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Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase. ... a specific inhibitor of NFκB p65 subunit activity or siRNA-mediated p65 knockdown, confirmed the requirement of p65 for RON ... p44/42 mitogen-activated protein kinase, and c-Jun-NH2-kinase ( 16- 21). Phase I human trials have been performed showing that ... Anti-p65 polyclonal antibody was purchased from Abcam. Anti-pIKKα/β (Ser180/181), IKK-α, anti-IKK-β, anti-pIκB-α, and anti-IκB- ...
  http://cancerres.aacrjournals.org/content/68/13/5185
*  Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2 | Cancer Research
To determine whether the same proteins interacted with the human IgH HS1,2 sequence in vivo, we performed a ChIP assay using ... This expression vector, which produces a mutant IκBα protein that retains the NF-κB p50/p65 heterodimer in the cytoplasm, was ... Negative controls included a no chromatin sample, no antibody sample, and nonspecific antibody (αIgG). Precipitated DNA was ... Grant P. A., Thompson C. B., Pettersson S. IgM receptor-mediated transactivation of the IgH 3′ enhancer couples a novel Elf-1- ...
  http://cancerres.aacrjournals.org/content/63/20/6666.long
*  Protocols and Video Articles Authored by Gaoqing Yang
We found also that the ORF3 proteins of genotype 4 and rabbit HEV interacted with all of the human proteins identified by the ... as well as Cyp27B1 or VDR inhibitors. Furthermore, either the TLR2 or TLR6 antibody reduced vitamin D3 signaling and tumor cell ... Heterotrimeric G Proteins Serve As a Converging Point in Plant Defense Signaling Activated by Multiple Receptor-like Kinases ... While the sequence of the decorin core protein is determined by the gene encoding its structure, the structure of its GAG chain ...
  https://www.jove.com/author/Gaoqing_Yang
*  Plus it
The siRNAs targeting the human GSK-3β gene (5′-AAG AAT CGA GAG CTC CAG ATC-3′, designated as #4 and 5′-AAG TAA TCC ACC TCT GGC ... GSK-3β Inhibitor-Induced TRAIL Sensitization Depends on Caspase-8 Activity. Caspase-8 is a critical mediator for death receptor ... Protein concentration in the cell lysates was measured by a Protein Assay Kit (Bio-Rad). An equal amount of protein from each ... induces apoptosis in human prostate cancer cells that is inhibitable by Bcl-2. Oncogene, 20: 3757-3765, 2001. ...
  http://mct.aacrjournals.org/content/2/11/1215
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CREB-binding protein/p300 are transcriptional coactivators of p65. Proc Natl Acad Sci U S A 1997;94:2927-32. ... Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. Oncogene 2006;25:6817-30 ... A, Western blotting and qPCR were done with a p65-specific antibody and primer/probe mix, respectively. B, Western blotting and ... Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 2001;20:7597-609. ...
  http://mct.aacrjournals.org/content/10/9/1644
*  Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis | Retrovirology | Full Text
Although HTLV-1 harbors an oncogene, tax, that transforms T cells in vitro and induces leukemia in transgenic mice, tax ... Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus responsible for the development of adult T-cell leukemia ... HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein. Oncogene. ... Manel N, Battini JL, Taylor N, Sitbon M. HTLV-1 tropism and envelope receptor. Oncogene. 2005;24:6016-25.View ArticlePubMed ...
  https://retrovirology.biomedcentral.com/articles/10.1186/s12977-016-0249-x
*  XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent...
... their downstream effector c-Jun, and in turn inhibiting transcription of c-Jun-regulated the miR-200a. Our study uncovered a ... Human XIAP was knockdown with short-hairpin RNA in two different bladder cancer cell lines, T24T and UMUC3. Two XIAP mutants, ... Anti-IAP therapy is reported to be closely related to epidermal growth factor receptor (EGFR) expression level. However, ... Mechanistic studies indicated that BIR domain activated the protein phosphatase 2 (PP2A) activity by decreasing the ...
  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-016-0376-9
*  US5962415A - Compositions comprising a peptide inhibitor of nuclear protein translocation and an immunosuppressant and methods...
The compositions have, in addition to at least one immunosuppressant, at least one polypeptide inhibitor of nuclear ... Novel compositions of immunosuppressants, such as cyclosporin, and polypeptide inhibitors of cytoplasmic protein nuclear ... Receptor protein for human B cell stimulatory factor-2 Bretscher et al. 1997. Ezrin: a protein requiring conformational ... and Human Retrovirus 11:885. Proviral DNA content (gag) was measured using polymerase chain reaction analysis as described in ...
  https://patents.google.com/patent/US5962415?oq=ascentive
*  Protocols and Video Articles Authored by Jing Huang (Translated to Portuguese)
... inhibitor Icotinib by analyzing protein expression and amplification of EGFR proto-oncogene in esophageal squamous cell ... Jun, 2016 , Pubmed ID: 26980473 Epidermal growth factor receptor (EGFR) has been reported to be overexpressed and amplified in ... Human CD8+ T Cells Mediate Protective Immunity Induced by a Human Malaria Vaccine in Human Immune System Mice Vaccine. Aug, ... Notably, blockage of NF-κB p65 and/or MAPK p38 with their specific inhibitors strongly attenuated B7-H3-amplified inflammatory ...
  https://www.jove.com/author/Jing_Huang?language=Portuguese
*  Protocols and Video Articles Authored by Jing Huang
Quantitative Phase Imaging Study of Dormant and Active Human Cancer Cells' ... inhibitor Icotinib by analyzing protein expression and amplification of EGFR proto-oncogene in esophageal squamous cell ... Jun, 2016 , Pubmed ID: 26980473 Epidermal growth factor receptor (EGFR) has been reported to be overexpressed and amplified in ... Human CD8+ T Cells Mediate Protective Immunity Induced by a Human Malaria Vaccine in Human Immune System Mice Vaccine. Aug, ...
  https://www.jove.com/author/Jing_Huang
*  Patente US6025194 - Nucleic acid sequence of senescence asssociated gene - Google Patentes
Isolated, purified, and recombinant nucleic acids and proteins corresponding to the human GC6 gene and its mRNA and protein ... products, as well as peptides and antibodies corresponding to the GC6 protein can be used to identify senescent cells, ... Human gene GC6 is expressed more abundantly in senescent cells than young cells. ... kinase H69011 211285 sno oncogene H66704 211864 TNF receptor II associated protein (TRAF2) H69474 212414 retinoic acid receptor ...
  http://www.google.es/patents/US6025194
*  AKT3 AKT serine/threonine kinase 3 [Homo sapiens (human)] - Gene - NCBI
RAC-gamma serine/threonine protein kinase. v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma). NP_ ... are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the ... gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires ... EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG) EGFR tyrosine kinase inhibitor resistance, ...
  https://www.ncbi.nlm.nih.gov/gene/10000
*  Other | Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors
The proto-oncogene c-kit, localized to human chromosome 4, encodes a transmembrane receptor, CD117/c-kit, belonging to the ... an antibody against LOX-1 suppressed leukocyte infiltration and protein exudation [10]. However, the effects of LOX-1 ... p65), RelB, NF-B1 (p50/p105), and NF-B2 (p52/p100).31 Currently, a couple of zero spontaneous animal choices for MCL, although ... GAGs) such as for example hyaluronic acidity (HA) heparan sulfate (HS) and chondroitin sulfate can be found in the vitreous gel ...
  http://researchreport-digital.com/category/other/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Proteomic analyses of human, rat, mouse, and chick eCSF have identified many proteins that may be necessary for CSF function. ... A Cell Free Assay System Estimating the Neutralizing Capacity of GM-CSF Antibody using Recombinant Soluble GM-CSF Receptor ... nuclear translocation of the p65 subunit of NF-κB (p65), and secretion of the hallmark proinflammatory cytokine, tumor necrosis ... Yukiko Doi, Hideyuki Takeuchi, Hiroyuki Mizoguchi, Kazuya Fukumoto, Hiroshi Horiuchi, Shijie Jin, Jun Kawanokuchi, Bijay ...
  https://www.jove.com/visualize/abstract/25062013/granulocyte-colony-stimulating-factor-attenuates-oligomeric-amyloid
*  Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in...
Human Col II was treated with HNE at different molar ratios (MR) (1:20 to 1:200; Col II:HNE). Articular chondrocytes were ... It inhibited α1β1 integrin and Col II expression as well as ERK1/2 and NF-κB-p65 phosphorylation, but, in contrast, markedly ... Adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and α1β1 integrin at protein and mRNA levels were ... Col II, cyclooxygenase-2 (COX-2), MAPK, NF-κB-p65 levels were analyzed by Western blotting. The formation of α1β1 integrin- ...
  https://arthritis-research.biomedcentral.com/articles/10.1186/ar3173
*  October 2016 - New β-secretase inhibitors for treatment of Alzheimer's disease
Goat anti-human HNF4α antibody (1:200) mouse anti-rat Nanog antibody (1:500) FITC-labeled goat anti-mouse IgG (1:500) and Cy3- ... CD45 is a protein tyrosine phosphatase receptor that is critically important for T and B cell antigen receptor-mediated ... Cdx2 can be able to connect to the p65 subunit of NFκB and for that reason avoid the NFκB binding and activation from the Cox-2 ... mRNA had been increased as soon as 4 h after initiation of lifestyle and peaked at 8 h accompanied by a rise in Env Gag/Pol and ...
  http://healthyguide.info/2016/10/
*  RegenerativeMedicine.net - Article Archives
CD4 receptor and a fusogenic protein can target cells expressing HIV-1 envelope proteins Stem cell mediated transfer of a human ... attenuate HIV-1 infectivity Targeting the intracellular WT1 oncogene product with a therapeutic human antibody The human gene ... human C4b-binding protein Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in ... We found an increase in Lgr5 levels in CRC cells overexpressing L1, p65 or SMOC-2, suggesting that L1-mediated CRC progression ...
  http://regenerativemedicine.net/NewsletterArchives.asp?qEmpID=11325&qCat=RMJ