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*  CXCL1/CEN4q FISH Probe - (FG0043) - Products - Abnova
... and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or ... Chemokine signaling pathway. *Cytokine-cytokine receptor interaction. *Epithelial cell signaling in Helicobacter pylori ... Human breast cancer (FFPE) stained with CXCL1/CEN4q FISH Probe. Human breast cancer showed no CXCL1 gene amplification ... chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=FG0043
*  Protocols and Video Articles Authored by Lixin Liu
We conclude that the exogenous SDF-1alpha enhances leukocyte-endothelial cell interactions and induces modest and endothelial P ... in response to CXC chemokine MIP-2 (CXCL2) or KC (CXCL1). However, leukocyte emigration was severely impaired in PI3Kgamma ... Impaired Angiogenesis and Mobilization of Circulating Angiogenic Cells in HIF-1alpha Heterozygous-null Mice After Burn Wounding ... A Down-regulatable E-selectin Ligand is Functionally Important for PSGL-1-independent Leukocyte-endothelial Cell Interactions ...
  https://www.jove.com/author/Lixin_Liu
*  Cellular Kinetics of Perivascular MSC Precursors
H. Gerhardt and C. Betsholtz, "Endothelial-pericyte interactions in angiogenesis," Cell and Tissue Research, vol. 314, no. 1, ... CSC-chemokine ligand-1 (CXCL1) and -8 (CXCL8), macrophage migration inhibitory factor (MIF), CC-chemokine ligand 2 (CCL2), and ... EC Interactions Regulate Pericyte Recruitment and Angiogenesis. The formation of new capillaries during angiogenesis requires a ... A. Armulik, A. Abramsson, and C. Betsholtz, "Endothelial/pericyte interactions," Circulation Research, vol. 97, no. 6, pp. 512- ...
  https://www.hindawi.com/journals/sci/2013/983059/
*  Bcl-2 Orchestrates a Cross-talk between Endothelial and Tumor Cells that Promotes Tumor Growth | Cancer Research
Cancer CXC chemokine networks and tumour angiogenesis. Eur J Cancer 2006; 42: 768-78. ... 5C, a-c). These data show that the cross-talk initiated by endothelial cells that results in up-regulated Bcl-2, CXCL1, and ... They show that interactions between endothelial cells and tumor cells are mutually relevant, and that factors secreted by ... Role of endothelial cell survival and death signals in angiogenesis. Angiogenesis 1999; 3: 101-16. ...
  http://cancerres.aacrjournals.org/content/67/20/9685
*  006848 - B6.129S2(C)-Cxcr2|tm1Mwm|/J
... impaired angiogenesis, altered growth of induced/implanted tumors, splenomegaly, lymphadenopathy, and increased susceptibility ... CXC chemokine receptor 2 but not C-C chemokine receptor 1 expression is essential for neutrophil recruitment to the cornea in ... CXCL1/KC and CXCL2/MIP-2 are critical effectors and potential targets for therapy of Escherichia coli O157:H7-associated renal ... Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung. J Clin Invest 116(3):695-702. PubMed: ...
  https://www.jax.org/strain/006848
*  Tissue Factor and PAR2 Signaling in the Tumor Microenvironment | Arteriosclerosis, Thrombosis, and Vascular Biology
... focused on the TF-VIIa-induced ELR CXC-type chemokine CXCL1 that binds CXCR256 and has proangiogenic activities on endothelial ... Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor. Proc ... Blocking the TF substrate interaction and coagulation with a selective antibody decreased spontaneous metastasis of these ... TF-VIIa-PAR2 signaling was the major stimulus for upregulation of the immune and angiogenesis regulators CXCL1, IL8, GM-CSF, ...
  http://atvb.ahajournals.org/content/29/12/1999
*  JCI - Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone
Intriguingly, ELISA analysis showed reduced levels of CXCL1 in CXCL5-/- vossicles versus WT. Although CXCL1, a cytokine that ... This interaction between tumor and bone is critical, especially at the early stages of tumor growth. The importance of bone in ... Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell ... CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity. 2010;33(1):106-117.. View ...
  https://www.jci.org/articles/view/92466
*  Identification of Secreted Proteins that Mediate Cell-Cell Interactions in an In vitro Model of the Lung Cancer...
Role of CXCL1 and IL-18. CXCL1 was the most abundant chemokine detected in the cocultures ( Table 1). CXCL1 RNA levels ... Tissue-specific microvascular endothelial cell lines from H-2K(b)-tsA58 mice for studies of angiogenesis and metastasis. Cancer ... Cancer CXC chemokine networks and tumour angiogenesis. Eur J Cancer 2006; 42: 768-78. ... Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular ...
  http://cancerres.aacrjournals.org/content/68/17/7237
*  US20110081408A1 - Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms - Google...
... are over-expressed in the tumor using methods of the invention and administer antibodies against that over-expressed chemokine ... The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti-chemokine ... The angiogenesis was inhibited by antibodies against CXCR1, CXCR2, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6 CXCL7, CXCL8, CXCR4, ... Modulating the interaction of the chemokine, B Lymphocyte Hemoattractant, and its Receptor, BLR1 ...
  https://patents.google.com/patent/US20110081408A1/en
*  Role of Chemokine Network in the Development and Progression of Ovarian Cancer: A Potential Novel Pharmacological Target
Cancer cells recruit endothelial cells through the activity of several chemokines, cytokines, and growth factors. Angiogenesis ... CXCL8/IL-8 and CXCL1-3/GRO. , and and CXCL5/ENA-78 induce angiogenesis through the activation of direct mechanisms on ... including endothelial cells, T and B cells, dendritic cells, chondrocytes, endometrial stromal cells. The interaction of CXCL12 ... A. Ottaiano, R. Franco, A. A. Talamanca et al., "Overexpression of both CXC chemokine receptor 4 and vascular endothelial ...
  https://www.hindawi.com/journals/jo/2010/426956/
*  Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma
... a potent inhibitor of angiogenesis and endothelial cell migration [68, 69]. OSCC primary tumors that do not metastasize have ... K. Pietras and A. Östman, "Hallmarks of cancer: interactions with the tumor stroma," Experimental Cell Research, vol. 316, no. ... Processing of proinflammatory chemokines (CXCL1, -4, -8, -9, -11, -12), proforms of cytokines (proTNF-α, proIL-1β), cell ... Therefore, CXCL8-induced expression of MMP-9 may be cell-type specific [96-98]. The chemokine receptor, CXCR4, modulates the ...
  https://www.hindawi.com/journals/tswj/2013/920595/
*  Plus it
Chemokines can affect angiogenesis via binding to chemokine receptors expressed on endothelial cells, leading to increased ... Role of chemokines in angiogenesis: CXCL12/SDF‐1 and CXCR4 interaction, a key regulator of endothelial cell responses. ... The chemokine CXCL1 induces proliferation in epithelial ovarian cancer cells by transactivation of the epidermal growth factor ... CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. Immunity 2012;37: ...
  http://cancerimmunolres.aacrjournals.org/content/2/12/1125
*  Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) (CXCL1) Antikörper
293 verschiedene CXCL1 Antikörper vergleichen. Alle direkt auf antikörper-online bestellbar! ... GAG interactions and receptor activity of CXCL1 monomers and dimers are fine-tuned to regulate neutrophil trafficking for ... is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1 ... CXCL1/8 secreted by adipose-derived mesenchymal stem cells could promote breast cancer angiogenesis. ...
  https://www.antikoerper-online.de/autophagie-pathway-94/cxcl1-antibody-227/
*  Protocols and Video Articles Authored by Elisa A. Liehn (Translated to Danish)
Importance of CXC Chemokine Receptor 2 in the Homing of Human Peripheral Blood Endothelial Progenitor Cells to Sites of ... The modulation of the CCL2/CCR2, CCL5/CCR1-CCR5, CXCL12/CXCR4 pathways by preventing receptor--ligand interaction, chemokine- ... By supporting the adhesion and proliferation of endothelial progenitor cells, RGD/CXCL1 coating of stents may help to ... Differential Roles of Angiogenic Chemokines in Endothelial Progenitor Cell-induced Angiogenesis Basic Research in Cardiology. ...
  https://www.jove.com/author/Elisa+A._Liehn?language=Danish
*  IJMS | Free Full-Text | Advances in Proteomic Techniques for Cytokine Analysis: Focus on Melanoma Research | HTML
CXCL1. chemokine (C-X-C motif) ligand 1 (GROα). DDA. data dependent acquisition. ... it possesses additional functions in angiogenesis and matrix-metalloproteinase activation. Angiogenesis and metastases of ... vascular endothelial growth factor A. References. *Ferlay, J.; Steliarova-Foucher, E.; Lortet-Tieulent, J.; Rosso, S.; Coebergh ... Not only cellular interactions with extracellular matrix but also enzymes (e.g., matrix remodelling proteases), secreted ...
  https://www.mdpi.com/1422-0067/18/12/2697/htm
*  Pleiotropic effects of cancer cells' secreted factors on human stromal (mesenchymal) stem cells | Stem Cell Research & Therapy ...
The biological interaction between stromal (mesenchymal) stem cells (MSCs) and cancer cells remains incompletely understood. ... we observed no evidence of differentiation of MSCs into pericytes or endothelial-like cells using an in vitro angiogenesis ... CXCL1: Chemokine (C-X-C motif) ligand 1. CXCL2: Chemokine (C-X-C motif) ligand 2 ... The biological interaction between stromal (mesenchymal) stem cells (MSCs) and cancer cells remains incompletely understood. ...
  https://stemcellres.biomedcentral.com/articles/10.1186/scrt325
*  CXCR2 in Acute Lung Injury
"Blockade of the chemokine receptor CXCR2 inhibits pancreatic cancer cell-induced angiogenesis," Cancer Letters, vol. 241, no. 2 ... The murine CXCL1 and CXCL2/3, functional homologues of human growth-related oncogenes (GROα, -β, and -γ), and CXCL 8, have been ... J. Reutershan, M. A. Morris, T. L. Burcin et al., "Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into ... There are further investigations on this receptor necessary about its functions and interactions in relation to other receptors ...
  https://www.hindawi.com/journals/mi/2012/740987/
*  Plus it
... the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis. ... of hepatocyte growth factor and vascular endothelial growth factor during uveal melanoma-monocyte in vitro interactions. ... Expression and migratory analysis of 5 human uveal melanoma cell lines for CXCL12, CXCL8, CXCL1, and HGF. J Carcinog 2007;6:2. ... CXC chemokine receptor 4 is expressed in uveal malignant melanoma and correlates with the epithelioid-mixed cell type. Cancer ...
  http://clincancerres.aacrjournals.org/content/14/4/951
*  Molecular Prognostic Factors in Gastric Cancer | IntechOpen
Chemokine (C-X-C motif) ligand (CXCL1) seems to play a major role in tumor metastasis; it has been previously reported that its ... Angiogenesis is an essential event in tumor growth and spread. VEGF has demonstrated a major role in tumor angiogenesis, growth ... cytokine-cytokine receptor interaction, and ECM receptor interaction, the plasminogen activation cascade, as well as signaling ... Vascular endothelial growth factor, hypoxia-inducible factor 1 alpha and CD34 expressions in early-stage gastric tumors: ...
  https://www.intechopen.com/books/gastric-cancer/molecular-prognostic-factors-in-gastric-cancer/
*  A Dietary Tomato Supplement Prevents Prostate Cancer in TRAMP Mice | Cancer Prevention Research
Interaction of tomato lycopene and ketosamine against rat prostate tumorigenesis. Cancer Res 2008;68:4384-91. ... Angiogenesis and prostate cancer: identification of a molecular progression switch. Cancer Res 2001;61:2736-43. ... Role of vascular endothelial growth factor in prostate cancer. Urology 2006;68:244-8. ... Although less impressive in terms of magnitude, a significantly lower concentration of the angiostatic IP-10 chemokine was ...
  http://cancerpreventionresearch.aacrjournals.org/content/3/10/1284.full
*  Cell Transplantation 22(12) Abstracts
Angiogenesis and inflammation were observed at these sites via an optical imaging probe. Injected GFP+ BMCs migrated from the ... To that end, interactions between adipose tissue-derived stromal cells (ASCs) and bone marrow cells (BMCs) were initially ... However, when anti-CXC chemokine receptor type 4 antibody was injected at regular intervals, the migration of GFP+ BMCs ( ... the pericyte/endothelial cell marker CD146, and the mesenchymal stem cell markers CD73, CD90, CD105, and CD44 but did not ...
  https://www.cognizantcommunication.com/component/content/article/700
*  Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex | The Journal of Immunology
... regulates angiogenesis and endothelial cell cytokine production. J. Immunol. 167: 4137-4140. ... and culture supernatants were assayed for the presence of CXCL1 by ELISA. The medium control CXCL1 levels are indicated with a ... Ligand-independent chemokine expression is not observed in fibroblasts overexpressing either IL-17RA or IL-17RC alone (Fig. 2⇑a ... It is plausible that ligand binding alters the conformation of IL-17RA to favor a productive, heterotypic interaction with IL- ...
  http://www.jimmunol.org/content/177/1/36
*  The role of the EP receptors for prostaglandin E2 in skin and skin cancer
The interaction of the EP1, EP2 and EP4 receptors with EGFR raises some interesting questions and options, and is very ... The effect of EP2 deletion on TPA-induced inflammation and angiogenesis were also assessed. There was a significant reduction ... Additionally, in cultured keratinocytes, the EP3 agonist suppressed CXCL1 expression and production induced by TNFα, indicating ... porcine brain endothelial cells, and rat liver [68], suggesting the ubiquitous nature of this localization. In chronically UV- ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3236828/?lang=en-ca
*  Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer | Cancer Research
Evidence for the interaction of fibroblast growth factor-2 with the lymphatic endothelial cell marker LYVE-1. Blood 2013;121: ... Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. ... B, RT-PCR analyses of CXCL4, CXCL4L1, CXCL1, and CXCL5 mRNA from BxPC3 cells treated with 5′-Aza and/or TSA (left). RT-PCR ... CXCL4L1 inhibited endothelial cell but not BXPC3 cell proliferation (Fig. 5A and B, left; ref. 3). Invasion of endothelial ...
  http://cancerres.aacrjournals.org/content/76/22/6507
*  Chemokines in Atherosclerosis | Arteriosclerosis, Thrombosis, and Vascular Biology
CXCL1/KC (keratinocyte-derived chemokine), or its human ortholog GRO (growth-regulated oncogene)-α.53 Both arterial CXCL1 and ... Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. ... The biological relevance of chemokine-proteoglycan interactions. Biochem Soc Trans. 2006; 34: 422-426. ... Liehn EA, Schober A, Weber C. Blockade of keratinocyte-derived chemokine inhibits endothelial recovery and enhances plaque ...
  http://atvb.ahajournals.org/content/28/11/1897.long