*  Fat cell enlargement is an independent marker of insulin resistance and 'hyperleptinaemia'.
Cell size and insulin action on glucose uptake capacity in vitro were assessed in isolated fat cells. Insulin sensitivity in ... RESULTS: Negative correlations were found between subcutaneous fat cell size and insulin sensitivity assessed as M-value during ... Fat cell enlargement is an independent marker of insulin resistance and 'hyperleptinaemia'.. Lundgren, M ... In non-diabetic subjects, omental fat cell size was independently and negatively correlated with insulin action in subcutaneous ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:681624
*  Patent US20050187142 - Zinc-free and low-zinc insulin preparations having improved stability - Google Patents
... an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least one ... The invention also relates to the production of such insulin preparations and their use as pharmaceutical formulations. ... The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, ... human insulin, bovine insulin, or porcine insulin, or another animal insulin), an insulin analog, an insulin derivative, and ...
  http://www.google.com/patents/US20050187142?dq=5,832,511
*  Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus - Full Text View - ClinicalTrials.gov
Insulin resistance is characterized by an impaired response to the physiologic effects of insulin and leads to decreased ... Therefore in the insulin-resistant state, blood glucose and insulin levels are increased. The relationship between improved ... Change from baseline in Insulin [ Time Frame: Weeks 4, 8, and 12 or Final Visit. ]. *Change from baseline in Proinsulin/insulin ... Combination oral therapy and eventually insulin are usually required to maintain lower blood glucose levels but can result in ...
  https://clinicaltrials.gov/ct2/show/study/NCT00760344?show_locs=Y
*  Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance and...
WP4 - Severe Insulin-Deficient Diabetes (SIDD) - mechanisms & pathways. *WP5 - Severe Insulin-Resistant Diabetes (SIRD) - ... Mechanisms of Defective Insulin Secretion in Type 2 Diabetes. *NFAT signaling in chronic and acute inflammation. A novel target ... Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP. *Lipid metabolism in the pancreatic beta ... Also, the insulin secretory response to intravenous glucagon-like peptide 1 was reduced in vivo. Similarly, islets stimulated ...
  https://www.ludc.lu.se/eva-degerman-pi/publication/5c964935-3efc-480b-a55c-f0bf6347a2a8
*  Snails' speedy insulin | UNews
Putting snail insulin to work. Studying the structure of the cone snail insulin could help researchers modify human insulin to ... Tests on insulin receptors in the lab showed that although the snail insulin was less effective than human insulin, it was ... Human insulin is a hormone that is produced in the pancreas and secreted to aid in the body's uptake of glucose. The insulin ... It's how insulin is stored in the pancreas. But injected insulin must de-aggregate into individual molecules before doing a ...
  https://unews.utah.edu/snails-speedy-insulin/
*  Market Study - Global Human Insulin Market Size, Share, Growth, Trends and Forecast To 2020: Acute Market Reports - Get News
Modern human insulin by type - long action human insulin, rapid acting human insulin and premixed human insulin. North America ... Traditional human insulin by type - short acting human insulin, intermediate acting human insulin and premixed human insulin. ... Modern human insulin - long action human insulin, rapid acting human insulin and premixed human insulin. Canada market ... Traditional human insulin - short acting human insulin, intermediate acting human insulin and premixed human insulin. Modern ...
  http://www.getnews.info/513607/market-study-global-human-insulin-market-size-share-growth-trends-and-forecast-to-2020-acute-market-reports.html
*  Patent US7021309 - Method of use of monomeric insulin as a means for improving the ... - Google Patents
Particles of insulin and in particular monomeric insulin delivered to the surface of lung tissue will be absorbed into the ... The monomeric insulin may be a dry powder but is preferably in a liquid formulation delivered to the patient from a hand-held, ... Further, the rate at which blood glucose is lowered is increased by the use of monomeric insulin. ... The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin ...
  http://www.google.com/patents/US7021309?dq=6,243,373
*  Insulin Treatment Reverses the Insulin Resistance of Type II Diabetes Mellitus | Diabetes Care
Type II diabetic subjects are both insulin-deficient and insulin-resistant. Recent studies suggest that the insulin resistance ... Insulin Treatment Reverses the Insulin Resistance of Type II Diabetes Mellitus. J A Scarlett, R S Gray, J Griffin, J M Olefsky ... Insulin Treatment Reverses the Insulin Resistance of Type II Diabetes Mellitus. J A Scarlett, R S Gray, J Griffin, J M Olefsky ... Insulin Treatment Reverses the Insulin Resistance of Type II Diabetes Mellitus Message Subject (Your Name) has forwarded a page ...
  http://care.diabetesjournals.org/content/5/4/353
*  9 Diabetes Statistics and Basal Insulin Facts That May Surprise You
Basal insulin facts. Basal insulin is the insulin that works in the background between meals and overnight. This means it's the ... amount of insulin is given to cover meals. Using the insulin pump is a good way to adjust the basal insulin levels in a very ... long-acting insulin is injected once or twice a day to mimic basal insulin. Those with type 1 would then take insulin to cover ... Ask the Expert: Basal Insulin Therapy for Type 2 Diabetes. Ask the Expert: Basal Insulin Therapy for Type 2 Diabetes. Get the ...
  https://www.drugs.com/health/diabetes-basal-insulin/statistics-3402/
*  IP] remaining insulin
But is it , , really? When calculating "insulin on board" does one really want to estimate , , insulin _activity_ or insulin ... The Minimed uses a scale , , that approximates insulin activity based on manufacturer data (90% of the , , insulin activity ... insulin-pumpers.org *Follow-Ups: *[IP] Re remaining insulin *From: Liz Davis ,email @ redacted, ... perhaps the insulin absorption does, and, therefore, perhaps the Cozmo method , , is superior for calculating "insulin on board ...
  http://www.insulin-pumpers.org/mail/archive/mail-insulin-pumpers/Sep2003/msg00864.html
*  Improved insulin-sensitivity in mice heterozygous for PPAR-gamma defi" by P D. Miles, Y Barak et al.
Likewise, the insulin-induced suppression of hepatic glucose production was significantly greater in the PPAR-gamma(+/-) mice ... Nor was there a difference in glucose excursion between the groups of mice during oral glucose tolerance test, but insulin ... PPAR-gamma improves insulin sensitivity, a similar effect is obtained by genetically reducing the expression levels of the ... To gain insight into the role of this nuclear receptor in insulin resistance and diabetes, we conducted metabolic studies in ...
  https://mouseion.jax.org/stfb2000_2009/162/
*  Insulin index - Wikipedia
... the Insulin Index is based upon blood insulin levels. The Insulin Index represents a comparison of food portions with equal ... The Insulin Index of a food represents how much it elevates the concentration of insulin in the blood during the two-hour ... "An insulin index of foods: the insulin demand generated by 1000-kJ portions of common foods" (PDF). American Journal of ... The insulin index compares foods in amounts with equal overall caloric content (250 kcal or 1000 kJ). Insulin indexes are ...
  https://en.wikipedia.org/wiki/Insulin_index
*  Insulin analog - Wikipedia
However, some insulin analogues, such as insulin detemir, bind to albumin rather than fat like earlier insulin varieties, and ... Basal insulin support is required throughout the day representing about 50% of daily insulin requirement, the insulin amount ... "Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus". Cochrane Database of ... Bovine insulin and porcine insulin may be considered as the first clinically used insulin analogs (naturally occurring, ...
  https://en.wikipedia.org/wiki/Insulin_analog
*  Intensive insulin therapy - Wikipedia
The insulin pump is about the size of a beeper. It can be programmed to send a steady stream of insulin as basal insulin. It ... This insulin is referred to as basal insulin secretion, and constitutes almost half the insulin produced by the normal pancreas ... Long-acting insulin analogs such as insulin glargine (brand name Lantus, made by Sanofi-Aventis) and insulin detemir (brand ... These three components of the insulin regimen are commonly referred to as basal insulin, bolus insulin, and high glucose ...
  https://en.wikipedia.org/wiki/Intensive_insulin_therapy
*  Prediabetes & Insulin Resistance | NIDDK
Defines insulin resistance and prediabetes and describes diagnosis. Lists ways to treat these conditions to help avoid ... Prediabetes & Insulin Resistance. What is insulin?. Insulin is a hormone made in the pancreas, an organ located behind the ... What happens with insulin resistance?. In insulin resistance, muscle, fat, and liver cells do not respond properly to insulin ... Insulin's Role in Blood Glucose Control. When blood glucose levels rise after a meal, the pancreas releases insulin into the ...
  https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance
*  Pancreatic Islet Transplantation | NIDDK
Over time, insulin production declines as well, so many people with type 2 diabetes eventually need to take insulin. ... However, long-term insulin independence is difficult to maintain, and eventually most recipients needed to start taking insulin ... Diabetes develops when the pancreas does not make enough insulin, the body's cells do not use insulin effectively, or both. As ... Type 2 diabetes usually begins with a condition called insulin resistance, in which the body has trouble using insulin ...
  https://www.niddk.nih.gov/health-information/diabetes/overview/insulin-medicines-treatments/pancreatic-islet-transplantation
*  Insulin Action/Molecular Metabolism | Diabetes
Thank you for your interest in spreading the word about Diabetes.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
  http://diabetes.diabetesjournals.org/content/66/Supplement_1/A487
*  Insulin
... testing for insulin level is most frequently ordered following a low glucose and/or when someone has acute or chronic ... The test for insulin measures insulin from both sources while the C-peptide test reflects insulin produced by the pancreas. ... al (2001). Elecsys Insulin Assay: Free Insulin Determination and the Absence of Cross-Reactivity with Insulin Lispro. Clinical ... Insulin resistance. High. Normal or somewhat elevated. Not enough insulin produced by the beta cells (as seen in diabetes, ...
  https://labtestsonline.org/tests/insulin
*  Insulin detemir - Wikipedia
Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin ... Insulin detemir is a long-acting human insulin analogue for maintaining the basal level of insulin. Novo Nordisk markets it ... Treat-to-Target Trial Comparing Insulin Detemir With NPH Insulin as Add-On Therapy to Oral Glucose-Lowering Drugs in Insulin- ... 16%, P = 0.008). Compared with NPH insulin, the risk for all hypoglycemia with insulin detemir was reduced by 47% (P < 0.001) ...
  https://en.wikipedia.org/wiki/Insulin_detemir
*  insulin | Infoplease
Insufficiency of insulin in the body results in diabetes . Insulin was one of the first products to be manufactured using ...
  https://www.infoplease.com/encyclopedia/medicine/anatomy-and-physiology/anatomy-and-physiology/insulin
*  Definition: Insulin Injections
Although researchers are testing other ways to give insulin, it's only available now in a form that must be injected just under ... Insulin Injections. Insulin is a hormone that lowers the level of glucose (a type of sugar) in the blood by helping glucose ... There are many types of injectable insulin, both short- and long-acting. Most people with diabetes take insulin injections ... Although researchers are testing other ways to give insulin, it's only available now in a form that must be injected just under ...
  http://kidshealth.org/NemoursXML/en/parents/insulin-injections.html
*  Word! Insulin Injections
Insulin Injections. Say: in-suh-lin in-jek-shuns. Insulin is an important hormone that keeps your body working. If a person ... There are many types of injectable insulin, both short- and long-acting. Most people with diabetes take insulin injections ... doesn't make enough of this substance, he or she may need to get insulin injections, or shots. ...
  http://kidshealth.org/en/kids/word-insulin-injections.html?view=ptr&WT.ac=k-ptr
*  Word! Insulin Resistance
... the body doesn't let insulin do its job as well and it's harder for glucose to get into the cells. This is called insulin ... Even though the pancreas is still making insulin, ... This is called insulin resistance. People who have insulin ... but the insulin can't work the way it should. Even though the pancreas is still making insulin, the body doesn't let insulin do ... Kids who are starting to get type 2 diabetes are still able to make insulin, ...
  http://kidshealth.org/CookChildrens/en/kids/word-insulin-resistance.html
*  Blood Test: Insulin
... or any other conditions related to abnormal insulin production. ... Blood Test: Insulin. Resources. Please Note: By clicking a link ...
  http://kidshealth.org/en/parents/test-insulin.html?view=rr&WT.ac=p-rr
*  Blood Test: Insulin
... or any other conditions related to abnormal insulin production. ... Insulin works like a key that opens the doors to cells and ... For good health, the body must be able to keep insulin and glucose levels in balance. With too little insulin, blood sugar ... causing the pancreas to overcompensate and produce more insulin. Insulin resistance is common among obese people who may go on ... or any other conditions related to abnormal insulin production. It's often used to diagnose and monitor insulin resistance, a ...
  http://kidshealth.org/PrimaryChildrens/en/parents/test-insulin.html