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*  Stephan Busque | Stanford Medicine Profiles
Chimerism, Graft Survival, and Withdrawal of Immunosuppressive Drugs in HLA Matched and Mismatched Patients After Living Donor ... While transplantation without transfusion of intraoperative RBCs was associated with superior patient and graft survival, these ... Kidney and Blood Stem Cell Transplantation That Eliminates Requirement for Immunosuppressive Drugs Recruiting The Stanford ... There were nine graft losses other than deaths with a functioning graft, of which six were preceded by delayed graft function ( ...
  https://med.stanford.edu/profiles/stephan-busque
*  Origin of neointimal endothelium and α-actin-positive smooth muscle cells in transplant arteriosclerosis
Graft survival rates are significantly improved after solid organ transplantation since the introduction of new ... immunosuppressive drugs in the last two decades. From that time, not acute rejection but CTD and TA have become a major problem ... Again, three grafts were analyzed and from each graft eight nuclei were isolated. After allogeneic cardiac transplantation, ... Three months after transplantation, irradiated grafts showed severe TA, similar to nonirradiated grafts, suggesting recipient ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC209313/
*  Potential and Limitation of HLA-Based Banking of Human Pluripotent Stem Cells for Cell Therapy
... transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy. ... and HLA-DR for the long-term graft survival in addition to immunosuppressive drugs. Although important progresses have been ... "Effect of human leukocyte antigen compatibility on kidney graft survival: comparative analysis of two decades," Transplantation ... Consequently, immunosuppressive treatments are mandatory in protocols of transplantation to reduce the risk of rejection. ...
  https://www.hindawi.com/journals/jir/2014/518135/
*  Immunomodulatory plasticity of mesenchymal stem cells: a potential key to successful solid organ transplantation | SpringerLink
Immunosuppressive (IS) drugs employed to maintain the allograft have shown excellent... ... Organ transplantation remains to be a treatment of choice for patients suffering from irreversible organ failure. ... Immunosuppressive (IS) drugs employed to maintain the allograft have shown excellent short-term graft survival, but, their long ... Immunosuppressive drugs for kidney transplantation. N Engl J Med. 2004;351(26):2715-29.PubMedCrossRefGoogle Scholar ...
  https://link.springer.com/article/10.1186/s12967-018-1403-0
*  Frontiers | Differential Sensitivity of Regulatory and Effector T Cells to Cell Death: A Prerequisite for Transplant Tolerance ...
... immunosuppressive therapies currently used to prevent graft rejection are still endowed with severe side effects impairing ... immunosuppressive therapies currently used to prevent graft rejection are still endowed with severe side effects impairing ... Thus, the development of graft-specific, non toxic innovative therapeutic strategies has become a major challenge, the goal ... Thus, the development of graft-specific, non toxic innovative therapeutic strategies has become a major challenge, the goal ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2015.00242/full
*  Delayed Graft Function Summary Report | CureHunter
The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION. ... General dysfunction of an organ occurring immediately following its transplantation. ... and in the case of clinical trials performed to assess the safety and efficacy of new immunosuppressive drugs.". 01/01/2009 - " ... "Mycophenolate mofetil improves long-term graft survival following renal transplantation in patients experiencing delayed graft ...
  http://www.curehunter.com/public/keywordSummaryD051799-Delayed-Graft-Function.do
*  GM-CSF Restores Innate, But Not Adaptive, Immune Responses in Glucocorticoid-Immunosuppressed Human Blood In Vitro | The...
... new immunosuppressive drugs with improved efficacy and decreased toxicity has led to a substantial improvement in the survival ... Natural killer cell and αβ and γδ lymphocyte traffic into the liver graft immediately after liver transplantation. ... The survival of the animals and the acceptance of the graft were assessed daily over a period of 4 wk. The immunosuppressed and ... GM-CSF does not promote skin graft rejection, but enables the survival of infected immunosuppressed and transplanted mice. We ...
  http://www.jimmunol.org/content/171/2/938
*  New Transplant Possible Breakthrough! - Hepatitis Social - MedHelp
... doctors say they have developed a technique that could free many patients from having to take anti-rejection drugs for the rest ... With all successful transplantation, both graft and recipient become genetic composites. Where donors were available, chimerism ... So, liver transplant recipients are sometimes weened off all immunosuppressive drugs even without the donor bone marrow. I ... A majority of liver recipients have been able to acquire an immunosuppressant-free state after 10-year survival. Animal models ...
  https://www.medhelp.org/posts/Hepatitis-Social/New-Transplant-Possible-Breakthrough/show/413529
*  Transplantation and the Use of Raltegravir in HIV-Infected Patients - Full Text View - ClinicalTrials.gov
Determine graft survival and performance following transplantation in this population and compare to similar data in HIV- ... the potential interactions with commonly used immunosuppressive drugs, and the pharmacokinetic (PK) /pharmacodynamic (PD) ... Evaluate drug-drug interactions between raltegravir and current transplant immunosuppressant regimens.. *Determine RAL ... drug-drug interactions with raltegravir are infrequent. The absence of such concerns appears to make raltegravir a potentially ...
  https://clinicaltrials.gov/ct2/show/NCT01793467?term=%22+January+23%2C++2013%22%3A%22+February+22%2C++2013%22%5BFIRST-RECEIVED-DATE%5DAND+HIV%5BCONDITION%5D&rank=6
*  The X-Linked Inhibitor of Apoptosis Protein Enhances Survival of Murine Islet Allografts | Diabetes
Early attempts at clinical islet transplantation used corticosteroids in combination with other immunosuppressive drugs and ... Graft survival curves were generated using Kaplan-Meier life-table analysis, and the two survival curves were compared using ... and the potential for long-term survival of these grafts remains unknown. Moreover, clinical islet transplantation is still ... Graft survival analysis.. Nonfasting, morning blood glucose concentrations were measured every 2nd day posttransplant on tail ...
  http://diabetes.diabetesjournals.org/content/54/9/2533
*  Universal Stem Cell Product Could Overcome Key Challenges in Donor Organ T... (Durham NC (PRWEB) July 09 2013 An int...)
... team of researchers published results demonstrating that a universal stem cell product increases the long-term survival of ... "If transplantation procedures could be conducted with lower requirements for immunosuppressive drugs, this could provide a ... "In the group with no treatment, the grafts were rejected in less than two weeks; short term immunosuppressive drug treatments ... rats given a combination of short-term immunosuppressive treatment and MAPC exhibited a high percentage of prolonged survival, ...
  http://www.bio-medicine.org/biology-technology-1/Universal-Stem-Cell-Product-Could-Overcome-Key-Challenges-in-Donor-Organ-Transplants-26760-1/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, long term high-dose multi-drug immunosuppressive therapy is required to ensure graft survival, bearing the risk of ... graft arteriosclerosis, GA, mouse models, transplantation, graft, vessels, arteries, mouse, animal model, surgical techniques ... To date, orthotopic hind limb transplantation in rats has been the preferred rodent model for reconstructive transplantation ( ... the majority of IBM patients are not responsive to treatment with immunosuppressive or immunomodulatory drugs to counteract ...
  https://www.jove.com/visualize/abstract/24587248/mebendazole-reduces-vascular-smooth-muscle-cell-proliferation
*  Assessment Of the Safety and Benefit of Prospective Immunosuppressive Drug Withdrawal in Liver Transplantation and Prediction...
In liver transplantation up to 20% of recipients can completely discontinue immunosuppressive therapy maintaining normal graft ... Operational tolerance defined as liver transplant survival with immunosuppressive drug interruption and without liver ... Assessment Of the Safety and Benefit of Prospective Immunosuppressive Drug Withdrawal in Liver Transplantation and Prediction ... ASSESSMENT OF THE SAFETY AND BENEFIT OF PROSPECTIVE IMMUNOSUPPRESSIVE DRUG WITHDRAWAL IN LIVER TRANSPLANTATION AND PREDICTION ...
  https://clinicaltrials.gov/ct2/show/NCT00647283
*  Short-Bowel Syndrome: Background, Anatomy, Pathophysiology
Better graft survival rates are achieved when patients receive their transplant before complications secondary to short-gut ... The discovery and clinical implementation of powerful immunosuppressive drugs, such as FK506 (tacrolimus) and cyclosporine A, ... Intestinal transplantation was first attempted in dogs in 1959. The procedures failed because of the great concentration of ... Data from Howard et al and Ladefoged et al revealed that the 4-year survival rate in patients who depend on parenteral ...
  https://emedicine.medscape.com/article/193391-overview
*  WHO | How can we achieve global equity in provision of renal replacement therapy?
2), and survival can be complicated by the affordability of immunosuppressive drugs, malnutrition and infectious disease, in ... Maximizing graft survival through exploration of barriers to optimal care such as poor affordability of immunosuppressive ... Kidney transplantation. Successful kidney transplantation is associated with significant improvements in survival and quality ... Transplantation 2005; 79: 53-66.. *Global Alliance for Transplantation. Strategic direction setting and operational guidelines ...
  http://www.who.int/bulletin/volumes/86/3/07-041715/en/
*  About Us | Pitt Immunology Symposium | University of Pittsburgh
... clinical liver transplantation and introduced the immunosuppressive drugs that revolutionized clinical transplantation, STI's ... clinical research programs seek to improve short and long-term graft and patient survival through innovation and translation of ... Thomas E. Starzl Transplantation Institute. The Starzl Transplantation Institute (STI) is a multidisciplinary environment where ... We are seeking answers that will provide the solutions to transplantation's most challenging problems. In the tradition of our ...
  http://immunology-events.pitt.edu/about-us
*  ORBi: Browsing ORBi
However, so far, there are no data indicating that mycophenolate mofetil increases liver transplant patient or graft survivals ... Mycophenolate mofetil is an important drug in the modern immunosuppressive arsenal. Mycophenolate mofetil is the semisynthetic ... In randomised trials, mycophenolate mofetil decreased the rate of acute rejection after liver transplantation, without a ... Mycophenolate mofetil is an important drug in the modern immunosuppressive arsenal. Mycophenolate mofetil is the semisynthetic ...
  http://orbi.ulg.ac.be/browse?type=type&sort_by=1&order=DESC&rpp=100&etal=3&value=%23A00&offset=38100
*  Organ transplantation and skin cancer: basic problems and new perspectives - Zurich Open Repository and Archive
... photosensitization by drugs, the impact of immunosuppressive drugs and inflammation as a driver of carcinogenesis. ... Solid organ transplant and subsequent graft survival have increased worldwide, while immunosuppression has prevented rejection ... photosensitization by drugs, the impact of immunosuppressive drugs and inflammation as a driver of carcinogenesis. ... Solid organ transplant and subsequent graft survival have increased worldwide, while immunosuppression has prevented rejection ...
  http://www.zora.uzh.ch/id/eprint/41825/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, long term high-dose multi-drug immunosuppressive therapy is required to ensure graft survival, bearing the risk of ... Orthotopic liver transplantation (OLT) in rats using a whole or partial graft is an indispensable experimental model for ... To date, orthotopic hind limb transplantation in rats has been the preferred rodent model for reconstructive transplantation ( ... Medicine, Issue 80, Upper Extremity, Swine, Microsurgery, Tissue Transplantation, Transplantation Immunology, Surgical ...
  https://www.jove.com/visualize/abstract/23449685/new-workhorse-flaps-in-hand-reconstruction
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, long term high-dose multi-drug immunosuppressive therapy is required to ensure graft survival, bearing the risk of ... after liver transplantation. Rapid regeneration is also considered essential for the survival of SFS grafts. ... graft arteriosclerosis, GA, mouse models, transplantation, graft, vessels, arteries, mouse, animal model, surgical techniques ... Orthotopic liver transplantation (OLT) in rats using a whole or partial graft is an indispensable experimental model for ...
  https://www.jove.com/visualize/abstract/24709852/suppression-graft-regeneration-not-ischemiareperfusion-injury-is
*  Nonmyeloablative allogeneic hematopoietic stem cell transplantation for autoimmune disease - Pavletic - 2004 - Arthritis &...
... the use of immunosuppressive drugs for GVHD prevention, and the establishment of a donor immune system that may replace a " ... Graft-versus-leukemia reactions after bone marrow transplantation. Blood 1990; 75: 555-62.. *PubMed , ... Chronic GVHD is of particular concern due to its potential impact on survival and quality of life, and better prevention ... Graft rejection, which represents a rare but lethal complication after myeloablative transplantation, is slightly more common ...
  http://onlinelibrary.wiley.com/doi/10.1002/art.20452/full
*  Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction | Proceedings of the...
In vivo immunosuppressive effect of tautomycetin on graft survival after heterocardiac transplantation in rat ... These drugs are effective immunosuppressive agents, but they are not free of problems. Because calcineurins are found in many ... Immunosuppressive Effect of TMC in Vivo.. To assess the in vivo immunosuppressive effect of TMC, we measured allograft survival ... As shown in Table 1, graft survival was prolonged for more than 100 days in the CsA-treated group. The grafted heart survived ...
  http://www.pnas.org/content/99/16/10617?ijkey=1b4bb1b824b40f595d78b2a8fcbd45e5f70b8584&keytype2=tf_ipsecsha
*  Plus it
... could not only prolong graft survival but might also enable decreased concentrations of immunosuppressive drugs to be effective ... Islet alone versus islet after kidney transplantation: metabolic outcomes and islet graft survival. Transplantation 2009;88:820 ... Histologic graft assessment after clinical islet transplantation. Transplantation 2009;88:1286-1293pmid:19996928. ... Since immunosuppressive drugs (26) and the immune attack on islets could contribute to β-cell dysfunction in grafts, we also ...
  http://diabetes.diabetesjournals.org/content/63/1/12
*  Immunosuppression after renal transplantation
In these two studies the graft survival rates at 1 year were 90% or higher in the rapamycin groups. The immunosuppressive ... The use of anti-fibrogenic ancillary drugs may help. Finally, one of the most challenging issues in organ transplantation is ... graft survival over 3-year follow-up showed that the cumulative incidence of graft loss (including graft loss as a result of ... Immunosuppressive effects of a sirolimus/cyclosporine combination regimen for renal transplantation. Transplantation 1998; 66: ...
  https://www.uninet.edu/cin2000/conferences/Grinyo/Grinyo.htm
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, long term high-dose multi-drug immunosuppressive therapy is required to ensure graft survival, bearing the risk of ... To date, orthotopic hind limb transplantation in rats has been the preferred rodent model for reconstructive transplantation ( ... bone grafting, regenerative therapy, chondrocytes, cell culture, isolation, transplantation, animal model ... focusing on the transplantation methods and subsequent outcome measures to analyze the efficacy of cell transplantation. ...
  https://www.jove.com/visualize/abstract/24098678/long-term-evaluation-impact-autologous-peripheral-blood-stem-cell