*  Iron Balance Study of DFO and GT56-252 in Patients With Transfusional Iron Overload Secondary to Beta-Thalassemia - AdisInsight
Iron Balance Study of DFO and GT56-252 in Patients With Transfusional Iron Overload Secondary to Beta-Thalassemia Next Previous ... Iron Balance Study of DFO and GT56-252 in Patients With Transfusional Iron Overload Secondary to Beta-Thalassemia Completed ...
  http://adisinsight.springer.com/trials/700245173?error=cookies_not_supported&code=1be70ccc-dfc2-44ca-bb16-d468815605bd
*  Rare Iron Overloads Except C282Y Homozygosity : Description and Characterization. - Full Text View - ClinicalTrials.gov
Iron Overload. Iron Metabolism Disorders. Metabolic Diseases. Iron. Hepcidins. Trace Elements. Micronutrients. Growth ... iron overloads except C282Y homozygosity Patients with an iron overloads except C282Y homozygosity ... Proved hepatic iron overload: using a dosage of iron hepatic concentration either on hepatic biopsy, or by MRI according to the ... One of chronic iron overload profiles is a deficit in hepcidin. Hepcidin is the regulating hormone for iron. This specific ...
  https://clinicaltrials.gov/ct2/show/NCT01541813
*  Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron...
Iron chelation. Iron balance. Secondary iron overload. deferoxamine. deferasirox. Deferiprone. 1- Beta-thalassemia major ... Subjects with transfusional iron overload secondary to thalassemia major , sickle cell disease showing up-trend in SF aged 6 ... Iron Overload. beta-Thalassemia. Hemosiderosis. Anemia, Hemolytic, Congenital. Anemia, Hemolytic. Anemia. Hematologic Diseases ... Liver iron ,14 mg/g dry weight- by R2 MRI. 2- Sickle cell disease. 3- Other causes of transfusional iron hemosiderosis. ...
  https://clinicaltrials.gov/ct2/show/NCT01511848?recr=Open&cond=%22Ferritins%22&rank=11
*  High-Tc Susceptometer to Monitor Transfusional Iron Overload - Full Text View - ClinicalTrials.gov
Measuring the amount of iron in the body is important because either too much (iron overload) or too little iron (iron ... Iron. Iron overload. Hepatic iron concentration. High-temperature superconductivity. Magnetic susceptibility. Susceptometer. ... Iron stored in the liver can be magnetized to a small degree when placed in a magnetic field. In patients with iron overload, ... has transfusional iron overload or is healthy with no known disorder affecting body iron stores, ...
  https://clinicaltrials.gov/ct2/show/NCT01241357?term=hemolytic+anemia+OR+G6PD+OR+paroxysmal+nocturnal+hemoglobinuria+OR+thalassemias&recr=Open&fund=01&rank=8
*  Iron Overload in Stem Cell Transplant Recipients - Full Text View - ClinicalTrials.gov
We will examine the iron status in these patients by MRI and by screening for mutations in genes known to cause iron overload. ... Iron Overload in Stem Cell Transplant Recipients. The safety and scientific validity of this study is the responsibility of the ... Genetic determinants of iron overload- HFE status. [ Time Frame: Pre-HSCT ]. Biospecimen Retention: Samples With DNA. ... The goal of this study is to examine the impact of iron overload in patients undergoing a bone marrow transplant. We believe ...
  https://clinicaltrials.gov/show/NCT00806715
*  Deferasirox may revolutionize the way chronic iron overload is treated
... By American Society of Hematology, Apr 23, 2006 - 6:22: ... The results of an international study on deferasirox, a new drug that may revolutionize the way chronic iron overload is ... were selected for this study because complications of chronic iron overload have been best studied in those with this disease. ... and adults diagnosed with chronic iron overload was conducted in a dozen countries worldwide. People with beta-thalassemia, an ...
  http://www.rxpgnews.com/deferasirox/Deferasirox_may_revolutionize_the_way_chronic_iron_4128_printer.shtml
*  Early cardiac iron overload in children with transfusion-dependent anemias | Haematologica
... a total iron dose similar to that previously reported.3 Moreover, in all these patients the degree of cardiac iron overload was ... no detectable cardiac iron overload was observed in children under the age of 9.5 years. Another study showed that cardiac iron ... Early cardiac iron overload in children with transfusion-dependent anemias. Juliano Lara Fernandes, Antonio Fabron, Monica ... Early cardiac iron overload in children with transfusion-dependent anemias. Juliano Lara Fernandes, Antonio Fabron, Monica ...
  http://www.haematologica.org/content/94/12/1776
*  Impact of iron overload in myelodysplastic syndromes. | Aplastic Anemia and MDS International Foundation
... which can lead to iron overload. Some patients may already have iron overload before transfusions begin, as a result of ... Iron overload has been linked to hepatic, cardiac, and endocrine dysfunction, although its exact contribution to cardiac ... which can lead to iron overload. Some patients may already have iron overload before transfusions begin, as a result of ... Thus, iron overload may negatively influence survival in patients with MDS, especially those with lower-risk disease. Iron ...
  http://www.aamds.org/research-article/impact-iron-overload-myelodysplastic-syndromes
*  Efficacy and Safety of Deferasirox in Non-transfusion Dependent Thalassemia Patients With Iron Overload and a One Year Open...
During the core and extension, the effects of treatment on iron overload in the liver will be evaluated using magnetic ... Iron Overload. Anemia, Hemolytic, Congenital. Anemia, Hemolytic. Anemia. Hematologic Diseases. Hemoglobinopathies. Genetic ... Efficacy and Safety of Deferasirox in Non-transfusion Dependent Thalassemia Patients With Iron Overload and a One Year Open- ... Iron Metabolism Disorders. Metabolic Diseases. Iron. Deferasirox. Trace Elements. Micronutrients. Growth Substances. ...
  https://clinicaltrials.gov/ct2/show/NCT00873041?cond=%22Alpha-Thalassemia%22&rank=4
*  Iron Overload Easily Treated
Iron overload can lead to organ failure if left unchecked, but once diagnosed it is easily treated by avoiding certain foods ... However, iron overload can occur in 2 to 5 percent of people. (I wrote about iron overload and the genetic condition known as ... Long-term iron overload can result in blood clots, liver cancer, heart attack, and even death.. The good news is that iron ... The treatment for iron overload is to avoid foods that contain refined flour (iron is often added to the flour) and to undergo ...
  https://www.newsmax.com/health/dr-brownstein/iron-overload-blood-oxygen-anemia/2012/03/05/id/481954/
*  Effect of dietery fats and iron overload on hepatic lipid peroxidation in rats for Elshafey Rahma Abd Elfatah Abd Elrazek
Effect of dietery fats and iron overload on hepatic lipid peroxidation in rats for Elshafey Rahma Abd Elfatah Abd Elrazek ... Effect of dietery fats and iron overload on hepatic lipid peroxidation in rats for Elshafey Rahma Abd Elfatah Abd Elrazek * ... Effect of dietery fats and iron overload on hepatic lipid peroxidation in rats for Elshafey Rahma Abd Elfatah Abd Elrazek ... Effect of dietery fats and iron overload on hepatic lipid peroxidation in rats for Elshafey Rahma Abd Elfatah Abd Elrazek ...
  http://www.philadelphia.edu.jo/newlibrary/eng/english-books/671-english-books/93017-engb-93017
*  Evaluation of a new tablet formulation of deferasirox to reduce chroni | TCRM
Iron chelating agents are utilized to reduce iron overload, as they form a complex with iron, leading to its clearance. Iron ... chronic transfusions ultimately cause iron overload. Without correction, iron overload can lead to end-organ damage, resulting ... Keywords: iron chelation therapy, transfusional iron overload, deferasirox ... This paper is intended to provide an overview of iron overload, with a focus on deferasirox, and its recently approved ...
  https://www.dovepress.com/evaluation-of-a-new-tablet-formulation-of-deferasirox-to-reduce-chroni-peer-reviewed-article-TCRM
*  Confounder-Corrected Quantitative MRI Biomarker of Hepatic Iron Content - Full Text View - ClinicalTrials.gov
Iron Overload. Iron Metabolism Disorders. Iron. Hemochromatosis. Hemosiderosis. Metabolic Diseases. Metal Metabolism, Inborn ... Measurement of LIC is critical for detection and staging of iron overload, and for monitoring iron-reducing chelator therapies ... Subjects with no known history of iron overload or liver disease will undergo an MRI scan. ... Subjects with known or suspected iron overload will undergo serum ferritin measurement and an MRI scan. ...
  https://clinicaltrials.gov/ct2/show/NCT02025543?term=MRI+iron+overload+liver&rank=15
*  Iron overload - Wikipedia
Human iron metabolism Iron deficiency Hider, Robert C.; Kong, Xiaole (2013). "Chapter 8. Iron: Effect of Overload and ... Iron overload, also known as haemochromatosis, indicates accumulation of iron in the body from any cause. The most important ... Lu JP, Hayashi K. Transferrin receptor distribution and iron deposition in the hepatic lobule of iron-overloaded rats. Pathol ... Selective iron deposition in pancreatic islet B cells of transfusional iron-overloaded autopsy cases. Pathol Int. 1994 Mar;44(3 ...
  https://en.wikipedia.org/wiki/Iron_overload
*  African iron overload - Wikipedia
African iron overload, also known as (Bantu siderosis, or Dietary iron overload), is an iron overload disorder first observed ... Penetrance of Q248H as a cause of iron overload is most likely low. Excess hepatic iron in dietary iron overload is typically ... Iron Overload Study Research, Investigators. "Hemochromatosis and Iron Overload Screening (HEIRS) study design for an ... Dietary iron overload is the consumption of large amount of home-brewed beer with high amount of iron content in it. Preparing ...
  https://en.wikipedia.org/wiki/African_iron_overload
*  Congenital dyserythropoietic anemia - Wikipedia
"Iron Overload. Medical information about Iron Overload , Patient". Patient. Retrieved 2016-01-29. Heimpel, Hermann; ... This is true for ferritin levels and iron levels in the organs as well, it is important for patients to go regularly for ... It is more important to check iron levels in the organs through MRI scans, however, than to simply get regular blood tests to ... or deferiprone to eliminate the excess iron that accumulates. Removal of the spleen and gallbladder are common. Hemoglobin ...
  https://en.wikipedia.org/wiki/Congenital_dyserythropoietic_anemia
*  Genetic testing - Wikipedia
African iron overload Over-absorption of iron; accumulation of iron in vital organs (heart, liver, pancreas); organ damage; ... "African iron overload". Genetics Home Reference. Retrieved 2018-01-24. Galanello, Renzo; Origa, Raffaella (2010-05-21). "Beta- ... an iron overload disorder), before any signs or symptoms appear. The results of predictive and presymptomatic testing can ... and loss of position and vibration senses Hereditary hemochromatosis Over-absorption of iron; accumulation of iron in vital ...
  https://en.wikipedia.org/wiki/Genetic_testing
*  Porphyria cutanea tarda - Wikipedia
Certain mutations in the HFE gene cause hemochromatosis (an iron overload disorder). People who have these mutations are also ... Additional risk factors include alcohol abuse, excess iron (from iron supplements as well as cooking on cast iron skillets), ... A borderline iron deficiency has been found to have a protective affect by limiting heme synthesis. In the absence of iron, ... Sampietro, M; Fiorelli, G; Fargion, S (1999). "Iron overload in porphyria cutanea tarda". Haematologica. 84 (3): 248-53. PMID ...
  https://en.wikipedia.org/wiki/Porphyria_cutanea_tarda
*  Thalassemia - Wikipedia
Iron overload: People with thalassemia can get an overload of iron in their bodies, either from the disease itself or from ... Multiple blood transfusions can result in iron overload. The iron overload related to thalassemia may be treated by chelation ... Complications may include iron overload from the transfusions with resulting heart or liver disease, infections, and ... Cianciulli P (October 2008). "Treatment of iron overload in thalassemia". Pediatr Endocrinol Rev. 6 (Suppl 1): 208-13. PMID ...
  https://en.wikipedia.org/wiki/Thalassemia
*  Gideon Koren - Wikipedia
Victorhoffbrand, A (2005). "Deferiprone therapy for transfusional iron overload". Best Practice & Research Clinical Haematology ... August 1998). "Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major". The New ... double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major ...
  https://en.wikipedia.org/wiki/Gideon_Koren
*  Hemosiderosis - Wikipedia
Lu JP, Hayashi K (1994). "Selective iron deposition in pancreatic islet B cells of transfusional iron-overloaded autopsy cases ... Limiting blood transfusions and institution of iron chelation therapy when iron overload is detected are important when ... "Transferrin receptors and selective iron deposition in pancreatic B cells of iron-overloaded rats". Acta Pathol Jpn. 41 (9): ... "Transferrin receptor distribution and iron deposition in the hepatic lobule of iron-overloaded rats". Pathol Int. 45 (3): 202-6 ...
  https://en.wikipedia.org/wiki/Hemosiderosis
*  Compound heterozygosity - Wikipedia
2008-01-17). "Iron-Overload-Related Disease in HFE Hereditary Hemochromatosis". New England Journal of Medicine. 358 (3): 221- ... excess absorption of iron. These variants all reflect a failure in a metabolic pathway associated with iron metabolism, however ... Compound heterozygotes are often observed only through subclinical symptoms such as excess iron. Disease is rarely observed in ... "Compound heterozygous hemochromatosis genotype predicts increased iron and erythrocyte indices in women". Clinical Chemistry. ...
  https://en.wikipedia.org/wiki/Compound_heterozygosity
*  Penetrance - Wikipedia
2008-01-17). "Iron-Overload-Related Disease in HFE Hereditary Hemochromatosis". New England Journal of Medicine. 358 (3): 221- ... Individuals who are homozygotes for the C282Y allele of the HFE gene are at risk for developing lethal concentrations of iron, ... For hereditary hemochromatosis, a disease caused by excess intestinal iron absorption, the degree of penetrance has been a ... deeming that a homozygote is affected with the disease if they simply have elevated blood iron levels, but no physiological ...
  https://en.wikipedia.org/wiki/Penetrance
*  Deferasirox - Wikipedia
Its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such ... "FDA Approves First Oral Drug for Chronic Iron Overload" (Press release). United States Food and Drug Administration. November 9 ... "Current status of iron overload and chelation with deferasirox". Indian J Pediatr. 74 (8): 759-64. doi:10.1007/s12098-007-0134- ... for children 6 years and older for chronic iron overload from repeated blood transfusions. The half-life of deferasirox is ...
  https://en.wikipedia.org/wiki/Deferasirox
*  The families left behind by the merchant seamen of the 1870s - dawlish chronicles
"She was in a small garret with a sloping roof and the most modest fireplace I ever saw; just three bits of iron laid from side ... This lady's husband had also committed to a ship that proved to have been overloaded. He came home and, according to her "got ... and of overloading ships far beyond their safe draughts. His name lives on in "The Plimsoll Line" - the marking on ships' hulls ... had been lost at sea shortly before in an overloaded ship. Plimsoll spoke to a customs officer, "a Mr. B--l", a customs officer ...
  https://dawlishchronicles.com/the-families-left-behind-by-merchant-seamen-of-the-1870s/