*  Professor Helen McShane - Nuffield Department of Medicine
Prime-boost immunization strategies involve using two different vaccines, each encoding the same antigen, some weeks apart. ... Genetically modified BCG vaccines and boosted BCG strategies also protected guinea pigs to the same extent as BCG but not ... measles vaccine, measles-mumps-rubella vaccine, mumps vaccine, rubella vaccine, rotavirus vaccine, smallpox vaccine, varicella ... Boosting BCG with a subunit vaccine, and/or replacing BCG with an improved BCG are both strategies currently being investigated ...
  https://www.ndm.ox.ac.uk/principal-investigators/researcher/helen-mcshane
*  Study of Pre-clearance of Latent Tuberculosis Infection And BCG Revaccination - Full Text View - ClinicalTrials.gov
Biological: BCG strain Danish Intradermal Bacillus Calmette-Guerin (BCG) live-attenuated vaccine prepared using the Danish 1331 ... Precursor frequencies of mycobacterial antigen-specific T cells will be measured by ELISPOT using standard methods and SOPs [ ... for 30 days prior to immunization and for the 2-year period of study follow-up. ... Biological: BCG strain Danish Intradermal Bacillus Calmette-Guerin (BCG) live-attenuated vaccine prepared using the Danish 1331 ...
  https://clinicaltrials.gov/show/NCT01119521?order=134
*  DiVA - Søkeresultat
We assessed in vitro and in vivo a recombinant BCG-expressing CSp (BCG-CS) as malaria vaccine candidate. Immunisation of BALB/c ... Mycobacterium bovis Bacillus Calmette-Guérin (BCG) has been utilized as a vector to deliver vaccine candidate antigens. We ... BCG-CS) circumsporozoite protein (CSp) as a malaria vaccine candidate. Immunization of BALB/c mice with BCG-CS augmented the ... BCG-CS induced higher phagocytic activity in macrophages as compared to wt-BCG. Finally, BCG-CS induced CSp-specific antibodies ...
  http://www.diva-portal.org/smash/resultList.jsf?dswid=0&searchType=SUBJECT&language=no&onlyFullText=false&af=%5B%5D&aq=%5B%5B%7B%22categoryId%22%3A%2211553%22%7D%5D%5D
*  Vaccines | Free Full-Text | DNA/MVA Vaccines for HIV/AIDS
DNA vaccines have evolved as a clinically safe and effective platform for priming HIV-specific cellular and humoral responses ... Since the initial proof-of-concept studies examining the ability of antigen-encoded plasmid DNA to serve as an immunogen, ... bovis BCG by Coadministration with Plasmid DNA Encoding a Tuberculosis Prototype Antigen ... DNA Immunization for HIV Vaccine Development. Previous Article in Special Issue. Recent Developments in Preclinical DNA ...
  http://www.mdpi.com/2076-393X/2/1/160
*  Mucosal immunity and novel tuberculosis vaccine strategies: route of immunisation-determined T-cell homing to restricted lung...
... either designed to replace BCG itself or to boost pre-existing BCG responses. In particular, viral-based booster vaccines are ... Following immunisation, local dendritic cell populations acquire antigens and subsequently migrate to the local draining lymph ... However, parenteral intramuscular immunisation is unable to provide protection despite the apparent presence of antigen- ... Therefore, there has been a pressing need for the development of new booster vaccines to enhance existing BCG-induced immunity ...
  http://err.ersjournals.com/content/24/136/356
*  Neonatal vaccination with Mycobacterium bovis BCG: potential effects as a priming agent shown in a heterologous prime-boost...
In Paper II, we investigated the role of the BCG vaccination as a priming vaccine in a heterologous prime-boost immunization ... Immunization with the same antigen during the postnatal life increased antigen-specific recall IFN-γ responses and protection ... BCG vaccine; Neonates; Heparin-binding hemagglutinin Identifiers. URN: urn:nbn:se:su:diva-39195DOI: 10.1016/j.vaccine.2009.04. ... The results showed that the neonatal BCG vaccination primed the immune system for a relevant antigen and showed a generalized ...
  http://su.diva-portal.org/smash/record.jsf?pid=diva2:319025
*  Blood and Lymph Unit 3 Flashcards by Kristen Stahl | Brainscape
QuantiFERON-TB Gold test is preferred to skin testing when someone has BCG immunization. Human specific antigens are added to ... A person can have a positive PPD if they have been immunized with the Bacille Calmette-Guerin (BCG) vaccine when they were born ... Cross reaction of foreign antigen with self: foreign+self antigen. would be good if we could identify antigens that start rxn. ... Often by the time symptoms show up, triggering antigen is long gone. Coupling Self antigen with Foreign Antigen "carrier": have ...
  https://www.brainscape.com/flashcards/blood-and-lymph-unit-3-4806757/packs/6999439
*  Churg-Strauss syndrome following cessation of allergic desensitization vaccination: a case report
... flu and measles vaccine and BCG (Bacillus of Calmette and Guerin) inoculation. Also to be considered is vaccine components such ... CSS has been associated with hyposensitizing immunization to candidin, polymicrobial and acarian or unspecific antigens [7]. In ... The vaccines were first administered twice weekly, every Monday and every Wednesday for four months and again this year, for a ... leukotriene antagonists or in this case probably due to invigoration of the immune system with antigen stimulation. Here, we ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2904789/
*  Mucosal Vaccines, Book by Hiroshi Kiyono (Hardcover) | chapters.indigo.ca
Buy the Hardcover Book Mucosal Vaccines by Hiroshi Kiyono at Indigo.ca, Canada's largest bookstore. + Get Free Shipping on ... J. Ulmer, Current View of DNA Immunization for Mucosal Vaccines.. S. Langermann, Recombinant BCG as Vector for Mucosal Immunity ... M.R. Neutra and J.-P. Kraehenbuhl, Antigen Uptake by M Cells for Effective Mucosal Vaccines.. Mucosal Modulation for Induction ... D. Hoft, Oral BCG.. Mucosal Vaccines for Viral Diseases: P.L. Ogra, Polio Viruses and Mucosal Vaccines.. P.F. Wright, Mucosal ...
  https://www.chapters.indigo.ca/en-ca/books/mucosal-vaccines/9780124105805-item.html
*  Frontiers | Plasmacytoid dendritic cells: development, functions, and role in atherosclerotic inflammation | Physiology
... antigens that suggests for great therapeutic potential of these DCs for development of DC-based anti-atherogenic vaccines. ... antigens that suggests for great therapeutic potential of these DCs for development of DC-based anti-atherogenic vaccines. ... Notably, atheroprotective tolerogenic DCs could be induced by certain self-antigens or bacterial ... Notably, atheroprotective tolerogenic DCs could be induced by certain self-antigens or bacterial ...
  https://www.frontiersin.org/articles/10.3389/fphys.2014.00279/full
*  SCID Syndromes
Live immunizations, including rotavirus, measles, mumps, rubella, varicella, and BCG vaccines, should not be administered. ... Diagnostic assessment for occult viral infection using antigen-based assay (culture or PCR) should be carried out for EBV, CMV ... deficiency are due to mutations in key cellular proteins involved in gene recombination that form the T cell and B cell antigen ... and all live immunizations should be withheld. ...
  https://www.psychiatryadvisor.com/pediatrics/scid-syndromes/article/619893/
*  The International Society of Travel Medicine
These specific antigens are absent in most environmental mycobacteria and most importantly all strains of BCG vaccine. ... Would you recommend any supplemental testing to determine true latent exposure to TB versus prior BCG immunization? Assuming ... who had also received BCG vaccination sometime during childhood. Since the various BCG vaccine preparations vary in efficacy ... but specificity of the TST and its positive predictive value drop considerably if one has received BCG vaccine in the past. By ...
  http://www.istm.org/newsshare200907
*  ASMscience | Pathophysiology and Immu
Combination vaccines which consist of BCG and one or more booster immunizations with important mycobacterial antigens ( ... In dermal BCG lesions, the percentage of mononuclear cells containing cytokine mRNA and protein was highest during the first 3 ... suggests that the most effective tuberculosis vaccines would contain not only the most appropriate mycobacterial antigens but ... including those produced by DNA vaccines) will probably provide the most effective protection against active disease. The major ...
  http://www.asmscience.org/content/book/10.1128/9781555817138.ch03
*  ASMscience | Tuberculosis and Nontube
... vaccines, and tuberculosis in enclosed populations. Section II covers both classic and more recent clinical manifestations of ... Combination vaccines which consist of BCG and one or more booster immunizations with important mycobacterial antigens ( ... The chapter discusses mechanisms of immune control of tuberculosis, and talks about BCG vaccine. Immunization with BCG induces ... that additional tuberculosis vaccine development should focus on identifying a booster vaccine to follow BCG immunization, or ...
  http://www.asmscience.org/content/book/10.1128/9781555817138
*  Development of Vaccines against Visceral Leishmaniasis
... while immunization with BCG-LCR1 elicited better protection [45]. Vaccine efficacy was influenced by the site of immunization ... and new vaccines under development include recombinant antigen vaccines and both live and killed whole-cell vaccines. ... expression by antigen-specific T cells. Thus, analogous to a human VL vaccine, an effective CVL vaccine needs to induce strong ... The L. donovani A2 antigen was expressed in L. tarentolae, which normally lacks this protein [150] and used as a vaccine strain ...
  https://www.hindawi.com/journals/jtm/2012/892817/
*  Study of AERAS-402 in Healthy Infants - Full Text View - ClinicalTrials.gov
BCG-vaccinated infants. Vaccine. 2015 Jun 9;33(25):2944-54. doi: 10.1016/j.vaccine.2015.03.070. Epub 2015 Apr 28. ... Efforts to increase TB protection in children include new vaccines for primary immunizations as well as combinations of ... It presents Mtb antigens in the setting of a new, live, replication-deficient adenovirus vaccine that may increase T cell- ... Has completed simultaneous enrollment in Aeras Vaccine Development Registry protocol. *Had BCG vaccination ≥ 3 months prior to ...
  https://clinicaltrials.gov/show/NCT01198366?order=164
*  Vaccine Therapy in Treating Patients With Transitional Cell Cancer of the Bladder
RATIONALE: Vaccines made from peptides may make the body build an immune response to kill tumor cells. Biological therapies, ... 1 Protein Immunization of Post-Cystectomy Patients With Transitional Cell Carcinomas Expressing NY-ESO-1 or LAGE-1 Antigen. ... Determine the safety and tolerability of NY-ESO-1 peptide vaccine, BCG, and. sargramostim (GM-CSF) in post-cystectomy patients ... Patients receive NY-ESO-1 peptide vaccine mixed with BCG intradermally (ID) once weekly on. weeks 1 and 2. Patients then ...
  http://www.knowcancer.com/cancer-trials/NCT00070070/
*  Anatomy and Physiology of the Immune System, Part 3 -- Natural Health Newsletter
Most vaccines, other than the flu vaccine, are based on antigens that are quite old. Even flu vaccines, though, are based on ... 3. "BCG - the current vaccine for tuberculosis." Initiative for Vaccine Research (IVR). World Health Organization. Accessed 7 ... Specific immunization involves the injection of a reduced-strength antigen into the blood to enable the body to then produce ... A vaccine is only as good as the antigen included in it. That means, that when it comes to flu vaccines, for example, they are ...
  https://jonbarron.org/article/anatomy-and-physiology-immune-system-part-3
*  Frontiers | Current and novel approaches to vaccine development against tuberculosis | Cellular and Infection Microbiology
BCG) that protects children from severe forms of TB, but fails to protect adults. Taken together, there is a growing need to ... is focused on the discussion surrounding current strategies and innovations being explored to discover new protective antigens ... Taken together, there is a growing need to conduct basic and applied research to develop novel vaccine strategies against TB. ... The past decade has seen significant progress in developing new vaccine candidates, but the most fundamental questions in ...
  https://www.frontiersin.org/articles/10.3389/fcimb.2012.00154/full
*  Plus it
... provided by results of randomized Phase III trials in which immunization with the melanoma differentiation antigen GM2 and BCG ... Cancer vaccines: single-epitope anti-idiotype vaccine versus multiple-epitope antigen vaccine. Cancer Immunol. Immunother., 49: ... Vaccines Inducing Humoral and Cellular Responses against Carbohydrate Antigens.. Breast cancer vaccines in which Tn, TF, sialyl ... BCG, Bacillus Calmette-Guérin; NDV, Newcastle disease virus; APC, antigen-presenting cell; HLA, human leukocyte antigen; GM-CSF ...
  http://clincancerres.aacrjournals.org/content/9/9/3222
*  Infections and cancer: the "fifty shades of immunity" hypothesis | BMC Cancer | Full Text
For instance, a prior immunization with BCG vaccine, which has antigenic similarity with human endogenous retroviruses (HERV-K- ... The immune recognition of specific antigens expressed by cancer cells, called tumor-associated antigens (TAA), is a necessary ... Vaccine. 2009;27:6950-8.PubMedView ArticleGoogle Scholar. *. Mastrangelo G, et al. Does yellow fever 17D vaccine protect ... Prior immunisation of patients with malignant melanoma with vaccinia or BCG is associated with better survival. An European ...
  https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3234-4/
*  KAKEN - Research Projects | Development of immunoadjuvants for vaccine. (KAKENHI-PROJECT-07557336)
... injection of rhHBsAg 4 weeks after immunization, mice immunized with Vac/BCG-CWS and Vac/TDN as well as Vac/MDP-Lys (L18) ... BCG-CWS) and trehalose-6,6-dimycolate (TDM) augmented antibody response to recombinant human hepatitis B surface antigen ( ... BCG-CWS (Vac/BCG-CWS) or 50 mug/mouse of TDA (Vac/TDM) in o/w emulsion formulatoin, both mice immunized with Vac/BCG-CWS and ... Immunoadjuvant / BCG-cell-wall / Glycolipid (TDM) / MDP derivatives / Recombinant human hepatitis B virus vaccine (rhHBsAg) / ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557336/
*  Recommendations of the Advisory Committee on Immunization Practices (ACIP): Use of Vaccines and Immune Globulins in Persons ...
BCG BCG vaccine is not routinely recommended for use in the United States for prevention of tuberculosis (TB). BCG vaccine is ... Other Killed Antigens Other vaccines containing killed antigens, including cholera, plague, and anthrax, do not pose a risk to ... Meningococcal Vaccine Routine immunization with the quadrivalent vaccine is recommended for certain high-risk groups, including ... vaccines or higher doses of vaccines but that do not contraindicate use of any particular vaccine. ...
  https://www.cdc.gov/mmwr/preview/mmwrhtml/00023141.htm
*  Mechanisms
... certain vaccines such as the pertussis vaccine (Giudice, Gervaix, Costantinoet al.1993) and the BCG have at least one antigen ... Immunization starting at birth may have the opposite effect than immunization starting after 2 months for several reasons. ... The ability of the vaccines antigens to induce autoimmunity is not limited to HCG since a vaccine comprising a diphtheria ... Animal and human experiments show that vaccine antigens, in killed vaccines, do not have to be covalently attached to ...
  http://vaccines.net/mechanis.htm
*  Federal Register :: Biological Products; Bacterial Vaccines and Toxoids; Implementation of Efficacy Review
... and labeling of bacterial vaccines and toxoids with... ... recommendations of the Panel on Review of Bacterial Vaccines ... BCG vaccines are not recommended for routine immunization in the United States. The two currently U.S.-licensed BCG vaccines ... Bacterial vaccines and bacterial antigens with "no U.S. standard of potency," (2) bacterial vaccines and toxoids with standards ... BCG Vaccine. On July 17, 1990, FDA revoked the license for BCG Vaccine at the request of the manufacturer. ...
  https://www.federalregister.gov/documents/2004/12/29/04-28322/biological-products-bacterial-vaccines-and-toxoids-implementation-of-efficacy-review