*  Mycophenolic acid - Wikipedia
... it would become an immunosuppressive drug that could be used for autoimmune diseases and in organ transplantation. In 1981 he ... "Mycophenolate mofetil decreases acute rejection and may improve graft survival in renal transplant recipients when compared ... It was first approved by the US Food and Drug Administration on 3 May 1995 for use in kidney transplantation. Mycophenolate is ... doi:10.1016/S0140-6736(14)60635-8. Allison, Anthony C (2000). "Immunosuppressive drugs: the first 50 years and a glance forward ...
  https://en.wikipedia.org/wiki/Mycophenolic_acid
*  Stephan Busque | Stanford Medicine Profiles
Chimerism, Graft Survival, and Withdrawal of Immunosuppressive Drugs in HLA Matched and Mismatched Patients After Living Donor ... While transplantation without transfusion of intraoperative RBCs was associated with superior patient and graft survival, these ... Kidney and Blood Stem Cell Transplantation That Eliminates Requirement for Immunosuppressive Drugs Recruiting The Stanford ... There were nine graft losses other than deaths with a functioning graft, of which six were preceded by delayed graft function ( ...
  https://med.stanford.edu/profiles/stephan-busque
*  Origin of neointimal endothelium and α-actin-positive smooth muscle cells in transplant arteriosclerosis
Graft survival rates are significantly improved after solid organ transplantation since the introduction of new ... immunosuppressive drugs in the last two decades. From that time, not acute rejection but CTD and TA have become a major problem ... Again, three grafts were analyzed and from each graft eight nuclei were isolated. After allogeneic cardiac transplantation, ... Three months after transplantation, irradiated grafts showed severe TA, similar to nonirradiated grafts, suggesting recipient ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC209313/
*  Potential and Limitation of HLA-Based Banking of Human Pluripotent Stem Cells for Cell Therapy
... transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy. ... and HLA-DR for the long-term graft survival in addition to immunosuppressive drugs. Although important progresses have been ... "Effect of human leukocyte antigen compatibility on kidney graft survival: comparative analysis of two decades," Transplantation ... Consequently, immunosuppressive treatments are mandatory in protocols of transplantation to reduce the risk of rejection. ...
  https://www.hindawi.com/journals/jir/2014/518135/
*  Ischemia time legal definition of ischemia time
... immunosuppressive drugs regimen, time to diuresis, and cause of ESRD did not influence the survival rate.. Graft survival rate ... status at time of transplantation, diabetes mellitus, cause of liver disease, and serum albumin.. Study Identifies Factors to ...
  https://legal-dictionary.thefreedictionary.com/ischemia+time
*  Immunomodulatory plasticity of mesenchymal stem cells: a potential key to successful solid organ transplantation | SpringerLink
Immunosuppressive (IS) drugs employed to maintain the allograft have shown excellent... ... Organ transplantation remains to be a treatment of choice for patients suffering from irreversible organ failure. ... Immunosuppressive (IS) drugs employed to maintain the allograft have shown excellent short-term graft survival, but, their long ... Immunosuppressive drugs for kidney transplantation. N Engl J Med. 2004;351(26):2715-29.PubMedCrossRefGoogle Scholar ...
  https://link.springer.com/article/10.1186/s12967-018-1403-0
*  Liver Transplantation: Non-Adherence to Treatment Regime Linked to Adverse Clinical Outcomes in Organ Recipients
Over the past decade, advances in surgical techniques and immunosuppressive drug therapies have resulted in improved survival ... Unfortunately, non-adherence to post-transplantation treatment results in 15% of graft losses and about 50 % of late acute ... Brief overviews of drug interactions in liver transplant patients. Drug interactions with immunosuppressive medications can ... All of the immunosuppressive drugs together increase the risk of infection and cancer. It is important to have regular checkups ...
  https://www.medindia.net/news/healthinfocus/liver-transplantation-non-adherence-to-treatment-regime-linked-to-adverse-clinical-outcomes-in-organ-recipients-145605-1.htm
*  Frontiers | Differential Sensitivity of Regulatory and Effector T Cells to Cell Death: A Prerequisite for Transplant Tolerance ...
... immunosuppressive therapies currently used to prevent graft rejection are still endowed with severe side effects impairing ... immunosuppressive therapies currently used to prevent graft rejection are still endowed with severe side effects impairing ... Thus, the development of graft-specific, non toxic innovative therapeutic strategies has become a major challenge, the goal ... Thus, the development of graft-specific, non toxic innovative therapeutic strategies has become a major challenge, the goal ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2015.00242/full
*  Frontiers | Live Images of Donor Dendritic Cells Trafficking via CX3CR1 Pathway | Immunology
... heart graft into BALB/c recipient model.Results: Majority of GFP positive cells located in the middle of cardiac myocyte and ... heart graft into BALB/c recipient model. Results: Majority of GFP positive cells located in the middle of cardiac myocyte and ... images from 72hours at cardiac graft showed many of GFP positive cells move to vessel areas. In addition, significant ... images from 72hours at cardiac graft showed many of GFP positive cells move to vessel areas. In addition, significant ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00412/full
*  Delayed Graft Function Summary Report | CureHunter
The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION. ... General dysfunction of an organ occurring immediately following its transplantation. ... and in the case of clinical trials performed to assess the safety and efficacy of new immunosuppressive drugs.". 01/01/2009 - " ... "Mycophenolate mofetil improves long-term graft survival following renal transplantation in patients experiencing delayed graft ...
  http://www.curehunter.com/public/keywordSummaryD051799-Delayed-Graft-Function.do
*  Protocols and Video Articles Authored by Tobias Deuse (Translated to Hebrew)
Therefore, FK778 is a novel, highly desirable immunosuppressive drug for transplantation medicine. ... To assess allograft survival, recipients were treated for a maximum of 10 days and grafts were harvested after cessation of the ... or a combination of both drugs for 10 days was used for prevention of acute graft rejection. Grafts of untreated animals were ... Beneficial immunosuppressive effects have been suggested for the combination of both drugs. The Brown Norway-Lewis rat ...
  https://www.jove.com/author/Tobias_Deuse?language=Hebrew
*  GM-CSF Restores Innate, But Not Adaptive, Immune Responses in Glucocorticoid-Immunosuppressed Human Blood In Vitro | The...
... new immunosuppressive drugs with improved efficacy and decreased toxicity has led to a substantial improvement in the survival ... Natural killer cell and αβ and γδ lymphocyte traffic into the liver graft immediately after liver transplantation. ... The survival of the animals and the acceptance of the graft were assessed daily over a period of 4 wk. The immunosuppressed and ... GM-CSF does not promote skin graft rejection, but enables the survival of infected immunosuppressed and transplanted mice. We ...
  http://www.jimmunol.org/content/171/2/938
*  New Transplant Possible Breakthrough! - Hepatitis Social - MedHelp
... doctors say they have developed a technique that could free many patients from having to take anti-rejection drugs for the rest ... With all successful transplantation, both graft and recipient become genetic composites. Where donors were available, chimerism ... So, liver transplant recipients are sometimes weened off all immunosuppressive drugs even without the donor bone marrow. I ... A majority of liver recipients have been able to acquire an immunosuppressant-free state after 10-year survival. Animal models ...
  https://www.medhelp.org/posts/Hepatitis-Social/New-Transplant-Possible-Breakthrough/show/413529
*  Transplantation and the Use of Raltegravir in HIV-Infected Patients - Full Text View - ClinicalTrials.gov
Determine graft survival and performance following transplantation in this population and compare to similar data in HIV- ... the potential interactions with commonly used immunosuppressive drugs, and the pharmacokinetic (PK) /pharmacodynamic (PD) ... Evaluate drug-drug interactions between raltegravir and current transplant immunosuppressant regimens.. *Determine RAL ... drug-drug interactions with raltegravir are infrequent. The absence of such concerns appears to make raltegravir a potentially ...
  https://clinicaltrials.gov/ct2/show/NCT01793467?term=%22+January+23%2C++2013%22%3A%22+February+22%2C++2013%22%5BFIRST-RECEIVED-DATE%5DAND+HIV%5BCONDITION%5D&rank=6
*  The X-Linked Inhibitor of Apoptosis Protein Enhances Survival of Murine Islet Allografts | Diabetes
Early attempts at clinical islet transplantation used corticosteroids in combination with other immunosuppressive drugs and ... Graft survival curves were generated using Kaplan-Meier life-table analysis, and the two survival curves were compared using ... and the potential for long-term survival of these grafts remains unknown. Moreover, clinical islet transplantation is still ... Graft survival analysis.. Nonfasting, morning blood glucose concentrations were measured every 2nd day posttransplant on tail ...
  http://diabetes.diabetesjournals.org/content/54/9/2533
*  JCI Insight - Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma
Although immunosuppressive drugs (e.g., FK506) are used to facilitate allograft survival and prevent graft-versus-host disease ... Bortezomib plays a central role as a drug in MM therapies, both in transplantation-eligible and -ineligible patients. However, ... Such resistance must be overcome if MM patients are to enjoy improved survival rates. Panobinostat, an FDA-approved drug, when ... Calcineurin inhibitors such as FK506 and cyclosporine A are widely used in clinical practice as immunosuppressive drugs (10). ...
  https://insight.jci.org/articles/view/85061
*  RFA-AI-10-019: Genomics of Transplantation Cooperative Research Program (U01, U19)
Genomics of Transplantation Cooperative Research Program (U01, U19) RFA-AI-10-019. NIAID ... Similarly, while one-year graft survival is equivalent for African-Americans and Caucasians, long-term graft survival rate is ... Similarly, the efficacy and toxicity of immunosuppressive agents have correlated with polymorphisms in drug metabolizing ... graft rejection and contribute to long-term graft survival?. Investigator(s). Are the PD/PIs, collaborators, and other ...
  https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-10-019.html
*  Research | Transplantation Laboratory | University of Helsinki
... and targeted therapy for primary graft failure, acute rejection, and chronic allograft dysfunction. ... The new immunosuppressive drugs do not prevent primary graft dysfunction or chronic allograft dysfunction. On the other hand, ... In order to improve quality of life and patient survival, we must be able to predict, which transplants are doomed to be lost ... Primary graft dysfunction is the leading cause of death within the first 30 days after transplantation. Thereafter, chronic ...
  https://www.helsinki.fi/en/researchgroups/transplantation-laboratory/research
*  Universal Stem Cell Product Could Overcome Key Challenges in Donor Organ T... (Durham NC (PRWEB) July 09 2013 An int...)
... team of researchers published results demonstrating that a universal stem cell product increases the long-term survival of ... "If transplantation procedures could be conducted with lower requirements for immunosuppressive drugs, this could provide a ... "In the group with no treatment, the grafts were rejected in less than two weeks; short term immunosuppressive drug treatments ... rats given a combination of short-term immunosuppressive treatment and MAPC exhibited a high percentage of prolonged survival, ...
  http://www.bio-medicine.org/biology-technology-1/Universal-Stem-Cell-Product-Could-Overcome-Key-Challenges-in-Donor-Organ-Transplants-26760-1/
*  Short-Bowel Syndrome: Background, Anatomy, Pathophysiology
Better graft survival rates are achieved when patients receive their transplant before complications secondary to short-gut ... The discovery and clinical implementation of powerful immunosuppressive drugs, such as FK506 (tacrolimus) and cyclosporine A, ... Intestinal transplantation was first attempted in dogs in 1959. The procedures failed because of the great concentration of ... Data from Howard et al and Ladefoged et al revealed that the 4-year survival rate in patients who depend on parenteral ...
  https://emedicine.medscape.com/article/193391-overview
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, long term high-dose multi-drug immunosuppressive therapy is required to ensure graft survival, bearing the risk of ... graft arteriosclerosis, GA, mouse models, transplantation, graft, vessels, arteries, mouse, animal model, surgical techniques ... To date, orthotopic hind limb transplantation in rats has been the preferred rodent model for reconstructive transplantation ( ... the majority of IBM patients are not responsive to treatment with immunosuppressive or immunomodulatory drugs to counteract ...
  https://www.jove.com/visualize/abstract/24587248/mebendazole-reduces-vascular-smooth-muscle-cell-proliferation
*  About Us | Pitt Immunology Symposium | University of Pittsburgh
... clinical liver transplantation and introduced the immunosuppressive drugs that revolutionized clinical transplantation, STI's ... clinical research programs seek to improve short and long-term graft and patient survival through innovation and translation of ... Thomas E. Starzl Transplantation Institute. The Starzl Transplantation Institute (STI) is a multidisciplinary environment where ... We are seeking answers that will provide the solutions to transplantation's most challenging problems. In the tradition of our ...
  http://immunology-events.pitt.edu/about-us
*  Assessment Of the Safety and Benefit of Prospective Immunosuppressive Drug Withdrawal in Liver Transplantation and Prediction...
In liver transplantation up to 20% of recipients can completely discontinue immunosuppressive therapy maintaining normal graft ... Operational tolerance defined as liver transplant survival with immunosuppressive drug interruption and without liver ... Assessment Of the Safety and Benefit of Prospective Immunosuppressive Drug Withdrawal in Liver Transplantation and Prediction ... ASSESSMENT OF THE SAFETY AND BENEFIT OF PROSPECTIVE IMMUNOSUPPRESSIVE DRUG WITHDRAWAL IN LIVER TRANSPLANTATION AND PREDICTION ...
  https://clinicaltrials.gov/ct2/show/NCT00647283
*  WHO | How can we achieve global equity in provision of renal replacement therapy?
2), and survival can be complicated by the affordability of immunosuppressive drugs, malnutrition and infectious disease, in ... Maximizing graft survival through exploration of barriers to optimal care such as poor affordability of immunosuppressive ... Kidney transplantation. Successful kidney transplantation is associated with significant improvements in survival and quality ... Transplantation 2005; 79: 53-66.. *Global Alliance for Transplantation. Strategic direction setting and operational guidelines ...
  http://www.who.int/bulletin/volumes/86/3/07-041715/en/
*  Frontiers | A Novel Model on DST-Induced Transplantation Tolerance by the Transfer of Self-Specific Donor tTregs to a Haplotype...
The mechanisms responsible for the beneficial effect on graft survival have been a topic of research and debate for decades and ... be within reach of a procedure making it possible to establish donor specific tolerance with minimal or no immunosuppressive ... The mechanisms responsible for the beneficial effect on graft survival have been a topic of research and debate for decades and ... We further suggest that that this biological process, here termed MHC-II recruitment, is a vital survival mechanism for organs ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00009/full