Cardiovascular response to group I metabotropic glutamate receptor activation in NTS | Regulatory, Integrative and Comparative...
... of DHPG was utilized to establish the dose-response relationship and dose of drug that produced 50% of the maximal response (ED ... Immediately at the end of the 1-min period of antagonist injections, the agonist injection was repeated. In addition, agonist ... A minimum of 5 min between sequential injections of agonists was used to allow baseline parameters to return to preinjection ... The dose of drug that produced 50% of the maximal response (ED50) was 50-100 μM. The response to microinjection of equal ...http://ajpregu.physiology.org/content/276/5/R1469
Self-administration of the D1 agonist SKF 82958 is mediated by D1, not D2, receptors.
We have previously reported that two D1 dopamine agonists, SKF 82958 and SKF 77434, are readily self-administered by rats. ... Dose-Response Relationship, Drug. Male. Raclopride. Rats. Rats, Sprague-Dawley. Receptors, Dopamine D1 / agonists*. Receptors, ... 7922577 - The effects of systemic and intracerebral injections of d1 and d2 agonists on brain sti.... 16061357 - Effects of ... Conditioning, Operant / drug effects. Dopamine Agonists / administration & dosage, pharmacology*. Dopamine Antagonists / ...http://www.biomedsearch.com/nih/Self-administration-D1-agonist-SKF/8867867.html
Hypertension sub-cluster 20
Dose-response relationships of intravenously administered terbutaline in children with asthma. Fuglsang G - - 1989 ... a selective alpha-1 adrenoceptor agonist), clonidine and xylazine (selective alpha-2 adrenoceptor agonists) were investigated ... Intravenous injection of clonidine produces a biphasic blood pressure response, a transient increase followed by a prolonged ... Effects of clonidine on anesthetic drug requirements and hemodynamic response during aortic ... ...http://www.biomedsearch.com/cluster/89/Hypertension/sub-20-p12.html
Tardive dyskinesia - Wikipedia
The D2 hypersensitivity hypothesis is also supported by evidence of a dose-response relationship, withdrawal effects, studies ... this can happen from the individual having an increased dose of an antipsychotic drug. Often the symptoms of tardive dyskinesia ... Botox injections are used for minor focal dystonia, but not in more advanced tardive dyskinesia. Benzodiazepines are an ... From 2008, there have been reported cases of the anti-psychotic medication aripiprazole, a partial agonist at D2 receptors, ...https://en.wikipedia.org/wiki/Tardive_dyskinesia
UB-165: A Novel Nicotinic Agonist with Subtype Selectivity Implicates the α4β2* Subtype in the Modulation of Dopamine Release...
Data points for agonist dose-response relationships (after subtraction of nonspecific release determined in the presence of ... to give the EC50 for the upward phase of the dose-response curve and Umax, the maximum upregulation produced by the drug tested ... The efflux of86Rb+ from preloaded mouse thalamic synaptosomes in response to nicotinic agonists is proposed to reflect the ... Oocytes were injected the next day with 10-50 ng of mRNA encoding αx and βx nAChR subunits in an injection volume of 50 nl. The ...http://www.jneurosci.org/content/20/8/2783
To evaluate the dose-response relationship of the antinociception to somatic pain by pentazocine and whether pentazocine ... However, several lines of evidence show that KOR agonists or mixed agonist-antagonists with KOR agonistic property exert ... Fifty minutes after the subcutaneous pentazocine injection mice received intraperitoneal injection of acetic acid. The amount ... The pentazocine used in Chien and Pasternak's study was optically pure (−)-isomer; however, the drug used in our study was a ...http://jpet.aspetjournals.org/content/338/2/579
Diabetes and Cancer | Diabetes Care
A Phase 1/2 Dose Finding Study of an Experimental New Drug CS7017, an Oral PPARy Agonist Taken by Mouth Twice Daily in ... Direct data concerning dose-response characteristics of cancers to glucose are sparse, but it is relevant that most cancers ... Moreover, the relationship between serum levels of insulin and regulation of insulin receptor levels in neoplastic tissues has ... Subcutaneous injection of insulin results in significantly higher levels of circulating insulin in the systemic circulation ...http://care.diabetesjournals.org/content/33/7/1674.full
Frontiers | Novel GLP-1 Analog Supaglutide Reduces HFD-Induced Obesity Associated with Increased Ucp-1 in White Adipose Tissue...
... activities in response to cold challenge. Glucose tolerance and insulin resistance were evaluated by intraperitoneal glucose ... activities in response to cold challenge. Glucose tolerance and insulin resistance were evaluated by intraperitoneal glucose ... this dose-response relationship was not found in its weight sparing effects in db/db mice, implying different mechanisms ... supaglutide at a dosage of 300 μg/kg was effective in improving glucose tolerance 216 h after a single drug-injection ( ...https://www.frontiersin.org/articles/10.3389/fphys.2017.00294/full
Comparison of the Spinal Actions of the micro-Opioid Remifentanil with Alfentanil and Morphine in the Rat | Anesthesiology |...
Intrathecal and intraperitoneal agonist dose response curves and time effect curves were obtained for all agents. Naloxone ... injection 10 min before intrathecal drug delivery. ... To address the relationship between supraspinal side effects ... Therefore, we sought to examine the action of intrathecal remifentanil and, for comparison, two opioid agonists (morphine and ... In contrast, the dose-response curve for remifentanil was flat until the highest dose at which time a peak increase in the ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1949335
Patent US4753635 - Inducing analgesia by implantation of cells releasing neuroactive substances - Google Patents
4 shows dose-response relationships for the effect of nicotine on pain sensitivity in animals with spinal cord bovine ... The abscissa is the time course of responses to noxious stimuli following drug injections. Time 0 indicates the pre-injection ... and stimulating said cells or tissue by infecting a nicotinic or muscarinic agonist to release effective amount of analgesic ... such as nicotine or muscarinic agonists and the like. Analgesia thus induced can also be conveniently manipulated or reversed ...http://www.google.com/patents/US4753635?dq=7,339,580
Guideline for the management of chronic asthma in children - 2009 update
... the dose-response relationships have been less well studied. Use of ICSs for up to 2 years has not been shown to induce ... Beta-agonists through metered-dose inhaler with valved holding chamber versus nebulizer for acute exacerbation of wheezing or ... Specific drug and non-drug factors involved in non-adherence are listed in Table XI. ... Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma. Cochrane Database Syst Rev 2006(2): ...http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742009001200024&lang=en
A&A -- Table of Contents (101 )
There was a strong logarithmic dose-response relationship between postoperative opioid dose and POV (r2= 0.98, P , 0.01), as ... Spinal injection of small-dose (SD) bupivacaine decreases the likelihood of hypotension compared with large-dose (LD) ... but the two drugs depressed the late phase response. DPMA suppressed both phase responses. CPA was the most potent drug among ... Antinociception of intrathecal adenosine receptor subtype agonists in rat formalin test.. Yoon MH, Bae HB, Choi JI ...https://hkca.edu.hk/ANS/Download/A&A/A&AAbst0511.htm
Enhancement of Morphine Analgesic Effect with Induction of μ-Opioid Receptor Endocytosis in Rats | Anesthesiology | ASA...
... the dose effects of three opioid agonists on the MOR internalization of dorsal horn neurons as well as analgesic response of ... Addition of a low dose of DAMGO or fentanyl seems to allow the partial agonist morphine to behave as a full agonist, thereby ... Rats were subjected to the hot plate test 5 min after intrathecal injection of indicated agonists (percent maximum possible ... In D , data in A - C were replotted to explore the relationship between MOR internalization and analgesic effects of DAMGO ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1931224
It has been shown that full KOR agonists with MOR agonist activities, but not pure KOR agonists, have inverted U-shaped dose- ... 1999) Dose-response relationship of intrathecal morphine for postcesarean analgesia. Anesthesiology 90:437-444. ... 1997) Intracisternal injection of opioids induces itch-associated response through μ-opioid receptors in mice. Jpn J Pharmacol ... in Advances in Drug Research, eds Harper NJ, Simmonds AB (Academic Press, New York), pp 79-119. ...http://jpet.aspetjournals.org/content/305/1/173
JCI - Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine
... latency after drug - baseline latency)/(10 - baseline latency) × 100]. Morphine doses used in cumulative dose-response studies ... Morphine injection (10 mg/kg, s.c. twice daily) was started on the second day of the vivo-morpholino oligo injection for 5 days ... Mu opioid receptor agonist-induced β-arrestin 2 recruitment and G protein activation in CHO cells stably transfected with exon ... Overall, the mu agonists morphine, endomorphin 1, and fentanyl stimulated [35S]GTPγS binding with full efficacy relative to ...https://www.jci.org/articles/view/88760
Autonomic | Acetylcholine | Epinephrine
... contractility in the range 1.Autonomic Pharmacology Absorption.50 µg/min such infusions have a dose/response relationship ( ... the drug is also used to raise perfusion pressure during cardio-pulmonary bypass 61 . consistent with its minimal β-agonist ... injections of 2 to 10 mg may be given.m. it is used to treat hypotension during spinal anaesthesia and C-P bypass. diastolic ... inferred by the pronounced effect of GTP on the binding of agonists the M1-receptor appears to be involved in the regulation of ...https://www.scribd.com/document/66049354/Autonomic
Protocols and Video Articles Authored by Mark J. Henderson (Translated to Danish)
A clear dose-response relationship was detected in all murine strains. The magnitude of the NPD response to 20 muM lubiprostone ... We hypothesized that ClC-2 agonists would provide a parallel pathway for chloride secretion. Using nasal potential difference ( ... then the effect of bilateral dorsal mPFC light delivery on reinstatement of food seeking was assessed after injections of the ... a putative ClC-2 agonist). Baseline, amiloride-inhibited, chloride-free gluconate-substituted Ringer with amiloride and low- ...https://www.jove.com/author/Mark++J._Henderson?language=Danish
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Odorant/receptor pairs with varying response scores were selected and tested in dose response. These data indicate that a ... There has been much progress in the identification of agonist ligands for PXR, however, there are limited descriptions of drug- ... Data are transferred from the SoftMax Pro software to construct concentration-response relationships of TRPA1 activators and ... Finally, current injection cannot mimic the chemical changes in the cell that occurs with the opening of ion channels. ...https://www.jove.com/visualize/abstract/23077649/structural-mechanism-n-methyl-d-aspartate-receptor-type-1-partial
Modification of cocaine self-administration by buspirone (buspar®): potential involvement of D3 and D4 dopamine receptors. -...
Dose-Response Relationship, Drug. *Drug Interactions. *G Protein-Coupled Inwardly-Rectifying Potassium Channels/genetics ... Number of cocaine injections that were self-administered in the 100-min drug component during which that dose was available or ... Buspirone, a 5-HT1A partial agonist approved for the treatment of anxiety, has been reported to also bind with high affinity to ... Serotonin Receptor Agonists/pharmacology*. *Tritium/pharmacokinetics. Substances. *Dopamine Agents. *G Protein-Coupled Inwardly ...https://www.ncbi.nlm.nih.gov/pubmed/22827916?dopt=Abstract
Persantine Cheap Order - Cheapest Persantine With Overnight Delivery - Can U Persantine
Data from small dose-response studies show an apparent dose relationship for tremor, nervousness, and palpitations. Children 1 ... Our Persantine IV dipyridamole Side Effects Drug Center provides a comprehensive view of available drug information on the ... It should not be used in patients whose asthma can be managed by occasional use of inhaled, short-acting beta 2-agonists. ... Prior to adding the Sodium Pertechnetate Tc99m Injection to the vial, inspect the vial carefully for the presence of damage, ...http://persantine.hnit.info
Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system. - PubMed - NCBI
Dose-Response Relationship, Drug. *Drinking/drug effects. *Drinking Behavior/drug effects. *Drug Administration Routes ... Drug injections were given 95 min before ethanol access, and alcohol consumption was monitored at 30, 60, 90, and 120 min. ... Here we evaluated whether buprenorphine, a partial agonist at micro-opioid and NOP receptors, would reduce ethanol consumption ... Similar to prototypical micro-agonists, the two lowest doses of buprenorphine significantly increased ethanol consumption (p ...https://www.ncbi.nlm.nih.gov/pubmed/16533497
Activation of P2Y1 Nucleotide Receptors Induces Inhibition of the M-Type K+ Current in Rat Hippocampal Pyramidal Neurons
For dose-response curves, currents were measured at ‒30 mV after steady-state I-V relationships were obtained using a ramp ... The hydrolyzable agonist ADP (10 μM) produced 32% inhibition, whereas the metabotropic glutamate receptor 1/5 agonist DHPG [(S ... 1A). In confirmation, addition of the M-channel blocking drug XE991 at 3 μM (Wang et al., 1998) reduced the steady outward ... P2Y1 agonists inhibit M-type K+ currents. The identified pyramidal neurons exhibited the characteristic slowly deactivating ...http://pubmedcentralcanada.ca/pmcc/articles/PMC1855006/
For comparison, the concentration-response relationship for WIN, a potent synthetic CB1R agonist, was determined. In 52 (91%) ... where Icon and Idrug are the Ca2+ currents before and after agonist application, respectively. The concentration-response ... Data are the mean ± S.E.M. Each point on the dose-response curves represents the mean inhibition from 3 to 54 cells, except for ... also showed that partial agonists of α2-adrenergic receptors clonidine and oxymetazoline behaved as full agonist after ...http://molpharm.aspetjournals.org/content/65/3/665
Protocols and Video Articles Authored by Gaoqing Yang
The lack of dose-response relationships was related to features of the biomarker: it does not reflect the Mn in brain ... who reported injection drug use risk, had â‰¥ 2 sex partners, and who disclosed their HIV status to some but not all of their ... In this study, a cell-based high-throughput PPARs (PPARÎ±/Î²/Î³) model was developed for the screening of PPARs agonists. The ... Methacholine, a cholinergic-muscarinic agonist, hyperpolarized SMC in endothelium-intact mesenteric arteries from wide-type ...https://www.jove.com/author/Gaoqing_Yang
... injection of β-3R antagonist (100 μl: 10.0 μg/g) and after 20 min received an i.p. injection of the β3-adrenoceptor agonist. (5 ... To test whether the thermogenic response to leptin is intact in DIO mice, we used a high i.p. dose of leptin, which produces a ... Drug treatment was as follows: (1) Mice received a single intraperitoneal (i.p.) injection of recombinant murine leptin ( ... Melanocortin agonists have not been successful in human weight loss trials because they cause increases in cardiovascular tone ...http://www.jneurosci.org/content/31/34/12189