In the kidney, the first portion of the nephron, called the proximal tubule (PT), performs the majority of solute reabsorption ... The role of claudin-2 in the proximal tubule and kidney stone disease. ... In contrast, claudin-3 is expressed only within the proximal straight tubule (PST). Furthermore, claudin-2 and claudin-3 ... that proximal delivery of calcium to the loops of Henle is important in the pathogenesis of nephrocalcinosis and kidney stone ...

Development of a microphysiological model of human kidney proximal tubule ...

Autophagy in proximal tubules protects against acute kidney injury. / Jiang, Man; Wei, Qingqing; Dong, Guie et al. In: Kidney ... Autophagy in proximal tubules protects against acute kidney injury. In: Kidney International. 2012 ; Vol. 82, No. 12. pp. 1271- ... Autophagy in proximal tubules protects against acute kidney injury. Kidney International. 2012 Dec 2;82(12):1271-1283. doi: ... Autophagy in proximal tubules protects against acute kidney injury, Kidney International, vol. 82, no. 12, pp. 1271-1283. ...

... kidney proximal straight tubule epithelial cell cell types (synonyms: N/A). Kidney proximal straight tubule epithelial cells ... They are also involved in drug metabolism and the progression of kidney diseases. ... play a crucial role in kidney function, reabsorbing substances from the filtrate and maintaining pH balance. ... Kidney Proximal Straight Tubule Epithelial Cell. .css-o5yzfm{height:24px;margin:0;}. .css-ymbp62{border:none;height:unset; ...

Learn About targeting treatments to the Proximal Tubule as a Therapeutic goal for the Kidney. Watch our YouTube video to learn ... Home › Resources › Videos and webinars › The Kidney as a Therapeutic Target: Targeting Therapeutics to the Proximal Tubule ... The Kidney as a Therapeutic Target: Targeting Therapeutics to the Proximal Tubule. ...

Kidney Tubules, Proximal / cytology* * Kidney Tubules, Proximal / metabolism * Mice Substances * Hypoxia-Inducible Factor 1 ... allow inactivation of HIF-1alpha by tetracycline-inducible Cre-loxP-mediated recombination in primary renal proximal tubule ...

Kidney Tubules, Proximal / metabolism* * Kidney Tubules, Proximal / physiopathology * Male * Mice, Knockout * Obesity / ... localization in the renal proximal tubule. Glucose reabsorption in the proximal tubule (via Sglt1 and Sglt2) has emerged as an ... reabsorption in the proximal tubule via the Sglts. To test this hypothesis, Olfr1393 wild-type (WT) and knockout (KO) mice were ... likely as a regulator of Na+-glucose cotransport in the proximal tubule. ...

keywords = "cold storage, kidney injury, kidney transplantation, p53, proximal tubule",. author = "Xiaohong Xiang and Jiefu Zhu ... Here, we report that p53 in kidney proximal tubules plays a critical role in cold storage/transplantation kidney injury and ... Here, we report that p53 in kidney proximal tubules plays a critical role in cold storage/transplantation kidney injury and ... Here, we report that p53 in kidney proximal tubules plays a critical role in cold storage/transplantation kidney injury and ...

Vormann, M. K. et al. Nephrotoxicity and kidney transport assessment on 3D perfused proximal tubules. AAPS J. 20, 1-11 (2018). ... Naumovska, E. et al. Direct on-chip differentiation of intestinal tubules from induced pluripotent stem cells. Int. J. Mol. Sci ... Schutgens, F. et al. Tubuloids derived from human adult kidney and urine for personalized disease modeling. Nat. Biotechnol. 37 ... kidney44,45, and gut46,47,48, as well as the microvasculature49,50,51. The OrganoPlate consists of either 40 or 96 chips in a ...

The proximal tubules of epithelial cells in the kidney express cauxin. This protein is secreted into the urine from the renal ...

Renal tubular dysgenesis is a severe kidney disorder characterized by abnormal development of the kidneys before birth. Explore ... In particular, kidney structures called proximal tubules are absent or underdeveloped. These structures help to reabsorb. ... Without functional proximal tubules, the kidneys cannot produce urine (a condition called anuria). ... is required for normal development of the kidneys (particularly of the proximal tubules) and other tissues. ...

... depends on proximal parts of of kidney tubules which contain pumps or transport system to secrete drugs. Elimination will be ... Precise dose hard to achieve: lubraderm How can kidney failure or liver disease alter the the drug levels? if the kidneys ... kidneys What drugs are best absorbed? non-ionized and lipophillic How are some drugs stored? by being bound to the protein ... kidneys and blood, sweat and saliva Why is nitroglycerine given sublingually? to get it directly in the blood stream and bypass ...

SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule. Kidney Int. 2020;98:1296-307. DOIPubMedGoogle Scholar ... Kidney. Spiked vesicles in cytoplasm (3). CCVs. Roufosse et al. (28). Abbate et al. (11). Kidney. Spiked vesicle in cytoplasm ( ... Visualization of putative coronavirus in kidney. Kidney Int. 2020;98:231-2. DOIPubMedGoogle Scholar ... Kissling S, Rotman S, Gerber C, Halfon M, Lamoth F, Comte D, et al. Collapsing glomerulopathy in a COVID-19 patient. Kidney Int ...

The Intratubular and Intracrine Renin-Angiotensin System in the Proximal Tubules of the Kidney and Its Roles in Angiotensin II- ...

1963) Single proximal tubules of Necturus kidney. VIII. Na and K determination by glass electrodes. The American Journal of ...

... epithelial cells of the proximal tubules in kidneys express L-FABP mRNA [6] . A previous study has shown L-FABP to be a ... 2) HCV antibody positive, Hepatitis B surface antigen positive, chronic kidney disease, polycystic kidney disease, Other Causes ...

Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int. 2002 Jul. 62(1):237-44 ... 41] This protein has low basal expression in the normal kidney but is up-regulated in the proximal tubule in post-ischemic ... Characteristics of an Ideal Marker for Kidney Disease. An ideal biomarker for acute kidney injury (AKI) or chronic kidney ... IL-18 is formed in the proximal tubules and can be detected in the urine. [34] In mouse models, IL-18 has been shown to ...

Autophagy in proximal tubules protects against acute kidney injury. Kidney Int. 2012;82(12):1271-1283.. View this article via: ... Both abdominal ultrasound and MRI scan revealed small-sized kidneys (the left kidney was 8.4*4.0 cm and the right kidney was ... AQP2, a water channel protein located in the kidney collecting tubule. Bar: 10 μm (B) Mitochondrial morphology in tubular ... Abdominal ultrasound and MRI scans showed abnormal changes in both kidneys without cysts (the size of the left kidney was 7.2* ...

sheep: 10 mg/kg bw, intubation caused death after 18 h, also degeneration of the proximal tubules of kidneys [82]. ... myocardial oxidative damage; [54] oxidative injuries in chick embryonic livers and kidneys [55]; growth retardation and ... by Fusarium avenaceum strains isolated from norwegian grain and the cytotoxicity of rice culture extracts to porcine kidney ...

ADAM17 substrate release in proximal tubule drives kidney fibrosis JCI Insight, 2016-08-18;1(13):.. Species: Human. Sample ...

In the kidney reactivity was localized to the proximal tubules. Lung alveolar lining including type I and II pneumocytes ...

"Gene expression profile of renal proximal tubules regulated by proteinuria," Kidney International, vol. 61, no. 5, pp. 1577- ... while in kidney, Gimap4 and Gimap8 were expressed significantly higher than Gimap1 and Gimap9 (. ) (Figure 3). No significant ... and kidney (stripes). Significance is represented as follows: is and is . ... While we can exclude the involvement of the members of the Gimap family proximal to D4Rhw6 (Gimap8, Gimap9, Gimap4, Gimap6, and ...

... distal renal tubules, colonic mucosa, and salivary glands, consistent with HE4 gene expression. In addition to consistent ... and kidney. In a series of 175 human adult tumors, gene expression was highest in ovarian serous carcinomas. However, ... There was strong staining within the distal convoluted tubules of the kidney, with equivocal staining of the proximal ... Elsewhere, respiratory epithelium, distal renal tubules, and salivary glands were also consistently immunoreactive. Colonic ...

Proprotein convertase subtilisin/kexin type 9 targets megalin in the kidney proximal tubule and aggravates proteinuria in ... Title: Proprotein convertase subtilisin/kexin type 9 targets megalin in the kidney proximal tubule and aggravates proteinuria ... involved_in kidney development ISS Inferred from Sequence or Structural Similarity. more info ... It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a ...

The current review focuses on the role of the eCB system in normal kidney function and various diseases, such as diabetes and ... It is present in both the central nervous system and peripheral organs including the kidney. ... The effects of HG and HA were recently tested in another cell type within the kidney, the proximal tubules. In this work, ... Elevated cannabinoid receptor 1 and G protein-coupled receptor 55 expression in proximal tubule cells and whole kidney exposed ...

Dent disease is a chronic kidney disorder that occurs almost exclusively in males. Explore symptoms, inheritance, genetics of ... In affected individuals, kidney problems result from damage to structures called proximal tubules. Signs and symptoms of this ... Studies suggest that mutations in the CLCN5 or OCRL gene disrupt the reabsorption function of the proximal tubules, which leads ... calcium deposits in the kidneys (nephrocalcinosis), and kidney stones (nephrolithiasis). Kidney stones can cause abdominal pain ...

... and of the proximal convoluted tubules and glomeruli of the kidneys. Acute renal toxicity may persist for several weeks ... liver and of the proximal convoluted tubules and glomeruli of the kidneys. ... Inhalation of massive amounts of gasoline may result in fatty degeneration of the proximal convoluted tubules and glomeruli and ... Repeated exposure to very high levels of gasoline can cause poor appetite, weakness, and even brain or kidney damage. Gasoline ...

Mimicking Proximal Tubule Cell functioning for Artificial Kidney Applications. K. Guha, National Institute of Technology ... Personalized nanomedicine for the treatment of vascular hypertension in polycystic kidney disease models. R. Pala, S.M. Nauli, ...

Overall goal was to isolate an anion transport protein found in proximal convoluted tubule cells of rat kidney nephron. 1 ... Overall goal was to isolate an anion transport protein found in proximal convoluted tubule cells of rat kidney nephron. ...