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*  Kinetic-segregation model of T cell activation - Wikipedia
... the immobilized conventional antibody poses less prominent spatial constraints than the immobilized superagonistic antibody. ... However, when these antibodies are immobilized (either by secondary antibody bound to plastic or by Fc receptors on other cells ... Immobilized superagonistic antibodies bound to CD28 exclude CD45 phosphatases completely and the signal leading to T-cell ... However, its authors suggest it might be also applied to CD28 triggering by superagonistic antibodies (mitogenic antibodies). ...
  https://en.wikipedia.org/wiki/Kinetic-segregation_model_of_T_cell_activation
*  31st week of 2011 patent applcation highlights part 43
Superagonistic Anti-CD28 Antibodies - The present invention relates to one or more nucleic acid(s) encoding a binding molecule ... The electrode is then exposed to an antibody-enzyme liquid comprising an antibody-enzyme species, said antibody-enzyme species ... The present invention provides for the retention of catalysts and other immobilized entities within a reaction region. In one ... MONOCLONAL ANTIBODY STRO-4 - The present invention relates to a monoclonal antibody designated STRO-4 which specifically binds ...
  http://www.patentsencyclopedia.com/hgl/08-04-11/08-04-11_43