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*  A Study to Assess Treatment With 2 Different Dosing Schedules of Trabectidin Administered to Patients With Advanced Cancer
Cancer that has metastasized (spread) to the central nervous system. - Active viral hepatitis or chronic liver disease. - ... Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open ... Yondelis will be administered intravenously (i.v.) via a central. catheter (tube) into a central vein once a week (0.58 mg/m2 ... 24-hour infusion on Day 1 of every 21-day treatment cycle) until disease progression.. Patients in each arm will be pretreated ...
  http://www.knowcancer.com/cancer-trials/NCT00060944/
*  Phase IB/II Trial Combining Vinorelbine With Sorafenib as First-Line Treatment in Patients With Metastatic Breast Cancer - Full...
Presence of life-threatening disease or central nervous system localizations.. *Evidence of HER-2 positive breast cancer, ... Intervention/treatment Experimental: Sorafenib and Vinorelbine Drug: Sorafenib and Vinorelbine vinorelbine, administered as a ... Uncontrolled bacterial, viral or fungal infection.. *Previous history of ischemic disease.. *Patients with previous history of ... Clinically significant hepatic disease with respect to hepatitis B, hepatitis C, cirrhosis or other liver diseases. ...
  https://clinicaltrials.gov/ct2/show/NCT00764972
*  Search of: Lyme disease | 'Borrelia Infections' - List Results - ClinicalTrials.gov
Central Nervous System Infections. *Bacterial Meningitis. *Viral Meningitis. *(and 9 more...). *Other: Community-acquired CNS ... A School-Based Intervention to Reduce Lyme Disease. *Lyme Disease. *Behavioral: Education ... Cure VCP Disease, Inc.. Lowe Syndrome Association. Pitt Hopkins. Cure Batten Disease. Hypnic Jerk/Sleep Myoclonus. CoRDS. July ... Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford. *Rare Disorders ...
  https://clinicaltrials.gov/ct2/results?term=Lyme+disease&cond=%22Borrelia+Infections%22
*  A Study to Evaluate the Safety and Effectiveness of WF10 Given to Patients With Late-Stage HIV Disease
The purpose of this study is to see if it is safe and effective to give WF10 to adults with late-stage HIV disease. WF10 is... ... and PRION DISEASES may involve the central nervous system as a primary or secondary process. ... Encephalitis, Viral. Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary ... is critical for monitoring AIDS epidemic and assessing the effectiveness of intervention measures. However, current methods for ...
  https://www.bioportfolio.com/resources/trial/126887/A-Study-to-Evaluate-the-Safety-and-Effectiveness-of-WF10-Given-to.html
*  Tiny chemical change in horse herpes virus can have lethal effect
... and lower levels of the virus reached the central nervous system. The mutation also made the virus more susceptible to ... altered one amino acid in the viral enzyme known as DNA polymerase and rendered the virus unable to cause neurological disease ... so interventions should be equally rigorous for all infections," said Osterrieder. ... The researchers postulate that herpes viruses evolve toward strains that produce less disease, so they think that the more ...
  https://www.innovations-report.com/html/reports/life-sciences/report-95970.html
*  Changes in Cerebral Function in Treatment Naive HIV-1 Infected Subjects Commencing Either Boosted Atazanavir With Truvada or...
... other chronic viral infections (such as chronic hepatitis C co-infection), age and central nervous system (CNS) antiretroviral ... Condition or disease Intervention/treatment Phase HIV Impaired Cognition Drug: standard care Drug: novel treatment Phase 4 ... which may be associated with the evolution of NC function impairment is the direct effect of cART on the central-nervous-system ... Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information ...
  https://clinicaltrials.gov/show/NCT01367236?order=144
*  Biobehavioral Interventions for HIV-negative, Stimulant Using Men Who Have Sex With Men - Full Text View - ClinicalTrials.gov
Sexually Transmitted Diseases, Viral. Sexually Transmitted Diseases. Immunologic Deficiency Syndromes. Immune System Diseases. ... Central Nervous System Stimulants. Antiviral Agents. Anti-Infective Agents. Reverse Transcriptase Inhibitors. Nucleic Acid ... The two interventions were implemented simultaneously:. The CM or NCYC intervention, remunerating (via vouchers) the ... Biobehavioral Interventions for HIV-negative, Stimulant Using Men Who Have Sex With Men. This study has been completed. ...
  https://clinicaltrials.gov/show/NCT01140880?order=146
*  Dal Canto MC[au] - PubMed - NCBI
Citations may include links to full-text content from PubMed Central and publisher web sites. ... Viral hyperinfection of the central nervous system and high mortality after hematopoietic stem cell transplantation for ... HIV-1 and its causal relationship to immunosuppression and nervous system disease in AIDS: a review. ... Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis. ...
  https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Dal+Canto+MC%5Bau%5D&dispmax=50
*  MARCH Central Nervous System Substudy - Full Text View - ClinicalTrials.gov
Condition or disease Intervention/treatment HIV-1 Infection Drug: Arm 1 TNucleotide Analogue Reverse Transcriptase Inhibitors ... The cerebrospinal fluid will be used to measure maraviroc levels and an ultrasensitive CSF HIV-1 viral load. These results will ... MARCH Central Nervous System Substudy. The safety and scientific validity of this study is the responsibility of the study ... Maraviroc Switch Central Nervous System (CNS) Substudy: a Substudy of MARCH, a Randomised, Open-label Study to Evaluate the ...
  https://clinicaltrials.gov/show/NCT01637233?order=229
*  LINFOTARGAM: Treatment With Chemotherapy Plus Rituximab and Highly Active Antiretroviral Therapy in Patients With Diffuse Large...
Drug: R-CHOP Drug: Highly active antiretroviral therapy Drug: Central nervous system (CNS) prophylaxis Drug: Prophylaxis of ... Virus Diseases. Sexually Transmitted Diseases, Viral. Sexually Transmitted Diseases. Lymphoma, Non-Hodgkin. Slow Virus Diseases ... Condition or disease Intervention/treatment Phase HIV Infections Diffuse Large B Cell Lymphoma ... Drug: Central nervous system (CNS) prophylaxis methotrexate (12 mg) cytarabine (30 mg) hydrocortisone (20 mg) ...
  https://clinicaltrials.gov/show/NCT00466258?order=207
*  PA-14-095: Eradication of HIV-1 from Central Nervous System Reservoirs (R01)
Eradication of HIV-1 from Central Nervous System Reservoirs (R01) PA-14-095. NIMH ... model of HIV/AIDS and CNS disease have shown that the levels of brain viral RNA were lowered in response to effective HAART, ... or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of ... focused solely on the central nervous system (CNS) of HIV-infected persons treated with Highly Active Anti-Retroviral Therapy ( ...
  https://grants.nih.gov/grants/guide/pa-files/PA-14-095.html
*  Gladstone Institutes - Wikipedia
Katerina Akassoglou-Showed that the blood protein called fibrinogen plays a role in diseases of the central nervous system. Her ... cardiovascular disease, neurological disease and viral/immunological disease. Scientists working in all three disease areas use ... that molecular interactions between blood and the brain can be targets for therapeutic intervention in neurological diseases ... Inflammation and neurodegenerative disease. Studying abnormal inflammatory responses by immune cells in the central nervous ...
  https://en.wikipedia.org/wiki/Gladstone_Institutes
*  St. PETERsburg Pain and Alcohol Intervention With Naltrexone and Nalmefene - Full Text View - ClinicalTrials.gov
Sexually Transmitted Diseases, Viral. Sexually Transmitted Diseases. Immunologic Deficiency Syndromes. Immune System Diseases. ... Central Nervous System Depressants. Physiological Effects of Drugs. Narcotic Antagonists. Sensory System Agents. Peripheral ... Condition or disease Intervention/treatment Phase HIV Infection Alcohol Use Pain Drug: Low dose naltrexone Drug: Nalmefene ... PETERsburg Pain and Alcohol Intervention With Naltrexone and Nalmefene (PETER PAIN). The safety and scientific validity of this ...
  https://clinicaltrials.gov/show/NCT03278886
*  Behavior Change and Maintenance Intervention for HIV+ MSM Methamphetamine Users - Full Text View - ClinicalTrials.gov
Genital Diseases, Male. Genital Diseases, Female. Methamphetamine. Central Nervous System Stimulants. Physiological Effects of ... Virus Diseases. Sexually Transmitted Diseases, Viral. Immunologic Deficiency Syndromes. Immune System Diseases. Chemically- ... Intervention Phase HIV Infections Substance Abuse Sexually Transmitted Diseases Behavioral: EDGE counseling, no maintenance ... Peripheral Nervous System Agents. Dopamine Agents. Neurotransmitter Agents. Molecular Mechanisms of Pharmacological Action. ...
  https://clinicaltrials.gov/show/NCT00432926?order=118
*  Early Intensification of Antiretroviral Therapy Including Enfuvirtide in HIV-1-Related Progressive Multifocal...
Brain Diseases. Central Nervous System Diseases. Nervous System Diseases. Encephalitis, Viral. Central Nervous System Viral ... Intervention Phase Leukoencephalopathy, Progressive Multifocal HIV Infections Drug: Enfuvirtide Drug: Tenofovir-Emtricitabine ... Slow Virus Diseases. Infectious Encephalitis. Encephalitis. Central Nervous System Infections. Demyelinating Diseases. ... Sexually Transmitted Diseases, Viral. Sexually Transmitted Diseases. Immunologic Deficiency Syndromes. Immune System Diseases. ...
  https://clinicaltrials.gov/show/NCT00120367?order=290
*  Safety and Anti-HIV Activity of Capravirine Alone and in Combination With Other Anti-HIV Drugs - Full Text View -...
Sexually Transmitted Diseases, Viral. Sexually Transmitted Diseases. Immunologic Deficiency Syndromes. Immune System Diseases. ... done between days 2 and 7 to measure how well capravirine gets into the central nervous system. ... Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information ... Patients will have the option of having blood drawn daily on days 2 through 7 to measure HIV-1 viral load and of having a ...
  https://clinicaltrials.gov/show/NCT00005673?order=177
*  A Pilot Study to Assess the Feasibility of Switching, Individuals Receiving Atripla With Continuing Central Nervous System (CNS...
Condition or disease Intervention/treatment Phase HIV Drug: tenofovir/emtricitabine/rilpivirine Phase 3 ... Has acute viral hepatitis including, but not limited to, A, B, or C ... A Pilot Study to Assess the Feasibility of Switching, Individuals Receiving Atripla With Continuing Central Nervous System (CNS ... A Pilot Study to Assess the Feasibility of Switching, Individuals Receiving Atripla With Continuing Central Nervous System (CNS ...
  https://clinicaltrials.gov/show/NCT01701882?order=208
*  Clinical Trial of CNS-targeted HAART (CIT2) - Full Text View - ClinicalTrials.gov
Sexually Transmitted Diseases, Viral. Sexually Transmitted Diseases. Immunologic Deficiency Syndromes. Immune System Diseases. ... Randomized trial of central nervous system-targeted antiretrovirals for HIV-associated neurocognitive disorder. Clin Infect Dis ... Condition or disease Intervention/treatment Phase HIV Infections Drug: FDA Approved Antiretroviral Therapy (see list below) ... CIT2 is a strategy for targeting HAART (Highly Active Antiretroviral Therapy) to the CNS (Central Nervous System) in patients ...
  https://clinicaltrials.gov/show/NCT00624195?order=44
*  Atripla to Raltegravir Switch Study for CNS Toxicity - Full Text View - ClinicalTrials.gov
Sexually Transmitted Diseases, Viral. Sexually Transmitted Diseases. Immunologic Deficiency Syndromes. Immune System Diseases. ... To assess the rate of neuropsychiatric and central nervous system (CNS) toxicity as measured from baseline to 4 weeks of ... Intervention/treatment Experimental: All Subjects Truvada/Raltegravir All Subjects will receive the same intervention, Truvada/ ... The rate of neuropsychiatric and central nervous system (CNS) toxicity as measured after 12 weeks of raltegravir therapy as ...
  https://clinicaltrials.gov/show/NCT01195467?order=278
*  List of ICD-9 codes E and V codes: external causes of injury and supplemental classification - Wikipedia
Other central nervous system depressants and anesthetics causing adverse effects in therapeutic use (E939) Psychotropic agents ... inoculation against certain viral diseases V05 Need for other prophylactic vaccination and inoculation against single diseases ... Injury due to legal intervention by gas (E973) Injury due to legal intervention by blunt object (E974) Injury due to legal ... Central nervous system stimulants causing adverse effects in therapeutic use (E941) Drugs primarily affecting the autonomic ...
  https://en.wikipedia.org/wiki/List_of_ICD-9_codes_E_and_V_codes:_external_causes_of_injury_and_supplemental_classification
*  Sam Schmidt Paralysis Foundation - Wikipedia
The central nervous system is better protected than any other system or organ in the body. Its main line of defense is the ... On the other hand, poliomyelitis (a viral infection) or Lou Gehrig's disease (ALS, amyotrophic lateral sclerosis) can affect ... Many organs and tissues in the body can recover after injury without intervention. Unfortunately, some cells of the central ... The central nervous system (CNS) controls most functions of the body and mind. It consists of two parts: the brain and the ...
  https://en.wikipedia.org/wiki/Sam_Schmidt_Paralysis_Foundation
*  Myelitis - Wikipedia
... for immune system to cause inflammatory response anywhere in the central nervous system, the cells from immune system must pass ... Poliomyelitis: disease caused by viral infection in the gray matter with symptoms of muscle paralysis or weakness Leukomyelitis ... to evaluate for structural lesions that may require surgical intervention, or disseminated disease. Adding gadolinium further ... Central nervous system nerve regeneration would be able to repair or regenerate the damage caused to the spinal cord. It would ...
  https://en.wikipedia.org/wiki/Myelitis
*  Cytopathology - Wikipedia
... bone and skin cytology Kidney and adrenal cytology Liver and pancreas cytology Central nervous system cytology Eye cytology ... viral, and/or bacterial reactive changes immune reactions cell aging amyloidosis autoimmune diseases Various normal functions ... and intervention cytology. In this method, cells are collected after they have been either spontaneously shed by the body (" ... Cytopathology is commonly used to investigate diseases involving a wide range of body sites, often to aid in the diagnosis of ...
  https://en.wikipedia.org/wiki/Cytopathology
*  Human microbiota - Wikipedia
Because many of the basic science studies showed some efficacy of probiotics on central nervous system function, this ... "Altered Oral Viral Ecology in Association with Periodontal Disease". MBio. 5 (3): e01133-14. doi:10.1128/mBio.01133-14. PMC ... Studies in 2009 questioned whether the decline in biota (including microfauna) as a result of human intervention might impede ... Inflammatory bowel disease consists of two different diseases: ulcerative colitis and Crohn's disease and both of these ...
  https://en.wikipedia.org/wiki/Human_microbiota
*  Ganciclovir - Wikipedia
It achieves a concentration in the central nervous system of about 50% of the plasma level. About 90% of plasma ganciclovir is ... Similar dosing is used to prevent disease in high-risk patients, such as those infected with human immunodeficiency virus (HIV ... It is first phosphorylated to ganciclovir monophosphate by a viral kinase encoded by the cytomegalovirus (CMV) gene UL97 during ... "Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis". The Cochrane Database ...
  https://en.wikipedia.org/wiki/Ganciclovir