Cell Commun Signal 15:24 (2017). Read more (PubMed: 28637464) » *Singh NK et al. Cyclic AMP Response Element Binding Protein ... Synthetic peptide corresponding to a region within N terminal amino acids 2-51 (GSRCALALAV LSALLCQVWS SGVFELKLQE FVNKKGLLGN ... The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res. 38:D142-D148 (2010) . ... Kaiso differentially regulates components of the Notch signaling pathway in intestinal cells.. ...http://www.abcam.cn/dll1-antibody-ab84620.html
Signal Protein-Derived Peptides as Functional Probes and Regulators of Intracellular Signaling
... Alexander O. Shpakov ... J. M. Taylor and R. R. Neubig, "Peptides as probes for G protein signal transduction," Cellular Signalling, vol. 6, no. 8, pp. ... "The peptide strategy as a novel approach to the study of G protein-coupled signaling systems," in Signal Transduction Research ... "Different role of intracellular loops of glucagon-like peptide-1 receptor in G-protein coupling," Regulatory Peptides, vol. 111 ...https://www.hindawi.com/journals/jaa/2011/656051/ref/
Lhermitte-Duclos disease - Wikipedia
Deficiencies of intracellular signaling peptides and proteins. GTP-binding protein regulators. GTPase-activating protein. * ... Like cowden syndrome, patients with Lhermitte-Duclos disease often have mutations in enzymes involved in the Akt/PKB signaling ...https://en.wikipedia.org/wiki/Lhermitte-Duclos_disease
Li-Fraumeni syndrome - Wikipedia
Deficiencies of intracellular signaling peptides and proteins. GTP-binding protein regulators. GTPase-activating protein. * ... Mutated p53 proteins are typically more stable than wild-type, and can inhibit the activity of the wild-type protein in ... The tetramerization domain plays a major role in the oligomerization of the p53 protein, which exists as a tetramer. This ... With pH in the low to normal physiological range (up to 7.5), the mutant protein forms normal oligomers and retains its ...https://en.wikipedia.org/wiki/Li-Fraumeni_syndrome
FHL2 | Cancer Genetics Web
Protein Binding. *Intracellular Signaling Peptides and Proteins. *Promoter Regions. *Colorectal Cancer. *Cytoplasm ... and its protein functions as an important adaptor and modifier in protein-protein interactions. Both of their structures are ... LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis.. Mol Cell Biol. ... Four-and-a-half LIM-only protein 2 (FHL2) is an important mediator in many signaling pathways. In this study, we analyzed the ...http://www.cancerindex.org/geneweb/FHL2.htm
SKIL | Cancer Genetics Web
Intracellular Signaling Peptides and Proteins. *Tumor Markers. Tag cloud generated 25 June, 2015 using data from PubMed, MeSH ... protein binding - protein complex binding - protein domain specific binding - protein heterotrimerization - protein ... What pathways are this gene/protein implicaed in?. Show (1). SKIL is involved in:. - TGF beta signaling pathway BIOCARTA. Data ... TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four ...http://www.cancerindex.org/geneweb/SKIL.htm
Genetic analysis of iron citrate toxicity in yeast: implications for mammalian iron homeostasis.
0/Fungal Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/RTG2 protein, S cerevisiae; 0/Saccharomyces cerevisiae ... Fungal Proteins / physiology. Homeostasis. Intracellular Signaling Peptides and Proteins. Iron / metabolism*, toxicity*. ... Proteins; 7439-89-6/Iron; 77-92-9/Citric Acid; EC 18.104.22.168/Citrate (si)-Synthase ...http://www.biomedsearch.com/nih/Genetic-analysis-iron-citrate-toxicity/12471153.html
MAPKAPK2 | Cancer Genetics Web
Intracellular Signaling Peptides and Proteins. *Transcription Factors. *Phosphorylation. *Transfection. *HSP27 Heat-Shock ... protein kinase activity - protein phosphorylation - protein serine/threonine kinase activity - Ras protein signal transduction ... Toll signaling pathway - toll-like receptor 1 signaling pathway - toll-like receptor 2 signaling pathway - toll-like receptor 3 ... toll-like receptor 4 signaling pathway - toll-like receptor signaling pathway - TRIF-dependent toll-like receptor signaling ...http://www.cancerindex.org/geneweb/MAPKAPK2.htm
CAMTA1 | Cancer Genetics Web
Intracellular Signaling Peptides and Proteins. *Molecular Sequence Data. *Hemangioendothelioma, Epithelioid. *Brain Tumours ... The tumor nuclei showed distinct break-apart signals with individual green and/or red signals, indicating the presence of ... a protein that is highly expressed in endothelial cells, in-frame to the carboxyl terminus of CAMTA1, a protein that is ... What does this gene/protein do?. Show (5). CAMTA1 is implicated in:. - cytoplasm - DNA binding - nucleus - regulation of ...http://www.cancerindex.org/geneweb/CAMTA1.htm
Hypocretin deficiency in narcoleptic humans is associated with abdominal obesity.
0/Carrier Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins ... Intracellular Signaling Peptides and Proteins*. Male. Middle Aged. Narcolepsy / blood, complications*. Neuropeptides / ... Carrier Proteins. Case-Control Studies. Cross-Sectional Studies. Female. Humans. Hypersomnolence, Idiopathic / blood, ...http://www.biomedsearch.com/nih/Hypocretin-deficiency-in-narcoleptic-humans/12972686.html
Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt...
0/Intracellular Signaling Peptides and Proteins; 0/Stilbenes; 0/TP53 protein, human; 0/Tumor Suppressor Protein p53; 0/Wnt ... Intracellular Signaling Peptides and Proteins / metabolism. Proto-Oncogene Proteins c-akt / metabolism. RNA Interference. ... Effect of IGF-1R siRNA (A), and resveratrol (B) on IGF-1R/Wnt signaling pathway proteins. A - HT-29 cells were treated with ... 0/Antineoplastic Agents, Phytogenic; 0/CCND1 protein, human; 0/CDKN1B protein, human; 0/FOXO3 protein, human; 0/Forkhead ...http://www.biomedsearch.com/nih/Resveratrol-suppresses-IGF-1-induced/20504360.html
Sleep-deprivation regulates α-2 adrenergic responses of rat hypocretin/orexin neurons.
G Protein-Coupled Inwardly-Rectifying Potassium Channels / metabolism. Intracellular Signaling Peptides and Proteins / ... 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/Receptors, Adrenergic, alpha-2; 0/orexins; 4205-90-7/ ... 2006RGS proteins have a signalling complex: Interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins. ... Lomazzi M,Slesinger PA,Luscher C. Year: 2008Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins.Trends ...http://www.biomedsearch.com/nih/Sleep-Deprivation-Regulates-2-Adrenergic/21347440.html
Gadd45-alpha and Gadd45-gamma utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cells.
... the mechanisms by which Gadd45 proteins inhibit cell cycle con ... The Gadd45 family of proteins, which includes alpha, beta, and ... 0/Cell Cycle Proteins; 0/GADD45A protein, human; 0/GADD45G protein, human; 0/Intracellular Signaling Peptides and Proteins; 0/ ... Intracellular Signaling Peptides and Proteins / metabolism*. JNK Mitogen-Activated Protein Kinases / metabolism*. Liver ... MAP Kinase Signaling System*. Male. Middle Aged. Nuclear Proteins / metabolism*. Transfection. p38 Mitogen-Activated Protein ...http://www.biomedsearch.com/nih/Gadd45-alpha-gamma-utilize-p38/19048389.html
Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1.
0/Intracellular Signaling Peptides and Proteins; 0/NEDD8 protein, human; 0/Protein Subunits; 0/Recombinant Fusion Proteins; 0/ ... Intracellular Signaling Peptides and Proteins / chemistry*, genetics, metabolism*. Models, Molecular. Molecular Dynamics ... Peptide Hydrolases / chemistry*, genetics, metabolism*. Protein Multimerization. Protein Structure, Quaternary. Protein ... Protein Subunits. Recombinant Fusion Proteins / chemistry, genetics, metabolism. Sequence Homology, Amino Acid. Ubiquitins / ...http://www.biomedsearch.com/nih/Insights-into-regulation-human-COP9/23288897.html
A role of the histaminergic system for the control of feeding by orexigenic peptides.
0/Ghrelin; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptide Y; 0/Neuropeptides; 0/Peptide Hormones; 0/Receptors ... Intracellular Signaling Peptides and Proteins / pharmacology*. Male. Mice. Mice, Knockout. Motor Activity / drug effects. ... Peptide Hormones / pharmacology*. Rats. Rats, Wistar. Receptors, Histamine H1 / deficiency. Time Factors. ... 14984806 - Effect of central administration of prolactin-releasing peptide on feeding in chicks.. 8076156 - Development of a ...http://www.biomedsearch.com/nih/role-histaminergic-system-control-feeding/16872646.html
Hypocretin (orexin) cell loss in Parkinson's disease.
0/Glial Fibrillary Acidic Protein; 0/Hypothalamic Hormones; 0/Intracellular Signaling Peptides and Proteins; 0/Melanins; 0/ ... Intracellular Signaling Peptides and Proteins / analysis*, deficiency. Male. Melanins / analysis. Middle Aged. Neurons / ... Glial Fibrillary Acidic Protein / analysis. Humans. Hypothalamic Hormones / analysis. Hypothalamus / chemistry, pathology. ... Next Document: Endothelial protein C receptor is overexpressed in rheumatoid arthritic (RA) synovium and mediates t.... ...http://www.biomedsearch.com/nih/Hypocretin-orexin-cell-loss-in/17491094.html
Brain orexin promotes obesity resistance.
Intracellular Signaling Peptides and Proteins / metabolism*. Neuropeptides / metabolism*. Obesity / metabolism*. Rats. Rats, ... Hypocretin/orexin peptide signaling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal ... Orexin-mediated signaling As discussed above, the orexin peptides exert their effects by binding to two closely related G ... Intracellular Foxa2 signaling from the insulin receptor may be a mechanism allowing orexin neurons to sense the state of ...http://www.biomedsearch.com/nih/Brain-orexin-promotes-obesity-resistance/22803681.html
proto oncogene proteins c bcl 2
Scientific Experts about proto oncogene proteins c bcl 2 ... intracellular signaling peptides and proteins , apoptosis ... The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Kui ... proto oncogene proteins c bcl 2. Summary. Summary: Membrane proteins encoded by the BCL-2 GENES and serving as potent ... Although these insights into interactions among BCL-2 family proteins reveal how these proteins are regulated, a unifying ...http://www.labome.org/topics/chemicals/and/peptides/intracellular/apoptosis/proto-oncogene-proteins-c-bcl-2-14888.html
Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis.
... the protein phosphatase Eya1, cooperate to promote cell differentiation and survival during mouse organ development. Here, we ... 0/Homeodomain Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/LIM-Homeodomain Proteins; 0/Nerve Tissue Proteins; 0 ... Intracellular Signaling Peptides and Proteins / genetics, physiology*. LIM-Homeodomain Proteins. Molecular Sequence Data. ... 0/Six1 protein, zebrafish; 0/Transcription Factor Pit-1; 0/Transcription Factors; 0/Zebrafish Proteins; 0/homeobox protein ...http://www.biomedsearch.com/nih/Eya1-required-lineage-specific-differentiation/16458879.html
The cell cycle machinery and asym... preview & related info | Mendeley
Insect Proteins: metabolism. *Intracellular Signaling Peptides and Proteins. *Neurons. *Neurons: cytology. *Neurons: physiology ... Moreover, we show that the maintenance of this apical protein complex is essential for the correct execution of asymmetric ... Finally, the localization of the various asymmetrically localized proteins shows cell cycle dependence; however, the ... while in delaminated mitotic neuroblasts the maintenance of the apical cortical localization of these proteins is dependent on ...https://www.mendeley.com/research-papers/cell-cycle-machinery-asymmetric-cell-division-neural-progenitors-drosophila-embryonic-central-nervou/
Distribution of ceramide and PAR-4 during cell division | Open-i
Intracellular Signaling Peptides and Proteins*. *Nerve Tissue Proteins*. *Neurons/cytology/metabolism*. *Stem Cells/cytology/ ... Cell death and survival of neural progenitor (NP) cells are determined by signals that are largely unknown. We have analyzed ... Cell death and survival of neural progenitor (NP) cells are determined by signals that are largely unknown. We have analyzed ... Apoptotic cells also stained for proliferating cell nuclear antigen (a nuclear mitosis marker protein), but not for nestin (a ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2172704_200212067f8&req=4
Distribution of activated Src and total Src in fibrinog | Open-i
Intracellular Signaling Peptides and Proteins. *Mice. *Mice, Knockout. *Mutation. *Platelet Activation/drug effects ... Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. ... Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. ... thus providing a paradigm for initiation of integrin signaling to the actin cytoskeleton. ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2199242_0112113f4&req=4
ZFIN Publication: Zecchin et al., 2007
Intercellular Signaling Peptides and Proteins/genetics*; Intracellular Signaling Peptides and Proteins; Membrane Proteins/ ... Notch signaling has been shown to be a major mechanism controlling these cell-fate choices. So far, the pleiotropy of Delta and ... Animals; Base Sequence; Calcium-Binding Proteins/genetics*; Cell Differentiation/physiology; DNA Primers (all 13) Animals; Base ... Finally, overexpression of Notch1a-intracellular-domain in the whole pancreas primordium or specifically in beta-cells helped ...https://zfin.org/ZDB-PUB-061031-7
RT-PCR analysis on the expression of Jak2 and Bcl-xL mR | Open-i
Intracellular Signaling Peptides and Proteins. *Liver/embryology/immunology. *Mice. *Mice, Knockout. *Molecular Sequence Data ... Among 4289 genes, including Bcl-2 family, caspases, cytokines, and signal transduction molecules, 184 genes were significantly ... Among 4289 genes, including Bcl-2 family, caspases, cytokines, and signal transduction molecules, 184 genes were significantly ... or signal transduction molecules. The expression of Anamorsin was completely dependent on stimulation with growth factors such ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2211823_20031858f6&req=4
Characterization of local valency in promoting LCL ad | Open-i
Intracellular Signaling Peptides and Proteins. *Ligands. *Neoplasms/etiology/metabolism/pathology. *Signal Transduction ... Bottom Line: Nonactivated lymphoid cells attach preferentially to polymerized ECM proteins yet are unable to attach to ... A) LCL or M21 cells were assessed for attachment to wells coated with either recombinant adenovirus penton base (PB) protein ( ... Adhesion to multimeric PB was entirely dependent on integrin αvβ3, since either LM609 or a peptide antagonist of this integrin ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2132930_JCB9807120.f3&req=4
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