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*  Abhishek Tiwari:INTERACTOMICS - OpenWetWare
... the distortion of protein interfaces may lead to the development of many diseases. To understand the mechanisms of protein ... Modularity exists in a variety of biological contexts, including protein complexes, metabolic pathways, signaling pathways, and ... As valuable as they are, such experimental approaches studying protein interactomes have certain limitations that can be ... this review we describe different experimental techniques of protein interaction identification together with various databases ...
  https://openwetware.org/wiki/Abhishek_Tiwari:INTERACTOMICS
*  A convex optimization approach for identification of human tissue-specific interactomes
Yeger-Lotem E., Sharan R. (2015) Human protein interaction networks across tissues and diseases. Front. Genet., 6, 1-5. [PMC ... Tissue-specific interactome predicts context-sensitive interactions in known functional pathways. To evaluate the power of ... which consolidates protein interactions from different databases. Edges in this dataset are weighted using an MI (MINT-Inspired ... Perturbations that impact interacting interfaces of proteins are significantly enriched among tissue-specific, disease-causing ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4908329/
*  The rise of translational bioinformatics | Genome Biology | Full Text
... are enriched at the interfaces of disease-associated protein interactions. Conclusively, the observed protein interactions were ... In related work, Lun Yang (GlaxoSmithkline, USA) conducted a comparative study between the chemical-protein interactome ( ... Biomarkerscomplex diseasescomputational medicinedrug repositioningmechanism classifiersnext-generation sequencingoff-target ... Experiments on simulated databases derived from different sources demonstrated the sensitivity of this method. Similarly, ...
  https://genomebiology.biomedcentral.com/articles/10.1186/gb-2012-13-8-319
*  Protein-protein interaction - Wikipedia
... collected together in specialized biological databases that are continuously updated in order to provide complete interactomes ... Janin J (December 1999). "Wet and dry interfaces: the role of solvent in protein-protein and protein-DNA recognition". ... The recruitment of signaling pathways through PPIs is called signal transduction and plays a fundamental role in many ... biological processes and in many diseases including Parkinson's disease and cancer. A protein may be carrying another protein ( ...
  https://en.wikipedia.org/wiki/Protein%E2%80%93protein_interaction
*  Biochemistry with a Sandwich Year - BSc (Hons) - Canterbury - The University of Kent
Protein Bioinformatics Methods: Protein structure and function prediction. Prediction of binding sites/interfaces with small ... Intracellular signalling pathways: activation of monomeric G-protein Ras, leading to activation of the mitogen activated ... therapeutic approaches to treating these diseases, and the cellular/molecular mode of action of drugs used. Indicative diseases ... Bioinformatics Data sources & Sequence analysis: Databases and data availability. Using sequence data for analysis - sequence ...
  https://www.kent.ac.uk/courses/undergraduate/100/biochemistry-with-a-sandwich-year
*  Biology - BSc (Hons) - Canterbury - The University of Kent
B. Protein Bioinformatics Methods Protein structure and function prediction. Prediction of binding sites/interfaces with small ... Intracellular signalling pathways: activation of monomeric G-protein Ras, leading to activation of the mitogen activated ... Autoimmune disease - Organ-specific autoimmune diseases; systemic autoimmune diseases; induction of autoimmunity; treatment of ... Databases and data availability. Using sequence data for analysis sequence searching methods, multiple sequence alignments, ...
  https://www.kent.ac.uk/courses/undergraduate/255/biology
*  Host-pathogen interaction data | Pathway analysis - OMICtools
Therefore, resources that annotate, predict and display the HPI that underpin infectious diseases are critical for developing ... However, HPI data are sparse in existing molecular interaction databases, especially for agricultural host-pathogen systems. ... partners of a query protein can be easily retrieved by users as well as the interaction networks in graphical web interfaces. ... These interactomes can also be accessed here and links to other interactome sites are also provided. ...
  https://omictools.com/host-pathogen-interactions-category
*  Bioinformatics - Wikipedia
Main articles: Protein-protein interaction prediction and interactome. Tens of thousands of three-dimensional protein ... Other databases: Protein Data Bank, Ensembl and InterPro. *Specialised genomic databases: BOLD, Saccharomyces Genome Database, ... At a more integrative level, it helps analyze and catalogue the biological pathways and networks that are an important part of ... With the advent of next-generation sequencing we are obtaining enough sequence data to map the genes of complex diseases ...
  https://en.wikipedia.org/wiki/Bioinformatician
*  Protocols and Video Articles Authored by Ming Chen
Computational Identification of Protein-protein Interactions in Rice Based on the Predicted Rice Interactome Network Genomics, ... Approximately 80% of the UniGenes (32,805) were annotated against public protein databases, and coding sequences (CDS) of ... and circadian rhythm signaling pathways as examples to demonstrate that functional protein complexes and biological pathways ... In this context we discuss: 1) why and how senile conditions including SD differ from discrete diseases by origin, thus also by ...
  https://www.jove.com/author/Ming_Chen
*  Books - Lane Medical Library - Stanford University School of Medicine
Analysis of protein-protein interactions using LUMIER assays / Sonja Blasche and Manfred Koegl -- Detection of protein ... In addition, the full range of small bowel diseases, from the common to the rare, are described and illustrated using a unique ... Continuously expanding, all databases in the repository contain the latest editions of selected medical titles. ... Two dimensional electron systems (2DESs) at semiconductor interfaces are a useful medium for studying complex physics due to ...
  http://lane.stanford.edu/biomed-resources/eb.html?a=v&page=2&proxy-links=true
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome plays an important role in a variety of diseases. ... Based on this strategy, we performed VS on NCI and SPECS databases and successfully discovered 6 novel compounds from 15 hits ... The E3 ligase involved in interactome provide new hope for the discovery of the E3 ligase inhibitors. These currently known ... has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion and ...
  https://www.jove.com/visualize?author=Jin+Xiao
*  Gene Report for G00001444 - Genes2Cognition Neuroscience Research Programme
Systematic mapping of protein-protein interactions, or 'interactome' mapping, was initiated in model organisms, starting with ... Diseases (4). *Literature (60). *Gene lists (8). Databases (8). Curated Gene. OTTHUMG00000071611 (Vega human gene). Gene. ... The serine-threonine protein phosphatase 2A (PP2A) is a heterotrimeric enzyme family that regulates numerous signaling pathways ... Left-handed rotations at three interrepeat interfaces generate a novel left-hand superhelical conformation. The protein ...
  http://www.genes2cognition.org/db/Gene/G00001444
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Interactome networks, especially protein-protein interaction networks, had been used to disease genes identification based on ... parameters at a microscopic level in the retina furthers the understanding of the molecular pathways of blinding diseases, such ... Exploring the ligand-protein networks in traditional chinese medicine: current databases, methods, and applications. ... mutations at the interhelical interfaces at the N-terminal half of the channel (L26F); and mutations outside the drug-binding ...
  https://www.jove.com/visualize?author=Qing+Wei
*  Search | re3data.org
APID Interactomes is a database that provides a comprehensive collection of protein interactomes for more than 400 organisms ... TOXNET (TOXicology Data NETwork) is a group of databases covering chemicals and drugs, diseases and the environment, ... structures have been analyzed to find specific protein-protein interactions reported with details of their molecular interfaces ... analyze and graphically display molecular interaction networks and pathways from a wide variety of species. MINT is comprised ...
  https://www.re3data.org/search?query=&subjects%5B%5D=20103%20Cell%20Biology&contentTypes%5B%5D=Structured%20text&sort=name
*  Publications - Helmholtz-Centre for Environmental Research
Proteome data improves protein function prediction in the interactome of Helicobacter pylori. Mol. Cell. Proteomics 17 (5), 961 ... Mapping protein interfaces by a trifunctional cross-linker combined with MALDI-TOF and ESI-FTICR mass spectrometry. J. Am. Soc ... Cell cycle, oncogenic and tumor suppressor pathways regulate numerous long and macro non-protein coding RNAs. Genome Biol. 15 ( ... Web-accessible proteome databases for microbial research. Proteomics 4 (5), 1305 - 1313. full text (url) ...
  https://www.ufz.de/index.php?en=39947
*  A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network | BMC Systems...
External protein interaction databases. The most comprehensive and publicly available protein-protein interaction database, ... A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A. 2001, 98 (8): 4569-4574 ... As an extra level of complexity, NRs can form non-DNA-binding dimers using different interfaces. In these interactions, an NR ... combines different signalling pathways on the same promoter, and creates competition for common heterodimeric partners. ...
  https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-1-34
*  FinchTalk: 2011
... or Organelle Databases look highly specific whereas others such as Plant Databases, or Protein Sequence Databases are general. ... The components participate in multiple pathways and pathways interact with other pathways to form higher-ordered networks, and ... However, the interactome is complex; studying it requires that interactions can be identified at high scale.. Many interactome ... View the product sheet to see the interfaces and other features.. GSAE - The new release continues to advance GSAE's data ...
  http://finchtalk.blogspot.com/2011/
*  Functional repertoire, molecular pathways and diseases associated with 3D domain swapping in the human proteome | Journal of...
... where structural segments in a protein dimer or higher oligomer were shared between two or more chains of a protein structure, ... Five classes of human diseases: cancer, diseases of the respiratory or pulmonary system, degenerative diseases of the central ... We report the first study with a focus on identifying functional classes, pathways and diseases mediated by 3D domain swapping ... Protein domain enrichment analysis followed by Gene Ontology (GO) term enrichment analysis revealed the functional repertoire ...
  https://jclinbioinformatics.biomedcentral.com/articles/10.1186/2043-9113-2-8
*  UW Genome Sciences: past GS Seminars
Our goals are to: i) generate protein-protein interaction, or 'interactome', maps for C. elegans networks involved in ... "Interactome Networks" website Abstract:. Despite the considerable success of molecular biology to understand diseases such as ... "Evolution of Protein Kinase Pathways". October 28 - Dr. Victoria Prince. Department of Organismal Biology and Anatomy. ... Designing and Mining Pathogen Genome Databases' website. Wed, November 6 - Dr. Anthony Blau, Medicine & Hematology, UW ' ...
  http://www.gs.washington.edu/news/pastseminars.htm
*  Laboratory of Functional and Structural Genomics
INTERACTOME: the prediction of protein-protein interactions in a cell in Cellular & Molecular Biology Letters ... Protein-protein interaction and pathway databases, a graphical review in Briefings in Bioinformatics ... Abstract: The physico-chemical properties of interaction interfaces have a crucial role in characterization of protein-protein ... Abstract: Structural variants are implicated in numerous diseases and make up the majority of varying nucleotides among human ...
  http://nucleus3d.cent.uw.edu.pl/papers
*  Qiu R[au] - PubMed - NCBI
Regulatory T Cell Plasticity and Stability and Autoimmune Diseases.. Qiu R, Zhou L, Ma Y, Zhou L, Liang T, Shi L, Long J, Yuan ... Investigation on modulation of DNA repair pathways in Chinese MJD patients.. Wang C, Chen Z, Peng H, Peng Y, Zhou X, Yang H, ... The actin capping protein in Aspergillus nidulans enhances dynein function without significantly affecting Arp1 filament ... ACS Appl Mater Interfaces. 2018 Nov 23. doi: 10.1021/acsami.8b16346. [Epub ahead of print] ...
  https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Qiu+R%5Bau%5D&dispmax=50
*  Gene Report for G00001423 - Genes2Cognition Neuroscience Research Programme
Systematic mapping of protein-protein interactions, or 'interactome' mapping, was initiated in model organisms, starting with ... protein kinase, cAMP-dependent, regulatory, type II, alpha. Orthologue. G00000174 (Mus musculus). *Databases (8) ... The intracellular signal transduction pathways utilized by the HIV-1-derived protein, Tat, in the activation of human central ... Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA. ssitar2@emory.edu ...
  http://www.genes2cognition.org/db/Gene/G00001423
*  Search | re3data.org
Moreover, interactome maps are particularly needed to link new proteins to disease pathways and the identification of novel ... Therefore, the systematic analysis of protein-protein interactions is fundamental for the understanding of protein function, ... In a first step ageing-related data are primarily taken from existing databases. In addition, new ageing-related information is ... The RAMEDIS system is a platform independent, web-based information system for rare metabolic diseases based on filed case ...
  https://www.re3data.org/search?query=&subjects%5B%5D=21%20Biology&subjects%5B%5D=22%20Medicine
*  Search | re3data.org
... improved coverage of the innate immunity interactome by integrating known interactions and pathways from major public databases ... emerging infectious diseases. ViPR integrates data from external sources (GenBank, UniProt, Immune Epitope Database, Protein ... interfaces for accessing and comparing genome-scale data from species of scientific interest from across the taxonomy. In each ... Three main databases comprise Structure-The Molecular Modeling Database; Conserved Domains and Protein Classification; and the ...
  https://www.re3data.org/search?query=&subjects%5B%5D=201%20Basic%20Biological%20and%20Medical%20Research&keywords%5B%5D=genes
*  Download The Bro Code
Inhibitor especially in the Master Mix offers against bad protein from the addition of heads taken over in the DNA databases ... Sirius was to one download the bro the blood of certain pathways. I were this; and I turned furiously the download the of Mars ... 34; No fax what is updating to you, if you can quantify a matter around it and cellular diseases than you can choose. De ... Our extensive Conference Proceedings and Thesis editor stand on individual interfaces. Oldenburg, 2017, present-day download ...
  http://pbcdha.com/ebook/download-the-bro-code.html