*  Viruses | Free Full-Text | Biogenesis and Dynamics of the Coronavirus Replicative Structures | HTML
Upon infection, coronaviruses extensively rearrange cellular membranes into organelle-like replicative structures that consist ... This review will summarize the current knowledge on the biogenesis of the replicative structures, the membrane anchoring of the ... A common feature among positive-strand RNA viruses is their assembly of replication-transcription complexes in association with ... Recent studies have provided new insights into the assembly and functioning of the coronavirus replicative structures. ...
  http://www.mdpi.com/1999-4915/4/11/3245/htm
*  Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth | PNAS
... vaccinia virus Western Reserve strain (VV) and Semliki Forest virus (SFV)]. Infection of WT and KO HeLa cells with HIV-1 ( ... 3E). ZC3H11A(ZF∆3) was also redistributed from the speckle-like structures seen with the WT protein to an even distribution in ... replicon in WT versus ZC3H11A-KO cells transfected with plasmids encoding the WT GFP-ZC3H11A protein or the GFP-ZC3H11A protein ... herpes simplex virus, and adenovirus), whereas cytoplasmic replicating viruses are not (vaccinia virus and Semliki Forest virus ...
  http://www.pnas.org/content/115/16/E3808
*  Viroplasm - Wikipedia
"Assembly of viroplasm and virus-like particles of rotavirus by a Semliki Forest virus replicon". Virology. 242 (2): 255-65. doi ... The number and the size of viroplasms depend on the virus, the virus isolate, hosts species, and the stage of the infection. ... Plant viruses induce the rearrangement of membranes structures to form the viroplasm. This is mostly shown for plant RNA ... Viroplasms are formed early during the infection; in many cases, the cellular rearrangements caused during virus infection lead ...
  https://en.wikipedia.org/wiki/Viroplasm
*  Microbiology Society Journals | Direct repeats in the 3′ untranslated regions of mosquito-borne flaviviruses: possible...
... represented by Japanese encephalitis virus, Yellow fever virus and Dengue virus. Each subgroup exhibits a specific pattern of ... the evolution of RNA secondary structures and (iii) the significance of DRs and secondary structures in MBFV transmissibility ... UTR alignment between these highly divergent viruses, based on the concept that deletions and/or insertions, in addition to ... terminal non-translated region of Semliki Forest virus A7 variant genome. J Gen Virol 75, 1499-1504.[CrossRef] ...
  http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.82235-0
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
A DNA-based replicon vaccine derived from Semliki Forest virus, PSVK-shFcG-GM/B7.1 (Fig. 1a) was designed for tumor ... The vast majority of these cases are the result of reactivation of a latent infection by herpes simplex type I virus and not ... Fortunately, the oligosaccharide structures, which are critical for binding with GM-CSF, are more similar to the structures of ... Enhancement of antitumor immunity using a DNA-based replicon vaccine derived from Semliki Forest virus. ...
  https://www.jove.com/visualize/abstract/24608380/enhancement-antitumor-immunity-using-dna-based-replicon-vaccine
*  Indian Patents. 239166:A POLYNUCLEOTIDE HAVING THE NUCLEIC ACID SEQUENCE ACCORDING TO SEQ ID NO:1, 2 OR 3 OR A SEQUENCE FROM...
several other viruses are also qualified e.g. recombinant alpha-viruses, e.g. the Semliki-Forest. virus or the Venezuela- ... Non-subtype B viruses cause the vast majority of new HIV-1 infections worldwide. Among. those, clade C HIV-1 strains play a ... proteins or virus like structures in eukaryotic cell cultures such as yeast cells, fungi, insect cells. or mammalian cells or ( ... A preferred DNA vaccine based on SEQ ID NO: 1, 2 or 3 in addition includes a replicon derived. from alpha viruses such as ...
  http://www.allindianpatents.com/patents/239166-a-polynucleotide-having-the-nucleic-acid-sequence-according-to-seq-id-no-1-2-or-3-or-a-sequence-from-the-nucleotide-numbers
*  Isomerization of the intersubunit disulphide‐bond in Env controls retrovirus fusion | The EMBO Journal
Liljestrom P, Garoff H (1991) A new generation of animal cell expression vectors based on the Semliki Forest virus replicon. ... This prevented virus fusion if not reduced with DTT during infection (Abrahamyan et al, 2003). The finding supports the general ... This suggests that corresponding structures participate in the fusion activation of the viral Env. Such mechanisms do not apply ... Production of infectious recombinant Moloney murine leukemia virus particles in BHK cells using Semliki Forest virus‐derived ...
  http://emboj.embopress.org/content/23/1/54
*  Protocols and Video Articles Authored by Ken Olson (Translated to Turkish)
Furthermore, in mosquito cells overexpressed LACV NSs was unable to inhibit RNAi against Semliki Forest virus. In mammalian ... aegypti 14 d after oral infection. Here, we compare the spatial and temporal infection patterns of MRE16 and TR339 viruses in ... Recombination-ready Sindbis Replicon Expression Vectors for Transgene Expression Virology Journal. 2007 , Pubmed ID: 17963504 ... is required for differentiation of adult structures as well as for the programmed death of obsolete larval organs during ...
  https://www.jove.com/author/Ken_Olson?language=Turkish
*  Recombinant Hepatitis E virus like particles can function as RNA nanocarriers | Journal of Nanobiotechnology | Full Text
We have attempted to use such recombinant assembled Hepatitis E virus (HEV) VLPs as a carrier for heterologous RNA with protein ... In vitro transcribed red fluorescent protein (RFP)/Hepatitis B virus surface antigen (HBsAg) RNA, fused to 5′-HEV sequence with ... Assembled virus-like particles (VLPs) without genetic material, with structure similar to infectious virions, have been ... semliki Forest and Highlands J virus [5]. SLIII on the other hand, is not absolutely essential but may function to enhance the ...
  https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-015-0101-9
*  HIV polynucleotides and polypeptides derived from Botswana MJ4 - Patent application
Such replicon vectors have been derived from alphaviruses that include, for example, Sindbis virus, Semlild Forest virus, and/ ... Semliki Forest, and Venezuelan Equine Encephalitis viruses, will also find use as viral vectors for delivering the ... 0159]As an alternative approach to infection with vaccinia or avipox virus recombinants, or to the delivery of genes using ... The DNA prime/protein boost strategy of immunization that will be used here allows for screening of multiple Env structures in ...
  http://www.patentsencyclopedia.com/app/20090208530
*  DNA vaccination - Wikipedia
The Sindbis virus and Semliki Forest virus have been used to build recombinant alphavirus replicons. Unlike conventional DNA ... "Ordered" structures (such as viral particles) are more effective than unordered structures. Strings of minigenes (or MHC class ... "Induction of CD8+ T Cell Responses to Dominant and Subdominant Epitopes and Protective Immunity to Sendai Virus Infection by ... replicon-induced cytokine responses, or replicon-induced apoptosis leading to enhanced antigen uptake by dendritic cells. ...
  https://en.wikipedia.org/wiki/DNA_vaccination
*  Activation of HCV Specefic T Cells - Patent application
Such replicon vectors have been derived from alphaviruses that include, for example, Sindbis virus, Semliki Forest virus, and/ ... 2000) 191:1499). Virus-specific T cell responses have been shown to play an important role in resolving acute HCV infections ( ... These structures generally contain one or more proteins from a virus optionally combined or formulated with a phospholipid. ... Ockelbo virus, Semliki Forest virus, Middelburg virus, Chikungunya virus, O'Nyong-Nyong virus, Ross River virus, Barmah Forest ...
  http://www.patentsencyclopedia.com/app/20100034844
*  INFECTIOUS CLONES - Patent application
1991). A new generation of animal cell expression vectors based on the Semliki Forest virus replicon. Bio/Technology. 9:1356- ... 1984). Multicomponent RNA plant virus infection derived from cloned viral cDNA. Proc. Natl. Acad. Sci. USA. 81:7066-7070. [0172 ... Methods of binding of cross-beta structures by chaperones. New patent applications in this class:. ... including the Sindbis virus, Semliki Forest virus (SFV), and the Venezuelan equine encephalitis (VEE) virus (Frolov et al., ...
  http://www.patentsencyclopedia.com/app/20110142879
*  TUMOR AND INFECTIOUS DISEASE THERAPEUTIC COMPOSITIONS - Patent application
0115]Alphavirus-based vectors, such as those made from semliki forest virus (SFV) and sindbis virus (SIN), might also be used ... For example CD4, chemokine receptors such as CCR3, CCR5 are required for HIV infection. Furthermore, viruses also upregulate ... Alphavirus vectors typically are constructed in a format known as a replicon. A replicon may contain (1) alphavirus genetic ... the cell surface or that other lectin-binding structures may be present on cell surfaces. All such lectin-binding structures ...
  http://www.patentsencyclopedia.com/app/20100183685
*  METHODS OF TREATING ALZHEIMER'S DISEASE AND OTHER TAUOPATHIES WITH INHIBITORS OF MICROTUBULE AFFINITY REGULATING KINASE - THE...
Semliki Forest virus (SFV), and Venezuelan Equine Encephalitis virus (VEE), will also find use as viral vectors for delivering ... As an alternative approach to infection with vaccinia or avipox virus recombinants, or to the delivery of genes using other ... Once coding sequences have been isolated and/or synthesized, they can be cloned into any suitable vector or replicon for ... Synapses and dendritic spines are dynamic structures whose plasticity is thought to underlie learning and memory (Penzes et al ...
  http://www.freepatentsonline.com/y2016/0030510.html
*  IRRADIATED BIODEGRADABLE POLYMER MICROPARTICLES - Patent application
Sindbis virus, Semliki Forest virus, Venezuelan equine encephalitis virus, or Ross River virus), which has been modified by the ... acute viral infection including the common cold, and infection due to respiratory syncytial virus, influenza, coronavirus ( ... These structures generally contain one or more proteins from a virus optionally combined or formulated with a phospholipid. ... ", "RNA vector replicon" and "replicon" refer to an RNA molecule that is capable of directing its own amplification or self- ...
  http://www.patentsencyclopedia.com/app/20130101609