Mucosal immunity and novel tuberculosis vaccine strategies: route of immunisation-determined T-cell homing to restricted lung...
... either designed to replace BCG itself or to boost pre-existing BCG responses. In particular, viral-based booster vaccines are ... Following immunisation, local dendritic cell populations acquire antigens and subsequently migrate to the local draining lymph ... However, parenteral intramuscular immunisation is unable to provide protection despite the apparent presence of antigen- ... Therefore, there has been a pressing need for the development of new booster vaccines to enhance existing BCG-induced immunity ...http://err.ersjournals.com/content/24/136/356
Neonatal vaccination with Mycobacterium bovis BCG: potential effects as a priming agent shown in a heterologous prime-boost...
In Paper II, we investigated the role of the BCG vaccination as a priming vaccine in a heterologous prime-boost immunization ... Immunization with the same antigen during the postnatal life increased antigen-specific recall IFN-γ responses and protection ... BCG vaccine; Neonates; Heparin-binding hemagglutinin Identifiers. URN: urn:nbn:se:su:diva-39195DOI: 10.1016/j.vaccine.2009.04. ... The results showed that the neonatal BCG vaccination primed the immune system for a relevant antigen and showed a generalized ...http://su.diva-portal.org/smash/record.jsf?pid=diva2:319025
Churg-Strauss syndrome following cessation of allergic desensitization vaccination: a case report
... flu and measles vaccine and BCG (Bacillus of Calmette and Guerin) inoculation. Also to be considered is vaccine components such ... CSS has been associated with hyposensitizing immunization to candidin, polymicrobial and acarian or unspecific antigens . In ... The vaccines were first administered twice weekly, every Monday and every Wednesday for four months and again this year, for a ... leukotriene antagonists or in this case probably due to invigoration of the immune system with antigen stimulation. Here, we ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2904789/
Mucosal Vaccines, Book by Hiroshi Kiyono (Hardcover) | chapters.indigo.ca
Buy the Hardcover Book Mucosal Vaccines by Hiroshi Kiyono at Indigo.ca, Canada's largest bookstore. + Get Free Shipping on ... J. Ulmer, Current View of DNA Immunization for Mucosal Vaccines.. S. Langermann, Recombinant BCG as Vector for Mucosal Immunity ... M.R. Neutra and J.-P. Kraehenbuhl, Antigen Uptake by M Cells for Effective Mucosal Vaccines.. Mucosal Modulation for Induction ... D. Hoft, Oral BCG.. Mucosal Vaccines for Viral Diseases: P.L. Ogra, Polio Viruses and Mucosal Vaccines.. P.F. Wright, Mucosal ...https://www.chapters.indigo.ca/en-ca/books/mucosal-vaccines/9780124105805-item.html
The International Society of Travel Medicine
These specific antigens are absent in most environmental mycobacteria and most importantly all strains of BCG vaccine. ... Would you recommend any supplemental testing to determine true latent exposure to TB versus prior BCG immunization? Assuming ... who had also received BCG vaccination sometime during childhood. Since the various BCG vaccine preparations vary in efficacy ... but specificity of the TST and its positive predictive value drop considerably if one has received BCG vaccine in the past. By ...http://www.istm.org/newsshare200907
Study of AERAS-402 in Healthy Infants - Full Text View - ClinicalTrials.gov
BCG-vaccinated infants. Vaccine. 2015 Jun 9;33(25):2944-54. doi: 10.1016/j.vaccine.2015.03.070. Epub 2015 Apr 28. ... Efforts to increase TB protection in children include new vaccines for primary immunizations as well as combinations of ... It presents Mtb antigens in the setting of a new, live, replication-deficient adenovirus vaccine that may increase T cell- ... Has completed simultaneous enrollment in Aeras Vaccine Development Registry protocol. *Had BCG vaccination ≥ 3 months prior to ...https://clinicaltrials.gov/show/NCT01198366?order=164
Vaccine Therapy in Treating Patients With Transitional Cell Cancer of the Bladder
RATIONALE: Vaccines made from peptides may make the body build an immune response to kill tumor cells. Biological therapies, ... 1 Protein Immunization of Post-Cystectomy Patients With Transitional Cell Carcinomas Expressing NY-ESO-1 or LAGE-1 Antigen. ... Determine the safety and tolerability of NY-ESO-1 peptide vaccine, BCG, and. sargramostim (GM-CSF) in post-cystectomy patients ... Patients receive NY-ESO-1 peptide vaccine mixed with BCG intradermally (ID) once weekly on. weeks 1 and 2. Patients then ...http://www.knowcancer.com/cancer-trials/NCT00070070/
Anatomy and Physiology of the Immune System, Part 3 -- Natural Health Newsletter
Most vaccines, other than the flu vaccine, are based on antigens that are quite old. Even flu vaccines, though, are based on ... 3. "BCG - the current vaccine for tuberculosis." Initiative for Vaccine Research (IVR). World Health Organization. Accessed 7 ... Specific immunization involves the injection of a reduced-strength antigen into the blood to enable the body to then produce ... A vaccine is only as good as the antigen included in it. That means, that when it comes to flu vaccines, for example, they are ...https://jonbarron.org/article/anatomy-and-physiology-immune-system-part-3
Live immunizations, including rotavirus, measles, mumps, rubella, varicella, and BCG vaccines, should not be administered. ... Diagnostic assessment for occult viral infection using antigen-based assay (culture or PCR) should be carried out for EBV, CMV ... deficiency are due to mutations in key cellular proteins involved in gene recombination that form the T cell and B cell antigen ... and all live immunizations should be withheld. ...http://www.neurologyadvisor.com/pediatrics/scid-syndromes/article/619895/
... provided by results of randomized Phase III trials in which immunization with the melanoma differentiation antigen GM2 and BCG ... Cancer vaccines: single-epitope anti-idiotype vaccine versus multiple-epitope antigen vaccine. Cancer Immunol. Immunother., 49: ... Vaccines Inducing Humoral and Cellular Responses against Carbohydrate Antigens.. Breast cancer vaccines in which Tn, TF, sialyl ... BCG, Bacillus Calmette-Guérin; NDV, Newcastle disease virus; APC, antigen-presenting cell; HLA, human leukocyte antigen; GM-CSF ...http://clincancerres.aacrjournals.org/content/9/9/3222
Infections and cancer: the "fifty shades of immunity" hypothesis | BMC Cancer | Full Text
For instance, a prior immunization with BCG vaccine, which has antigenic similarity with human endogenous retroviruses (HERV-K- ... The immune recognition of specific antigens expressed by cancer cells, called tumor-associated antigens (TAA), is a necessary ... Vaccine. 2009;27:6950-8.PubMedView ArticleGoogle Scholar. *. Mastrangelo G, et al. Does yellow fever 17D vaccine protect ... Prior immunisation of patients with malignant melanoma with vaccinia or BCG is associated with better survival. An European ...https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3234-4/
KAKEN - Research Projects | Development of immunoadjuvants for vaccine. (KAKENHI-PROJECT-07557336)
... injection of rhHBsAg 4 weeks after immunization, mice immunized with Vac/BCG-CWS and Vac/TDN as well as Vac/MDP-Lys (L18) ... BCG-CWS) and trehalose-6,6-dimycolate (TDM) augmented antibody response to recombinant human hepatitis B surface antigen ( ... BCG-CWS (Vac/BCG-CWS) or 50 mug/mouse of TDA (Vac/TDM) in o/w emulsion formulatoin, both mice immunized with Vac/BCG-CWS and ... Immunoadjuvant / BCG-cell-wall / Glycolipid (TDM) / MDP derivatives / Recombinant human hepatitis B virus vaccine (rhHBsAg) / ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557336/
Recommendations of the Advisory Committee on Immunization Practices (ACIP): Use of Vaccines and Immune Globulins in Persons ...
BCG BCG vaccine is not routinely recommended for use in the United States for prevention of tuberculosis (TB). BCG vaccine is ... Other Killed Antigens Other vaccines containing killed antigens, including cholera, plague, and anthrax, do not pose a risk to ... Meningococcal Vaccine Routine immunization with the quadrivalent vaccine is recommended for certain high-risk groups, including ... vaccines or higher doses of vaccines but that do not contraindicate use of any particular vaccine. ...https://www.cdc.gov/mmwr/preview/mmwrhtml/00023141.htm
... certain vaccines such as the pertussis vaccine (Giudice, Gervaix, Costantinoet al.1993) and the BCG have at least one antigen ... Immunization starting at birth may have the opposite effect than immunization starting after 2 months for several reasons. ... The ability of the vaccines antigens to induce autoimmunity is not limited to HCG since a vaccine comprising a diphtheria ... Animal and human experiments show that vaccine antigens, in killed vaccines, do not have to be covalently attached to ...http://vaccines.net/mechanis.htm
Developing whole mycobacteria cell vaccines for tuberculosis: Workshop proceedings, Max Planck Institute for Infection Biology,...
Although a more effective TB vaccine is needed to replace or enhance the limited effectiveness of BCG in all age groups, ... Inactivated whole cell TB and non-tuberculous mycobacterial vaccines, intended as immunotherapy or as safer immunization ... particularly given the limited understanding of the specific Mtb antigens necessary to generate an immune response capable of ... Although a more effective TB vaccine is needed to replace or enhance the limited effectiveness of BCG in all age groups, ...http://www.zora.uzh.ch/id/eprint/115979/
Frontiers | Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities |...
New advances in the comprehension of the mechanisms of antigen presentation by dendritic cells, in the immune responses ... Cutaneous melanoma is a highly immunogenic tumor; therefore most of the attempts to produce cancer vaccines have been addressed ... New advances in the comprehension of the mechanisms of antigen presentation by dendritic cells, in the immune responses ... as well as the understanding of the role of immunosuppressor molecules such as Cytotoxic T-lymphocyte antigen-4 (CTLA-4), which ...https://www.frontiersin.org/articles/10.3389/fimmu.2012.00103/full
A Randomized Trial of Ex vivo CD40L Activation of a Dendritic Cell Vaccine in Colorectal Cancer Patients: Tumor-Specific Immune...
... we based the route of immunization on our observations in murine models of enhanced antigen-specific T-cell proliferation and ... A tumor vaccine consisting of irradiated autologous tumor cells plus Bacillus Calmette-Guerin (BCG) has been used in phase III ... After 24 hours of incubation, DCs were pulsed with antigens for 24 hours. The following antigens were used: KLH at 25 μg/mL and ... vaccine generated an order of magnitude greater antitumor immunity than immunization with irradiated tumor cells plus the ...http://clincancerres.aacrjournals.org/content/16/22/5548
Protocols and Video Articles Authored by Yonghong Wan (Translated to Dutch)
However, it is increasingly believed that the current BCG vaccine will continue to be used as a childhood vaccine and that more ... The expansion of antigen-specific CD8(+) T cells following immunization of lethally irradiated hosts paralleled the recovery of ... based vaccines have not been explored for immunization against tuberculosis. A gene-modified DC vaccine expressing ... vaccines expressing mutant forms of the tumor antigen, dopachrome tautomerase, to investigate the relationship between antigen ...https://www.jove.com/author/Yonghong_Wan?language=Dutch
Mucosal Immunization with Recombinant Lactococcus lactis | Springer for Research & Development
... pointed out that despite many years of intensive vaccine research and the development of sophisticated effective vaccines, ... New use of BCG for recombinant vaccines. Nature 1991; 351:456-460.CrossRefGoogle Scholar ... Salmonella as carriers of heterologous antigens In: O'Hagan DT ed. Novel Delivery Systems for Oral Vaccines. Florida: CRC Press ... Biodegradable microspheres: vaccine delivery system for oral immunization. Curr Topics in Microbiol and Immunol. 1989; 146:59- ...https://rd.springer.com/chapter/10.1007/978-3-662-07548-7_5
Addressing Parents' Concerns: Do Multiple Vaccines Overwhelm or Weaken the Infant's Immune System? | Special Articles |...
Clark A, Rudd P. Neonatal BCG immunization. Arch Dis Child.1992;67 :473- 474. ... Of course, most vaccines contain far fewer than 100 antigens (for example, the hepatitis B, diphtheria, and tetanus vaccines ... measles or varicella vaccines)21,22 or live bacterial vaccines (eg, BCG vaccine)23,24 may develop disseminated infections with ... Combination vaccines for childhood immunization: recommendations of the Advisory Committee on Immunization Practices, the ...http://pediatrics.aappublications.org/content/109/1/124
Immunization with DNA vaccines encoding different mycobacterial antigens elicits a Th1 type immune response in lambs and...
Plasmids p-85A-BCG and p-Hsp65 seem to elicit a stronger protective immune response against M. paratuberculosis by evaluating ... Immunization with DNA vaccines encoding different mycobacterial antigens elicits a Th1 type immune response in lambs and ... Immunization with DNA vaccines encoding different mycobacterial antigens elicits a Th1 type immune response in lambs and ... Each group was vaccinated as following (A: physiological solution; B: Gudair™; C: p-85A-Mav; D: p-85A-BCG; E: p-Hsp65). Immune ...http://eprints.uniss.it/1174/
Study of Pre-clearance of Latent Tuberculosis Infection And BCG Revaccination - Full Text View - ClinicalTrials.gov
Biological: BCG strain Danish Intradermal Bacillus Calmette-Guerin (BCG) live-attenuated vaccine prepared using the Danish 1331 ... Precursor frequencies of mycobacterial antigen-specific T cells will be measured by ELISPOT using standard methods and SOPs [ ... for 30 days prior to immunization and for the 2-year period of study follow-up. ... Biological: BCG strain Danish Intradermal Bacillus Calmette-Guerin (BCG) live-attenuated vaccine prepared using the Danish 1331 ...https://clinicaltrials.gov/show/NCT01119521?order=134
Pasireotide, Everolimus and Selective Internal Radioembolization Therapy for Unresectable Hepatic Metastases - Full Text View -...
Examples of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio, bacillus Calmette-Guerin (BCG), ... Patients should not receive immunization with attenuated live vaccines within one week of study entry or during study period. ... Presence of Hepatitis B surface antigen (HepBSAg) or presence of hepatitis C antibody. History of, or current alcohol misuse/ ... Close contact with those who have received attenuated live vaccines should be avoided during treatment with everolimus. ...https://clinicaltrials.gov/ct2/show/NCT01469572
Evaluating Acceptability and Completeness of Overseas Immunization Records of Internationally Adopted Children | ELECTRONIC...
... children had a BCG scar, but only 83 (21%) had a vaccination record indicating BCG immunization. These findings-a BCG scar but ... UTD Immunization Status Among International Adoptees by Vaccine Combinations: UTD Status for 12- to 15-Month Vaccine Series ... response after HB immunization among the adoptees in this study found detectable antibody to hepatitis B surface antigen among ... In general, written documentation of immunizations should be accepted as evidence of previous immunization if the vaccines, ...http://pediatrics.aappublications.org/content/109/2/e22.full
Search of: HEPATITIS B VACCINE, RESPONSE TO - List Results - ClinicalTrials.gov
A Trial Investigating the Influence of BCG and Hepatitis B Immunisation at Birth on Neonatal Immune Responses: The Early Life ... Biological: HBV vaccine (Engerix-B, recombinant hepatitis B surface antigen, 20µg/mL/vial, GlaxoSmithKline, Belgium) ... 147 Studies found for: HEPATITIS B VACCINE, RESPONSE TO. Also searched for HEPATITIS B, Vaccination, and Immunization. See ... Immune Response to Hepatitis B Vaccine Challenge Dose in Subjects Who Received a Primary Neonatal Hepatitis B Vaccine.. * ...https://clinicaltrials.gov/ct2/results?cond=HEPATITIS%20B%20VACCINE,%20RESPONSE%20TO
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