lamin A constructs (WT: wild type, RW ... NP_492371). (B) Western blot analysis of unaffected human primary fibroblasts with antibodies against phospho-A-type lamins. ... Specific phosphorylation of Ser458 of A-type lamins in LMNA-associated myopathy patients ...
  http://jcs.biologists.org/content/123/22/3893.supplemental
*  Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β...
Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β ... Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β ... Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β ... Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β ...
  http://jcs.biologists.org/content/early/2009/01/06/jcs.026179
*  Emerin and A-type lamin-deficient cells have impaired m | Open-i
Emerin and A-type lamin-deficient cells have impaired mechanotransduction. (a) Expression of the mechanosensitive genes iex-1 ... and A-type lamin-deficient cells respectively, P , 0.05 for wild-type vs. emerin-deficient and wild-type vs. A-type lamin- ... and A-type lamin-deficient cells respectively, P , 0.05 for wild-type vs. emerin-deficient and wild-type vs. A-type lamin- ... for wild-type, emerin-deficient, and A-type lamin-deficient cells, respectively, P , 0.05 for wild-type vs. A-type lamin- ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2171355_200502148f6&req=4
*  RCSB PDB - Protein Feature View - SUN domain-containing protein 2 - Q9UH99 (SUN2 HUMAN)
Interacts with A-type lamin. Interaction with lamins B1 and C is hardly detectable (By similarity). Interacts with EMD and ... and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to ...
  http://www.rcsb.org/pdb/protein/Q9UH99
*  Whiting School of Engineering - Research Output - Johns Hopkins University
Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology. Kim, J. K., Louhghalam, A., Lee ... Lamin Type A Actins Objective Assessment of Surgical Technical Skill and Competency in the Operating Room. Vedula, S. S., Ishii ...
  https://jhu.pure.elsevier.com/en/organisations/whiting-school-of-engineering-3/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle
*  ml, 1 mg, 200 µl Ovalbumin Antibody (Monoclonal from Thermo Fisher Scientific, Inc.
Ox-LDL receptor 1, Lectin-type oxidized LDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, LOX- ... 200 µL Lamin C Antibody - $550.00 USD. *Lamin C Antibody. *Host Rabbit ... Ox-LDL receptor 1, Lectin-type oxidized LDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, LOX- ...
  http://www.thermofisher.com/1/1/indexc31.html
*  Lamin B1 maintains the functional plasticity of nucleoli | Journal of Cell Science
Nucleoli contain both A- and B-type lamins but are enriched in lamin B1. To reinforce the possibility that lamin B1 contributes ... Supporting this role, B-type lamins are present throughout development, whereas A-type lamins are expressed only following the ... Notably, this relative enrichment of lamin B1 correlated with a notable loss of lamin A/C (especially lamin A) (Fig. 4B, right ... relative to lamin A and C (LA/C). Note that although this analysis shows the relative content of A- and B-type lamins in ...
  http://jcs.biologists.org/content/122/10/1551
*  DNA Repair-Deficiency Disorders - Chromosome Instability Syndromes Summary Report | CureHunter
Lamin Type A (Lamin A)IBA 06/01/2013 - "The follow-up of the complete clinical course in the patient combined with functional ... 08/01/2012 - "We found that cPu accumulate spontaneously in the nuclear DNA of wild-type mice with age and to a greater extent ... 03/01/2014 - "Two-month-old wild-type (C57BL/6) and DNA repair-deficient Ercc1(-/Δ) mice were exposed to tobacco smoke by ... 12/15/2008 - "DNA-repair-deficient Rad54/Rad54B mice are more sensitive to clastogens than wild-type mice.". 01/01/1983 - "The ...
  http://www.curehunter.com/public/keywordSummaryD049914.do
*  Academic Bibliography
Deregulation of focal adhesion formation and cytoskeletal tension due to loss of A-type lamins Tobias Corne (UGent) , Tom ... Your filters: cql: author='Gabriele, Sylvain' or (type exact bookEditor and editor='Gabriele, Sylvain') ... iframe src="https://biblio.ugent.be/publication?limit=5&q=author%3D%22Gabriele%2C+Sylvain%22+or+(type+exact+bookEditor+and+ ...
  https://biblio.ugent.be/publication?q=author%3D%22Gabriele%2C+Sylvain%22+or+
*  "The role of Drosophila Lamin C in muscle function and gene expression" by George Dialynas, Sean D. Speese et al.
The GAL4-UAS system was used to express wild-type and mutant forms of Lamin C (the presumed Drosophila A-type lamin), in an ... Lamins, classified as A- or B-types on the basis of biochemical properties, have a conserved globular head, central rod and C- ... In humans, mutations in A-type lamins give rise to diseases that exhibit tissue-specific defects, such as Emery-Dreifuss ... Drosophila is being used as a model to determine tissue-specific functions of A-type lamins in development, with implications ...
  https://escholarship.umassmed.edu/neurobiology_pp/8/
*  Unique and Shared Functions of Nuclear Lamina LEM Domain Proteins in Drosophila | Genetics
... and B-type lamins, Lamin C and lamin Dm0, respectively (Pinto et al. 2008; Schulze et al. 2009). These shared protein partners ... Nuclei were stained for DNA (DAPI, gray), Lamin C, or lamin Dm0 (green), HP1 (red), or FG-Nups (red). The lamin Dm0 staining of ... the lamin Dm0 was found in one to seven O-shaped lamin Dm0-containing structures, which lacked lamin C and DNA (Figure 2D). In ... E) Confocal images of ventral nerve cord cells from wild-type (wt) and bocks−/− mutant third-instar larvae stained for lamin Dm ...
  http://www.genetics.org/content/197/2/653
*  Progeroid syndromes - Wikipedia
A-type lamins promote genetic stability by maintaining levels of proteins which have key roles in NHEJ and HR.[77] Mouse cells ... Defects in Lamin A/C[edit]. Lamin is required at the inner nuclear membrane to ensure the nucleus keeps its shape. Mutations in ... There are eight types of XP (XP-A through XP-G), plus a variant type (XP-V), all categorized based on the genetic cause. XP can ... "A dual role for A-type lamins in DNA double-strand break repair". Cell Cycle. 10 (15): 2549-60. doi:10.4161/cc.10.15.16531. PMC ...
  https://en.wikipedia.org/wiki/Accelerated_aging_disease
*  Lamin B1 Antibody
Lamin B1 Polyclonal Antibody from Invitrogen for Western Blot and Immunohistochemistry (Paraffin) applications. This antibody ... Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a ... lamin C and lamin Adel10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin ... Cite Lamin B1 Polyclonal Antibody. The following antibody was used in this experiment: Lamin B1 Polyclonal Antibody from Thermo ...
  https://www.thermofisher.com/antibody/product/Lamin-B-Antibody-Polyclonal/PA5-32474
*  Mechanosensing by the nucleus: From pathways to scaling relationships | JCB
Lamins are A-type (lamins A and C from the LMNA gene) or B-type (lamins B1 and B2) and tether the nucleus to the cytoskeleton ... B-type lamin levels remain relatively constant (for lamin B1, m ∼0.2, and for lamin B2, m ∼0.0). Thus, whereas collagens and ... supporting the notion that farnesylated lamins (i.e., pre-lamin A, progerin, and B-type lamins) are all more tightly anchored ... revealed that the concentration of A-type lamins scales over several orders of magnitude with tissue stiffness Et:. [. Lamin A ...
  http://jcb.rupress.org/content/early/2017/01/01/jcb.201610042
*  BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells | JCB
Loss of A-type lamins and genomic instability. Cell Cycle. 8:3860-3865. doi:10.4161/cc.8.23.10092. ... A dual role for A-type lamins in DNA double-strand break repair. Cell Cycle. 10:2549-2560. doi:10.4161/cc.10.15.16531. ... Regulating the levels of key factors in cell cycle and DNA repair: new pathways revealed by lamins. Cell Cycle. 10:3652-3657. ... Images show the types of chromosomal aberrations observed. A total of 400 metaphases were analyzed in one experiment (100 per ...
  http://jcb.rupress.org/content/200/2/187
*  Protocols and Video Articles Authored by Brian K. Kennedy (Translated to Swedish)
Jul, 2006 , Pubmed ID: 16809772 Mutations in the LMNA gene, which encodes all A-type lamins, including lamin A and lamin C, ... indicating that this property is specific to A-type nuclear lamins. These findings indicate that A-type lamins can promote ... Reintroduction of lamin A, lamin C, or pRB restores p16(ink4a)-responsiveness to Lmna(-/-) cells. An array of lamin A mutants, ... 2007 , Pubmed ID: 17896003 BACKGROUND: A-type lamins, predominantly lamins A and C, are nuclear intermediate filaments believed ...
  https://www.jove.com/author/Brian+K._Kennedy?language=Swedish
*  Welcome to LibAge, the ageing reference resource
Lamin Type A/genetics/metabolism *Membrane Proteins/genetics/metabolism *Metalloendopeptidases/genetics/metabolism ...
  http://libage.ageing-map.org/entries/tags/495/