*  Mitochondrial Dysregulation in the Pathogenesis of Diabetes: Potential for Mitochondrial Biogenesis-Mediated Interventions
... lower whole-body energy requirements and have decreased rates of oxygen consumption resulting in higher metabolic efficiency ... J. P. Silva, M. Köhler, C. Graff et al., "Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with ... The multiplicity of mitochondrial functions has made it a logical target for the study of metabolic diseases, and, given that ... and their responses are attenuated when compared to healthy subjects suggesting that a higher intensity and/or duration of ...
  https://www.hindawi.com/journals/jdr/2012/642038/
*  Intake of Lactobacillus reuteri Improves Incretin and Insulin Secretion in Glucose-Tolerant Humans: A Proof of Concept |...
The slightly increased incretin and insulin concentrations are within the physiological range of metabolic responses, which ... For determination of in vivo whole-body energy expenditure and substrate oxidation from measuring oxygen consumption and carbon ... Tissue-Specific Insulin Sensitivity and Substrate Oxidation. Whole-body insulin sensitivity was not affected by intervention. ... GLP-2 primarily targets intestinal mucosa promoting growth and intestinal integrity (8). Both GLP-1 and GLP-2 are processed ...
  http://care.diabetesjournals.org/content/38/10/1827
*  Protocols and Video Articles Authored by Stephan M. Jakob
... for improving the outcome for such patients include approaches that both increase tissue oxygen delivery and reduce metabolic ... Targeted Tissue Perfusion Versus Macrocirculation-guided Standard Care in Patients with Septic Shock (TARTARE-2S): Study ... 76 (22) mL x min(-1) x m(-2) (not significant)]. The reduction of splanchnic oxygen consumption by dopamine in sepsis suggests ... Since electroencephalogram (EEG) responses to different sedation regimens vary, we assessed electrophysiologic responses to two ...
  https://www.jove.com/author/Stephan++M._Jakob
*  AMPK activation-protean potential for boosting healthspan | SpringerLink
Ostman E, Granfeldt Y, Persson L, Bjorck I (2005) Vinegar supplementation lowers glucose and insulin responses and increases ... McCarty MF (2001b) Does regular ethanol consumption promote insulin sensitivity and leanness by stimulating AMP-activated ... Effects of simvastatin and metformin on inflammation and insulin resistance in individuals with mild metabolic syndrome. Am J ... Evidence for a central role of adipose tissue. Diabetes Care 20(12):1863-1869PubMedGoogle Scholar ...
  https://link.springer.com/article/10.1007%2Fs11357-013-9595-y
*  Frontiers | Dietary fat overload reprograms brown fat mitochondria | Physiology
Interestingly, the metabolic responses triggered by HFD were accompanied by changes in mitochondrial dynamics characterized by ... offspring pups exposed to HFD during pregnancy and lactation displayed reduced mitochondrial mass but high oxidative efficiency ... Interestingly, the metabolic responses triggered by HFD were accompanied by changes in mitochondrial dynamics characterized by ... Herein, we investigated the mitochondrial responses in BAT of female mice exposed to high fat diet (HFD) at different steps of ...
  https://www.frontiersin.org/articles/10.3389/fphys.2015.00272/full
*  Protocols and Video Articles Authored by Yu-Ju Chen
The target organs/tissues/cells include kidney, brain, gastrointestinal tissues, blood/immune cells, and stem cells. In the ... Mdivi-1 also prevented PE-induced hypertrophic growth and oxygen consumption in rat neonatal cardiomyocytes. We reveal the ... The findings in this study may also shed light on the development of new therapeutic targets for metabolic bone diseases such ... Nitric Oxide Physiological Responses and Delivery Mechanisms Probed by Water-soluble Roussin's Red Ester and {Fe(NO)2}10 DNIC ...
  https://www.jove.com/author/Yu-Ju_Chen
*  Fight Aging! Newsletter, June 6th 2011 - Fight Aging!
errant immune responses which mistakenly target the body's own proteins rather than foreign invaders can now be examined in ... Physical exercise improves the efficiency of the capillary system and increases the oxygen supply to the brain, thus enhancing ... may converge by causing an activation of mitochondrial oxygen consumption to promote increased formation of reactive oxygen ... metabolic activity and oxygen intake in neurons, and increases neurotrophin levels and resistance to stress. Regular exercise ...
  https://www.fightaging.org/archives/2011/06/fight-aging-newsletter-june-6th-2011/
*  Cancer as a metabolic disease | Nutrition & Metabolism | Full Text
Ramanathan and co-workers showed that oxygen consumption was greater, but oxygen dependent (aerobic) ATP synthesis was less in ... energy is a simple way to target energy metabolism in glycolysis-dependent tumor cells while enhancing the metabolic efficiency ... damages tissue morphogenetic fields that eventually produce neoplastic cells [123, 124, 166]. Part of this tissue damage will ... Sato K, Kashiwaya Y, Keon CA, Tsuchiya N, King MT, Radda GK, Chance B, Clarke K, Veech RL: Insulin, ketone bodies, and ...
  https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-7-7
*  Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophilareveals a species-general network of aging and...
The data suggest that MnSOD up-regulation and a retrograde signal of reactive oxygen species from the mitochondria normally ... that the pattern of gene expression caused by MnSOD was similar to that observed in long-lived Caenorhabditis elegans insulin- ... implicate a species-conserved net of coordinated genes that affect the rate of senescence by modulating energetic efficiency, ... function as an intermediate step in the extension of lifespan caused by reduced insulin-like signaling in various species. The ...
  https://genomebiology.biomedcentral.com/articles/10.1186/gb-2007-8-12-r262
*  Mechanisms of cell survival in hypoxia and hypothermia | Journal of Experimental Biology
... since metabolic pathways are often not only specific to particular tissues but may express unique Q10 responses to forced ... Jodie Rummer applied for a Travelling Fellowship from JEB to gather data on oxygen consumption rates of coral reef fishes at ... While there are many other possible systemic co-mediators of metabolic rate (e.g. cortisosteroids, insulin, glucagon, thyroid ... Less is known about the metabolic efficiency of the processes that make up SMR in vertebrates. These involve stoichiometric ...
  http://jeb.biologists.org/content/204/18/3171
*  Synthroid generic (Thyroxine) 200 mcg, 125 mcg, 100 mcg, 75 mcg, 50 mcg, 25 mcg. Trusted Synthroid.
The balance between oxygen demand and consumption is reÀected by the arterial lactate level: when oxygen demand exceeds con- ... The wound margins and the tissues within the base of the wound are usually blackened by smoke and may show signs of burning ... Modified live vaccines may be viru- immunologic responses and protect the host from the lent in animals that are ... Once absorbed, calcium is carried by duodenum, with efficiency of adsorption being de- the plasma as ionized calcium, protein- ...
  http://kiwiandanemu.org/wp-content/vol/block39/view4/
*  The Chin-Sang Lab reads | The Chin-Sang Lab
α-KG inhibits ATP synthase and, and leads to reduced ATP content, decreased oxygen consumption, and increased autophagy in both ... Some of the physiological phenotypes previously attributed to peripheral AAK-2 activity on metabolic targets may instead be due ... Grizzly bears prepare for hibernation by increased insulin sensitivity via down regulation of PTEN in fat tissue. ... Jordan Ward has provided new improvements for better efficiency of CRISPR Cas9 HDR. 1) Use a better sgRNA (sgRNA F+E) 2) Use ...
  http://post.queensu.ca/~chinsang/the-chin-sang-lab-reads/blog/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Insulin release by the pancreas induces glucose uptake by insulin-sensitive tissues, most notably the brain, skeletal muscle, ... In addition this model reproduces the physiological and metabolic responses of the liver sufficiently accurately to obviate the ... One factor contributing to this multifactorial disorder is the consumption of a high fat diet, a behavior that has been shown ... High Efficiency Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes and Characterization by Flow Cytometry ...
  https://www.jove.com/visualize/abstract/22649556/topiramate-induced-modulation-hepatic-molecular-mechanisms-an-aspect
*  Staff Profile - Faculty of Medical Sciences - Newcastle University
Rapid detection of hypoxic islet stress by oxygen consumption rate using a standardised beta cell model. In: Diabetes UK ... Towards muscle-targeted gene therapy for diabetes: Tetracycline-repressible transcriptional regulation of (pro)insulin ... Comparison of appetite responses to high- and low-glycemic index postexercise meals under matched insulinemia and fiber in type ... Contaminating exocrine tissue as a source of MCP-1 in islet transplantation. In: Diabetes UK Professional Conference. 2015, ...
  http://www.ncl.ac.uk/medicalsciences/research/groups/profile/jimshaw.html
*  Veterinary Sciences | Free Full-Text | Cats and Carbohydrates: The Carnivore Fantasy? | HTML
Evolutionary events adapted the cat's metabolism and physiology to this diet strictly composed of animal tissues and led to ... unique digestive and metabolic peculiarities of carbohydrate metabolism. The domestic cat still closely resembles its wild ... In addition, different starch sources evoke different postprandial glucose and insulin responses due to variances in chemical ... insulin sensitivity and energetic efficiency of weight gain. Br. J. Nutr. 2011, 106, S64-S77. [Google Scholar] [CrossRef] [ ...
  http://www.mdpi.com/2306-7381/4/4/55/htm
*  Cardiac Metabolism Imaging and Chemotherapy Cardiotoxicity | OMICS International
Progression of heart failure is associated with cardiac remodeling and a change in the efficiency of oxygen consumption. An ... increased catecholamine level and activation affects the heart and produces several metabolic responses mimicking stress ... the heart's consumption of energy) (Figure 1 and Table 1) [3-5]. Most chemotherapeutic agents that damage cardiac tissue affect ... Chemotherapy targets the tumor cell cycle by arresting or slowing cell division, thereby leading to apoptosis or autophagy ( ...
  https://www.omicsonline.org/open-access/cardiac-metabolism-imaging-and-chemotherapy-cardiotoxicity-2161-0495-1000213.php?aid=67039
*  Autonomic | Acetylcholine | Epinephrine
Physiological Responses to Cholinergic Stimulation Tissue Eye Sphincter muscle (iris) Ciliary muscle Heart SA node Atria AV ... the work of the heart and its O 2 consumption are markedly increased the cardiac efficiency. β2 α α1. work output/O 2 ... and limits peripheral perfusion with resultant tissue hypoxia and metabolic acidosis Clinical Uses 1.Autonomic Pharmacology ... 4. use.hyperkinetic syndrome 3. this also increases myocardial work & oxygen consumption. 67 . cardiac arrest . Parkinsonism ...
  https://www.scribd.com/document/66049354/Autonomic
*  Plus it
Rate of oxygen consumption in intact cells. Measurements of oxygen consumption of whole cells were done as described previously ... Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med 1995; 333: 550-4. ... Beyond the reported effects of metformin on insulin-responsive tissues, little is known about the effects of metformin on other ... These data suggest that p53 is a regulator of multiple adaptive metabolic responses that compensate for bioenergetic compromise ...
  http://cancerres.aacrjournals.org/content/67/14/6745
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
This paper thoroughly describes the steps involved in preparing saponin-skinned cardiac fibers for oxygen consumption ... The retina is a tissue that lines the interior of the eye and it is the only tissue that allows for a non-invasive analysis of ... Further, this method can be used to identify novel therapeutic targets at cellular level and to test the effectiveness of new ... Several publications have also demonstrated that ROS are involved in insulin sensitivity 11, 12. Numerous methods to evaluate ...
  https://www.jove.com/visualize/abstract/25269026/oxidative-stress-is-associated-with-an-increased-antioxidant-defense
*  WikiGenes - Leukocytes
High efficiency latency and activation of herpes simplex virus in human cells. Wigdahl, B.L., Scheck, A.C., De Clercq, E., Rapp ... Fish consumption among healthy adults is associated with decreased levels of inflammatory markers related to cardiovascular ... A new category of metabolic disease involving the absence of peroxisomes. Datta, N.S., Wilson, G.N., Hajra, A.K. N. Engl. J. ... Regulation of immune responses by TGF-beta. Letterio, J.J., Roberts, A.B. Annu. Rev. Immunol. (1998) [Pubmed] ...
  http://www.wikigenes.org/e/mesh/e/1430.html
*  Plus it
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. ... Although hypothalamic inflammation shares several features with responses observed in peripheral tissues (e.g., comparable ... a challenge that cannot be met without methodologies that can distinguish cellular responses to diet from metabolic alterations ... In simple terms, voluntary weight loss triggers increases of both appetite and energy efficiency, such that both sides of the ...
  http://diabetes.diabetesjournals.org/content/62/8/2629
*  Leptin resistance: a prediposing factor for diet-induced obesity | Regulatory, Integrative and Comparative Physiology
In this case, we consider the extent of the metabolic responses to the leptin antagonist to be a measure of functional leptin ... elevated oxygen consumption, and a substantial decrease in body weight, and the body fat reduced to near zero by day 10 (57). ... insulin, or glucose except for elevated serum triglycerides with high fructose consumption. The fructose-fed rats nonetheless ... Feed efficiency, expressed as the body weight gain per unit of food consumed, was increased during both the chow and HF feeding ...
  http://ajpregu.physiology.org/content/296/3/R493.long
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... organs and tissues and to contribute to the development of the many complications associated with obesity and the metabolic ... It also causes a decrease in body weight and fertility, as well as lower levels of plasma glucose, insulin, and IGF-1 in these ... One factor contributing to this multifactorial disorder is the consumption of a high fat diet, a behavior that has been shown ... We describe how to: induce stress in herbivores from predation risk; measure those stress responses, and measure the ...
  https://www.jove.com/visualize/abstract/23483989/effects-diet-composition-on-postprandial-energy-availability-during
*  Assessing mitochondrial dysfunction in cells | Biochemical Journal
... complexity of whole organisms and tissues makes it hard to infer mitochondrial dysfunction from changes in oxygen consumption ... In animal models, there may be exercise intolerance, poor grip strength, altered metabolic efficiency or failure to put on body ... particularly if they have insulin-dependent glucose uptake and insulin is not present) and prefer to oxidize either endogenous ... The three curves with filled symbols show the kinetic responses of the rates of each of the three modules in (A) to their ...
  http://www.biochemj.org/content/435/2/297
*  Protocols and Video Articles Authored by Min Zhu
... adipose tissue inflammation, and insulin resistance (IR) compared with obese WT mice. Reduced inflammation in obese/insulin ... stress responses, cell proliferation, the cytoskeleton, signal transduction, and metabolic processes. Therefore, the ... The hydrolysis efficiency under anaerobic conditions was comparable to the efficiency observed under sufficient micro-aeration ... Understanding the functional role of target, target expression and their downstream consequences were identified as important ...
  https://www.jove.com/author/Min_Zhu