Renal Fellow Network: How to best design RCTs for new transplant immunosuppressives
With the advent of drugs such as calcineurin inhibitors, induction agents such as thymoglobulin, azathioprine and later MMF, ... immunosuppressive therapy (38) infectious disease (24) interstitial nephritis (20) lupus nephritis (17) membranous nephropathy ...http://renalfellow.blogspot.com/2009/10/how-to-best-design-rcts-for-new.html
Mycophenolate mofetil in the treatment of uveitis in children | British Journal of Ophthalmology
Background: Mycophenolate mofetil (MMF) is a new immunosuppressive agent that effectively controls the intraocular inflammation ... All patients were given steroids or other immunosuppressive agents before initiating treatment with MMF. ... Conclusion: The results of our study are encouraging and suggest that MMF is an effective agent also in the treatment for ...http://bjo.bmj.com/content/91/2/180
Phase 1/2 Safety and Efficacy of PLX3397 in Adults With Relapsed or Refractory Acute Myeloid Leukemia (AML) - Tabular View -...
Patients on immunosuppressive therapy post HSCT, or with clinically significant graft-versus-host disease are excluded from ... For patients whose most recent anti-tumor treatment regimen consisted of a multi-agent cocktail, the patient must have a wash- ... Patients for Part 2 may be receiving systemic immunosuppressive treatment for management of GVHD at the time of screening and ... out period of at least 4 half-lives of the agent with the longest half-life. ...https://clinicaltrials.gov/ct2/show/record/NCT01349049
Immunosuppressive compounds - Vertex Pharmaceuticals, Inc.
This invention relates to a novel class of immunosuppressive compounds having an affinity for the FK-506 binding protein (FKBP ... Once bound to this protein, the immunosuppressive compounds inhibit the ... has been demonstrated to be a potent immunosuppressive agent. Tanaka, H. et al., J. Am. Chem. Soc. 109:5031-5033 (1987). FK-506 ... The immunosuppressive compounds of this invention have an affinity for the FK-506 binding protein which is located in the ...http://www.freepatentsonline.com/5192773.html
"Immunosuppressive strategies to avoid complications: The Achilles' hee" by Gregory Smallwood
RECENT FINDINGS: Immunosuppressive protocols that avoid or minimize the use of calcineurin inhibitors hold the promise of ... SUMMARY: It is important to appreciate that the long-term benefits of new immunosuppressive strategies have yet to stand the ... RECENT FINDINGS: Immunosuppressive protocols that avoid or minimize the use of calcineurin inhibitors hold the promise of ... SUMMARY: It is important to appreciate that the long-term benefits of new immunosuppressive strategies have yet to stand the ...https://digitalcommons.pcom.edu/scholarly_papers/1191/
5 Simple Techniques For causes of yeast infection
The chain of functions consists of quite a few actions-which consist of the infectious agent, reservoir, moving into a ... or because of an infectious ailment with immunosuppressive action (these types of as with measles, malaria or HIV disease). ... exposure to antimicrobial drugs or immunosuppressive chemical compounds (as might manifest adhering to poisoning or cancer ...http://tysontxbdl.jaiblogs.com/2072272/5-simple-techniques-for-causes-of-yeast-infection
JoVE Author Search: Sfriso P
Immunosuppressive Agents, Joint, Morbidity, Patients, Skin, Syndrome, Therapeutic, Treatment, Uveitis ... Immunosuppressive Agents, Joint, Morbidity, Patients, Skin, Syndrome, Therapeutic, Treatment, Uveitis. ...http://labindex.jove.com/author/Sfriso-P
Protective Immunity Project 01 - Full Text View - ClinicalTrials.gov
The immunosuppressive regimens that have allowed the emergence of successful transplant therapy not only inhibit T cell- ... and in emerging regimens that employ agents with novel mechanisms of action, such as the CD28 costimulation blockers, and/or ... To determine the effects of chronic immunosuppressive therapies on adaptive immunity [ Time Frame: 2 years ]. *To determine the ... However, it is not well understood how immunosuppressive medications may uniquely affect the immune response to infection. This ...https://clinicaltrials.gov/ct2/show/NCT00788021
Immunosuppressive Medications for Participants in ITN005CT (NCT00014911) - Full Text View - ClinicalTrials.gov
Anti-Bacterial Agents. Anti-Infective Agents. Antibiotics, Antineoplastic. Antineoplastic Agents. Antifungal Agents. ... Immunosuppressive Agents. Mycophenolic Acid. Immunologic Factors. Physiological Effects of Drugs. Calcineurin Inhibitors. ... Immunosuppressive regimen consisting of a single agent or some combination from among the following: tacrolimus, sirolimus, ... Immunosuppressive Medications for Participants in ITN005CT (NCT00014911). Expanded access is no longer available for this ...https://clinicaltrials.gov/ct2/show/NCT01309022?term=NIAID&recr=Open&no_unk=Y&sntx=
Immune Tolerance and Alloreactivity in Liver Transplant Recipients on Different Monotherapy Immunosuppressive Agents - Full...
Antifungal Agents. Anti-Infective Agents. Dermatologic Agents. Antirheumatic Agents. Antibiotics, Antineoplastic. ... Immune Tolerance and Alloreactivity in Liver Transplant Recipients on Different Monotherapy Immunosuppressive Agents. The ... Immunosuppressive Agents. Mycophenolic Acid. Immunologic Factors. Physiological Effects of Drugs. Calcineurin Inhibitors. ... Immune Tolerance and Alloreactivity in Liver Transplant Recipients on Different Monotherapy Immunosuppressive Agents. ...https://clinicaltrials.gov/ct2/show/NCT01678937
Renal Function Optimization With Mycophenolate Mofetil (MMF) Immunosuppressor Regimes (ALHAMBRA) - Full Text View -...
Immunosuppressive Agents. Immunologic Factors. Physiological Effects of Drugs. Calcineurin Inhibitors. Enzyme Inhibitors. ... Antineoplastic Agents. Antibiotics, Antitubercular. Antitubercular Agents. Anti-Bacterial Agents. Anti-Infective Agents. ...https://clinicaltrials.gov/ct2/show/NCT00290069
Immunosuppressive Agents | SpringerLink
Induction agents, or intense immunosuppression given at the time of transplant to prevent acute rejection,... ... Hardinger K.L., Agha I.A., Brennan D.C. (2016) Immunosuppressive Agents. In: Ljungman P., Snydman D., Boeckh M. (eds) ... Induction agents, or intense immunosuppression given at the time of transplant to prevent acute rejection, include polyclonal ... Rescue agents, or medications used to treat rejection, include corticosteroids, antithymocyte globulins, and alemtuzumab. When ...https://link.springer.com/chapter/10.1007/978-3-319-28797-3_3
Immunosuppressive agents for treating IgA nephropathy | Cochrane
Immunosuppressive agents for treating IgA nephropathy. IgA nephropathy is a common kidney disease that often leads to decreased ... Immunosuppressive agents for treating IgA nephropathy. Cochrane Database of Systematic Reviews 2015, Issue 8. Art. No.: ... Evidence for treatment effects of immunosuppressive agents on mortality, infection, and cancer is generally sparse or low- ... RCTs of treatment for IgAN in adults and children and that compared immunosuppressive agents with placebo, no treatment, or ...http://www.cochrane.org/CD003965/RENAL_immunosuppressive-agents-treating-iga-nephropathy
ATC - L04AX - Other immunosuppressive agents - Drugs-about.com
Other immunosuppressive agents. The Anatomical Therapeutic Chemical (ATC) classification system from Drugs-about.com includes ... L04 - Immunosuppressive agents*L04A - Immunosuppressive agents*L04AX - Other immunosuppressive agents *L04AX01 - Azathioprine* ...http://drugs-about.com/atc/l04ax.html
Risk of serious infections associated with use of immunosuppressive agents in pregnant women with autoimmune inflammatory...
Increased risk of infections is one of the most important concerns associated with the use of immunosuppressive agents as they ... Increased risk of infections is one of the most important concerns associated with immunosuppressive agents as they ... Results 71 out of 4961 pregnant women (0.2%) treated with immunosuppressive agents experienced serious infections. The crude ... Risk of serious infections associated with use of immunosuppressive agents in pregnant women with autoimmune inflammatory ...http://www.bmj.com/content/356/bmj.j895
Intracardiac thrombosis in Behçet's Disease successfully treated with immunosuppressive agents: A case of vascular...
Keywords: Behçet disease, immunosuppressive agents, intracardiac thrombus, thrombectomy, venous thromboembolism JOURNALS FREE ... Intracardiac thrombosis in Behçet's Disease successfully treated with immunosuppressive agents: A case of vascular ... and intense immunosuppressive treatment should be considered. ...https://www.jstage.jst.go.jp/article/irdr/7/1/7_2018.01006/_article
US5349060A - Rapamycin 31-ester with N,N-dimethylglycine derivatives useful as immunosuppressive agents - Google...
... which by virtue of its immunosuppressive activity is useful in treating transplantation rejection, host versus graft disease, ... flavoring agents, suspending agents, thickening agents, colors, viscosity regulators, stabilizers or osmo-regulators. Suitable ... Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents Patent Citations (23). * Cited ... Rapamycin 31-ester with N,N-dimethylglycine derivatives useful as immunosuppressive agents Download PDF Info. Publication ...https://patents.google.com/patent/US5349060A/en
Graft Versus Host Disease Medication: Immunosuppressive agents, Immunomodulating agents, Photoactive agents, Antineoplastic...
Ig-containing immunosuppressive agent. Immunosuppressive action generally similar to that of other antilymphocyte preparations ... Therapy includes immunosuppressive agents, antimetabolite and/or chemotherapeutic agents, antibodies and/or immunoglobulins, ... Immunosuppressive agents. Class Summary. Corticosteroids are the mainstay for treatment of GVHD. Corticosteroids cause profound ... The 2-morpholinoethyl ester of mycophenolic acid (MPA), an immunosuppressive agent. Inhibits purine synthesis and proliferation ...https://emedicine.medscape.com/article/429037-medication
Pediatric Systemic Lupus Erythematosus Medication: Antimalarial agents, Corticosteroids, Immunosuppressive agents, Calcium and...
Immunosuppressive agents. Class Summary. Evaluate children with signs of active nephritis to determine the WHO classification ... These agents elicit anti-inflammatory and immunosuppressive properties, cause profound and varied metabolic effects, and modify ... Antimalarial agents. Class Summary. Rash and other minor symptoms, including musculoskeletal symptoms, can be treated with ... Select a specific agent based on patient response to medication, history of previous drug allergy or reaction, and ease of use ...https://emedicine.medscape.com/article/1008066-medication
Mitosan - Antineoplastic Agents, Immunosuppressive Agents, Alkylating Agents, ATC:L01AB01
Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the ... Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents ...http://pharmacycode.com/Mitosan.html
Long-term outcomes of keratolimbal allograft for total limbal stem cell deficiency using combined immunosuppressive agents and...
CONCLUSION Correction of ocular surface deficits combined with an immunosuppressive regimen further improves the long-term ... Long-term outcomes of keratolimbal allograft for total limbal stem cell deficiency using combined immunosuppressive agents and ... Long-term outcomes of keratolimbal allograft for total limbal stem cell deficiency using combined immunosuppressive agents and ...https://www.semanticscholar.org/paper/Long-term-outcomes-of-keratolimbal-allograft-for-of-Liang-Sheha/3fb57f86b7ecc223ddbf800d35b82f1170b7f066
Lefunomide - Immunosuppressive Agents, Antivirals, Antiparasitics, Antineoplastic Agents, Anti-inflammatory...
Leflunomide is a pyrimidine synthesis inhibitor indicated in adults for the treatment of active rheumatoid arthritis (RA). RA is an auto-immune disease characterized by high T-cell activity. T cells have two pathways to synthesize pyrimidines: the salvage pathways and the de novo synthesis. At rest, T lymphocytes meet their metabolic requirements by the salvage pathway. Activated lymphocytes need to expand their pyrimidine pool 7- to 8-fold, while the purine pool is expanded only 2- to 3-fold. To meet the need for more pyrimidines, activated T cells use the de novo pathway for pyrimidine synthesis. Therefore, activated T cells, which are dependent on de novo pyrimidine synthesis, will be more affected by leflunomide's inhibition of dihydroorotate dehydrogenase than other cell types that use the salvage pathway of pyrimidine synthesis ...http://pharmacycode.com/Lefunomide.html
Metubine - Anti-Inflammatory Agents, Non-Steroidal, Antineoplastic Agents, Dermatologic Agents, Enzyme...
Immunosuppressive Agents. Metubine Brand names, Metubine Analogs *(+)-O,O'-Dimethylchondrocurarine Di-iodide ...http://pharmacycode.com/Metubine.html
Sal amarum - Anti-Inflammatory Agents, Non-Steroidal, Dermatologic Agents, Enzyme Inhibitors, ...
Anti-Inflammatory Agents, Non-Steroidal. * Dermatologic Agents. * Enzyme Inhibitors. * Immunosuppressive Agents. * ATC:D11AX15 ...http://pharmacycode.com/Sal_amarum.html
Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults - Full Text View - ClinicalTrials...
Investigational agent within 30 days of study entry. *Other condition that, in the opinion of the investigator, would affect ... Use of corticosteroids or immunosuppressive drugs within 30 days of study entry. Participants who have used topical or nasal ...https://clinicaltrials.gov/ct2/show/NCT00537147?term=dengue&rank=92&show_xprt=Y