*  A subserosal, pedunculated, multilocular uterine leiomyoma with ovarian tumor-like morphology and histological architecture of...
... and pathologists should be aware that such leiomyomas can mimic adenomatoid tumors. Additionally, perivascular epithelioid cell ... and typical cases of leiomyoma are easily diagnosed by imaging study. However, uterine leiomyomas are often altered by ... We describe the 17th reported case of a uterine leiomyoma clinically diagnosed as an ovarian tumor; however, the present case ... Clinicians need to be aware that a subserosal leiomyoma with cystic and hydropic degeneration can mimic an ovarian tumor, ...
  https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-016-1167-1
*  Journal of Postgraduate Medicine: Leiomyoblastoma of the stomach. : <b>AK Sarda,...
A comparative electron microscopic study of a leiomyosarcoma and bizarre leiomyoma (leiomyoblastoma) of the stomach. Am J Clin ... Gastric epithelioid leiomyoma and leiomyosarcoma (leiomyoblastoma). Cancer 1976; 38:708-728.. 6. Stavorovsky M, Morag B, ... Radiologically, leiomyoblastomas are markedly similar to leiomyomas and lelomyosarcomas, the only differentiating feature being ... of leiomyoblastomas are intramural with more than 50% showing surface ulceration[9]. About 4% of these tumours may be ...
  http://www.jpgmonline.com/printarticle.asp?issn=0022-3859
*  An unusual case of uterine cotyledonoid dissecting leiomyoma with adenomyosis | Diagnostic Pathology | Full Text
... as observed in cotyledonoid dissecting leiomyomas of conventional type. In addition, numerous non-neoplastic glands of ... She had a pelvic mass followed-up for 6 years with a diagnosis of leiomyoma. However, increase in tumor size and cystic changes ... Thus far, over 30 cases of cotyledonoid dissecting leiomyoma have been reported, none of which have described the presence of ... We present a unique case of cotyledonoid dissecting leiomyoma with adenomyosis. A 40-year-old Japanese female presented with ...
  https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-016-0523-1
*  Potential causes of subfertility in patients with intramural fibroids | Fertility Research and Practice | Full Text
Epitheloid leiomyoma. These benign leiomyomas have at least 50 % of cells as epitheloid, but demonstrate a low mitotic rate (, ... Further research may correlate leiomyoma microscopic subtypes with different effects on human fertility.. Table 1 Leiomyoma ... LeiomyomaFibroidsImplantationUterine peristalsisPseudocapsule. Introduction. Uterine leiomyomas, or fibroids, can occur in up ... Impact of intramural leiomyomata in patients with a normal endometrial cavity on in vitro fertilization-embryo transfer cycle ...
  https://fertilityresearchandpractice.biomedcentral.com/articles/10.1186/s40738-015-0005-2
*  Gastrointestinal stromal tumors | SpringerLink
On microscopic view, GIST either show spindle cell [a hematoxylin-stain (HE)] or epithelioid differentiation (b), HE, the ... Miettinen M, Furlong M, Sarlomo-Rikala M et al (2001) Gastrointestinal stromal tumors, intramural leiomyomas, and ... Knop S, Schupp M, Wardelmann E et al (2006) A new case of Carney triad: gastrointestinal stromal tumours and leiomyoma of the ... Miettinen M, Kopczynski J, Makhlouf HR et al (2003) Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas ...
  https://link.springer.com/article/10.1007%2Fs00384-011-1353-y
*  Comparison Study in the Treatment of Uterine Fibroids Uterine Fibroid Embolization Using BeadBlock™ Embolic Agent - Full Text...
The purpose of the study is to conduct a comparison between BeadBlock™ and Embosphere in uterine fibroid embolization. Baseline and follow-up MR Imaging data will be made with respect to changes in fibroid and uterus perfusion and fibroid and uterine volume. This is a 12 months study (12 month follow up for all enrollees). The primary end-point will be the degree of fibroid devascularization as seen at contrast-enhanced MRI performed 3 months (+/- 15 days) after UAE procedure. In addition we will assess symptom reduction in patients that have undergone uterine fibroid embolization with Bead Block™ and Embosphere®.. Primary Objective 1. To assess the change in fibroid devascularization as seen at contrast-enhanced MRI performed after UAE and at three (3) months (+/- 15 days) following the UAE, and compare the changes between BeadBlock™ and Embosphere.. Secondary Objective. 1. To assess the change in fibroid devascularization as seen at contrast-enhanced MRI performed several days after UAE ...
  https://clinicaltrials.gov/ct2/show/NCT00361036?term=fibroids&rank=4
*  Comparison Study in the Treatment of Uterine Fibroids Uterine Fibroid Embolization Using BeadBlock™ Embolic Agent - Full Text...
The purpose of the study is to conduct a comparison between BeadBlock™ and Embosphere in uterine fibroid embolization. Baseline and follow-up MR Imaging data will be made with respect to changes in fibroid and uterus perfusion and fibroid and uterine volume. This is a 12 months study (12 month follow up for all enrollees). The primary end-point will be the degree of fibroid devascularization as seen at contrast-enhanced MRI performed 3 months (+/- 15 days) after UAE procedure. In addition we will assess symptom reduction in patients that have undergone uterine fibroid embolization with Bead Block™ and Embosphere®.. Primary Objective 1. To assess the change in fibroid devascularization as seen at contrast-enhanced MRI performed after UAE and at three (3) months (+/- 15 days) following the UAE, and compare the changes between BeadBlock™ and Embosphere.. Secondary Objective. 1. To assess the change in fibroid devascularization as seen at contrast-enhanced MRI performed several days after UAE ...
  https://clinicaltrials.gov/ct2/show/NCT00361036?term=fibroids&rank=5
*  Grant Abstract: Targeting Adenovirus for Gene Therapy of Uterine Leiomyoma
Abstract: DESCRIPTION (provided by applicant): Uterine leiomyoma (fibroids) are the most common gynecologic tumors in premenopausal women and the leading indication for hysterectomy. Uterine fibroids are also a major health disparity issue being 3-4 folds more frequent in African American compared to white women. We have generated most of the literature on the utility of fibroid gene therapy, demonstrating its potential as a localized treatment for uterine leiomyoma that can control the disease while preserving fertility potential. In this proposal we are aiming to screen a wide range of improved adenoviral vector transductional and transcription modifications, to develop an optimal uterine fibroids ON-normal tissue OFF targeted adenoviral vector for effective and safe localized treatment of uterine fibroids. In this revised competing renewal application, we propose three specific aims; Specific aim one: we will assess adenovirus targeting ...
  https://ods.od.nih.gov/Funding/abstract.aspx?g=5R01HD046228-08
*  Reason for Review Uterine fibroids are extremely common and LY2228820 - Aurora Kinases as Druggable Targets in Cancer Therapy
Reason for Review Uterine fibroids are extremely common and LY2228820 can cause significant morbidity yet the exact etiology of these tumors remains elusive and there are currently no long-term treatments available. from uterine fibroids. Additionally fibroid stem cells were isolated and appear to be necessary for growth. The recent discovery of somatic mutations involving MED12 or HMGA2 in the majority of fibroids and the links to their pathophysiology were also significant advances. LY2228820 Summary The recent shift in focus from hormones to fibroid stem cells and genetic aberrations should lead not only to a deeper understanding of the specific etiology of fibroids but also to the discovery of new therapeutic targets. Targeting the products of genetic LY2228820 mutations or fibroid stem cells has the potential to achieve both better control of current tumors and the prevention of new fibroids. through local conversion of androgens by aromatase[19]. Fibroids have been shown to have higher ...
  http://www.exposed-skin-care.net/2016/09/04/reason-for-review-uterine-fibroids-are-extremely-common-and-ly2228820/
*  Analysis of MED12 Mutation in Multiple Uterine Leiomyomas in South Korean patients
1. Catherino WH, Parrott E, Segars J. Proceedings from theNational Institute of Child Health and Human Development conference on the Uterine Fibroid Research Update Workshop. Fertil Steril. 2011;95:9-12 2. Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect. 2003;111:1037-54 3. Sandberg AA. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyoma. Cancer genetics and cytogenetics. 2005;158:1-26 4. Parker WH. Etiology, symptomatology, and diagnosis of uterine myomas. Fertil Steril. 2007;87:725-36 5. Makinen N, Mehine M, Tolvanen J, Kaasinen E, Li Y, Lehtonen HJ. et al. MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas. Science. 2011;334:252-5 6. Heinonen HR, Sarvilinna NS, Sjöberg J, Kämpjärvi K, Pitkänen E, Vahteristo P. et al. MED12 ...
  http://www.medsci.org/v15p0124.htm
*  Development of a Non-Invasive Treatment for Uterine Leiomyoma (Fibroids) - Full Text View - ClinicalTrials.gov
Uterine leiomyomas (fibroids) represent a major public health problem with few effective therapies. Currently, the only definitive treatment is hysterectomy and women are demanding alternative therapies to surgery. We have developed a new approach to the treatment of uterine fibroids based on collaborative laboratory research into the molecular, ultra-structural, and histopathologic changes that occur with the transformation of normal uterine myocytes into abnormal myocytes comprising uterine fibroids. We have confirmed that excessive, dysregulated collagen production (fibrosis) and abnormal collagen deposition is an underlying etiology in the pathogenesis of leiomyoma. We will test the hypothesis that an anti-tumor drug (Pirfenidone) will decrease the size of clinically relevant leiomyomas by 30%. The specific aim is to compare the effects of pirfenidone with placebo on ...
  https://clinicaltrials.gov/ct2/show/NCT00332033?term=fibroids&rank=13
*  H2 2017 Uterine Leiomyoma (Uterine Fibroids) Market Pipeline Review | Medgadget
Description: Uterine Leiomyoma (Uterine Fibroids) - Pipeline Review, H2 2017, provides an overview of the Uterine Leiomyoma (Uterine Fibroids) (Non Maligna
  https://www.medgadget.com/2017/07/h2-2017-uterine-leiomyoma-uterine-fibroids-market-pipeline-review.html
*  Uterine Fibroid
If you're suffering from fibroids and the symptoms that come with it (menstrual cramping, heavy menstrual bleeding, etc.), then perhaps you need to try the natural Chinese medicine treatments of acupuncture and Chinese herbal medicine. They can reduce the size of your fibroids and eviscerate your symptoms.. Uterine fibroids are benign tumors that are also called myomas or uterine leiomyomas. Uterine fibroids are made up of connective tissue and smooth uterine muscles. This condition affects about 20 percent of women ages 35 years and over. In some women, uterine fibroids do not manifest any symptoms; in other women, they can cause signs and symptoms like pelvic pain or discomfort, painful sexual intercourse, backache (if there is compression in the nerves and muscles), urinary frequency (if there is compression in the bladder), constipation (if there is compression in the rectum), stomach bloating or discomfort, menstrual cramps, heavy menstrual bleeding, ...
  http://www.ehealthdirectory.net/tag/uterine-fibroid/
*  Sabinet | Uterine artery embolisation for uterine leiomyomas : research
Background. Many forms of minimally invasive treatment have gained substantial popularity, both with the medical fraternity and the public. With the correct clinical indications and in skilled hands, uterine artery embolisation (UAE) has been accepted internationally as part of the standard of care that should be offered to patients with symptomatic uterine leiomyomas (fibroids). Objectives. To introduce UAE as an effective and safe treatment option in patients with symptomatic fibroids in the Western Cape Provincial Service, South Africa. Methods.Setting: Groote Schuur and Tygerberg hospitals, Western Cape. Design: Prospective observational multi-centre study. Methods: 36 women (mean age 38 years, range 30 - 47 years) with symptomatic fibroids were treated with UAE between November 2009 and February 2012. Pre-procedure magnetic resonance imaging (MRI) followed by a 6-month clinical follow-up plus MRI or an ultrasound scan were performed. Results. The ...
  http://journals.co.za/content/m_sajog/20/1/EJC152195
*  Intramural myomas: to treat or not to treat | IJWH
Intramural myomas: to treat or not to treat Mayra J Thompson, Bruce R Carr Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA Abstract: A debate among gynecologic and reproductive surgeons is whether or not there is a clinical need to treat all intramural myomas. Considerations include myoma size and number, ability to access them, whether or not they compromise the endometrium, and treatment effect on gynecologic, reproductive, and obstetric outcomes. We conducted a detailed study regarding intramural myomas, their prevalence in subject populations, the imaging methods used to detect them, their growth rate, their suspected adverse effects on gynecologic, fertility, and obstetric outcomes, and the effectiveness of various treatment methods. The growing body of evidence reported in the literature supports the need to manage intramural myomas and to treat them appropriately. Keywords: ...
  https://www.dovepress.com/intramural-myomas-to-treat-or-not-to-treat-peer-reviewed-article-IJWH
*  nanoHUB.org - Resources: [Illinois] Cancer Community Symposium 2012: The Inhibitory Effects of the Antifibrotic Drug...
Uterine leiomyomas are the most prevalent benign tumors of the reproductive tract in women. Available treatments for leiomyomas are limited to surgical procedures or hormonal therapy, which are costly and have significant side effects. In an effort to develop alternative therapeutic strategies, we tested the drug halofuginone (HF) in primary leiomyoma smooth muscle cells (LSMCs) in vitro and in vivo. Our results show that treatment of LSMCs with 50nM HF in vitro caused a significant decrease in …
  http://nanohub.org/resources/13943
*  Lirias: Identification of CUX1 as the recurrent chromosomal band 7q22 target gene in human uterine leiomyoma
Uterine leiomyomas are benign solid tumors of mesenchymal origin which occur with an estimated incidence of up to 77% of all women of reproductive age. The majority of these tumors remains symptomless, but in about a quarter of cases they cause leiomyoma-associated symptoms including chronic pelvic pain, menorrhagia-induced anemia, and impaired fertility. As a consequence, they are the most common indication for pre-menopausal hysterectomy in the USA and Japan and annually translate into a multibillion dollar healthcare problem. Approximately 40% of these neoplasms present with recurring structural cytogenetic anomalies, including del(7)(q22), t(12;14)(q15;q24), t(1;2)(p36;p24), and anomalies affecting 6p21 and/or 10q22. Using positional cloning strategies, we and others previously identified HMGA1, HMGA2, RAD51L1, MORF, and, more recently, NCOA1 as primary target (fusion) genes associated with tumor initiation in four of ...
  https://lirias.kuleuven.be/handle/123456789/357662
*  uterine fibroids - Articles
uterine fibroids - MedHelp's uterine fibroids Center for Information, Symptoms, Resources, Treatments and Tools for uterine fibroids. Find uterine fibroids information, treatments for uterine fibroids and uterine fibroids symptoms.
  http://www.medhelp.org/tags/show/16954/uterine-fibroids?section=articles
*  Questionnaire Study to Assess Quality of Life After Treatment of Fibroids - Tabular View - ClinicalTrials.gov
Uterine fibroids are the most common benign uterine tumor affecting approximately 70% of all women in the United States. Sixty percent of the 600,000 hysterectomies performed in the United States annually are done because of uterine fibroids. Hysterectomy has been the definitive treatment for fibroids and has been demonstrated to be effective in controlling symptoms. However, there have been few studies comparing the outcome of hysterectomy to other surgical and non-surgical therapies or to the outcomes experienced by a 'normal' population, i.e. those not diagnosed with fibroids. Similarly, the relative effectiveness of myomectomy and uterine fibroid embolization has not been evaluated in the context of other fibroid therapies and minimally invasive variations. Fibroid symptoms experienced by patients are subjective and have not been shown to correlate with fibroid number, size, location, or any other clinical measure of fibroids. As symptoms and their impact are the primary outcomes experienced ...
  https://clinicaltrials.gov/ct2/show/record/NCT00390494
*  Uterine fibroids - Symptoms and causes - Mayo Clinic
Uterine fibroids - Learn about fibroid tumors, including what fibroids are, fibroid symptoms, fibroid risk factors and possible fibroid treatments.
  https://www.mayoclinic.org/diseases-conditions/uterine-fibroids/symptoms-causes/syc-20354288
*  What's inside a fibroid - can uterine fibroids cause cramps
The Cellect-Budwig Protocol contains several items which are known to shrink tumors. As CF symptoms progress, they can develop a chronic cough that produces globs of thick, heavy, discolored mucus. A study has indicated that women who had Uterine Fibroid Embolization had successful pregnancies. Uterine fibroids are growths of muscular and fibrous cells hysterectomy for very large fibroids or attached to, the wall of the uterus.
  http://easy-flat-stomach-exercises.info/Fibroid-4cm/whats-inside-a-fibroid
*  Sonalleve Fibroid Ablation Pivotal Clinical Trial for MR-HIFU of Uterine Fibroids - Full Text View - ClinicalTrials.gov
Uterine Fibroids are the most common benign tumors in pre- and peri-menopausal women. Fibroids occur in 20-50% of women over 30 years of age, and with increasing size can produce pain, menorrhagia, pressure, bloating and urinary and bowel compression symptoms. Fibroids may also cause infertility. Symptomatic fibroids impact health and well-being of the female including lost work hours and reduced quality of life.. Current medical treatments include invasive removal of the fibroid (hysterectomy, myomectomy), drug therapy, or treatments causing necrosis of the fibroid tissue such as ablation (freezing or heating) or embolization. It has been estimated that 600,000 hysterectomies are performed per year in the United States and more than half of the conducted hysterectomies are due to fibroids. For the relief of symptoms, women wishing to preserve the uterus may choose between invasive procedures of myomectomy, Uterine Artery Embolization (UAE), ablation or cryotherapy. The surgically invasive ...
  https://clinicaltrials.gov/ct2/show/NCT01504308
*  Symptoms of fibroid tumor in uterus symptoms - uterine fibroid embolization pva
A recent comparative study between UFE and LUAO found the two procedures to be equally effective in reducing bleeding when measured with pictorial charts. That is why treatment for large fibroids in uterus hysterectomy women with fibroids do not have difficulty conceiving but experience recurrent pregnancy loss. Intramural or myometrial fibroids: They are the most common type of fibroids and develop on the uterine muscular wall. A quarter of a million American women a year lose their uterus because they have fibroids.
  http://endometriosispain.info/Benign-Fibroid-Tumor/symptoms-of-fibroid-tumor-in-uterus-symptoms
*  Uterus fibroid tumors and herpes - fibroids diet advice for diabetics
I know there've been times when you were just so frustrated with dealing with the pain and many other unpleasant symptoms of having uterine fibroids such as heavy bleeding, infertility, very large fibroids that make you look pregnant, etc. When I went for an ultrasound the physician's assistant told me it looked perfect - like there was never best food for fibroids fibroid there. Fibroids are the reason given for an estimated one-third of the 60,000 hysterectomies performed in Canada each year. Because uterine fibroids are only a problem if they cause symptoms, your doctor will only look for uterine fibroids if you have symptoms. The contraceptive pill is a popular method of contraception that stops an egg being released from the ovaries to prevent pregnancy.
  http://easy-flat-stomach-exercises.info/Fibroid-Tumors-Symptoms/uterus-fibroid-tumors-and-herpes
*  Genome-Wide Progesterone Receptor Binding: Cell Type-Specific and Shared Mechanisms in T47D Breast Cancer Cells and Primary...
Background Progesterone, via its nuclear receptor (PR), exerts an overall tumorigenic effect on both uterine fibroid (leiomyoma) and breast cancer tissues, whereas the antiprogestin RU486 inhibits growth of these tissues through an unknown mechanism. Here, we determined the interaction between common or cell-specific genome-wide binding sites of PR and mRNA expression in RU486-treated uterine leiomyoma and breast cancer cells. Principal Findings ChIP-sequencing revealed 31,457 and 7,034 PR-binding sites in breast cancer and uterine leiomyoma cells, respectively; 1,035 sites overlapped in both cell types. Based on the chromatin-PR interaction in both cell types, we statistically refined the consensus progesterone response element to G•ACA• • •TGT•C. We identified two striking differences between uterine leiomyoma and breast cancer cells. First, the cis-regulatory elements ...
  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029021
*  Plus it
Our studies determined that both RARs and RXRs are expressed in rat leiomyomas, indicating that these tumors have the potential to be responsive to retinoid treatment. Indeed, it has also been reported that human leiomyoma cells in culture express RAR and RXR receptors and were responsive to treatment with all-trans-retinoic acid (Boettger-Tong et al., 1997). In addition, Boettger-Tong et al. (1997)have demonstrated that cultured leiomyoma cells respond to retinoids and that ATRA inhibits estrogen-stimulated proliferation in uterine myometrium in vivo and in smooth muscle and fibroid tumor cells in vitro (Boettger-Tong and Stancel, 1995; Boettger-Tong et al., 1997). The results from our study demonstrated that both the primary tumors and the continuous cell lines derived from Eker rat leiomyomas expressed similar RXR and RAR profiles, ...
  http://jpet.aspetjournals.org/content/295/2/677
*  Uterine Fibroids Treatment - 5 fibroid breast tumors
Hysteroscopy: This is an outpatient or inpatient surgical procedure and is performed under general anaesthesia or spinal anaesthesia. The fibroid period wont stop Society for the Study of Vulvar Diseases classification of vulvodynia includes any type of vulvar pain. Sometimes, the fibroid is cut into pieces and removed through a small incision in the abdominal wall. Women who start menstruating from an early age have an increased risk of developing fibroid tumors. Uterine fibroids are hormonally responsive; estradiol and progesterone stimulate their growth, and gonadotrophin-releasing hormone agonists shrink them.
  http://easy-flat-stomach-exercises.info/Uterine-Fibroids-Treatment/Uterine-Fibroids-Treatment-154275
*  Uterine Fibroid Embolization Gaining Popularity
Women suffering from back pain, pelvic pressure, frequent urination or abnormal periods, uterine fibroids could be to blame. Fibroids are
  http://www.medindia.net/news/view_news_main.asp?x=2423
*  Uterine Leiomyoma: Incidence
Another name for Uterine Leiomyoma is Uterine Fibroids. Facts about uterine fibroids: * About 20 percent of women over the age of 35 have uterine fibroids ...
  http://www.freemd.com/uterine-leiomyoma/incidence.htm
*  Uterine Leiomyoma: Underlying Cause
Another name for Uterine Leiomyoma is Uterine Fibroids. The cause of uterine fibroids is unknown. Uterine fibroid enlargement is stimulated by the female ...
  http://www.freemd.com/uterine-leiomyoma/underlying-cause.htm