A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies | Retrovirology...
... partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope ... The N242T mutation in the TW10240-249 epitope is a reversion mutation [26, 27] since the subject CH0131 did not have the HLA B* ... 3a). To determine if it was selected by cryptic T cell epitopes [29, 30] from alternative expression products in the HIV-1 ... Since the K43R mutation was found in the WF9 epitope restricted by the B*35 allele that CH0131 did not carry, it was mostly ...https://retrovirology.biomedcentral.com/articles/10.1186/s12977-017-0371-4
JCI - Homeostatic control of immunity by TCR peptide-specific Tregs
T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature. 1986. 324:258-260. View this ... Kumar, V, Tabibiazar, R, Geysen, HM, Sercarz, E. Immunodominant framework region 3 peptide from TCR V beta 8.2 chain controls ... Human T cell autoimmunity against myelin basic protein: CD4+ cells recognizing epitopes of the T cell receptor beta chain from ... pathogenic T cells recognizing this immunodominant peptide predominantly express the TCR Vβ8.2 chain (19-22); and (c) the ...https://www.jci.org/articles/view/23166
Physiological induction of regulatory Qa-1-restricted CD8+ T cells triggered by endogenous CD4+ T cell responses.
T cell-dependent autoimmune diseases are characterized by the expansion of T cell clones that recognize immunodominant epitopes ... T cell-dependent autoimmune diseases are characterized by the expansion of T cell clones that recognize immunodominant epitopes ... 21950267 - Oral immunotherapy with immunodominant t-cell epitope peptides alleviates allergic reac.... 8806807 - Colchicum ...http://www.biomedsearch.com/nih/Physiological-Induction-Regulatory-Qa-1/21738737.html
RCSB PDB - 1E27: Nonstandard peptide binding of HLA-B*5101 complexed with HIV immunodominant epitope KM1(LPPVVAKEI)...
Nonstandard Peptide Binding Revealed by Crystal Structures of Hla-B5101 Complexed with HIV Immunodominant Epitopes ... Nonstandard peptide binding of HLA-B*5101 complexed with HIV immunodominant epitope KM1(LPPVVAKEI). ...http://www.rcsb.org/pdb/explore/materialsAndMethods.do?structureId=1E27
Epitopes described in Diversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the...
Includes more than 95% of all published infectious disease, allergy, autoimmune, and transplant epitope data. ... Free resource for searching and exporting immune epitopes. ...http://www.iedb.org/pmId/20164421
Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level
Infection of mice with HSV-1 or influenza virus lacking one immunodominant CD8 epitope resulted in a shifted epitope hierarchy ... Consequences of immunodominant epitope deletion for minor influenza virus-specific CD8+-T-cell responses. J. Virol. 794329-4339 ... Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level. Christoph ... In animal models, conflicting results on the consequences of the lack of immunodominant CD8 epitopes on disease control have ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2268453/?lang=en-ca
CD8+ T Cells Specific for Immunodominant Trans-Sialidase Epitopes Contribute to Control of Trypanosoma cruzi Infection but Are...
To determine if immunodominant TS-specific CD8+ T cells are necessary for resistance to infection, we epitope-tolerized mice by ... CD8+ T Cells Specific for Immunodominant Trans-Sialidase Epitopes Contribute to Control of Trypanosoma cruzi Infection but Are ... CD8+ T Cells Specific for Immunodominant Trans-Sialidase Epitopes Contribute to Control of Trypanosoma cruzi Infection but Are ... CD8+ T Cells Specific for Immunodominant Trans-Sialidase Epitopes Contribute to Control of Trypanosoma cruzi Infection but Are ...http://www.jimmunol.org/content/early/2010/06/07/jimmunol.1000432
The Cytotoxic T-Lymphocyte Response against a Poorly Immunogenic Mammary Adenocarcinoma Is Focused on a Single Immunodominant...
The AH1 Epitope Is the Immunodominant MHC Class I-restricted Antigen of TS/A Cells.. To test whether gp70-specific CTL ... It is therefore very likely that the AH1 antigenic epitope becomes the tumor immunodominant antigen of TS/A cells when they are ... To study whether the AH1 peptide represents the immunodominant epitope of anti-TS/A CTL response, we restimulated spleen cells ... which has already been demonstrated to behave as the CTL-immunodominant epitope of CT26 colon carcinoma (19) . In addition, the ...http://cancerres.aacrjournals.org/content/63/9/2158
Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope •...
Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope. ... A problem in the search for an efficient vaccine against dengue virus is the immunodominance of the fusion loop epitope (FLE), ... In contrast, antibodies targeting the E dimer epitope (EDE), readily exposed at the E dimer interface over the region of the ...https://research.pasteur.fr/en/publication/covalently-linked-dengue-virus-envelope-glycoprotein-dimers-reduce-exposure-of-the-immunodominant-fusion-loop-epitope/
Studies of HIV-1 Infection in Newly Infected Individuals in Southern Africa - Full Text View - ClinicalTrials.gov
Immunodominant Epitopes. Haplotypes. Additional relevant MeSH terms: Infection. Communicable Diseases. HIV Infections. ... Novel and promiscuous CTL epitopes in conserved regions of Gag targeted by individuals with early subtype C HIV type 1 ...https://clinicaltrials.gov/show/NCT00006298?order=77
High-Resolution Structure Analysis of Antibody V5 and U4 Conformational Epitopes on Human Papillomavirus 16.
Immunodominant Epitopes. Subunits of the antigenic determinant that are most easily recognized by the immune system and thus ... Epitopes, B-lymphocyte. Antigenic determinants recognized and bound by the B-cell receptor. Epitopes recognized by the B-cell ... The highly detailed epitopes identified for the two antibodies provide a framework for continuing biochemical, genetic and ... Combinatorial peptide-based epitope mapping from Ebola virus DNA vaccines and infections reveals residue-level determinants of ...https://www.bioportfolio.com/resources/pmarticle/1906303/High-Resolution-Structure-Analysis-of-Antibody-V5-and-U4-Conformational-Epitopes-on.html
Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of Streptococcus pneumoniae | BMC...
The aim of this work was to identify the immunodominant epitopes of pneumococcal IgA1 protease involved in the human antibody ... Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of Streptococcus pneumoniae. ... Next, the presence of immunodominant epitopes within the selected antigen fragments was investigated. To this purpose, the ... Identification of a human immunodominant B-cell epitope within the GRA1 antigen of Toxoplasma gondii by phage display of cDNA ...https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-7-113
Method for identifying and validating dominant T helper cell epitopes using an HLA-DM-assisted class II binding assay - The...
Rational design of immunotherapeutics relies on clear knowledge of the immunodominant epitopes of antigens. Current methods for ... the immunodominant epitope is preferably one that stimulates and/or is recognized by T helper cells. The immunodominant epitope ... wherein the peptide is an immunogenic or immunodominant epitope of the antigen. In this method, the immunodominant epitope is ... the role of HLA-DM in the selection of immunodominant epitopes and permits de novo identification of immunodominant epitopes in ...http://www.freepatentsonline.com/8916340.html
Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement | Virology...
... due to the immunodominant nature of this epitope; in the serocomplex cross-reactive epitopes of EDIII, since the severity of ... Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement. ... Characterization of the epitope-specific immune profile. We utilized an epitope-specific IgG ELISA  to determine the ... In this report, by manipulating potentially pathogenic, immunodominant epitopes, we have altered the antibody response to ...https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-9-115
Antibody-Targeted NY-ESO-1 to Mannose Receptor or DEC-205 In Vitro Elicits Dual Human CD8+ and CD4+ T Cell Responses with Broad...
The CD8+ T cell response against the epitope (NY-ESO-1101-109 peptide) was found to be immunodominant in two HLA-B*4002+ ... CTL induction by cross-priming is restricted to immunodominant epitopes. Eur. J. Immunol. 39: 704-716. ... 4). These results indicate that targeted NY-ESO-1 can stimulate multiple epitope-specific CD8+ T cells, including all epitope- ... the immunodominant epitopes driving the CD8+ T cell response was expected to be within the overlapping NY-ESO-1101-110 region ...http://www.jimmunol.org/content/186/2/1218.long
Patent US4340535 - Cytotoxic products formed by covalent bonding of the A chain of ricin with ... - Google Patents
Monoclonal antibody specific for non-immunodominant epitope of hiv proteins. WO1998028298A1 *. 23 Dec 1997. 2 Jul 1998. ...http://www.google.com.au/patents/US4340535
Similar articles for PubMed (Select 18507432) - PubMed - NCBI
A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes ... HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides ... Induction of CTL response by a minimal epitope vaccine in HLA A*0201/DR1 transgenic mice: dependence on HLA class II restricted ... Identification of novel HLA-DR1-restricted epitopes from the hepatitis B virus envelope protein in mice expressing HLA-DR1 and ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=18507432
Frontiers | HLA-DO and Its Role in MHC Class II Antigen Presentation | Immunology
A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes ... HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides ... model that describes DO solely as an inhibitor of DM by preventing its major role in the selection of immunodominant epitopes ( ... Poluektov Y, Kim A, Hartman IZ, Sadegh-Nasseri S. HLA-DO as the optimizer of epitope selection for MHC Class II antigen ...https://www.frontiersin.org/articles/10.3389/fimmu.2013.00260/full
Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue...
... and exposes immunodominant epitopes (70); it renders MBP more susceptible to cleavage with cathepsin D (29), and may therefore ... Thus, PAD may not only generate epitopes on structural proteins that cause autoimmune diseases but may initially function as an ... The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on ... implying the possibility of an early ontogenic immunological response toward citrullinated protein epitopes (23). ...http://jem.rupress.org/content/205/9/2085
Immunodominant HER-2/neu Peptide Epitopes Determined by in Vivo Immunogenicity Also Bind MHC Class II Molecules with High ... Thus, immunodominant HER-2/neu peptide epitopes determined by in vivo immunogenicity also bind MHC class II molecules with high ... Immunodominant HER-2/neu peptide epitopes determined by in vivo immunogenicity also bind class II molecules with high affinity. ... A possible explanation for the lack of observed immune response is potential competition of the immunodominant epitopes at the ...http://clincancerres.aacrjournals.org/content/9/15/5559
Decreased levels of interleukin-12p40 in the serum of patients with Whipple's disease | SpringerLink
Liang Z, La Scola B, Raoult D (2002) Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei. Clin Diagn Lab ...https://link.springer.com/article/10.1007%2Fs00384-005-0778-6
MHC Class II Tetramers | The Journal of Immunology
Tetramer-guided epitope mapping: rapid identification and characterization of immunodominant CD4+ T cell epitopes from complex ... Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed ... First, what is the anticipated frequency of CD4 T cells recognizing immunodominant epitopes in the system? If there is no prior ... occasionally there are immunodominant epitopes from pathogens that bind promiscuously to multiple HLA class II molecules. When ...http://www.jimmunol.org/content/188/6/2477
Direct Ex Vivo Analysis of Activated, Fas-sensitive Autoreactive T Cells in Human Autoimmune Disease | JEM
The MBPp85-99 epitope is one of the immunodominant epitopes of MBP ((6), (7), (12)). We have previously determined the TCR ... 1990) T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature (Lond) 346:183-187, ... We measured the frequency of clonally expanded and persistent T cells recognizing the immunodominant MBPp8599 epitope in ... 1994) Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J Immunol ...http://jem.rupress.org/content/185/9/1585
Recent advances in coeliac disease | Gut
Fraser JS, Engel W, Ellis HJ, et al. Coeliac disease: in vivo toxicity of the putative immunodominant epitope. Gut2003;52:1698- ... Molberg O, Uhlen AK, Jensen T, et al. Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac ... Arentz-Hansen H, McAdam SN, Molberg O, et al. Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich ... Sjostrom H, Lundin KE, Molberg O, et al. Identification of a gliadin T-cell epitope in coeliac disease: general importance of ...http://gut.bmj.com/content/55/7/1037
T cell reactivity against the SmD183-119 C terminal peptide in patients with systemic lupus erythematosus | Annals of the...
Therefore, the SmD1 protein is a crucial component to investigate its molecular structure and immunodominant epitopes. ... A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus ... Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus. J Exp Med1996;183:2459-69. ... Therefore, the SmD183-119 peptide is both a major B and T cell epitope in SLE. The addition of dsDNA to rSmD1 even enhanced the ...http://ard.bmj.com/content/61/9/779
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