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*  Autoimmunity and the Pathogenesis of Diabetes
Autoimmunity.- The Concept of IDDM as an Autoimmune Disease.- The Association Between IDDM and HLA.- Etiologic Factors with ... The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present.- ... Implications for the Pathogenesis of IDDM.- The Autoantigen in IDDM.- Presentation of Autoantigen.- Autoantigen Recognition in ... www.MOLUNA.de Autoimmunity and the Pathogenesis of Diabetes [4190512] - 1. ...
  https://www.moluna.de/buch/4190512-autoimmunity+and+the+pathogenesis+of+diabetes/
*  Immunogenetics of Hashimoto's thyroiditis | Springer for Research & Development
Nagataki S, Eguchi K: Cytokines and immune regulation in thyroid autoimmunity. Autoimmunity. 1992, 13: 27-34.PubMedGoogle ... Pathogenesis of Hashimoto's thyroiditis. Autoimmunity in Hashimoto's thyroiditis. The development of the autoimmune failure of ... can explain non-specific mechanism of CTLA-4-mediated susceptibility to the development of thyroid autoimmunity. The ... that induces an autoimmune response against thyroid-specific antigens by infiltrating immune cells. The autoimmune process ...
  https://rd.springer.com/article/10.1186/1740-2557-2-1
*  Frontiers | The Footprints of Poly-Autoimmunity: Evidence for Common Biological Factors Involved in Multiple Sclerosis and...
... have been shown to have an increased susceptibility to develop chronic autoimmune thyroid diseases, in particular Hashimoto's ... mechanisms which may lead to the frequent coexistence of MS and HT by analyzing several factors related to the pathogenesis of ... have been shown to have an increased susceptibility to develop chronic autoimmune thyroid diseases, in particular Hashimoto's ... However, studies comparing such different pathologies of autoimmune origin are still missing till date.In the present study, we ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2018.00311/full
*  NIH Guide: GENDER IN THE PATHOGENESIS OF AUTOIMMUNITY: MECHANISMS
NINDS and NIAMS do not utilize the R03 mechanism. RESEARCH OBJECTIVES Background Autoimmune diseases, which disproportionately ... o mechanism(s) by which the autoreactive immune response is altered during pregnancy and in the post partum period; o the role ... and autoimmune thyroid disease, including both thyroiditis and Grave's disease, is six to ten times as common in women as men. ... This Program Announcement (PA), Mechanism of Gender's Effect in Pathogenesis of Autoimmunity, is related to the priority area ...
  https://grants.nih.gov/grants/guide/pa-files/PA-96-053.html
*  Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness | BMC Medicine | Full Text
... which is a systemic autoimmune disorder, and the underlying immune mechanism is as yet unknown [65]. A number of autoantibodies ... but indicate a putative shared immune pathogenesis of psychiatric disorder and organ-specific auto-immunity. Although organ- ... including thyroid autoimmune disease [64]. Moreover, these autoimmune diseases were also more prevalent in the parents of these ... In autoimmune arthritis, for example, PGE2 is part of a negative-feedback mechanism that attenuates the chronic inflammatory ...
  https://0-bmcmedicine-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1741-7015-11-74
*  Bioline International Official Site (site up-dated regularly)
Immune responses to Epstein-Barr virus in individuals with systemic and organ specific autoimmune disorders ... The exact mechanism involving EBV in the causation of systemic and organ specific autoimmune disease is elusive. Viral ... There are several viral infections including Epstein-Barr virus (EBV) implicated in the pathogenesis of autoimmune disorders. ... A diagnosis of Hashimoto's thyroiditis was made based on the presence of a lobular thyroid gland and the presence of anti- ...
  http://www.bioline.org.br/request?mb10037
*  A SNP in intron 1 of TSHR controls its thymic expression and susceptibility to Graves' disease suggesting central tolerance...
The effect of TSHR SNP rs179247 was thymus-specific and not observed in thyroid glands. These results constitute first evidence ... Graves' disease (GD) is the paradigm of an anti-receptor autoimmune disease with agonistic auto-antibodies against the ... concept that variable expression levels of major target autoantigens in the thymus influence the predisposition to autoimmunity ... thyrotropin receptor (TSHR) being the underlying pathogenic mechanism. TSHR belongs to the category of tissue-restricted ...
  https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-9-S2-P7
*  Frontiers | Increased Interleukin-23 in Hashimoto's Thyroiditis Disease Induces Autophagy Suppression and Reactive Oxygen...
These results demonstrate a key role for IL-23 in HT pathogenesis and provide a potential therapeutic strategy against IL-23 or ... In this study, we found that thyroid follicular cells (TFCs) from HT patients expressed an elevated level of interleukin-23 (IL ... These results demonstrate a key role for IL-23 in HT pathogenesis and provide a potential therapeutic strategy against IL-23 or ... In this study, we found that thyroid follicular cells (TFCs) from HT patients expressed an elevated level of interleukin-23 (IL ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2018.00096/full
*  HCV Research and News: Immunological alterations in hepatitis C virus infection
PATHOGENESIS OF HCV RELATED IMMUNE DISORDERS. HCV lymphotropism represents the most relevant step in the pathogenesis of virus- ... Thyroid disorders and HCV. Autoimmune thyroid involvement and hypothyroidism were significantly more frequent in patients with ... Subclinical hypothyroidism and thyroid autoimmunity were significantly more frequent in HCV + MC patients than in HCV-negative ... an autoimmune mechanism has been suggested as playing a role in some patients with HCV infection. This hypothesis is based on ...
  http://hepatitiscresearchandnewsupdates.blogspot.com/2013/12/immunological-alterations-in-hepatitis.html
*  Autoimmune Thyroid Disorders
... expanded our understanding of the mechanism involved in pathogenesis of AITD and the relationship between autoimmune thyroid ... Autoimmune Features. All forms of thyroid autoimmunity are associated with a lymphocytic infiltrate in the thyroid. These ... 3. Immune Mechanisms. A variety of immune mechanisms may be involved in the pathogenesis of Graves' hyperthyroidism. The major ... Mechanism of Thyroid Cell Injury. Several antibody and cell-mediated mechanisms contribute to thyroid injury in autoimmune ...
  https://www.hindawi.com/journals/isrn/2013/509764/
*  Aluminum?s Role in CNS-immune System Interactions leading to Neurological Disorders | OMICS International
Negro R (2008) Selenium and thyroid autoimmunity. Biologics 2: 265-273. *Clapp T, Siebert P, Chen D, Jones Braun L (2011) ... In vivo phosphate substitution as a mechanism for autoimmune stimulation. Although elution of antigen from Al particles at the ... Stinissen P, Medaer R, Raus J (1998) Myelin reactive T cells in the autoimmune pathogenesis of multiple sclerosis. Mult Scler 4 ... Well-established immune system triggers leading to autoimmune reactions are considered. Of these, aluminum, a known ...
  https://www.omicsonline.org/open-access/aluminums-role-in-cnsimmune-system-interactions-leading-to-neurological-disorders-14822-1745-7580-9-069.php?aid=20403
*  http://ufdc.ufl.edu/UFE0042955/00001
Autoimmune thyroid disease in primary Sjogren's syndrome. Am J Med 99:480484. 3. Strimlan, C. V., E. C. Rosenow, 3rd, M. B. ... the precise mechanism of action of IL22 is obscure with respect to many diseases and immune processes. However, within the past ... The challenge in attempting to understand the mechanism of human SjS pathogenesis is due to the difficult nature of detecting ... Autoimmunity induction by human T cell leukemia virus type 1 in transgenic mice that develop chronic inflammatory arthropathy ...
  http://ufdc.ufl.edu/UFE0042955/00001
*  Immunology and Pregnancy Losses: HLA, Autoantibodies and Cellular Immunity - Madame Curie Bioscience Database - NCBI Bookshelf
Immunopathological evaluation of placenta from women with recurrent pregnancy losses of immune etiologies often demonstrate ... or immune disorders were reported as possible etiologies.3-6 Despite the many etiologies, a majority of women with recurrent ... Thyroid autoimmunity and its association with nonorgan-specific antibodies and subclinical alterations of thyroid function in ... It is speculated anti-thyroid antibody serves as a marker for autoimmune activation and T cell dysfunction. Further study is ...
  https://www.ncbi.nlm.nih.gov/books/NBK6615/
*  j.imbio.2017.10.038
Regulatory B cells in autoimmune diseases and mucosal immune homeostasis. Autoimmunity 44, 58-68. Lifshitz, V., Weiss, R., ... Understanding in the potential mechanism of amyloid displayed in the immune system is still in the elementary state, whereas ... implications for the pathogenesis and treatment of Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 98, 10273-10278. ... β2-microglobulin Calcitonin Pulmonary small cell carcinoma Chronic hemodialysis Thyroid medullary carcinoma Secondary ...
  https://www.docme.ru/doc/2192837/j.imbio.2017.10.038
*  Autoimmune Thyroid Diseases
The two main types of autoimmune thyroid disease are Grave's disease and Hashimoto's thyroiditis. ... It is common for people to develop thyroid diseases, such as hyperthyroidism and hypothyroidism. ... Stress and Thyroid Autoimmunity. Stress and thyroid autoimmunity. Stress affects the immune system either directly or ... present appreciation of the pathogenesis of chronic widespread pain, and how our knowledge can be used to find lasting and ...
  https://www.sclero.org/scleroderma/autoimmune/thyroid/a-to-z.html
*  Frontiers | Thyrotropin Receptor Epitope and Human Leukocyte Antigen in Graves' Disease | Endocrinology
... were reported to be related to the pathogenesis in GD. Dysfunction of central tolerance in the thymus, or in peripheral ... were reported to be related to the pathogenesis in GD. Dysfunction of central tolerance in the thymus, or in peripheral ... is an organ-specific autoimmune disease, and Thyrotropin (TSH) receptor (TSHR) is a major autoantigen in this condition. Since ... is an organ-specific autoimmune disease, and Thyrotropin (TSH) receptor (TSHR) is a major autoantigen in this condition. Since ...
  https://www.frontiersin.org/articles/10.3389/fendo.2016.00120/full
*  Celiac Disease and Autoimmune-Associated Conditions
"Celiac disease in North Italian patients with autoimmune thyroid diseases," Autoimmunity, vol. 41, no. 1, pp. 116-121, 2008. ... A. Zhernakova, C. C. van Diemen, and C. Wijmenga, "Detecting shared pathogenesis from the shared genetics of immune-related ... The breakdown of gut-liver axis equilibrium has been implicated as a mechanism underlying this association. In CD, ... 3.2.2. Thyroid Diseases. CD has been found at an increased rate in patients with autoimmune thyroid disease (Grave's disease ...
  https://www.hindawi.com/journals/bmri/2013/127589/
*  Adipocytokines in Thyroid Dysfunction
Leptin is found to be immune modulator [5]. Adipokines are linked to autoimmune diseases [6]. Adipokines like adiponectin have ... Thyroid diseases have effects on metabolism and inflammation. The mechanism of these effects is not clear. Recently, there are ... It is also suggested that leptin and its receptors have a role in the pathogenesis of thyroid cancer. Leptin regulates multiple ... coexisting autoimmunity, and probably nutritional status. New adipocytokines that will be discovered in near future also may ...
  https://www.hindawi.com/journals/isrn/2013/646271/
*  Paraneoplastic neurological syndromes | Orphanet Journal of Rare Diseases | Full Text
As PNS are believed to be immune-mediated, suppression of the immune response represents another treatment approach. ... PNS are caused by autoimmune processes triggered by the cancer and directed against antigens common to both the cancer and the ... Detection of GAD-Ab in almost 70% of patients suggests an autoimmune mechanism. ... Recently, it has been suggested that cellular immune mechanisms play a critical role in the pathogenesis of PNS [63-65]. ...
  https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-2-22
*  Vitamin B12 deficiency anemia - Wikipedia
... pylori infection may cause gastric autoimmunity by a mechanism known as molecular mimicry. Antibodies produced by the immune ... Pernicious anemia is often found in conjunction with other autoimmune disorders, suggesting common autoimmune susceptibility ... The deficiency also may present with thyroid disorders.[page needed] In severe cases, the anemia may cause evidence of ... pylori is involved in the pathogenesis of the disease. A long-standing H. ...
  https://en.wikipedia.org/wiki/Vitamin_B12_deficiency_anemia
*  Yersinia enterocolitica - Wikipedia
This is most likely because of some immune-mediated mechanism. Y. enterocolitica seems to be associated with autoimmune Graves- ... Tomer Y, Davies T (1993). "Infection, thyroid disease, and autoimmunity" (PDF). Endocr Rev. 14 (1): 107-20. doi:10.1210/er.14.1 ... Fàbrega A, Vila J (2012). "Yersinia enterocolitica: pathogenesis, virulence and antimicrobial resistance". Enferm. Infecc. ... Y. enterocolitica infection has also been suggested to not be the cause of autoimmune thyroid disease, but rather is only an ...
  https://en.wikipedia.org/wiki/Yersinia_enterocolitica
*  Enzymatic Strategies to Detoxify Gluten: Implications for Celiac Disease
The proposed mechanism by which autoimmunity develops in CD is that the enzyme tTG generates additional antigenic epitopes by ... such as endocrine autoimmune diseases, thyroid diseases, and selective IgA deficiency, as well as of genetic disorders, such as ... Because symptoms may improve with a gluten-free diet, it is thought that gluten plays a key role in the pathogenesis of this ... In order to restrain the T cell-mediated immune response to dietary gluten, a different approach could be to consider tTG as a ...
  https://www.hindawi.com/journals/er/2010/174354/
*  JCI - Mechanisms for the induction of autoimmunity by infectious agents
Activation and clonal expansion of autoreactive lymphocytes is a critical step in the pathogenesis of autoimmune diseases. In ... Thyroid autoimmunity Basil Rapoport et al. * Autoantibodies as reporters identifying aberrant cellular mechanisms in ... Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science ... MC is a systemic autoimmune disease caused by vascular deposition of circulating immune complexes and complement. Its name is ...
  https://www.jci.org/articles/view/14235/
*  Molecular Alteration Analysis of Human Gut Microbial Composition in Graves' disease Patients
Köhling HL, Plummer SF, Marchesi JR, Davidge KS, Ludgate M. The microbiota and autoimmunity: Their role in thyroid autoimmune ... immune functioning [2] along with defense mechanism against pathogen [3]. The regulation of gut microbiota configuration has ... Therefore, the current study may provide a new insight into the GD pathogenesis and, in turn, explore its contribution in ... Antonelli A, Ferrari SM, Corrado A, Di Domenicantonio A, Fallahi P. Autoimmune thyroid disorders. Autoimmunity reviews. 2015;14 ...
  http://www.ijbs.com/v14p1558.htm
*  Biomedical Science - BSc (Hons) - Canterbury - The University of Kent
... induction of autoimmunity; treatment of autoimmune disease. Role of cytokines in the immune system - Properties of cytokines; ... 2. Mechanisms of Pathogenesis - spread in the body, disease mechanisms, mechanisms of cell killing (Herpes simplex and Polio), ... The chemiosmotic hypothesis, mechanism of ATP synthase, ATP yield, disorders associated with mutations in the mitochondrial ... The systems studied will include the following: thyroid gland, parathyroid gland and bone metabolism, adrenal gland, renal ...
  https://www.kent.ac.uk/courses/undergraduate/263/biomedical-science