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*  Frontiers | Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Cells |...
The antigen receptors on mature and immature T lymphocytes are coupled to phosphatidylcholine-specific phospholipase D ... The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nat Cell Biol ( ... Engagement of the T lymphocyte antigen receptor regulates association of son-of-sevenless homologues with the SH3 domain of ... RasGRP proteins have been studied most extensively in T- and B-lymphocytes. In these lymphocytes, RasGRP1 and RasGRP3 activate ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2013.00239/full
*  Lymphocytoblast - definition of lymphocytoblast by The Free Dictionary
n. A large, immature lymphocyte that has been activated by an antigen and divides to give rise to mature lymphocytes . lym′pho· ... A large, immature lymphocyte that has been activated by an antigen and divides to give rise to mature lymphocytes (B cells and ... lymphoblast - an immature lymphocyte. lymph cell, lymphocyte - an agranulocytic leukocyte that normally makes up a quarter of ... an abnormal cell consisting of a large nucleus and small cytoplasm that was once thought to be an immature lymphocyte and is ...
  http://www.thefreedictionary.com/lymphocytoblast
*  Regulatory Dendritic Cells for Immunotherapy in Immunologic Diseases
... blood dendritic cell antigen; CTLA4, cytotoxic T lymphocyte antigen-4; DC10 or DC-10, semi-mature or immature, respectively, IL ... Antigen presentation and immune regulatory capacity of immature and mature-enriched antigen presenting (dendritic) cells ... Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans. Blood (2002) 100( ... Immature or semi-mature dendritic cells that are incubated with, or differentiated in the presence of, tolerogenic factors (e.g ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3907717/
*  T independent antigen (TI) - Wikipedia
TI-2 antigens can activate only mature B lymphocytes. Immature B cells are anergized, so they do not elicit any immune response ... T independent antigen elicits antibody production by B lymphocytes without T lymphocyte involvement. There are 2 distinct ... TI-1 antigens activate B-cells via Toll like receptors, which are, in human, expressed on the surface of B lymphocytes after ... For most protein antigens, the production of antibodies by B lymphocytes is dependent on stimulation of helper T cells. However ...
  https://en.wikipedia.org/wiki/T_independent_antigen_(TI)
*  Immune System facts, information, pictures | Encyclopedia.com articles about Immune System
... the antigen binds to specific receptors on mature lymphocytes of both types. The antibody on B-lymphocytes recognizes and binds ... Many autoreactive clones are eliminated before they mature in the marrow and thymus, because when immature B or T cells have ... Antigen recognition by lymphocytes. The B lymphocyte's antigen receptor is a membrane-bound version of the antibody it will ... Further, while B lymphocytes can bind native antigens directly, T lymphocytes can only bind an antigen when it is degraded and ...
  https://www.encyclopedia.com/medicine/anatomy-and-physiology/anatomy-and-physiology/immune-system
*  Central tolerance - Wikipedia
Unlike mature peripheral lymphocytes, which become activated upon encountering their specific antigen, the immature lymphocytes ... B cells may encounter two types of antigen, multivalent cell surface antigens or low valence soluble antigens: When immature B ... If mature peripheral B cells encounter multivalent antigen (e.g. cell surfaces) they are eliminated via apoptosis. If mature B ... with immature lymphocytes being tolerance sensitive. Lederberg's theory that self-tolerance is 'learned' during lymphocyte ...
  https://en.wikipedia.org/wiki/Central_tolerance
*  Immunologic aspect of ovarian cancer and p53 as tumor antigen | Journal of Translational Medicine | Full Text
Furthermore the role of p53 as tumor antigen and its potential role as target antigen in ovarian cancer is summarized. Based on ... Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or ... cells influences the outcome of antigen recognition by CD8+ T cells was obtained in studies in which vaccination with mature ... Antigen presenting cells, most likely dendritic cells, can capture tumor antigens that are secreted or shed by tumor cells or ...
  https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-3-34
*  Cellular Signaling Events in B Lymphocytes | Springer for Research & Development
The B lymphocyte is the principal cellular mediator of the specific humoral immune response to infection. B cells arise from ... or apoptosis of immature B cells, (2) activation and proliferation of mature B cells, or (3) rescue of germinal center cells ... Reth, M., 1992, Antigen receptors on B lymphocytes, Annu. Rev. Immunol. 10: 97-121.PubMedGoogle Scholar ... Carter, R. H., and Fearon, D. T., 1992, CD19: Lowering the threshold for antigen receptor stimulation of B lymphocytes, Science ...
  https://rd.springer.com/chapter/10.1007/978-0-585-31728-1_4
*  CD38 - Product: Leica Biosystems
It is found on immature cells of the B and T cell lineages but not on most mature resting peripheral lymphocytes. It is also ... Although the CD38 molecule was originally identified as a T lymphocyte differentiation antigen, it is reported to be expressed ... Antigen Background The CD38 molecule is a type II single transmembrane glycoprotein with a molecular weight of 46 kD. It is an ... CD38 antigen has also been reported in neurofibrillary tangles, the pathological indicator of Alzheimer's disease that occurs ...
  https://www.leicabiosystems.com/ihc-ish-fish/immunohistochemistry-ihc-antibodies-novocastra-reagents/primary-antibodies/products/cd38/
*  Histopathological and immunohistochemical characterisation of hepatic granulomas in Leishmania donovani-infected BALB/c mice: a...
Immature vs mature: t = -38.410, P , 0.001; Immature vs clear: t = 4.181, P , 0.001 and mature vs clear: t = 18.669, P , 0.001 ... Clear granuloma composed mainly of lymphocytes (arrow). d Immunohistochemical detection of Leishmania donovani antigens (400 ... immature: t = -3.291, P , 0.001 and mature: t = -2.202, P , 0.029; 15 vs 63 dpi, immature: t = -5.691, P , 0.001 and mature: t ... The expression of Ly-6G within granulomas was higher in mature compared to immature and clear granulomas. Within mature ...
  https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-018-2624-z
*  Neurosecretory cell | definition of neurosecretory cell by Medical dictionary
Immature T cells are called thymocytes. Mature T cells are antigen specific. Their surface receptors (T cell receptors, abbrev ... null cells lymphocytes that lack the surface antigens characteristic of B and T lymphocytes; seen in active systemic lupus ... A lymphocyte that responds to specific antigens, with the assistance of antigen-presenting cells (APCs). T cells arise in the ... lymphocyte-like cells that lack specific antigen receptors and other surface markers characteristic of B and T lymphocytes; ...
  https://medical-dictionary.thefreedictionary.com/neurosecretory+cell
*  Segmented cell | definition of segmented cell by Medical dictionary
Immature T cells are called thymocytes. Mature T cells are antigen specific. Their surface receptors (T cell receptors, abbrev ... A lymphocyte that responds to specific antigens, with the assistance of antigen-presenting cells (APCs). T cells arise in the ... A cell derived from B or T lymphocytes that can quickly recognize a foreign antigen to which the body has been previously ... A cell derived from a B lymphocyte that has been sensitized to a specific foreign antigen and produces antibodies to that ...
  https://medical-dictionary.thefreedictionary.com/segmented+cell
*  Plus it
Impaired antigen-specific immunity after high-level SCI is a result of mature B lymphocyte cell death and impaired B-cell ... and immature transitional (blue; B220+AA4.1+) B lymphocytes. Mature B cells can be subdivided into follicular B cells (FOB; ... Loss of mature B cells is expected to stimulate compensatory lymphopoiesis, culminating in an increase in numbers of immature ( ... Gating strategies to define mature versus immature B cells are shown by box around red- or blue-shaded cell populations. B, ...
  http://www.jneurosci.org/content/33/32/12970
*  Control of B cell development and malignant transformation by microRNA-142 | The Journal of Immunology
... mice display a significant expansion of the B cell compartment due to the accumulation of immature and mature B lymphocytes. To ... that is characterized by hypoimmunoglobulinemia and failure to mount robust humoral immune responses to soluble antigen ... In contrast, miR-142 ablation had little effect on the frequency of small pre-B cell and immature B cell populations. ... mice with Eμ-myc transgenic mice that spontaneously develop a mix of pre-B cell and mature B cell lymphomas. We found that miR- ...
  http://www.jimmunol.org/content/198/1_Supplement/202.21
*  KAKEN - Research Projects | Analysis for molecular and cellular mechanism regulating differentiation, activation and programmed...
In contrast, immature lymphocytes usually undergo apoptosis, rather than proliferation, upon triggering through BCR.This is the ... Signaling through the BCR primarily drives mature B cells into proliferation leading to the expansion of antigen-specific ... 4) We showed the first direct evidence of a cross-talk between G-protein mediated signal pathway and antigen-receptor mediated ... Publications] X-M.Wu,M.Nakashima and T.Watanabe: 'Selective suppressin of antigen specific Th2 cells by continuous micro-dose ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08407012/
*  Identification of Toxoplasma gondii protein fractions induce immune response against melanoma in mice. | Sigma-Aldrich
Moreover, the capacity of mature DCs (mDCs) to induce lymphocyte proliferation was investigated. Ultimately, we analyzed the ... Immature DCs (iDCs) were treated by these protein fractions and were monitored for IL-12p70 and IL-10 production. ... Soluble tachyzoite antigens (STAgs) were fractionated by ammonium sulfate precipitation and subsequently by anion-exchange HPLC ... Therefore, in this study, we aimed to find the most effective protein components of T. gondii which are able to mature DCs and ...
  https://www.sigmaaldrich.com/catalog/papers/26152792
*  Plus it
1A). Immunostaining for mature endothelium antigen vWF or immature and mature endothelium antigen CD31 yielded similar results ... Sca-1 and CD31 are both mature endothelial and T lymphocyte markers, making it unclear if tumor fibroblast SDF-1 expression ... we analyzed intracranial KR158/ΔEGFR tumors for expression of pericyte antigen NG2, endothelial antigen CD31, and GFP by ... Many nonendothelial marrow-derived GFP+ cells were CD45+CD11b− (data not shown), consistent with marrow-derived lymphocytes. ...
  http://cancerres.aacrjournals.org/content/66/18/9054
*  A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering | BMC Genomics | Full Text
... mature B lymphocytes respond to BCR engagement by clonal expansion [1]. Increasing evidence suggests that immature and mature B ... King LB, Monroe JG: Immunobiology of the immature B cell: plasticity in the B-cell antigen receptor-induced response fine tunes ... Gene expression profiles of T1 immature and mature B lymphocytes in response to BCR triggering. (A) k-means clustering using ... Genes discriminating transcriptional profiles of splenic mature and T1 immature B lymphocytes. The analysis was based on one- ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-10-323
*  Frontiers | A Model of Dendritic Cell Therapy for Melanoma | Oncology
Dendritic cells are a promising immunotherapy tool for boosting an individual's antigen specific immune response to cancer. We ... Dendritic cells are a promising immunotherapy tool for boosting an individual's antigen specific immune response to cancer. We ... DCs are part of the antigen-specific (adaptive) immune response and function as antigen-presenting cells. Immature DCs are ... The first term in equation (5) reflects our assumption that there is a maximum rate at which mature DCs can enter the spleen. ...
  https://www.frontiersin.org/articles/10.3389/fonc.2013.00056/full
*  Human prophylactic vaccine adjuvants and their determinant role in new vaccine formulations
They stimulate immature and mature B cells in newborn, and IgM antibodies in CBA/N (xid) mice. In contrast, the TI-2 like ... Antigens can be classified as TD (most proteins) or TI. The TI responses are divided into types 1 and 2. The TI-1 inducing LPS ... This concept is strongly challenged by earlier data showing that uric acid crystals augment cytotoxic T lymphocyte (CTL) ... They only stimulate mature B cells, and this stimulation does not occur in newborn or xid mice (10). They induce IgM and IgG ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012007500067&lng=en&nrm=iso&tlng=en
*  B lymphocytes can regulate the maturation and function of human dendritic cells but are partially inefficient in systemic lupus...
Backgroundand objectives Mature dendritic cells (DCs) are stimulators of T cell immune response, whereas immature DCs support T ... the production of IL-12p70 required for antigen presentation and Th1 differentiation. They also inhibited the DC-induced T cell ... Peripheral blood monocytes were differentiated into immature DCs and then into mature DCs. Activated B cells were co-cultured ... Results Activated B cells restrained the development of monocytes into immature DCs and their differentiation into mature DCs. ...
  http://ard.bmj.com/content/71/Suppl_1/A34.1
*  Alfred Singer - Wikipedia
He is best known for his work regarding lymphocyte development, particularly the differentiation of immature CD4+8+ (double ... Singer's work is foundational in the understanding of T cells and MHC-restricted antigen recognition. Singer's work explores ... positive) thymocytes into mature T cells. ...
  https://en.wikipedia.org/wiki/Alfred_Singer
*  Antigen processing - Wikipedia
... stimulus and start antigen processing and move toward lymph nodes where these APCs present antigen to mature T lymphocytes. ... at immature stage) come in contact with antigenic cells or disease causing viruses etc. these cells produce an inflammatory ... Antigen processing is an immunological process that prepares antigens for presentation to special cells of the immune system ... Both MHC class I and II are required to bind antigen before they are stably expressed on a cell surface. MHC I antigen ...
  https://en.wikipedia.org/wiki/Antigen_processing
*  Non-homologous end joining - Wikipedia
... mature animals with an immature lymphocyte repertoire". Science. 261 (5125): 1175-8. doi:10.1126/science.8356452. PMID 8356452 ... "Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes". Science. 261 (5125): 1171-5. doi: ...
  https://en.wikipedia.org/wiki/Non-homologous_end_joining