A whole transcriptomal linkage analysis of gene co-regulation in insecticide resistant house flies, Musca domestica - Danish...
... protein kinase/phosphates and proteases may be involved in the regulation of resistance P450 gene regulation. Conclusion Taken ... adenylate and guanylate cyclases, protein kinases and phosphatases. The proteases group contained genes with digestive, ... signal transduction and kinases/phosphatases in regulation, and proteases in intra-cellular processes. The redox group ... The majority of these up-regulated genes fell within the SCOP categories of metabolism, general, intra-cellular processes, and ...http://www.forskningsdatabasen.dk/catalog/255802388
Adenylate kinase - Wikipedia
Adenylate Kinase is a signal transducing protein; thus, the balance between conformations regulates protein activity. ADK has a ... By continually monitoring and altering the levels of ATP and the other adenyl phosphates (ADP and AMP levels) adenylate kinase ... This process can be thought of as a bucket brigade of ADK molecules that results in changes in local intracellular metabolic ... Adenylate kinase, subfamily InterPro: IPR006259 UMP-CMP kinase InterPro: IPR006266 Adenylate kinase, isozyme 1 InterPro: ...https://en.wikipedia.org/wiki/Adenylate_kinase
Bupivacaine Inhibits Activation of Neuronal Spinal Extracellular Receptor-activated Kinase through Selective Effects on...
The activation of these postsynaptic receptors activates protein kinases such as PKA and PKC, and ERK pathway. AC = adenylate ... after bath application of intracellular stimulants, the protein kinase C activator phorbol ester 12-myristate-13-acetate (PMA, ... Chen C-C, Chang J, Chen WC: Potentiation of bradykinin-induced inositol phosphates production by cyclic AMP elevating agents ... the protein kinase C activator phorbol ester 12-myristate-13-acetate (PMA, 5 μm; A ), the protein kinase A activator forskolin ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1923305
Sphingolipids Metabolites: A New Class of Second Messengers in the Regulation of Cell Growth | SpringerLink
The interaction of growth factors with specific cell surface receptors triggers multiple intracellular signaling pathways that ... Y. Nishizuka, Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C, Science 258: 607 (1992 ... of the epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C, J. ... adenylate cyclase and cyclic AMP accumulation in S49 lymphoma cells preclude its use as a specific inhibitor of protein kinase ...https://link.springer.com/chapter/10.1007/978-1-4615-2421-2_12
Interferences | eClinpath
... adenylate kinase or glucose-6-phosphate will increase serum creatine kinase (CK) activity because they participate in the ... Total protein by refractometer: Lipids refract light, falsely increasing total protein measurement with this technique. ... Note that phosphate can increase with hemolysis as organic phosphates are converted to inorganic phosphates over time (with ... Release of intracellular constituents that are directly measured: Release of constituents or enzymes found in high ...http://www.eclinpath.com/test-basics/interferences/
PPT - Endocrine Physiology lecture 2 PowerPoint Presentation - ID:163946
Protein kinase C activity is further increased by calcium which is released by the action of inositol phosphates. ... do not have intrinsic kinase activity, but activate soluble, intracellular kinases such as the Jak kinases. ... Adenylate cyclase which catalyzes the conversion of ATP to cyclic AMP; *Guanylate cyclase which catalyzes the conversion of GMP ... These include cyclic nucleotide-dependent protein kinases *Calcium/calmodulin-dependent protein kinase, and protein kinase C ...https://www.slideserve.com/Thomas/endocrine-physiology-lecture-2
CALM2 calmodulin 2 [Homo sapiens (human)] - Gene - NCBI
... a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular ... The majority of Ca2+ in many organisms is bound to phosphates which form skeletal structures and also buffer Ca2+ levels in ... organism-specific biosystemCa2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase ... organism-specific biosystemThe Ca2+-calmodulin-dependent protein kinase (CaM kinase) cascade includes three kinases: CaM-kinase ...https://www.ncbi.nlm.nih.gov/gene/805
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases | BMC...
Lienhard GE, Secemski II: P1,P5-Di(adenosine-5')pentaphosphate, a potent multisubstrate inhibitor of adenylate kinase. J. Biol ... members of the histidine triad protein family such as the FHIT tumour suppresser protein and (in lower eukaryotes) the related ... Optimal [Mn2+] is approximately 4 mM, which is in contrast to that estimated for free intracellular [Mn2+] of below 0.5 μM [27 ... Previously, the human DIPP family comprised hDIPP-1, a ubiquitous enzyme able to hydrolyse both inositol phosphates and ...https://bmcbiochem.biomedcentral.com/articles/10.1186/1471-2091-3-20
Metabolic suppression during protracted exposure to hypoxia in the jumbo squid, Dosidicus gigas, living in an oxygen minimum...
eukaryotic elongation factor 2 kinase. eEF2. eukaryotic elongation factor 2. GSH. glutathione. HSP. heat shock protein. M. body ... Intracellular pH in relation to octopine and extracellular (hemolymph) pH. (A) Intracellular pH (pHi) is inversely related to ... For juvenile squid, adenylate analysis was done with a high performance liquid chromatographic method similar to that reported ... arginine phosphates) had been converted to arginine via acid hydrolysis (Arg-P=Σarginine-arginine). Arginine is reductively ...http://jeb.biologists.org/content/217/14/2555
Stable expression of a functional rat angiotensin II (AT1A) receptor in CHO-K1 cells: Rapid desensitization by angiotensin II |...
Shimuta SI, Kanashiro CA, Ferreira AT, Oshiro MEM, Paiva TB, Paiva ACM: Role of Na+ and protein kinase C in angiotensin ... Liggett SB, Ostrowski J, Chesnut LC, Kurose H, Raymond JR, Caron MG, Lefkowitz RJ: Sites in the third intracellular loop of the ... Baker KM, Singer HA, Aceto JF: Angiotensin II receptor mediated stimulation of cytosolic-free calcium and inositol phosphates ... Sibley DR, Lefkowitz RJ: Molecular mechanisms of receptor desensitization using the B-adrenergic receptor-coupled adenylate ...https://link.springer.com/article/10.1007%2FBF00926885
Mechanism of Cardiac Sarcolemmal Adenosine Triphosphate-sensitive Potassium Channel Activation by Isoflurane in a Heterologous...
The phosphotransfer enzymes such as creatine kinase or adenylate kinase provide a mechanism to communicate changes in the ... Requirement of multiple protein domains and residues for gating KATPchannels by intracellular pH. J Biol Chem 2001; 276:36673- ... Schulze D, Rapedius M, Krauter T, Baukrowitz T: Long-chain acyl-CoA esters and phosphatidylinositol phosphates modulate ATP ... Consequently, it has been demonstrated that under such conditions (pHi 7.4), activation of protein kinase C isoform PKC-ϵ is ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1931115
IJMS | Free Full-Text | A Dual Role of Strigolactones in Phosphate Acquisition and Utilization in Plants | HTML
Fe and Al phosphates, or is converted to organic phosphates (e.g., phytic acid) that are not immediately available for plants [ ... Woo, H.R.; Chung, K.M.; Park, J.H.; Oh, S.A.; Ahn, T.; Hong, S.H.; Jang, S.K.; Nam, H.G. ORE9, an F-box protein that regulates ... Duff, S.M.G.; Moorhead, G.B.G.; Lefebvre, D.D.; Plaxton, W.C. Phosphate starvation inducible bypasses of adenylate and ... PHT2 and PHT3 transporters also play important roles in intracellular Pi translocation or transport between plant organs . ...http://www.mdpi.com/1422-0067/14/4/7681/htm
Protein kinase A - Wikipedia
... using adenylate cyclase. Protein kinase A acts to phosphorylate many enzymes important in metabolism. For example, protein ... Extracellular hormones such as glucagon and epinephrine begin an intracellular signalling cascade that triggers protein kinase ... The liberated catalytic subunits can then catalyze the transfer of ATP terminal phosphates to protein substrates at serine, or ... Protein kinase Signal transduction G protein-coupled receptor Serine/threonine-specific protein kinase Myosin light-chain ...https://en.wikipedia.org/wiki/Protein_kinase_A
ADCY2 - Adenylate cyclase type 2 - Homo sapiens (Human) - ADCY2 gene & protein
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream ... activation of protein kinase A activity Source: Reactome. *adenylate cyclase-activating G-protein coupled receptor signaling ... p>This subsection of the 'Function' section describes a region in the protein which binds nucleotide phosphates. It always ... intracellular Source: BHF-UCL. *membrane Source: UniProtKB. *membrane raft Source: BHF-UCL ...http://www.uniprot.org/uniprot/Q08462
Regulation of Cyclin-Dependent Kinase 5 and Calcium/Calmodulin-Dependent Protein Kinase II by Phosphatidylinositol-Linked...
... and is attenuated by the protein kinase inhibitor calphostin C or by the intracellular calcium chelator BAPTA, indicating that ... Undie AS and Friedman E (1990) Stimulation of a dopamine D1 receptor enhances inositol phosphates formation in rat brain. J ... stimulates phospholipase-C activity independent of adenylate cyclase. J Pharmacol Exp Ther 248: 171-175. ... protein kinase A; PLCβ, phospholipase Cβ; cdk5, cyclin-dependent kinase 5; CaMK II, calcium/calmodulin-dependent protein kinase ...http://molpharm.aspetjournals.org/content/66/6/1500
Signaling Pathways Modulated by Dopamine Receptors | Springer for Research & Development
Knowledge of the intracellular signaling events altered by the binding of dopamine to its receptors is critical to the ... Haycock, J. W., Ahn, N. G., Cobb, M. H., and Krebs, E. G. (1992) ERK1 and ERK2, two microtubule-associated protein 2 kinases, ... Dopamine Receptor Adenylate Cyclase Pituitary Cell Pertussis Toxin Arachidonic Acid Release These keywords were added by ... Knowledge of the intracellular signaling events altered by the binding of dopamine to its receptors is critical to the ...https://rd.springer.com/chapter/10.1007/978-1-4757-2635-0_6
US6031002A - Method for enhancing female sexual response and a composition therefor - Google Patents
... thus stimulating adenylate cyclase and elevating intracellular cyclic AMP, leading to the activation of protein kinase with ... Or the absorption promoter may be a compound selected from a group consisting of monoalkyl phosphates and pharmaceutically ... The drug may work by increasing the intracellular concentrations of cyclic AMP. Alprostadil interacts with specific membrane ...https://patents.google.com/patent/US6031002A/en
glycogen metabolism Flashcards - Cram.com
cAMP dependant protein kinases' cAMP dependant protain kinases phosphorylate and activate what two enzymes? ... are the 2 Phosphates on UDP-glucose both from UTP? No, one is from UTP and the other remains from glucose-1-P. ... stored in intracellular vesicles. what two effects does insulin binding to muscle cells have on the glucose transporter GLUT-4 ... what, self-glycosylating, protein forms the initial glucose monomer chain from which glycogen can be formed? ...http://www.cram.com/flashcards/glycogen-metabolism-412096
BIOCHEMISTRY OF MAGNESIUM - PDF
Adenylate cyclase activtion is crucial for the control of anaphylactic reactions because high intracellular camp and cgmp ... This complex plays a key part in a phosphorylation cascade catalyzed by protein kinases. Alternatively, due to its capability ... Another metal ion (B) facilitates the leaving of the â- and ã-phosphates as well as phosphodiester bond formation (HARTWIG 2001 ... Since Mg 2+ accumulation directly or indirectly influences protein kinase C activation, it is possible that in diabetic ...http://docplayer.net/1925075-Biochemistry-of-magnesium.html
Frontiers | Depotentiation from Potentiated Synaptic Strength in a Tristable System of Coupled Phosphatase and Kinase |...
... exclusively explains how moderate and high elevation of intracellular calcium concentration triggers long-term depression (LTD ... A generic tristable system, which couples the phosphatase and kinase switches, ... further show that significant elevation of cytoplasmic calcium concentration switches activation of both kinase and phosphatase ... exclusively explains how moderate and high elevation of intracellular calcium concentration triggers long-term depression (LTD ...https://www.frontiersin.org/articles/10.3389/fncom.2016.00104/full
Patent US6492130 - Modulation of the sulfonylurea receptor and calcium in adipocytes for ... - Google Patents
These effects were attributed to sulfonylurea-induced inhibition of cAMP level and protein kinase A activity. Thus, rodent ... Intracellular Ca2+ ([Ca2+]i) plays a key role in the metabolic disorders associated with obesity and insulin resistance (1-3). ... an adenylate cyclase activator, induced a 48% increase in lipolysis in human adipocytes (p,0.05); this effect was reversed by ... and relatively minor amounts of citrates or phosphates. The ordinary skilled person would know of additional agents that are ...http://www.google.com/patents/US6492130?dq=6,123,819
The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance | SpringerLink
... protein kinase C, ERKs, phosphatidylinositol 3-kinases (PI3K), MAP kinases (MAPK) and Rho [6, 7, 8]. The situation concerning ... adenylate kinase, nucleoside diphosphate kinase, and potentially ecto-F1-Fo ATP synthases [21, 22, 23, 24, 25] that may ... The graph depicts a clear separation between surface-located (top) and intracellular (bottom) NTPDases. In addition, the major ... They also contribute to recycling of nucleosides derived from extracellular nucleoside phosphates and metabolic salvage ...https://link.springer.com/article/10.1007%2Fs11302-006-9003-5
Effects of temperature and anoxia upon the performance of in situ perfused trout hearts | Journal of Experimental Biology
... protein, adenylate, creatine, glycogen and lactate content, adenylate energy charge and [PCr]/[Cr]2). A nonparametric test ( ... and cardiac failure appears to be caused by increased levels of intracellular inorganic phosphates and reduced intracellular pH ... Christensen, M., Hartmund, T. and Gesser, H. (1994). Creatine kinase, energy-rich phosphates and energy metabolism in heart ... so the intracellular milieu, particularly intracellular phosphate and pH, is disturbed sooner. ...http://jeb.biologists.org/content/207/4/655
AK, adenylate kinase. *[ATP]i, intracellular ATP concentration. *CK, creatine kinase. *FFA, free fatty acid ... this is mediated by an intracellular phosphotransfer network that shuttles high energy-rich phosphates from the mitochondria to ... UCP, uncoupling protein. The ATP-sensitive K+ channel (KATP channel) activity plays a crucial role in glucose-stimulated ... with creatine kinase (CK) linking ATP generation to KATP channel closure and adenylate kinase (AK) regulating KATP channel ...http://diabetes.diabetesjournals.org/content/53/suppl_3/S113
... or protein kinase G-mediated mechanism, or via prostaglandin release and activation of adenylate cyclase-coupled prostaglandin ... with potential extracellular N-glycosylation sites and intracellular protein kinase C phosphorylation sites (Fig.1). ... P2Y4 and P2Y6 receptor promoted a steady accumulation of inositol phosphates for up to 60 min (Figs. 2A and3A). Although the ... by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A ...http://jpet.aspetjournals.org/content/297/1/43