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*  A2A Adenosine Receptor Signaling in Lymphocytes and the Central Nervous System Regulates Inflammation during Experimental...
A3 adenosine receptor agonist reduces brain ischemic injury and inhibits inflammatory cell migration in rats. Am. J. Pathol. ... CD73−/− mice or wild-type animals that are given either broad spectrum AR antagonists (such as caffeine) or A2AAR-specific ... adenosine's role in the immune response from its function in mediating immune cell migration into the CNS via the A2A receptor. ... Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor. ...
  http://www.jimmunol.org/content/188/11/5713.full
*  From 'Hellstrom Paradox-to anti-adenosinergic cancer immunotherapy
... of normal tissues from overactive immune cells by extracellular adenosine A2 receptors on the surface of immune cells. The A2 ... including an A2 receptor antagonist caffeine; (6) better tumor rejection observed in A2 receptor antagonist-treated mice is at ... T cells, including anti-tumor CD8+ T cells and human T cells, predominantly express A2AR and A2BR and not the A3 receptor [29, ... of normal tissues from overactive immune cells by extracellular adenosine A2 receptors on the surface of immune cells ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2096757/
*  Renal Adenosine in Health and Disease | Springer for Research & Development
... renal function in healthy and diseased kidney is mediated by activation of the four types of P1 purinergic adenosine receptors ... Reeves JJ, Jones CA, Sheehan MJ et al (1997) Adenosine A3 receptors promote degranulation of rat mast cells both in vitro and ... an adenosine A1 receptor antagonist, is mediated by cyclic adenosine monophosphate. Am J Kidney Dis 26:825-830PubMedCrossRef ... Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines. Cell ...
  https://rd.springer.com/chapter/10.1007%2F978-3-319-90808-3_19
*  Theophylline - Wikipedia
... and reduces inflammation and innate immunity nonselective adenosine receptor antagonist, antagonizing A1, A2, and A3 receptors ... "Caffeine Pharmacology". Website Medical News. Alboni et al. Effects of Permanent Pacemaker and Oral Theophylline in Sick Sinus ... Peters-Golden M, Canetti C, Mancuso P, Coffey MJ (2005). "Leukotrienes: underappreciated mediators of innate immune responses ... "Insights into the Regulation of TNF-α Production in Human Mononuclear Cells: The Effects of Non-Specific Phosphodiesterase ...
  https://en.wikipedia.org/wiki/Theophylline
*  Frontiers | Purinergic Signaling in Mast Cell Degranulation and Asthma | Pharmacology
... as well as by ATP-gated P2X receptors, plays a significant role in mast cell degranulation. Both adenosine and ATP can induce ... as well as by ATP-gated P2X receptors, plays a significant role in mast cell degranulation. Both adenosine and ATP can induce ... induced via the activation of G protein-coupled adenosine receptors and P2Y nucleotide receptors, ... induced via the activation of G protein-coupled adenosine receptors and P2Y nucleotide receptors, ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00947/full
*  Application # 2017/0143726. ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS TO MODULATE T CELL RESPONSES - Patents.com
A.sub.2a receptor antagonists in particular are provided to enhance imm ... Described are uses of A.sub.2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses ... cells to immune rejection. [0104] In one embodiment, the first A.sub.2a receptor antagonist stimulates an immune response for ... Specific antagonists of the A.sub.2a receptor include SCH-58261 (7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-t ...
  http://patents.com/us-20170143726.html
*  Adenosine A2A receptor - Wikipedia
3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists". Journal of Medicinal Chemistry. 46 (7 ... In addition, A2A receptor can negatively regulate overreactive immune cells, thereby protecting tissues from collateral ... "Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain". Frontiers in Bioscience. 13 (13): 2391-9. doi: ... Older research on adenosine receptor function, and non-selective adenosine receptor antagonists such as aminophylline, focused ...
  https://en.wikipedia.org/wiki/Adenosine_A2A_receptor
*  A1 Adenosine Receptor Upregulation and Activation Attenuates Neuroinflammation and Demyelination in a Model of Multiple...
... the activation of adenosine receptors on immune cells suppressed the production of proinflammatory mediators, including tumor ... Chou CC, Vickroy TW (2003) Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues. ... Although the soluble cytotoxic factor(s) remains unknown, studies with glutamate receptor antagonists failed to inhibit ... role of A3 adenosine receptors. J Immunol 156: 3435-3442. ... Neuroprotection by caffeine and adenosine A2A receptor blockade ...
  http://www.jneurosci.org/content/24/6/1521
*  Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling
Methotrexate and its therapeutic antagonists caffeine and theophylline, target a motogenic T-cell mechanism driven by ... Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3-activated killer T cells.. Hoskin DW, Butler ... Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors.. Sitkovsky M, Lukashev D., Nat. ... Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling. Linnemann C, Schildberg ...
  https://pub.uni-bielefeld.de/publication/1591412
*  Adenosine receptor - Wikipedia
Kalda A, Yu L, Oztas E, Chen JF (October 2006). "Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in ... while the A2B and A3 receptors are located mainly peripherally and are involved in processes such as inflammation and immune ... Similarly to A2A receptor, the A2B receptor promotes osteoblast differentiation. The osteoblast cell is derived from the ... The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as endogenous ...
  https://en.wikipedia.org/wiki/Adenosine_receptor
*  Purinergic signalling - Wikipedia
... leading to an accumulation of adenosine. On the other hand, the adenosine-receptor antagonist caffeine reverses the anti- ... doi:10.1016/S1043-2760(01)00387-3. Junger, Wolfgang G. (18 February 2011). "Immune cell regulation by autocrine purinergic ... On the other hand, nanomolar concentrations of adenosine activate A1 and A3 receptors, resulting in neutrophilic chemotaxis ... Formation of foam cells is inhibited by adenosine A2A receptors. Abnormal levels of ATP and adenosine are present in the ...
  https://en.wikipedia.org/wiki/Purinergic_signalling
*  Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors | JEM
Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation. J. Clin. Invest. 100:2849-2857. doi:10.1172/ ... Adenosine, adenosine receptors and the actions of caffeine. Pharmacol. Toxicol. 76:93-101. doi:10.1111/j.1600-0773.1995.tb00111 ... Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204: ... reuteri in combination with A2A receptor-specific antagonist SCH58261 (Fig. 7 A). We found that the A2A antagonist SCH58261 ...
  http://jem.rupress.org/content/early/2016/12/22/jem.20160961
*  Adenosine - Wikipedia
All adenosine receptor subtypes (A1, A2A, A2B, and A3) are G-protein-coupled receptors. The four receptor subtypes are further ... By nature of caffeine's purine structure, it binds to some of the same receptors as adenosine. Therefore, with the proviso that ... When adenosine enters the circulation, it is broken down by adenosine deaminase, which is present in red cells and the vessel ... "Adenosine receptors: therapeutic aspects for inflammatory and immune diseases". Nat Rev Drug Discov. 7 (9): 759-70. doi:10.1038 ...
  https://en.wikipedia.org/wiki/Adenosine
*  Plus it
... adenosine receptor antagonists theophylline and caffeine reverse the effects of methotrexate on the development of adjuvant ... Montesinos MC, Desai A, Delano D, Chen JF, Fink JS, Jacobson MA, and Cronstein BN (2003) Adenosine A2A or A3 receptors are ... the anti-inflammatory effects of methotrexate are mediated by adenosine acting at adenosine receptors on inflammatory cells in ... Medzihradsky JL (1984) Regulatory role for the immune complex in modulation of phagocytosis by 3-deazaadenosine. J Immunol 133: ...
  http://pharmrev.aspetjournals.org/content/57/2/163
*  Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.com
... receptor receptors brain antagonists adrenal gland CV-11974, TCV-116 non-peptide RGD- integrins Cells in immune system ... 16 Vector type Receptor Comments/areas of use Ref Adenosine or Adenosine Vessel wall analogues receptors Heart ADP, UDP, UTP ... E1, E2 spermine EC of tumors K spermine EC of tumors K Substance P EC of tumors K transforming EC of tumors K growth factor-. ... from proteins to caffeine) and which therefore may be employed as vectors for targeting. [0127] v) DNA-binding drugs may behave ...
  http://www.patents.com/us-20050002865.html
*  EGF Prevents the Neuroendocrine Differentiation of LNCaP Cells - Page 2
... as Taladegib illustrated from the pharmacological ramifications of caffeine, a nonselective antagonist of adenosine receptors, ... fighting capability cell that kick-starts effective immune Mouse monoclonal to CD4.CD4 is a co-receptor involved in immune ... and A3. Specifically, adenosine A1 receptor activity most carefully corresponds compared to that of the retaliatory metabolite ... and in cells with abundant adenosine A1 receptors, it might be that both AMP and Taladegib adenosine become retaliatory ...
  http://sprentland.com/page/2/
*  The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases
... immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy. ... The A2A receptor activity, a T-cell surface immune checkpoint protein, could lead to the discovery that adenosine in the tumor ... and A3 receptors [44-46]. These are G protein-coupled receptors, which present inhibitory action upon adenosine binding [20]. ... S. Shiozaki, S. Ichikawa, J. Nakamura, S. Kitamura, K. Yamada, and Y. Kuwana, "Actions of adenosine A2A receptor antagonist KW- ...
  https://www.hindawi.com/journals/jir/2018/4892473/
*  Session Listing | 2017 Drosophila Research Conference
Effect of Adenosine Signaling on Apoptosis in Imaginal Disc Cells Lucie Kucerova. 256A spargel/dPGC-1 knockdown protects ... IAP-antagonist expression is not sufficient to induce caspase activation during Drosophila endogenous cell death Sarah Neuman. ... Thickveins, a BMP receptor, determines the Size of the Primordial Germ Cell Pool via the Soma through a Non-Canonical BMP ... Innate immune signaling in the Drosophila larval fat body disrupts nutrient storage Brittany Martinez. 316A Activin-Beta/TGF- ...
  http://www.genetics-gsa.org/drosophila/2017/pages/sessionlisting/Posters.shtml
*  Rebound effect of modern drugs: Serious adverse event unknown by health professionals
Antidyspeptic agents (antacids, H2 receptor antagonists, misoprostol, sucralfate, and proton-pump inhibitors, among others) ... To increase the body of evidence for and the understanding of the rebound effect vis-à-vis clinical and experimental ... Analgesics (caffeine, calcium channel blockers, clonidine, ergotamine, methysergide, opiates, and salicylates, among others) ... Tan IL, McArthur JC, Clifford DB, Major EO, Nath A. Immune reconstitution inflammatory syndrome in natalizumab-associated PML. ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302013000600019&lng=en&nrm=iso&tlng=en
*  Items where Subject is "University of Westminster | Science and Technology | Life Sciences, School of (No longer in use)" -...
Lydyard, Peter M. and Porakishvili, Nino (2012) Cells, tissues and organs of the immune system. In: Immunology (8th edition). ... acts via Neuropeptide FF receptors to inhibit cyclic adenosine monophosphate release but has no Gonadotrophin-Releasing-Hormone ... The effects of glutamate receptor agonists and antagonists on mouse hypothalamic and hippocampal neuronal activity shown ... McMullen, Michael K., Whitehouse, Julie, Shine, Gillian, Whitton, Peter A. and Towell, Anthony (2012) Caffeine in hot drinks ...
  http://westminsterresearch.wmin.ac.uk/view/subjects/UOW2/2012.html
*  Frontiers | G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs | Frontiers in Aging...
The G protein coupled receptors (GPCRs) have been considered as one of the largest families of validated drug targets, which ... The G protein coupled receptors (GPCRs) have been considered as one of the largest families of validated drug targets, which ... a non-selective A1 and A2A adenosine receptor antagonist, to APPSwe transgenic mice. Caffeine treatment also improved cognition ... Adenosine Receptor. Introduction to Adenosine Receptor. Adenosine is found in all cells including glia and neurons, and plays ...
  https://www.frontiersin.org/articles/10.3389/fnagi.2016.00058/full
*  Cordyceps - Scientific Review on Usage, Dosage, Side Effects | Examine.com
Co-incubation with an A2a receptor antagonist (in this study, CSC was used; caffeine is a popular A2a antagonist) reduced the ... May interact with the immune system (in a matter of suppression) to indirectly be anti-cancer, but actions in cell cultures are ... This spike was vicariously through an upregulation of A2a adenosine receptors (3-7 fold increase) with a concomitant decrease ... increase in testosterone by 20%, but inhibition of A3 reduced it by 50%.[25] The ultimate effect of Cordycepin is that it ...
  https://examine.com/supplements/cordyceps/
*  WO2007028171A1 - Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1...
... foreign cells and cancer cells and produce substances that regulate the immune response. [0049] The term 'relapsed' refers to a ... serotonin antagonists, cannabinoids, and NK1 receptor antagonists. Examples of phenothiazine antiemetics include, but are not ... 00233] HCT-116 cells were treated with 1OmM SNS-595 or 10 mM etoposide for 6 h with or without 2mM caffeine. Compound was then ... In another embodiment, the adenosine analog is cladribine. In another embodiment, the adenosine analog is cladribine and the ...
  https://patents.google.com/patent/WO2007028171A1/en
*  Application # 2017/0319560. PYRAZOLE, TRIAZOLE AND TETRAZOLE OREXIN RECEPTOR ANTAGONISTS - Patents.com
The present invention is directed to pyrazole, triazole and tetrazole compounds which are antagonists of orexin receptors. The ... adenosine receptor antagonists, cholinergic agonists, NMDA receptor antagonists, serotonin receptor antagonists and dopamine ... Cell, 1998, 92, 573-585): the orexin-1 receptor (OX or OX1R) is selective for OX-A and the orexin-2 receptor (OX2 or OX2R) is ... Similarly, the subject compound may be administered with a pain reliever; a potentiator such as caffeine, an H2-antagonist, ...
  http://patents.com/us-20170319560.html
*  Uncategorized - Pharmacodynamic Biomarker Development for PI3K Pathway
Caffeine is normally a well-known antagonist of the receptor. Solid epidemiological evidence signifies that espresso drinkers ... We also assayed immune-modulatory cytokines and markers of T cell cytotoxicity aswell as T cell exhaustion markers as well as ... 28). It has additionally been reported the anti-inflammatory mediator, resolvin E1, promotes regeneration of periodontal cells ... e and f, Just like c and d but also for the agonists, adenosine (e) and NECA (f), respectively. All data will be the suggest ...
  http://www.baxkyardgardener.com/category/uncategorized/