*  Combination Chemotherapy in Treating Patients With Acute Promyelocytic Leukemia - Full Text View - ClinicalTrials.gov
... maintenance therapy in patients receiving induction tretinoin and daunorubicin hydrochloride with acute promyelocytic leukemia ... adult acute promyelocytic leukemia (M3). childhood acute promyelocytic leukemia (M3). adult acute myeloid leukemia with t(15;17 ... Leukemia. Leukemia, Promyelocytic, Acute. Neoplasms by Histologic Type. Neoplasms. Leukemia, Myeloid, Acute. Leukemia, Myeloid ... Acute promyelocytic leukemia Cytogenetically normal acute myeloid leukemia Familial acute myeloid leukemia with mutated CEBPA ...
  https://clinicaltrials.gov/ct2/show/NCT00276601?cond=%22Acute+promyelocytic+leukemia%22&rank=19
*  Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic...
Injection for First Line Treatment of Acute Promyelocytic Leukemia ... as late as the second month induction therapy. When TRISENOX is used in combination with tretinoin, prednisone prophylaxis is ... In combination with tretinoin for treatment of adults with newly-diagnosed low-risk acute promyelocytic leukemia (APL) whose ... Differentiation Syndrome: Patients with acute promyelocytic leukemia (APL) treated with TRISENOX have experienced symptoms of ...
  http://www.tevapharm.com/news/teva_announces_u_s_fda_approval_of_trisenox_arsenic_trioxide_injection_for_first_line_treatment_of_acute_promyelocytic_leukemia_01_18.aspx
*  acute promyelocytic leukemia childhood 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Remission Induction. Survival Analysis. Transplantation, Autologous. Transplantation, Homologous. Treatment Outcome. Tretinoin ... Leukemia, Promyelocytic, Acute / diagnosis. Leukemia, Promyelocytic, Acute / drug therapy. Oxides / therapeutic use. Tretinoin ... Title] Acute promyelocytic leukemia in childhood.. *Acute promyelocytic leukemia (APL) is a relatively rare form of acute ... Leukemia, Promyelocytic, Acute / genetics. Leukemia, Promyelocytic, Acute / pathology. *[Email] Email this result item Email ...
  http://www.bmlsearch.com/?kwr=acute+promyelocytic+leukemia+childhood+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  Pigments, Biological - DrugBank
Tretinoin. For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB ... In acute lymphocytic leukemia, methotrexate is indicated in the prophylaxis of meningeal leukemia and is used in maintenance ... Tretinoin. Retinoic acid receptor RXR-gamma. target. DB00755. Tretinoin. Nuclear receptor subfamily 0 group B member 1. target ... Tretinoin. Cellular retinoic acid-binding protein 1. transporter. DB00755. Tretinoin. Cellular retinoic acid-binding protein 2 ...
  https://www.drugbank.ca/categories/DBCAT000332
*  Renal Fellow Network: October 2012
I was recently rounding on a gentleman in the ICU with acute promyelocytic leukemia (APL) who, after starting induction therapy ... Luckily, it is highly responsive to therapy which usually includes tretinoin. Tretinoin allows the terminal differentiation of ... Recall that APL is a variant of acute myeloid leukemia (AML). APL is typically defined by the presence of a fusion gene linking ... ACEi/ARB (13) acid-base (46) acute kidney injury (77) amyloidosis (15) ANCA-associated disease (20) anemia of chronic kidney ...
  http://renalfellow.blogspot.com/2012/10/
*  Fludarabine/Carboplatin/Topotecan w/Thalidomide for Relapsed/Refractory AML, CML and MDS
intensive induction chemotherapy. - Acute promyelocytic leukemia. - t(15, 17). - Failed prior treatment with tretinoin and ... Acute myeloid leukemia meeting 1 of the following criteria:. - Previously untreated and not a candidate for anthracycline-based ... with no more than 1 prior intensive induction regimen. - Chronic myelogenous leukemia in blast crisis at diagnosis or after ... Determine the response rate of patients with relapsed/refractory or high-risk acute. myeloid leukemia, chronic myelogenous ...
  http://www.knowcancer.com/cancer-trials/NCT00053287/
*  acute promyelocytic leukemia | JillinoisRN
... tretinoin , 3 Replies Limitations Don't Define Who I Am. Posted on February 12, 2013. by JillinoisRN ... I was pretty sick in the hospital for six weeks… and initially I lost weight on the induction chemo. Then came the ... Tagged acute promyelocytic leukemia, acute promyelocytic leukemia apl, anxiety, APL, cancer, cancer effects, chemo brain, ... and acute promyelocytic leukemia (APL), or acute myelocytic leukemia- subtype M-3. The longterm effects of chemo have been ...
  https://jillinoisrn.com/tag/acute-promyelocytic-leukemia/
*  Retinoic acid syndrome - Wikipedia
"Clinical and biological features of acute promyelocytic leukemia patients developing retinoic acid syndrome during induction ... It is important for patients to discontinue the use of tretinoin due to the elevation of white blood cells and possible low ... is a potentially life-threatening complication observed in patients with acute promyelocytic leukemia (APML) and first thought ... Tallman MS (February 2002). "Retinoic acid syndrome: a problem of the past?". Leukemia. 16 (2): 160-1. doi:10.1038/sj.leu. ...
  https://en.wikipedia.org/wiki/Retinoic_acid_syndrome
*  Uitleg en opsomming van effecten van bepaalde supplementen en anti-oxidanten als aanvulling bij reguliere behandelingen van...
Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med 1991;324:1385- ... Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc Natl Acad Sci 1980;77 ... RA in vitro demonstrates growth inhibitory activity against at least 14 types of human cancers.24 Acute promyelocytic leukemia ... All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical Results. Blood 1990;76:1704- ...
  http://kanker-actueel.nl/NL/uitleg-en-opsomming-van-effecten-van-bepaalde-supplementen-en-anti-oxidanten-als-aanvulling-bij-reguliere-behandelingen-van-kanker.html
*  Idamycin PFS (idarubicin hydrochloride) dose, indications, adverse effects, interactions... from PDR.net
For induction therapy or post-remission therapy in adults with acute myelogenous leukemia (AML) in combination with cytarabine ... For the treatment of acute promyelocytic leukemia (APL). For the treatment of APL, in combination with other approved ... In a subgroup analysis of the AIDA 0493 study, induction therapy with tretinoin plus idarubicin resulted in a post-induction ... Following induction therapy with tretinoin (45 mg/m2/day PO in 2 divided daily doses until complete remission (CR) or a maximum ...
  http://www.pdr.net/drug-summary/Idamycin-PFS-idarubicin-hydrochloride-1018
*  Fludarabine/Carboplatin/Topotecan w/Thalidomide for Relapsed/Refractory AML, CML and MDS - Full Text View - ClinicalTrials.gov
Acute promyelocytic leukemia. *t(15, 17). *Failed prior treatment with tretinoin and arsenic ... Secondary to chemotherapy or an antecedent hematologic disorder and treated with no more than 1 prior intensive induction ... recurrent adult acute myeloid leukemia. secondary acute myeloid leukemia. untreated adult acute myeloid leukemia. blastic phase ... core binding factor acute myeloid leukemia cytogenetically normal acute myeloid leukemia familial acute myeloid leukemia with ...
  https://clinicaltrials.gov/ct2/show/NCT00053287
*  Homoharringtonine in Treating Patients With Refractory Acute Promyelocytic Leukemia - Full Text View - ClinicalTrials.gov
Refractory to tretinoin, anthracyclines, and arsenic-based therapy (including arsenic trioxide) and for which no other ... Patients who achieve a CR during induction therapy receive maintenance therapy comprising HH IV continuously on days 1-7. ... adult acute promyelocytic leukemia (M3). childhood acute promyelocytic leukemia (M3). adult acute myeloid leukemia with t(15;17 ... Leukemia. Leukemia, Promyelocytic, Acute. Neoplasms by Histologic Type. Neoplasms. Leukemia, Myeloid, Acute. Leukemia, Myeloid ...
  https://clinicaltrials.gov/ct2/show/NCT00030355?cond=%22Acute+promyelocytic+leukemia%22&rank=20
*  Leukemia 2011 TOM CLARKE
Acute Promyelocytic Leukemia (APL) Treatment. APL is the M3 subtype of AML (see Table 1 on page 11). Patients with APL are ... is a standard component of induction therapy for APL. ATRA is also known as tretinoin (Vesanoid®). Retinoic acid is capable of ... including acute myelogenous leukemia, acute myelocytic leukemia, acute myeloblastic leukemia and acute granulocytic leukemia. ... The four major types of leukemia are acute myeloid leukemia, chronic myeloid leukemia, acute lymphoblastic leukemia and chronic ...
  http://spotidoc.com/doc/67509/leukemia-2011-tom-clarke
*  Cancernet - Universidad de Chile
Warrell RP Jr, Frankel SR, Miller WH Jr, et al.: Differentiation therapy of acute promyelocytic leukemia with tretinoin (all- ... Special consideration must be given to induction therapy for acute promyelocytic leukemia (PML). Oral administration of ... mixed phenotype acute leukemias, mixed lineage acute leukemias, and hybrid acute leukemias) are types of acute leukemia in ... Acute Leukemias of Ambiguous Lineage. Acute leukemias of ambiguous lineage (also known as acute leukemias of undetermined ...
  http://bitmed.med.uchile.cl/Summary.html/CDR62869.html
*  AIDA 2000 Guidelines - Full Text View - ClinicalTrials.gov
Leukemia, Promyelocytic, Acute. Neoplasms by Histologic Type. Neoplasms. Leukemia, Myeloid, Acute. Leukemia, Myeloid. Tretinoin ... Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults ... However, secondary acute promyelocytic leukemia following 'cured' Hodgkin's disease or otehr cured malignancies may be included ... BMI correlates with higher risk of disease relapse and differentiation syndrome in patients with acute promyelocytic leukemia ...
  https://clinicaltrials.gov/ct2/show/NCT01064570?cond=%22Acute+promyelocytic+leukemia%22&rank=11
*  Teva pharmaceutical Industries | Investor Relations | News Release
In combination with tretinoin for treatment of adults with newly-diagnosed low-risk acute promyelocytic leukemia (APL) whose ... as late as the second month induction therapy. When TRISENOX is used in combination with tretinoin, prednisone prophylaxis is ... Differentiation Syndrome: Patients with acute promyelocytic leukemia (APL) treated with TRISENOX have experienced symptoms of ... approved first line treatment option for patients with acute promyelocytic leukemia." The new indication reinforces the current ...
  http://ir.tevapharm.com/phoenix.zhtml?c=73925&p=irol-newsArticle&ID=2326522
*  Steven Coutre | Stanford Medicine Profiles
Determinants of fatal bleeding during induction therapy for acute promyelocytic leukemia in the ATRA era. Blood Mantha, S., ... We randomized 481 patients (age ≥ 15 years) with untreated APL to either a standard induction regimen of tretinoin, cytarabine ... Classification and Risk Stratification for Acute Promyelocytic Leukemia CLINICAL LYMPHOMA MYELOMA & LEUKEMIA Coutre, S. 2010; ... acute lymphoid leukemia, chronic lymphocytic leukemia, chronic myeloid leukemia, multiple myeloma, prolymphocytic leukemia, ...
  https://med.stanford.edu/profiles/steven-coutre
*  Plus it
Koeffler H. P. Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood, 62: 709 ... marker isolated from human acute promyelocytic leukemia (M3). Blood, 77: 1080-1086, 1991. ... 25-dihydroxyvitamin D3 for growth inhibition and differentiation induction of human myelomonocytic leukemia cells by tretinoin ... 3 The abbreviations used are: AML, acute myeloid leukemia; ALL, acute lymphoblastic leukemia; CBP, cAMP-responsive element ...
  http://cancerres.aacrjournals.org/content/60/4/1139
*  Plus it
Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N. Engl. J. Med., 324: 1385- ... Takahashi N., Kubo Y., Iwahori A., Kawai K., Fukui T. Induction of apoptosis in the human promyelocytic leukemia cell line HL60 ... Clinically, patients with acute promyelocytic leukemia may initially respond to RA therapy with complete remission (39, 40, 41 ... Takahashi N., Iwahori A., Kawai K., Fukui T. Induction of differentiation in human promyelocytic leukemia cell line HL60 by a ...
  http://clincancerres.aacrjournals.org/content/7/11/3551
*  Plus it
Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med 1991;324:1385-93 ... Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by ... acute lymphoblastic leukemia, and acute myelogenous leukemia (AML). Samples were obtained during routine diagnostic procedures ... All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood 1990;76:1704- ...
  http://mct.aacrjournals.org/content/3/10/1249
*  Acute Promyelocytic Leukaemia | Springer for Research & Development
Acute Promyelocytic Leukaemia (APL) has drawn the attention of clinicians and scientists for its clinical and biological ... Lo-Coco F, Avvisati G, Vignetti M. Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk- ... Tretinoin toxicity in children with acute promyelocytic leukaemia. Lancet 1993; 342: 1394-1395.PubMedCrossRefGoogle Scholar ... Otero JC, Santillana S, Fereyros G. High frequency of acute promyelocytic leukemia among Latinos with acute myeloid leukemia. ...
  https://rd.springer.com/chapter/10.1007/978-0-387-69062-9_5
*  Azacitidine and Sonidegib in Treating Patients With Myeloid Malignancies - Mayo Clinic
Acute promyelocytic leukemia (APL, M3) unless failed regimens that included tretinoin, arsenic trioxide, anthracyclines and ... Relapsed or refractory AML exposed to ≤ 3 prior regimens (note, induction and consolidation including stem cell transplantation ... Acute myocardial infarction within 3 months. *Corrected Fridericia's QT (QTcF) > 450 msec for males and > 470 msec for females ... Active uncontrolled central nervous system (CNS) leukemia; NOTE: Positive (cyto)pathology is allowed and patient can receive ...
  http://www.mayo.edu/research/clinical-trials/cls-20111752
*  Vorinostat, Cytarabine, and Etoposide in Treating Patients With Relapsed and/or Refractory Acute Leukemia or Myelodysplastic...
Patients with acute promyelocytic leukemia t(15;17) must have failed prior tretinoin and arsenic trioxide-containing regimen ... No more than 3 prior courses of induction/reinduction chemotherapy, including induction and consolidation therapy or induction ... Acute Promyelocytic Leukemia Acute Myeloblastic Leukemia With Maturation Acute Myeloblastic Leukemia Without Maturation Acute ... Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Adult Acute Myelomonocytic Leukemia (M4) Adult Acute Promyelocytic Leukemia ...
  https://clinicaltrials.gov/ct2/show/NCT00357305?cond=%22Acute+myeloblastic+leukemia+with+maturation%22&rank=6
*  A Phase I Study of Bexarotene, a Retinoic X Receptor Agonist, in Non-M3 Acute Myeloid Leukemia | Clinical Cancer Research
Differentiation therapy of acute promyelocytic leukemia with tretinoin. N Engl J Med 1991;324:1385-93. ... Eighty-nine percent had had prior induction chemotherapy with 59% having had ≥2 induction attempts. Nineteen percent had ... All-trans retinoic-acid (ATRA) is a well-studied and effective treatment for acute promyelocytic leukemia (APL; refs. 1-3). APL ... Acute promyelocytic leukemia as a paradigm for targeted therapy. Semin Hematol 2004;41:27-32. ...
  http://clincancerres.aacrjournals.org/content/14/17/5619.long
*  Retinol - Wikipedia
... is used as chemotherapy for acute promyelocytic leukemia, a subtype of acute myelogenous leukemia. This is because cells of ... Retinoic acid, termed Tretinoin in clinical usage, is used in the treatment of acne and keratosis pilaris in a topical cream. ... It has numerous applications in the experimental induction of stem cell differentiation; amongst these are the differentiation ... Vitamin A acute toxicity occurs when an individual ingests vitamin A in large amounts more than the daily recommended value in ...
  https://en.wikipedia.org/wiki/Retinol