*  Relation between viral fitness and immune escape within the hepatitis C virus protease | Gut
Aims: We wished to explore whether the variability of the immunodominant CTL epitope at residues 1073-1081 of the NS3 protease ... Background: The hepatitis C virus (HCV) mutates within human leucocyte antigen (HLA) class I restricted immunodominant epitopes ... Conclusions: Viral fitness can indeed limit the variability of HCV within immunological epitopes. This helps to explain why ... Introduction of mutations at five positions of the 1073-1081 epitope prevented CTL recognition but three of these reduced ...
  http://gut.bmj.com/content/55/2/266
*  The Cytotoxic T-Lymphocyte Response against a Poorly Immunogenic Mammary Adenocarcinoma Is Focused on a Single Immunodominant...
The AH1 Epitope Is the Immunodominant MHC Class I-restricted Antigen of TS/A Cells.. To test whether gp70-specific CTL ... It is therefore very likely that the AH1 antigenic epitope becomes the tumor immunodominant antigen of TS/A cells when they are ... To study whether the AH1 peptide represents the immunodominant epitope of anti-TS/A CTL response, we restimulated spleen cells ... which has already been demonstrated to behave as the CTL-immunodominant epitope of CT26 colon carcinoma (19) . In addition, the ...
  http://cancerres.aacrjournals.org/content/63/9/2158
*  A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies | Retrovirology...
... partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope ... The N242T mutation in the TW10240-249 epitope is a reversion mutation [26, 27] since the subject CH0131 did not have the HLA B* ... 3a). To determine if it was selected by cryptic T cell epitopes [29, 30] from alternative expression products in the HIV-1 ... Since the K43R mutation was found in the WF9 epitope restricted by the B*35 allele that CH0131 did not carry, it was mostly ...
  https://retrovirology.biomedcentral.com/articles/10.1186/s12977-017-0371-4
*  JCI - Homeostatic control of immunity by TCR peptide-specific Tregs
T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature. 1986. 324:258-260. View this ... Kumar, V, Tabibiazar, R, Geysen, HM, Sercarz, E. Immunodominant framework region 3 peptide from TCR V beta 8.2 chain controls ... Human T cell autoimmunity against myelin basic protein: CD4+ cells recognizing epitopes of the T cell receptor beta chain from ... pathogenic T cells recognizing this immunodominant peptide predominantly express the TCR Vβ8.2 chain (19-22); and (c) the ...
  https://www.jci.org/articles/view/23166
*  Method for identifying and validating dominant T helper cell epitopes using an HLA-DM-assisted class II binding assay - The...
Rational design of immunotherapeutics relies on clear knowledge of the immunodominant epitopes of antigens. Current methods for ... the immunodominant epitope is preferably one that stimulates and/or is recognized by T helper cells. The immunodominant epitope ... wherein the peptide is an immunogenic or immunodominant epitope of the antigen. In this method, the immunodominant epitope is ... the role of HLA-DM in the selection of immunodominant epitopes and permits de novo identification of immunodominant epitopes in ...
  http://www.freepatentsonline.com/8916340.html
*  Physiological induction of regulatory Qa-1-restricted CD8+ T cells triggered by endogenous CD4+ T cell responses.
T cell-dependent autoimmune diseases are characterized by the expansion of T cell clones that recognize immunodominant epitopes ... T cell-dependent autoimmune diseases are characterized by the expansion of T cell clones that recognize immunodominant epitopes ... 21950267 - Oral immunotherapy with immunodominant t-cell epitope peptides alleviates allergic reac.... 8806807 - Colchicum ...
  http://www.biomedsearch.com/nih/Physiological-Induction-Regulatory-Qa-1/21738737.html
*  Immunodominance: When is it set?
... the more immunodominant that epitope is.. I commented on the paper at the time and said ". It's an interesting suggestion, and ... They looked at three epitopes (for CD4, T helper, T cells, not CTL; but guesses have been that the two groups of T cells have ... I'm sure there will be more epitopes examined by this technique over the next little while, so we'll see how well it holds up. ... First, they looked at a half-dozen known epitopes and asked how many precursor CTL there were for each. Their numbers were in ...
  http://www.iayork.com/MysteryRays/2008/06/15/immunodominance-when-is-it-set/
*  RCSB PDB - 1E27: Nonstandard peptide binding of HLA-B*5101 complexed with HIV immunodominant epitope KM1(LPPVVAKEI)...
Nonstandard Peptide Binding Revealed by Crystal Structures of Hla-B5101 Complexed with HIV Immunodominant Epitopes ... Nonstandard peptide binding of HLA-B*5101 complexed with HIV immunodominant epitope KM1(LPPVVAKEI). ...
  http://www.rcsb.org/pdb/explore/materialsAndMethods.do?structureId=1E27
*  Epitopes described in Diversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the...
Includes more than 95% of all published infectious disease, allergy, autoimmune, and transplant epitope data. ... Free resource for searching and exporting immune epitopes. ...
  http://www.iedb.org/pmId/20164421
*  Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level
Infection of mice with HSV-1 or influenza virus lacking one immunodominant CD8 epitope resulted in a shifted epitope hierarchy ... Consequences of immunodominant epitope deletion for minor influenza virus-specific CD8+-T-cell responses. J. Virol. 794329-4339 ... Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level. Christoph ... In animal models, conflicting results on the consequences of the lack of immunodominant CD8 epitopes on disease control have ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2268453/?lang=en-ca
*  GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65
... af Hällström-Reijonen, ... GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65}, volume = {49}, year = { ... T-cell hybridoma T33.1, which recognizes the GAD65 274-286 epitope in the context of HLA-DRB1*0401, was incubated with antigen- ... T-cell hybridoma T33.1, which recognizes the GAD65 274-286 epitope in the context of HLA-DRB1*0401, was incubated with antigen- ...
  https://lup.lub.lu.se/search/publication/96ce042e-9215-4796-9932-ed1b8ff5d5c6
*  CD8+ T Cells Specific for Immunodominant Trans-Sialidase Epitopes Contribute to Control of Trypanosoma cruzi Infection but Are...
To determine if immunodominant TS-specific CD8+ T cells are necessary for resistance to infection, we epitope-tolerized mice by ... CD8+ T Cells Specific for Immunodominant Trans-Sialidase Epitopes Contribute to Control of Trypanosoma cruzi Infection but Are ... CD8+ T Cells Specific for Immunodominant Trans-Sialidase Epitopes Contribute to Control of Trypanosoma cruzi Infection but Are ... CD8+ T Cells Specific for Immunodominant Trans-Sialidase Epitopes Contribute to Control of Trypanosoma cruzi Infection but Are ...
  http://www.jimmunol.org/content/early/2010/06/07/jimmunol.1000432
*  Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients. - PubMed - NCBI
d Relative distribution of epitope specificities. The percent prevalence of each epitope out of all epitopes recognized among ... Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients.. Scotto M1, ... Candidate epitopes were selected by ZnT8 plasmid DNA immunisation of HLA-A2/DQ8 transgenic mice and tested for T cell ... Color lines below X-axis show the position of each epitope within the ZnT8 structure, following the color code of panel a. c ...
  https://www.ncbi.nlm.nih.gov/pubmed/22526607
*  Immuno dominant epitope in E.coli for mouse 레포트
Immuno dominant epitope in E.coli for mouse, 면역 반응을 통한 polyclonal antibody의 제조와 이 polyclonal antibody를 이용한 IFA, SDS-PAGE, ... Immuno dominant epitope in E.coli for mouse. 등록일 2000.10.09 한글 (hwp) , 23페이지 , 가격 800원 ...
  http://report.dreamwiz.com/view/2000/1026898/
*  Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope •...
Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope. ... A problem in the search for an efficient vaccine against dengue virus is the immunodominance of the fusion loop epitope (FLE), ... In contrast, antibodies targeting the E dimer epitope (EDE), readily exposed at the E dimer interface over the region of the ...
  https://research.pasteur.fr/en/publication/covalently-linked-dengue-virus-envelope-glycoprotein-dimers-reduce-exposure-of-the-immunodominant-fusion-loop-epitope/
*  RePub, Erasmus University Repository: Differential epitope recognition in the immunodominant staphylococcal antigen A of...
Differential epitope recognition in the immunodominant staphylococcal antigen A of Staphylococcus aureus by mouse versus human ... Differential epitope recognition in the immunodominant staphylococcal antigen A of Staphylococcus aureus by mouse versus human ... By epitope mapping, we show that the protective human monoclonal antibody (humAb) 1D9 recognizes a conserved 62-residue N- ... The immunodominant staphylococcal antigen A (IsaA) is a potential target for active or passive immunization against the ...
  https://repub.eur.nl/pub/101458
*  The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of...
Differential antigen processing maybe responsible for the differences in both the quality and the quantity of epitopes produced ... Our data demonstrate that the 165 DRFYKSLRA173 epitope is most efficiently processed from precursors that contain two flanking ... influencing the immunodominance hierarchy of viral epitopes. Previously, we showed that the magnitude of the HIV-2 gag-specific ... particularly when responses are directed against an epitope, 165 DRFYKSLRA173 , within the highly conserved Major Homology ...
  https://www.rdm.ox.ac.uk/publications/525475
*  Studies of HIV-1 Infection in Newly Infected Individuals in Southern Africa - Full Text View - ClinicalTrials.gov
Immunodominant Epitopes. Haplotypes. Additional relevant MeSH terms: Infection. Communicable Diseases. HIV Infections. ... Novel and promiscuous CTL epitopes in conserved regions of Gag targeted by individuals with early subtype C HIV type 1 ...
  https://clinicaltrials.gov/show/NCT00006298?order=77
*  High-Resolution Structure Analysis of Antibody V5 and U4 Conformational Epitopes on Human Papillomavirus 16.
Immunodominant Epitopes. Subunits of the antigenic determinant that are most easily recognized by the immune system and thus ... Epitopes, B-lymphocyte. Antigenic determinants recognized and bound by the B-cell receptor. Epitopes recognized by the B-cell ... The highly detailed epitopes identified for the two antibodies provide a framework for continuing biochemical, genetic and ... Combinatorial peptide-based epitope mapping from Ebola virus DNA vaccines and infections reveals residue-level determinants of ...
  https://www.bioportfolio.com/resources/pmarticle/1906303/High-Resolution-Structure-Analysis-of-Antibody-V5-and-U4-Conformational-Epitopes-on.html
*  Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of Streptococcus pneumoniae | BMC...
The aim of this work was to identify the immunodominant epitopes of pneumococcal IgA1 protease involved in the human antibody ... Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of Streptococcus pneumoniae. ... Next, the presence of immunodominant epitopes within the selected antigen fragments was investigated. To this purpose, the ... Identification of a human immunodominant B-cell epitope within the GRA1 antigen of Toxoplasma gondii by phage display of cDNA ...
  https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-7-113
*  Brain natriuretic factor | definition of Brain natriuretic factor by Medical dictionary
Synonym: immunodominant epitope. natriuretic peptide. Any peptide that stimulates the kidneys to excrete salt and water. ... immunodominant peptide. Any of the peptides having a strong affinity for binding with class I or II histocompatibility antigens ... Immunodominant peptides are produced by antigen processing, are expressed on the surface of macrophages and other antigen- ...
  https://medical-dictionary.thefreedictionary.com/Brain+natriuretic+factor
*  Fine specificity of the various IVT and AVF-specific TC | Open-i
The T cell receptor (TCR) repertoires of cytotoxic responses to the immunodominant and subdominant HLA A11-restricted epitopes ... The T cell receptor (TCR) repertoires of cytotoxic responses to the immunodominant and subdominant HLA A11-restricted epitopes ... Epitope-dependent selection of highly restricted or diverse T cell receptor repertoires in response to persistent infection by ... Epitope-dependent selection of highly restricted or diverse T cell receptor repertoires in response to persistent infection by ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2198955_JEM.970171f2&req=4
*  Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis | Journal of...
Identified NF-L epitopes induced mild neurological signs similar to the observed with the NF-L protein, yet distinct from those ... These epitopes, algorithm-predicted peptides and encephalitogenic motifs within NF-L were screened for encephalitogenicity. ... In addition, defined T-cell epitopes in the NF-L protein might be involved in the pathogenesis of the disease. ... axons was analyzed by confocal microscopy of central nervous system tissues and T-cell and antibody responses to immunodominant ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-10-118
*  ASMscience | Lyme Borreliosis
Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease. Nat. Med. 5:1375-1382.. ... and specific serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant ... Association of antibiotic treatment-resistant Lyme arthritis with T cell responses to dominant epitopes of outer-surface ...
  http://www.asmscience.org/content/book/10.1128/9781555816490.chap11