*  Interleukin 5 - Wikipedia
... is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin ... Interleukin-5 is also expressed by eosinophils and has been observed in the mast cells of asthmatic airways by ... Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, ... Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a ...
  https://en.wikipedia.org/wiki/Interleukin_5
*  Interleukin-5 receptor - Wikipedia
The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and ... Takaki S, Kanazawa H, Shiiba M, Takatsu K (November 1994). "A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor ... Receptors, Interleukin-5 at the US National Library of Medicine Medical Subject Headings (MeSH). ... Takatsu K, Tominaga A (1991). "Interleukin 5 and its receptor". Prog. Growth Factor Res. 3 (2): 87-102. doi:10.1016/S0955-2235( ...
  https://en.wikipedia.org/wiki/Interleukin-5_receptor
*  Interleukin 5 receptor alpha subunit - Wikipedia
Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 ... Interleukin 5 receptor alpha subunit has been shown to interact with: Interleukin 5, Janus kinase 2, Protein unc-119 homolog, ... Scibek JJ, Evergren E, Zahn S, Canziani GA, Van Ryk D, Chaiken IM (2003). "Biosensor analysis of dynamics of interleukin 5 ... The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is ...
  https://en.wikipedia.org/wiki/Interleukin_5_receptor_alpha_subunit
*  Eosinophil - Wikipedia
High levels of interleukin-5 has been observed to up regulate the expression of adhesion molecules, which then facilitate the ... Yamaguchi Y, Suda T, Suda J, Eguchi M, Miura Y, Harada N, Tominaga A, Takatsu K (1988). "Purified interleukin 5 supports the ... Eosinophilia in mice models are shown to be associated with high interleukin-5 levels. Furthermore, mucosal bronchial biopsies ... access-date= requires ,url= (help) Sanderson, Colin (1992). "Interleukin-5, Eosinophils, and Disease". Blood. 79 (12): 3101- ...
  https://en.wikipedia.org/wiki/Eosinophil
*  Andrew N. J. McKenzie - Wikipedia
His identification of the cytokine Interleukin 13 and the subsequent unearthing of its central role in allergic asthma led to ... "Mutated interleukin-5 monomers are biologically inactive". Molecular Immunology. 28 (1-2): 155-158. doi:10.1016/0161-5890(91) ...
  https://en.wikipedia.org/wiki/Andrew_N._J._McKenzie
*  Eosinophilia - Wikipedia
Prakash Babu S, Chen YK, Bonne-Annee S, Yang J, Maric I, Myers TG, Nutman TB, Klion AD (2017). "Dysregulation of interleukin 5 ... interleukin 5, and histamine (though this has a narrow range of concentration). Harm resulting from untreated eosinophilia ... with some reports indicating that this may be mediated by interleukin production by tumor cells, especially IL-5 or IL-3. This ... Lymphoma cells have also been shown to produce IL-5 in these disorders. Other types of lymphoid malignancies have been ...
  https://en.wikipedia.org/wiki/Eosinophilia
*  Hypereosinophilia - Wikipedia
... interleukin 3, interleukin 5) that: a) cause bone marrow precursor cells, i.e. CFU-Eos, to proliferate and mature into ... interleukin 3, or interleukin 13. The disorder is usually indolent but infrequently progresses to T-cell lymphoma or Sezary ... interleukin 3, interleukin 5, and colony stimulating factor 2. However, no functional sequence genetic polylmophisms are found ... Prakash Babu S, Chen YK, Bonne-Annee S, Yang J, Maric I, Myers TG, Nutman TB, Klion AD (2017). "Dysregulation of interleukin 5 ...
  https://en.wikipedia.org/wiki/Hypereosinophilia
*  Reslizumab - Wikipedia
Reslizumab is an interleukin-5 antagonist monoclonal antibody. IL-5 is the major cytokine responsible for the growth and ... Reslizumab is a humanized monoclonal antibody against human interleukin-5(IL 5). Reslizumab binds specifically to IL 5, a key ... Reslizumab has a volume of distribution of approximately 5 L, clearance of approximately 7 mL/hour, and a half-life of about 24 ... Reslizumab binds to IL-5 with a dissociation constant of 81 pM and inhibiting IL-5 signaling, which reduces the production and ...
  https://en.wikipedia.org/wiki/Reslizumab
*  ETS2 - Wikipedia
Blumenthal SG, Aichele G, Wirth T, Czernilofsky AP, Nordheim A, Dittmer J (Apr 1999). "Regulation of the human interleukin-5 ... 89 (4): 1291-5. doi:10.1073/pnas.89.4.1291. PMC 48435 . PMID 1741383. Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC ( ... 5 (10): 1521-7. PMID 2250910. Watson DK, McWilliams MJ, Lapis P, Lautenberger JA, Schweinfest CW, Papas TS (Nov 1988). " ... doi:10.1016/0165-4608(86)90189-5. PMID 3021321. Fujiwara S, Fisher RJ, Seth A, Bhat NK, Showalter SD, Zweig M, Papas TS (Feb ...
  https://en.wikipedia.org/wiki/ETS2
*  SIGLEC8 - Wikipedia
Nutku-Bilir E, Hudson SA, Bochner BS (January 2008). "Interleukin-5 priming of human eosinophils alters siglec-8 mediated ... Ligation of Siglec-8 induces apoptosis in eosinophils, and, surprisingly, the normally pro-survival cytokines interleukin (IL)- ... "Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils". Laboratory Investigation; A Journal of ... IL-5 stimulation also appears to alter the mode of cell death of eosinophils induced by Siglec-8 ligation in that cell death ...
  https://en.wikipedia.org/wiki/SIGLEC8
*  Eosinophilic gastroenteritis - Wikipedia
Desreumaux P, Bloget F, Seguy D, Capron M, Cortot A, Colombel J, Janin A (1996). "Interleukin 3, granulocyte-macrophage colony- ... and interleukin 5 in eosinophilic gastroenteritis". Gastroenterology. 110 (3): 768-74. doi:10.1053/gast.1996.v110.pm8608886. ... 35 (6): 163-5. PMID 2077646. Jimenez-Saenz M, Villar-Rodriguez J, Torres Y, Carmona I, Salas-Herrero E, Gonzalez-Vilches J, ... 2 (5): 335-48. doi:10.1111/j.1365-2559.1978.tb01726.x. PMID 363591. Katz A, Goldman H, Grand R (1977). "Gastric mucosal biopsy ...
  https://en.wikipedia.org/wiki/Eosinophilic_gastroenteritis
*  Aeroallergen - Wikipedia
Desreumaux P, Bloget F, Seguy D, Capron M, Cortot A, Colombel J, Janin A (1996). "Interleukin 3, granulocyte-macrophage colony- ... and interleukin 5 in eosinophilic gastroenteritis". Gastroenterology. 110 (3): 768-74. doi:10.1053/gast.1996.v110.pm8608886. ... 35 (6): 163-5. PMID 2077646. Jimenez-Saenz M, Villar-Rodriguez J, Torres Y, Carmona I, Salas-Herrero E, Gonzalez-Vilches J, ... In EG cytokines IL-3, IL-5 and granulocyte macrophage colony stimulating factor (GM-CSF) may be behind the recruitment and ...
  https://en.wikipedia.org/wiki/Aeroallergen
*  Benralizumab - Wikipedia
It is directed against the alpha-chain of the interleukin-5 receptor (CD125). Two Phase 3 clinical trials of benralizumab, ...
  https://en.wikipedia.org/wiki/Benralizumab
*  Lymphocyte-variant hypereosinophilia - Wikipedia
Reslizumab, a newly developed antibody directed against interleukin 5 that has been successfully used to treat 4 patients with ... Schrezenmeier H, Thomé SD, Tewald F, Fleischer B, Raghavachar A (1993). "Interleukin-5 is the predominant eosinophilopoietin ... 5;9)(q31;p24) translocation creating gene fusion between the IL3 (at chromosome 5q31) and the JAK2 (at chromosome 9p24). The ... studies on the T cell receptor and IL-5 are not available and therefore not routine parts of the diagnostic work-up or criteria ...
  https://en.wikipedia.org/wiki/Lymphocyte-variant_hypereosinophilia
*  Granulocyte - Wikipedia
A polypeptide called interleukin-5 interacts with eosinophils and causes them to grow and differentiate; this polypeptide is ... 9 (5): 364-75. doi:10.1038/nri2532. PMID 19390567. Robinson p. 187 and Ernst pp. 7-10 Paoletti p. 62 Soehnlein, O.; Kenne, E.; ... doi:10.1016/S0065-2776(08)60351-X. ISBN 978-0-12-022439-5. Campbell p. 903 Akuthota, P.; Wang, H. B.; Spencer, L. A.; Weller, P ... Campbell, Neil A., Reece Jane B., Biology (6th edition), Pearson Education, Inc., 2002 ISBN 0-8053-6624-5. Delves, P.J., Martin ...
  https://en.wikipedia.org/wiki/Granulocyte
*  Mepolizumab - Wikipedia
It recognizes and blocks interleukin-5 (IL-5), a signalling protein of the immune system. Mepolizumab is approved by the U.S. ...
  https://en.wikipedia.org/wiki/Mepolizumab
*  CAG promoter - Wikipedia
"Expression vector system based on the chicken beta-actin promoter directs efficient production of interleukin-5". Gene. 79 (2 ... 1997 May 5;407(3):313-9. PMID 9175875 Alexopoulou AN, Couchman JR, and Whiteford JR. The CMV early enhancer/chicken beta actin ...
  https://en.wikipedia.org/wiki/CAG_promoter
*  Adaptive immune system - Wikipedia
Th2 also produce Interleukin 4, which facilitates B cell isotype switching. In general, Th2 responses are more effective ... The Th2 response is characterized by the release of Interleukin 5, which induces eosinophils in the clearance of parasites. ... 5 (9): 722-735. doi:10.1038/nri1686. PMID 16138104. Flajnik, MF; Kasahara, M (Jan 2010). "Origin and evolution of the adaptive ... 2 (5): e128. doi:10.1371/journal.pmed.0020128. PMC 1140945 . PMID 15916466. Schofield L, Grau GE (2005). "Immunological ...
  https://en.wikipedia.org/wiki/Adaptive_immune_system
*  GATA3 - Wikipedia
Siegel MD, Zhang DH, Ray P, Ray A (Oct 1995). "Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires ... Blumenthal SG, Aichele G, Wirth T, Czernilofsky AP, Nordheim A, Dittmer J (Apr 1999). "Regulation of the human interleukin-5 ... 127 (5): 1041-55. doi:10.1016/j.cell.2006.09.048. PMC 2646406 . PMID 17129787. Yagi R, Zhu J, Paul WE (Jul 2011). "An updated ... GATA-3 has been shown to promote the secretion of IL-4, IL-5, and IL-13 from Th2 cells, and induces the differentiation of Th0 ...
  https://en.wikipedia.org/wiki/GATA3
*  Eoxin - Wikipedia
... and interleukin 5. Furthermore, Eoxins stimulate vascular permeability in an ex vivo human vascular endothelial model system, ... Retrieved 5 January 2015. Since eosinophils are a rich source of these novel metabolites, we suggest the name eoxin instead of ... 87 (4-5): 159-63. doi:10.1016/j.plefa.2012.07.003. PMID 22921794. James A, Daham K, Backman L, Brunnström A, Tingvall T, Kumlin ... Thus, the names 14,1 5-leukotriene A4, C4, D4 and E4 are replaced with eoxin (Eox) A4, EoxC4, EoxD4 and EoxE4, respectively ( ...
  https://en.wikipedia.org/wiki/Eoxin
*  Syntenin-1 - Wikipedia
SDCBP has been shown to interact with: EFNB1, GRIK1, GRIK2, Interleukin 5 receptor alpha subunit, Merlin, RAB5A, SOX4, TRAF6, ... 18 (5): 541-58. doi:10.1101/gad.1151204. PMC 374236 . PMID 15014045. Chen F, Du Y, Zhang Z, Chen G, Zhang M, Shu HB, Zhai Z, ...
  https://en.wikipedia.org/wiki/Syntenin-1
*  Prostaglandin EP2 receptor - Wikipedia
Interleukin 4, and interleukin 13 from human blood mononuclear cells. EP2 receptor-deficient mice develop mild systolic and/or ... and reduces release of the pro-allergic cytokines Interleukin 5, ... responses including pro-inflammatory cytokine and interleukin ... 15 (5): 362-8. doi:10.1038/sj.ijir.3901042. PMID 14562138. Sugimoto Y, Nakato T, Kita A, Takahashi Y, Hatae N, Tabata H, Tanaka ...
  https://en.wikipedia.org/wiki/Prostaglandin_EP2_receptor
*  Helminthic therapy - Wikipedia
... interleukin 4, interleukin 5 and interleukin 10 of test subjects. These observations indicate that helminth therapy can provide ... Th2 immune responses result in the release of cytokines associated with inflammation reduction such as interleukin 4, ... June 2009). "Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to ... interleukin 5 and interleukin 10. These cytokines are thought to improve the symptoms of many autoimmune disorders. Conversely ...
  https://en.wikipedia.org/wiki/Helminthic_therapy
*  RFX2 - Wikipedia
1999). "Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Maijgren S, Sur I, Nilsson M, Toftgård R (2004). "Involvement of RFX proteins ... 71 (5): 1551-9. doi:10.1095/biolreprod.104.032268. PMID 15229132. Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a ... This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding ...
  https://en.wikipedia.org/wiki/RFX2
*  Familial eosinophilia - Wikipedia
The 5q31-q33 region contains a cytokine gene cluster that includes genes for Interleukin 3, interleukin 5, and granulocyte- ... A more recent study used a more sensitive assay for interleukin 5 to compare members of a single extended family with some ... Earlier studies found no evidence of abnormal blood levels of interleukin 5, interleukin 3, or granulocyte-macrophage colony ... A second family with asymptomatic eosinophilia over three generations likewise exhibited increased production of interleukin 5 ...
  https://en.wikipedia.org/wiki/Familial_eosinophilia