Potential role of protein tyrosine phosphatase nonreceptor type 13 in the control of oocyte meiotic maturation | Development
... binds and activates a tyrosine kinase receptor that most likely signals through activation of a phosphatidylinositol 3 kinase ( ... Protein tyrosine phosphatase nonreceptor type 13 (PTPN13) is a tyrosine phosphatase with multiple interacting domains that has ... Twelve hours later, oocyte extracts were prepared and the expression of the two constructs was detected using HA antibodies. (C ... In the functional studies we report here, we found that progesterone-induced oocyte maturation is significantly accelerated by ...http://dev.biologists.org/content/131/20/4987
Protein Regulation with Rapid Kinetics - ProteoTuner Systems
Regulation system works post-translationally resulting in rapid changes in protein level. ... Procollagen Type I C-Peptide * Tartrate-Resistant Acid Phosphatase (TRACP) * Osteocalcin Undercarboxylated Glu-OC ... Protein function in pathways *Functional analysis of subunits of a protein complex *Functional analysis of essential proteins ... The Kit contains a ProteoTuner destabilization domain (DD) source vector plus a primer mix that lets you PCR-amplify the DD tag ...http://www.clontech.com/US/Products/Inducible_Systems/Inducible_Protein_Stabilization/Plasmid?sitex=10020:22372:US&PROD=-mqMO_omottyNhRVff5dH94j:S&PROD_pses=ZG0B0C9E7B8AFFD7CCF9B59CC789757DCD65B4A1D153D9311E4931197F5C83C873E530352271BF96A31D40F21040EF642A00159932972384B2
Gentaur Molecular :Consort \ COMB 0.75 MM THICK 48 SAMPLE \ E4347
Tyrosine-protein phosphatase non-receptor type 11 (EC 188.8.131.52) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine ... LYN JTK8] Tyrosine-protein kinase Lyn (EC 184.108.40.206) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma ... Fmr1 Fmr-1] Synaptic functional regulator FMR1 (Fragile X mental retardation protein 1 homolog) (FMRP) (Protein FMR-1) (mFmr1p) ... Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62). [IKBKG FIP3 NEMO] NF- ...http://www.antibody-antibodies.com/product_det.php?id=196387&supplier=search&name=COMB%200.75%20MM%20THICK%2048%20SAMPLE
Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes | Breast...
... disruption of Stat5a/b phosphorylation during breast cancer progression through upregulation of the Jak2 tyrosine phosphatase, ... The array contained 59% estrogen receptor (ER)-positive, 42% progesterone receptor (PR)-positive, and 20% Her2-positive cases, ... Sakamoto K, Creamer BA, Triplett AA, Wagner KU: The Janus kinase 2 is required for expression and nuclear accumulation of ... Liu X, Gallego MI, Smith GH, Robinson GW, Hennighausen L: Functional rescue of Stat5a-null mammary tissue through the ...https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3328
Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 ... Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma. Cancer Prev Res ... Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism. Mol Cancer Ther ... including the kinase domain and the C-terminus (17). Phosphorylation of FGFR activates multiple intracellular signaling ...http://cancerpreventionresearch.aacrjournals.org/content/9/4/296
Mechanisms and functions of p38 MAPK signalling | Biochemical Journal
G-protein-coupled receptor kinase 2; GSK, glycogen synthase kinase; hDlg, human discs large; HePTP, haemopoietic tyrosine ... MAPK/ERK kinase kinase; MK, MAPK-activated protein kinase; MKK, MAPK kinase; MKP, MAPK phosphatase; MLK3, mixed-lineage kinase ... D domain, docking domain; EGFR, epidermal growth factor receptor; ERK, extracellular-signal-regulated kinase; FADD, Fas- ... TNF-receptor-associated factor; TTSS, type III secretion system; Ubc13, ubiquitin-conjugating enzyme 13; USF1, upstream ...http://www.biochemj.org/content/429/3/403
TREATMENT OF DYSTROPHIN FAMILY RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO DMD FAMILY - Patent...
... dystrophin-related protein Type 1, or utrophin), DRP2 (dystrophin-related protein Type 2), and dystrobrevins, have also been ... The corresponding polypeptide may possess additional functional domains or an absence of domains. Species variants are ... Reporter genes useful in the methods of the present invention include acetohydroxyacid synthase (AHAS), alkaline phosphatase ( ... Effective delivery of cross-species a3 adenosine-receptor antagonists to reduce intraocular pressure. ...http://www.patentsencyclopedia.com/app/20120046345
EndoU is a novel regulator of AICD during peripheral B cell selection | JEM
A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science. 269:242-244. doi:10.1126/science. ... which includes an N-terminal somatomedin B-like domain believed to be involved in protein-protein interactions (Gijsbers et al ... Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177:999-1008. doi:10.1084/jem.177.4.999 ... A thymidine kinase gene (tk) was inserted at the 5′ end of the EndoU gene sequence. (B) Homologous recombination of the ...http://jem.rupress.org/content/early/2013/12/10/jem.20130648
Extracellular Matrix Elasticity Modulates TGF-β-Induced p38 Activation and Myofibroblast Transdifferentiation in Human Tenon...
Giannone G Sheetz MP . Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways. Trends Cell ... among them the canonical SMAD pathway and mitogen-activated protein kinases such as p38. ... Adhesion-dependent receptor localization may have an important role. Integrins govern the localization and internalization of ... Serini G Bochaton-Piallat ML Ropraz P . The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by ...http://iovs.arvojournals.org/article.aspx?articleid=2187670
... a gene encoding the protein tyrosine phosphatase SHP-2 located at band 12q24.1. SHP2 mutations seem to facilitate melanin ... Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease. Am J Hum Genet. 2006 Feb. 78(2 ... reside in and around the broad intramolecular interaction surface between the N-SH2 and PTP domains of the PTPN11 protein, they ... Different types of skeletal anomalies have been documented in affected patients, including chest deformity (pectus excavatum, ...http://misc.medscape.com/pi/android/medscapeapp/html/A1096445-business.html
Involvement of the Neurotensin Receptor-3 in the Neurotensin-Induced Migration of Human Microglia | Journal of Neuroscience
1996) Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary ... is a type I receptor belonging to the new family of receptors sharing an N-terminal luminal domain related to the yeast sorting ... Functional signaling of the neurotensin receptor-3 in microglia. NT (10 nm) rapidly and transiently stimulated the ... SDS in the presence of phosphatase and protease inhibitor mixtures (1:100). Identical amounts of solubilized protein (∼40 μg) ...http://www.jneurosci.org/content/23/4/1198
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Here, we reveal that the Ret-like receptor tyrosine kinase (RTK), Stitcher (Stit), is required for cell growth and ... The type III secretion system (T3SS) is a protein delivery system which is involved in a wide spectrum of interactions, from ... Calcineurin is a eukaryotic protein phosphatase important for many signalling and developmental processes in cells. Inhibitors ... and uncommon functional groups (such as isonitrile, dichloroimine, isocyanate, and halogenated functional groups) are ...https://www.jove.com/visualize?author=Fergal+O%27Gara
Pharmacotherapy for Pulmonary Hypertension: Future Directions
... proliferator-activated receptor gamma ligands inhibit Rho/Rho kinase pathway by inducing protein tyrosine phosphatase SHP-2. ... ET-1 binds with two types of receptor; ETA receptor and ETB receptor. ETA receptor located on SMCs and cardiac myocytes, ... Mutations in the BMPR-II can be found in the ligand-binding domain in the cytoplasmic tail which promotes the development of PH ... Pulmonary vascular wall remodeling is the result of changes in structural and functional components in the pulmonary arteries. ...https://www.jbclinpharm.org/articles/pharmacotherapy-for-pulmonary-hypertension-future-directions-4158.html
Patente US20100092475 - Treatment method using egfr antibodies and src inhibitors and related ... - Google Patentes
... and SH1 or protein tyrosine kinase domain. Critical to the regulation of Src is a COOH-terminal tyrosine (Y530) that, when ... Furthermore, it shows that the anti-tumor activity of anti-EGFR antibodies require a receptor with a functional kinase domain. ... 55(14):3140-3148). The other binding domain may be an antibody that recognizes or targets a particular cell type, as in a ... A modulator may include a kinase inhibitor, phosphatase, etc.. *  There are several known small molecule inhibitors of ...http://www.google.es/patents/US20100092475
Association of Neisseria gonorrhoeae OpaCEA with Dendritic Cells Suppresses Their Ability to Elicit an HIV-1-Specific T Cell...
This allows the recruitment and subsequent activation of the Src homology domain 2 (SH2)-containing tyrosine phosphatases SHP-1 ... The role of the p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and phosphoinositide-3-OH kinase ... 2003) The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells. Eur J Immunol 33 ... CEACAM1-L and CEACAM1-S are coexpressed at different ratios in different cell types and in different functional states of a ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3570455/?lang=en-ca
Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for...
2012) Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis. Cancer Cell 22(3):389-403. ... 2007) Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 26(22):3291-3310 ... based primarily on receptor expression, that are valuable from a therapeutic perspective: (i) patients with estrogen receptor- ... S11 and S12). In contrast, CLPTM1, RERE, PTEN, and CD44 had different functional prognostic patterns (Figs. S11 and S12). ...http://www.pnas.org/content/114/11/E2215.full
CECAD: Publications 2010
The vascular endothelial growth factor receptor tyrosine kinase inhibitors vatalanib and pazopanib potently induce apoptosis in ... Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament ... Binding between Crossveinless-2 and Chordin von Willebrand factor type C domains promotes BMP signaling by blocking Chordin ... Bonn F, Pantakani K, Shoukier M, Langer T, Mannan AU (2010). Func-tional evaluation of paraplegin mutations by a yeast ...http://cecad.uni-koeln.de/Publications-2010.152.0.html?L=1%29
Or Gozani | Stanford Medicine Profiles
... tumor suppressor proteins ING4/5 and JADE1/2/3. Biochemical and functional analyses indicate that these domains interact with ... Finally, the PP2A phosphatase complex, a key negative regulator of the MAP kinase pathway, binds to MAP3K2 and this interaction ... The NSD (nuclear receptor SET domain-containing) family of histone lysine methyltransferases is a critical participant in ... Furthermore, ASH1L facilitates recruitment of LEDGF and wild-type MLL proteins to chromatin at key leukemia target genes and is ...https://med.stanford.edu/profiles/or-gozani
JoVE Search Results: Protein Kinase
Kinase, Leukemia, Chronic Myeloid Leukemia, Myeloid Leukemia, Hydrogen, ATP, Role, Atmosphere, Donors, Human, Kinases, Cancer, ... The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Abstract ... A global protein kinase and phosphatase interaction network in yeast. Abstract Levy, David E. New York University School of ... The tyrosine kinase Csk dimerizes through Its SH3 domain. Abstract Kozawa, Osamu. Gifu University Graduate School of Medicine. ...http://labindex.jove.com/group/Protein-Kinase
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The SH2 domain of Grb2 binds to growth factor receptors at phosphorylated tyrosine residues thus coupling receptor activation ... Examples include myosin light chain kinase10, Ca2+/CaM-dependent kinases (CaMKs)11 and phosphatases (e.g. calcineurin)12, and ... one may accelerate the identification of functional motifs in proteins and the development of peptide-based inhibitors of ... Cre recombinase is a Type I topoisomerase that catalyzes site-specific recombination of DNA between two loxP (locus of X-over ...https://www.jove.com/visualize/abstract/23990909/suppressor-cytokine-signaling-socs-5-utilises-distinct-domains-for
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma (Nat Genet, Aug 2014) | Cancer...
Next-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Epidermal Growth Factor Receptor-Mutant Non- ... PPARγ Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in ... Expression profiling of MED12-mutated and wild-type fibroadenomas revealed that MED12 mutations are associated with ... Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma (Cancer Res, May 2015) [time] => 08 May 2015 14:18:10 [postcat ...https://www.csi.nus.edu.sg/ws/research/exome-sequencing-identifies-highly-recurrent-med12-somatic-mutations-in-breast-fibroadenoma-nat-genet-aug-2014
Phospholipid composition and a polybasic motif determine D6 PROTEIN KINASE polar association with the plasma membrane and...
2011). Tyrosine phosphorylation controls brassinosteroid receptor activation by triggering membrane release of its kinase ... we also tested the binding of wild-type and mutant proteins in lipid overlay assays. In each but one case, the protein kinases ... 2015). D6 PROTEIN KINASE is a lipid domain-dependent mediator of Arabidopsis planar polarity. Nat. Plants 1, 15162. doi:10.1038 ... PI-kinases and phosphatases determine the abundance of different PI species in different membranes; PI biosensors indicate that ...http://dev.biologists.org/content/143/24/4687
Eif2ak3 - Eukaryotic translation initiation factor 2-alpha kinase 3 precursor - Mus musculus (Mouse) - Eif2ak3 gene & protein
... during the unfolded protein response (UPR) and in response to low amino acid availability (PubMed:11106749). Converts ... Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1 ... Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 ( ... phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of ...http://www.uniprot.org/uniprot/Q9Z2B5
IJMS | Free Full-Text | Aptamers and Their Potential to Selectively Target Aspects of EGF, Wnt/β-Catenin and TGFβ-Smad Family...
We propose that peptide aptamers can provide a very useful and new alternative for interfering with protein-protein ... By their targeting of short, linear motif type of interactions, peptide aptamers have joined nucleic acid aptamers for use in ... starting with the published as well as potential applications of aptamers targeting Epidermal Growth Factor Receptor signaling ... their high specificity and affinity for individual target proteins, and their use in high-throughput screening protocols. ...http://mdpi.com/1422-0067/14/4/6690/htm
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