Abstract 15820: Early and Pre-clinical Transcriptome Analysis by RNA Sequencing Identifies Mitochondrial Dysfunction and...
Introduction: Mutations in the LMNA gene, encoding Lamin A/C, cause several distinct phenotypes collectively referred to as ... Methods: Lmna-/- and control wild type (WT) mice were characterized for cardiac function (echocardiography) and cardiac ... Analysis by RNA Sequencing Identifies Mitochondrial Dysfunction and Inflammation as Early Phenotypic Consequences of Lamin A/C ... Analysis by RNA Sequencing Identifies Mitochondrial Dysfunction and Inflammation as Early Phenotypic Consequences of Lamin A/C ...http://circ.ahajournals.org/content/134/Suppl_1/A15820
Effects of mechanical stress and carvedilol in lamin A/C-deficient dilated cardiomyopathy | Garvan Institute of Medical Research
Sustained pressure overload generated by thoracic aortic constriction depressed ventricular contraction in young wild-type and ... Sustained pressure overload generated by thoracic aortic constriction depressed ventricular contraction in young wild-type and ... Mechanical stress-induced apoptosis has been proposed as the mechanism underpinning DCM in lamin A/C-deficient hearts, but ... Mechanical stress-induced apoptosis has been proposed as the mechanism underpinning DCM in lamin A/C-deficient hearts, but ...https://www.garvan.org.au/research/publications/10809
LAP2α-binding protein LINT-25 is a novel chromatin-associated protein involved in cell cycle exit | Journal of Cell Science
... together with A-type lamins and LAP2 proteins (Fig. 3A). However, unlike the majority of A/C-type lamins, LAP2α and LAP2β, LINT ... Whereas B-type lamins are essential for cell viability, A-type lamins are predominantly expressed in terminally differentiated ... Hutchison, C. J. and Worman, H. J. (2004). A-type lamins: guardians of the soma? Nat. Cell Biol. 6, 1062-1067. ... Lamina-associated polypeptide (LAP)2α interacts with the nucleoplasmic pool of A-type lamins (Dechat et al., 2000a). It is one ...http://jcs.biologists.org/content/120/5/737
CMR-Verified Interstitial Myocardial Fibrosis as a Marker of Subclinical Cardiac Involvement in LMNA Mutation Carriers | JACC:...
2007) Severe myocardial fibrosis caused by a deletion of the 5′ end of lamin A/C gene. J Am Coll Cardiol 49:2430-2439. ... 39 ± 14 years) and had a higher pro-B-type natriuretic peptide level (median 333 ng/l [25th to 75th percentiles: 62 to 1,943] ... Lamin A/C (LMNA) gene mutation, identified in 10% of familial dilated cardiomyopathy (DCM) patients, is associated with an ... 2007) Mid-myocardial fibrosis by cardiac magnetic resonance in patients with lamin A/C cardiomyopathy. J Cardiovasc Magn Reson ...http://imaging.onlinejacc.org/content/6/1/124
What does lamin type a mean?
Meaning of lamin type a. What does lamin type a mean? Information and translations of lamin type a in the most comprehensive ... Definition of lamin type a in the Definitions.net dictionary. ... Search for lamin type a on Amazon. *Search for lamin type a on ... What does lamin type a mean?. Definitions for lamin type a. Here are all the possible meanings and translations of the word ... Alternative searches for lamin type a:. *Search for Synonyms for lamin type a ...https://www.definitions.net/definition/lamin%20type%20a
The p.R482W substitution in A-type lamins deregulates SREBP1 activity in Dunnigan-type familial partial lipodystrophy. | Sigma...
Dunnigan type familial partial lipodystrophy (FPLD2; OMIM#151660) is caused in most cases by the A-type lamin R482W mutation. ... The p.R482W substitution in A-type lamins deregulates SREBP1 activity in Dunnigan-type familial partial lipodystrophy.. [ ... These interactions involve the Ig-fold of A-type lamins and are favored upon SREBP1 binding to its DNA target sequences. We ... In contrast, both overexpression of LMNA R482W in primary human preadipocytes and endogenous expression of A-type lamins R482W ...https://www.sigmaaldrich.com/catalog/papers/25524705
Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β...
Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β ... Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β ... Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β ... Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β ...http://jcs.biologists.org/content/early/2009/01/06/jcs.026179
Emerin and A-type lamin-deficient cells have impaired m | Open-i
Emerin and A-type lamin-deficient cells have impaired mechanotransduction. (a) Expression of the mechanosensitive genes iex-1 ... and A-type lamin-deficient cells respectively, P , 0.05 for wild-type vs. emerin-deficient and wild-type vs. A-type lamin- ... and A-type lamin-deficient cells respectively, P , 0.05 for wild-type vs. emerin-deficient and wild-type vs. A-type lamin- ... for wild-type, emerin-deficient, and A-type lamin-deficient cells, respectively, P , 0.05 for wild-type vs. A-type lamin- ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2171355_200502148f6&req=4
RCSB PDB - Protein Feature View - SUN domain-containing protein 2 - Q9UH99 (SUN2 HUMAN)
Interacts with A-type lamin. Interaction with lamins B1 and C is hardly detectable (By similarity). Interacts with EMD and ... and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to ...http://www.rcsb.org/pdb/protein/Q9UH99
Whiting School of Engineering - Research Output - Johns Hopkins University
Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology. Kim, J. K., Louhghalam, A., Lee ... Lamin Type A Actins Objective Assessment of Surgical Technical Skill and Competency in the Operating Room. Vedula, S. S., Ishii ...https://jhu.pure.elsevier.com/en/organisations/whiting-school-of-engineering-3/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle
DNA Repair-Deficiency Disorders - Chromosome Instability Syndromes Summary Report | CureHunter
Lamin Type A (Lamin A)IBA 06/01/2013 - "The follow-up of the complete clinical course in the patient combined with functional ... 08/01/2012 - "We found that cPu accumulate spontaneously in the nuclear DNA of wild-type mice with age and to a greater extent ... 03/01/2014 - "Two-month-old wild-type (C57BL/6) and DNA repair-deficient Ercc1(-/Δ) mice were exposed to tobacco smoke by ... 12/15/2008 - "DNA-repair-deficient Rad54/Rad54B mice are more sensitive to clastogens than wild-type mice.". 01/01/1983 - "The ...http://www.curehunter.com/public/keywordSummaryD049914.do
ml, 1 mg, 200 µl Ovalbumin Antibody (Monoclonal from Thermo Fisher Scientific, Inc.
Ox-LDL receptor 1, Lectin-type oxidized LDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, LOX- ... 200 µL Lamin C Antibody - $550.00 USD. *Lamin C Antibody. *Host Rabbit ... Ox-LDL receptor 1, Lectin-type oxidized LDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, LOX- ...http://www.thermofisher.com/1/1/indexc31.html
Lamin B1 maintains the functional plasticity of nucleoli | Journal of Cell Science
Nucleoli contain both A- and B-type lamins but are enriched in lamin B1. To reinforce the possibility that lamin B1 contributes ... Supporting this role, B-type lamins are present throughout development, whereas A-type lamins are expressed only following the ... Notably, this relative enrichment of lamin B1 correlated with a notable loss of lamin A/C (especially lamin A) (Fig. 4B, right ... relative to lamin A and C (LA/C). Note that although this analysis shows the relative content of A- and B-type lamins in ...http://jcs.biologists.org/content/122/10/1551
"The role of Drosophila Lamin C in muscle function and gene expression" by George Dialynas, Sean D. Speese et al.
The GAL4-UAS system was used to express wild-type and mutant forms of Lamin C (the presumed Drosophila A-type lamin), in an ... Lamins, classified as A- or B-types on the basis of biochemical properties, have a conserved globular head, central rod and C- ... In humans, mutations in A-type lamins give rise to diseases that exhibit tissue-specific defects, such as Emery-Dreifuss ... Drosophila is being used as a model to determine tissue-specific functions of A-type lamins in development, with implications ...https://escholarship.umassmed.edu/neurobiology_pp/8/
Unique and Shared Functions of Nuclear Lamina LEM Domain Proteins in Drosophila | Genetics
... and B-type lamins, Lamin C and lamin Dm0, respectively (Pinto et al. 2008; Schulze et al. 2009). These shared protein partners ... Nuclei were stained for DNA (DAPI, gray), Lamin C, or lamin Dm0 (green), HP1 (red), or FG-Nups (red). The lamin Dm0 staining of ... the lamin Dm0 was found in one to seven O-shaped lamin Dm0-containing structures, which lacked lamin C and DNA (Figure 2D). In ... E) Confocal images of ventral nerve cord cells from wild-type (wt) and bocks−/− mutant third-instar larvae stained for lamin Dm ...http://www.genetics.org/content/197/2/653
Progeroid syndromes - Wikipedia
A-type lamins promote genetic stability by maintaining levels of proteins which have key roles in NHEJ and HR. Mouse cells ... Defects in Lamin A/C. Lamin is required at the inner nuclear membrane to ensure the nucleus keeps its shape. Mutations in ... There are eight types of XP (XP-A through XP-G), plus a variant type (XP-V), all categorized based on the genetic cause. XP can ... "A dual role for A-type lamins in DNA double-strand break repair". Cell Cycle. 10 (15): 2549-60. doi:10.4161/cc.10.15.16531. PMC ...https://en.wikipedia.org/wiki/Accelerated_aging_disease
Lamin B1 Antibody
Lamin B1 Polyclonal Antibody from Invitrogen for Western Blot and Immunohistochemistry (Paraffin) applications. This antibody ... Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a ... lamin C and lamin Adel10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin ... Cite Lamin B1 Polyclonal Antibody. The following antibody was used in this experiment: Lamin B1 Polyclonal Antibody from Thermo ...https://www.thermofisher.com/antibody/product/Lamin-B-Antibody-Polyclonal/PA5-32474
Mechanosensing by the nucleus: From pathways to scaling relationships | JCB
Lamins are A-type (lamins A and C from the LMNA gene) or B-type (lamins B1 and B2) and tether the nucleus to the cytoskeleton ... B-type lamin levels remain relatively constant (for lamin B1, m ∼0.2, and for lamin B2, m ∼0.0). Thus, whereas collagens and ... supporting the notion that farnesylated lamins (i.e., pre-lamin A, progerin, and B-type lamins) are all more tightly anchored ... revealed that the concentration of A-type lamins scales over several orders of magnitude with tissue stiffness Et:. [. Lamin A ...http://jcb.rupress.org/content/early/2017/01/01/jcb.201610042
BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells | JCB
Loss of A-type lamins and genomic instability. Cell Cycle. 8:3860-3865. doi:10.4161/cc.8.23.10092. ... A dual role for A-type lamins in DNA double-strand break repair. Cell Cycle. 10:2549-2560. doi:10.4161/cc.10.15.16531. ... Regulating the levels of key factors in cell cycle and DNA repair: new pathways revealed by lamins. Cell Cycle. 10:3652-3657. ... Images show the types of chromosomal aberrations observed. A total of 400 metaphases were analyzed in one experiment (100 per ...http://jcb.rupress.org/content/200/2/187
Intermediate filament - Wikipedia
A-type lamins are only expressed following gastrulation. Lamin A and C are the most common A-type lamins and are splice ... B-type lamins are present in every cell. B type lamins, B1 and B2, are expressed from the LMNB1 and LMNB2 genes on 5q23 and ... Most types of intermediate filaments are cytoplasmic, but one type, the lamins, are nuclear. Unlike microtubules, IFs ... a type VI intermediate filament protein. Limited co-assembly in vitro to form heteropolymers with type III vimentin and type IV ...https://en.wikipedia.org/wiki/Intermediate_filament
Thymopoietin - Wikipedia
Furukawa K, Kondo T (Feb 1998). "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin". ... Furukawa K, Kondo T (Feb 1998). "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin". ... "Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins". Journal of Cell Science. 113 Pt 19 (19): 3473-84. PMID ... "Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins". Journal of Cell Science. 113 Pt 19 (19): 3473-84. PMID ...https://en.wikipedia.org/wiki/Thymopoietin
LMNA - Wikipedia
Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. ... Lamin A/C also known as LMNA is a protein that in humans is encoded by the LMNA gene. Lamin A/C belongs to the lamin family of ... Mounkes LC, Burke B, Stewart CL (2001). "The A-type lamins: nuclear structural proteins as a focus for muscular dystrophy and ... Cao H, Hegele RA (2002). "Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial ...https://en.wikipedia.org/wiki/LMNA
Evolution and spermatogenesis | Philosophical Transactions of the Royal Society B: Biological Sciences
2009 The B-type lamin is required for somatic repression of testis-specifc gene clusters. Proc. Natl Acad. Sci. USA 106, 3282- ... In the case of male germline stem cells, only one type of differentiated cell is produced in the process, i.e. the sperm. In ... 2009 The evolutionary origin and maintenance of sperm: selection for a small, motile gamete mating type. In Sperm biology: an ... The origin of sex, as opposed to mating type, is defined as the onset of anisogamy-gametes specialize in different directions. ...http://rstb.royalsocietypublishing.org/content/365/1546/1465
Anti-Lamin B1 antibody (HRP) [EPR8985(B)] Recombinant | Abcam
Anti-Lamin B1 recombinant antibody conjugated to HRP [EPR8985(B)] validated for WB, IHC and tested in Human. Referenced in 1 ... B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the ... Anti-Lamin B1 antibody [EPR8985(B)] (Alexa Fluor® 594) (ab216723) *Anti-Lamin B1 antibody [EPR8985(B)] - BSA and Azide free ( ... Anti-Lamin B1 antibody [EPR8985(B)] (ab133741) *Anti-Lamin B1 antibody [EPR8985(B)] - Nuclear Envelope Marker (Alexa Fluor® 488 ...http://www.abcam.com/lamin-b1-antibody-epr8985b-nuclear-loading-control-hrp-ab194109.html