*  A2A Adenosine Receptor Signaling in Lymphocytes and the Central Nervous System Regulates Inflammation during Experimental...
A3 adenosine receptor agonist reduces brain ischemic injury and inhibits inflammatory cell migration in rats. Am. J. Pathol. ... CD73−/− mice or wild-type animals that are given either broad spectrum AR antagonists (such as caffeine) or A2AAR-specific ... adenosine's role in the immune response from its function in mediating immune cell migration into the CNS via the A2A receptor. ... Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor. ...
  http://www.jimmunol.org/content/188/11/5713.full
*  From 'Hellstrom Paradox-to anti-adenosinergic cancer immunotherapy
... of normal tissues from overactive immune cells by extracellular adenosine A2 receptors on the surface of immune cells. The A2 ... including an A2 receptor antagonist caffeine; (6) better tumor rejection observed in A2 receptor antagonist-treated mice is at ... T cells, including anti-tumor CD8+ T cells and human T cells, predominantly express A2AR and A2BR and not the A3 receptor [29, ... of normal tissues from overactive immune cells by extracellular adenosine A2 receptors on the surface of immune cells ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2096757/
*  Theophylline - Wikipedia
... and reduces inflammation and innate immunity nonselective adenosine receptor antagonist, antagonizing A1, A2, and A3 receptors ... "Caffeine Pharmacology". Website Medical News. Alboni et al. Effects of Permanent Pacemaker and Oral Theophylline in Sick Sinus ... Peters-Golden M, Canetti C, Mancuso P, Coffey MJ (2005). "Leukotrienes: underappreciated mediators of innate immune responses ... "Insights into the Regulation of TNF-α Production in Human Mononuclear Cells: The Effects of Non-Specific Phosphodiesterase ...
  https://en.wikipedia.org/wiki/Theophylline
*  Frontiers | Purinergic Signaling in Mast Cell Degranulation and Asthma | Pharmacology
... as well as by ATP-gated P2X receptors, plays a significant role in mast cell degranulation. Both adenosine and ATP can induce ... as well as by ATP-gated P2X receptors, plays a significant role in mast cell degranulation. Both adenosine and ATP can induce ... induced via the activation of G protein-coupled adenosine receptors and P2Y nucleotide receptors, ... induced via the activation of G protein-coupled adenosine receptors and P2Y nucleotide receptors, ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00947/full
*  Application # 2017/0143726. ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS TO MODULATE T CELL RESPONSES - Patents.com
A.sub.2a receptor antagonists in particular are provided to enhance imm ... Described are uses of A.sub.2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses ... cells to immune rejection. [0104] In one embodiment, the first A.sub.2a receptor antagonist stimulates an immune response for ... Specific antagonists of the A.sub.2a receptor include SCH-58261 (7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-t ...
  http://patents.com/us-20170143726.html
*  Adenosine A2A receptor - Wikipedia
3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists". Journal of Medicinal Chemistry. 46 (7 ... In addition, A2A receptor can negatively regulate overreactive immune cells, thereby protecting tissues from collateral ... "Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain". Frontiers in Bioscience. 13 (13): 2391-9. doi: ... Older research on adenosine receptor function, and non-selective adenosine receptor antagonists such as aminophylline, focused ...
  https://en.wikipedia.org/wiki/Adenosine_A2A_receptor
*  A1 Adenosine Receptor Upregulation and Activation Attenuates Neuroinflammation and Demyelination in a Model of Multiple...
... the activation of adenosine receptors on immune cells suppressed the production of proinflammatory mediators, including tumor ... Chou CC, Vickroy TW (2003) Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues. ... Although the soluble cytotoxic factor(s) remains unknown, studies with glutamate receptor antagonists failed to inhibit ... role of A3 adenosine receptors. J Immunol 156: 3435-3442. ... Neuroprotection by caffeine and adenosine A2A receptor blockade ...
  http://www.jneurosci.org/content/24/6/1521
*  Purinergic signalling - Wikipedia
... leading to an accumulation of adenosine. On the other hand, the adenosine-receptor antagonist caffeine reverses the anti- ... doi:10.1016/S1043-2760(01)00387-3. Junger, Wolfgang G. (18 February 2011). "Immune cell regulation by autocrine purinergic ... On the other hand, nanomolar concentrations of adenosine activate A1 and A3 receptors, resulting in neutrophilic chemotaxis ... Formation of foam cells is inhibited by adenosine A2A receptors. Abnormal levels of ATP and adenosine are present in the ...
  https://en.wikipedia.org/wiki/Purinergic_signalling
*  Plus it
... adenosine receptor antagonists theophylline and caffeine reverse the effects of methotrexate on the development of adjuvant ... Montesinos MC, Desai A, Delano D, Chen JF, Fink JS, Jacobson MA, and Cronstein BN (2003) Adenosine A2A or A3 receptors are ... the anti-inflammatory effects of methotrexate are mediated by adenosine acting at adenosine receptors on inflammatory cells in ... Medzihradsky JL (1984) Regulatory role for the immune complex in modulation of phagocytosis by 3-deazaadenosine. J Immunol 133: ...
  http://pharmrev.aspetjournals.org/content/57/2/163
*  Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors | JEM
Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation. J. Clin. Invest. 100:2849-2857. doi:10.1172/ ... Adenosine, adenosine receptors and the actions of caffeine. Pharmacol. Toxicol. 76:93-101. doi:10.1111/j.1600-0773.1995.tb00111 ... Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204: ... reuteri in combination with A2A receptor-specific antagonist SCH58261 (Fig. 7 A). We found that the A2A antagonist SCH58261 ...
  http://jem.rupress.org/content/early/2016/12/22/jem.20160961
*  Adenosine receptor - Wikipedia
Kalda A, Yu L, Oztas E, Chen JF (October 2006). "Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in ... while the A2B and A3 receptors are located mainly peripherally and are involved in processes such as inflammation and immune ... Similarly to A2A receptor, the A2B receptor promotes osteoblast differentiation. The osteoblast cell is derived from the ... The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as endogenous ...
  https://en.wikipedia.org/wiki/Adenosine_receptor
*  Adenosine - Wikipedia
All adenosine receptor subtypes (A1, A2A, A2B, and A3) are G-protein-coupled receptors. The four receptor subtypes are further ... By nature of caffeine's purine structure, it binds to some of the same receptors as adenosine. Therefore, with the proviso that ... When adenosine enters the circulation, it is broken down by adenosine deaminase, which is present in red cells and the vessel ... "Adenosine receptors: therapeutic aspects for inflammatory and immune diseases". Nat Rev Drug Discov. 7 (9): 759-70. doi:10.1038 ...
  https://en.wikipedia.org/wiki/Adenosine
*  Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.com
... receptor receptors brain antagonists adrenal gland CV-11974, TCV-116 non-peptide RGD- integrins Cells in immune system ... 16 Vector type Receptor Comments/areas of use Ref Adenosine or Adenosine Vessel wall analogues receptors Heart ADP, UDP, UTP ... E1, E2 spermine EC of tumors K spermine EC of tumors K Substance P EC of tumors K transforming EC of tumors K growth factor-. ... from proteins to caffeine) and which therefore may be employed as vectors for targeting. [0127] v) DNA-binding drugs may behave ...
  http://www.patents.com/us-20050002865.html
*  Session Listing | 2017 Drosophila Research Conference
Effect of Adenosine Signaling on Apoptosis in Imaginal Disc Cells Lucie Kucerova. 256A spargel/dPGC-1 knockdown protects ... IAP-antagonist expression is not sufficient to induce caspase activation during Drosophila endogenous cell death Sarah Neuman. ... Thickveins, a BMP receptor, determines the Size of the Primordial Germ Cell Pool via the Soma through a Non-Canonical BMP ... Innate immune signaling in the Drosophila larval fat body disrupts nutrient storage Brittany Martinez. 316A Activin-Beta/TGF- ...
  http://www.genetics-gsa.org/drosophila/2017/pages/sessionlisting/Posters.shtml
*  Cordyceps - Scientific Review on Usage, Dosage, Side Effects | Examine.com
Co-incubation with an A2a receptor antagonist (in this study, CSC was used; caffeine is a popular A2a antagonist) reduced the ... May interact with the immune system (in a matter of suppression) to indirectly be anti-cancer, but actions in cell cultures are ... This spike was vicariously through an upregulation of A2a adenosine receptors (3-7 fold increase) with a concomitant decrease ... increase in testosterone by 20%, but inhibition of A3 reduced it by 50%.[25] The ultimate effect of Cordycepin is that it ...
  https://examine.com/supplements/cordyceps/
*  Items where Subject is "University of Westminster | Science and Technology | Life Sciences, School of (No longer in use)" -...
Lydyard, Peter M. and Porakishvili, Nino (2012) Cells, tissues and organs of the immune system. In: Immunology (8th edition). ... acts via Neuropeptide FF receptors to inhibit cyclic adenosine monophosphate release but has no Gonadotrophin-Releasing-Hormone ... The effects of glutamate receptor agonists and antagonists on mouse hypothalamic and hippocampal neuronal activity shown ... McMullen, Michael K., Whitehouse, Julie, Shine, Gillian, Whitton, Peter A. and Towell, Anthony (2012) Caffeine in hot drinks ...
  http://westminsterresearch.wmin.ac.uk/view/subjects/UOW2/2012.html
*  WO2007028171A1 - Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1...
... foreign cells and cancer cells and produce substances that regulate the immune response. [0049] The term 'relapsed' refers to a ... serotonin antagonists, cannabinoids, and NK1 receptor antagonists. Examples of phenothiazine antiemetics include, but are not ... 00233] HCT-116 cells were treated with 1OmM SNS-595 or 10 mM etoposide for 6 h with or without 2mM caffeine. Compound was then ... In another embodiment, the adenosine analog is cladribine. In another embodiment, the adenosine analog is cladribine and the ...
  https://patents.google.com/patent/WO2007028171A1/en
*  Abstracts - FIP - International Pharmaceutical Federation
Pharmacokinetics of lj-2698, a potent human a3 adenosine receptor antagonist, in rats ... Transplantation of islet cell clusters as an attractive strategy to overcome hypoxia induced cell death in pancreatic islet ... Evaluation of immune response to dncb and house dust mite antigen(hdm)-induced atopic dermatitis ... Analyzing efficacy, side effects, and perceptions survey of caffeine in korean population ...
  http://www.fip.org/?page=abstracts&action=favoriteaddlist&item=19936
*  Effects of Adenosine Receptor Antagonists on the In Vivo LPS-Induced Inflammation Model of Parkinson's Disease.
... receptor antagonist caffeine and the selective A(2A) receptor antagonist KW6002 on LPS-induced changes in the extracellular ... The study shows effects of the nonselective adenosine A(1)/A(2A) ... levels of dopamine (DA), glutamate, adenosine, hydroxyl radic ... 2008). It may be suggested that attenuation of glial cell activity by adenosine A2A receptor antagonists may diminish secretion ... Haskó G,Pacher P,Vizi ES,Illes P. Adenosine receptor signaling in the brain immune systemTrends Pharmacol SciYear: ...
  http://www.biomedsearch.com/nih/Effects-Adenosine-Receptor-Antagonists-In/23296550.html
*  IJMS | Free Full-Text | Neuroprotective and Therapeutic Strategies against Parkinson's Disease: Recent Perspectives | HTML
Adenosine Receptor Antagonists. Another potentially attractive target as a non-dopaminergic therapy is the adenosine A2A ... Barker, R.A. Developing Stem Cell Therapies for Parkinson's Disease: Waiting Until the Time Is Right. Cell Stem Cell 2014, 15, ... Ross, G.W.; Abbott, R.D.; Petrovitch, H.; White, L.R.; Tanner, C.M. Relationship between Caffeine Intake and Parkinson Disease ... In the earlier study, c-Abl was found to phosphorylate parkin and impair its E3 ligase activity, and eventually degenerate ...
  http://www.mdpi.com/1422-0067/17/6/904/htm
*  Journal of Neuroinflammation - ISSN: 1742-2094
Selective adenosine A2A receptor agonists and antagonists protect against spinal cord injury through peripheral and central ... Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis Author(s): Canova ... Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease Author(s): Chen Xuesong , Gawryluk ... Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in ...
  http://journaldatabase.info/journal/issn1742-2094
*  TRAP-14 AS A THERAPEUTIC AGENT - Patent application
... in all the cells. [0093]cAMP has been shown to be involved in the cardiovascular, nervous system, and immune mechanisms, cell ... NMDA receptor antagonist activity, augmentation of endogenous GABA inhibition; NO synthase inhibitor activity; iron binding ... 0086]Adenosine 3', 5'-cyclic monophosphate (cyclic AMP; cAMP) is one of the most important "second messengers" involved as a ... 0119]Examples for substance-related disorders are: alcohol related disorders, amphetamine related disorders, caffeine related ...
  http://www.patentsencyclopedia.com/app/20100210559
*  Buy Trental Online
Xanthine derivatives showed no activity on red blood cell tyrosine kinase. Furthermore, three xanthines, ie caffeine, ... Several of these agents, notably corticosteroids and prostaglandin E1, have been shown to be of no benefit in humans despite ... One other possible factor contributing to pruritus is the pattern of immune dysregulation. With advancing HIV buy trental -1 ... In addition, the JNK antagonist SP600125, but not the p38 inhibitor SB203580, prevents TNF-induced activation of S6 kinase, ...
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*  USE OF A PEPTIDE AS A THERAPEUTIC AGENT - Patent application
TL antagonists which can inhibit the proliferation of autoreactive T cells; cytokine antagonists; chemokine and adhesin ... immune response to body constituents or, in a broader sense, an immune response to self. The pathological immune response may ... In addition to the targeting of adhesion receptors by antibodies, small molecules that mimic epitopes of adhesion receptor ... 0118]Examples for substance-related disorders are: alcohol related disorders, amphetamine related disorders, caffeine related ...
  http://www.patentsencyclopedia.com/app/20100204140
*  Seiji Nishino | Stanford Medicine Profiles
Caffeine, an adenosine A1 and A2a receptor antagonist, is a widely consumed stimulant and also used for the treatment of ... and A3, 12.51 (4.75 to 19.94) mm Hg (A1 vs. A2 P = 0.249, A1 vs. A3 P < 0.001, A2 vs. A3 P < 0.001). In all of phase A, the ... receptors located on DA cell bodies (i.e., autoreceptors) for the regulation of cataplexy. Because the A11 cell group projects ... Thalidomide, immune modulation and narcolepsy SLEEP Kanbayashi, T., Nishino, S., Tafti, M., Hishikawa, Y., Dement, W. C., ...
  https://med.stanford.edu/profiles/seiji-nishino