Islet amyloid polypeptide, islet amyloid, and diabetes mellitus
Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of beta-cells of the pancreatic islets of ... IAPP was discovered through its ability to aggregate into pancreatic islet amyloid deposits, which are seen particularly in ... Islet amyloid polypeptide, islet amyloid, and diabetes mellitus. Westermark, Per Uppsala University, Disciplinary Domain of ... This review deals both with physiological aspects of IAPP and with the pathophysiological role of aggregated forms of IAPP, ...http://uu.diva-portal.org/smash/record.jsf?pid=diva2:433916
Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of...
... deficit in β-cells and islet amyloid derived from islet amyloid polypeptide (IAPP), a 37-amino acid peptide cosecreted with ... A total of 40 Sprague-Dawley rats (wild type; n = 7) and rats expressing human IAPP (HIP rats; n = 33) were used in the current ... Diabetes due to a progressive defectin beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP rat): a new ... Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic ...http://diabetes.diabetesjournals.org/content/58/7/1604.full
Altered immunoreactivity of islet amyloid polypeptide (IAPP) may reflect major modifications of the IAPP molecule in...
Altered immunoreactivity of islet amyloid polypeptide (IAPP) may reflect major modifications of the IAPP molecule in ... but label strongly IAPP in its amyloid form. The varying findings of IAPP immunoreactivity in pancreatic islets indicate that ... IAPP is a more amyloidogenic IAPP molecule and may be associated with an increased islet amyloid formation in vivo. ... MAb4A5 labels immunohistochemically cellular IAPP but not IAPP in islet amyloid deposits. In contrast to MAb4A5 polyclonal ...http://liu.diva-portal.org/smash/record.jsf?pid=diva2:545008
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism | JEM
human IAPP. IAPP. islet amyloid polypeptide. Mcc. microcin. PMD. protein misfolding disease. rpm. revolutions per minute. STZ. ... Induction of IAPP amyloid deposition in islets by incubation with synthetic IAPP aggregates. (See also Figs. S3 and S4.) (A) ... Appearance of IAPP aggregates was assessed by histologic studies using anti-IAPP antibody (A) or the amyloid-binding dye ThS (B ... Islet amyloid deposits, composed predominantly of a misfolded and aggregated form of the islet amyloid polypeptide (IAPP), are ...http://jem.rupress.org/content/214/9/2591
Islet Amyloid Polypeptide Amylin or Diabetes Associated Peptide or Insulinoma Amyloid Peptide or IAPP Pipeline Review, H2 2017...
Islet Amyloid Polypeptide Amylin or Diabetes Associated Peptide or Insulinoma Amyloid Peptide or IAPP Pipeline Review, H2 ... Islet Amyloid Polypeptide Amylin or Diabetes Associated Peptide or Insulinoma Amyloid Peptide or IAPP Islet amyloid polypeptide ... Amyloid Polypeptide Amylin or Diabetes Associated Peptide or Insulinoma Amyloid Peptide or IAPP Pipeline Review, H2 2017. ... Islet Amyloid Polypeptide Amylin or Diabetes Associated Peptide or Insulinoma Amyloid Peptide or IAPP pipeline Target ...https://www.bioportfolio.com/news/article/3410692/Islet-Amyloid-Polypeptide-Amylin-or-Diabetes-Associated-Peptide-or-Insulinoma-Amyloid-Peptide.html
Insights into Mechanisms of Amyloid Toxicity: Molecular Dynamics Simulations of the Amyloid andbeta-peptide (Aandbeta) and...
Molecular Dynamics Simulations of the Amyloid andbeta-peptide (Aandbeta) and Islet Amyloid Polypeptide (IAPP). ... A characteristic feature of T2D is the deposition of the islet amyloid polypeptide (IAPP) in the pancreatic islets of ... Functional amyloids found throughout nature have demonstrated that amyloid fibers are potential industrial biomaterials. This ... Discovery and Mechanisms of Small Molecule Amyloid Formation Inhibitors Velander, Paul William (Virginia Tech, 2018-01-17) ...https://vtechworks.lib.vt.edu/handle/10919/73773
Minireview: Secondary β-Cell Failure in Type 2 Diabetes-A Convergence of Glucotoxicity and Lipotoxicity. - Semantic Scholar
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism. *Abhisek Mukherjee, Diego ... Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology. *Rehana Akter, Ping Cao, +8 authors Daniel P Raleigh ...https://www.semanticscholar.org/paper/Minireview%3A-Secondary-%CE%B2-Cell-Failure-in-Type-2-of-Poitout-Robertson/531a3a8c7087583a2a14dfc1dff6988056b44b8e
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Islet amyloid polypeptide (IAPP or amylin) forms amyloid deposits in the islets of Langerhans; a process that is believed to ... General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers. ... The compounds do not induce a conformational change in IAPP and are ineffective inhibitors of IAPP amyloid formation, although ... IAPP and A?, the peptide responsible for amyloid formation in Alzheimer's disease, are particularly interesting in this regard ...https://www.jove.com/visualize/abstract/25260075/general-amyloid-inhibitors-critical-examination-inhibition-iapp
Protein Conformational Disease: Visit the Facts at a Glance
2017) Effects of protein corona on IAPP amyloid aggregation, fibril remodelling, and cytotoxicity. Scientific Reports 7 (1): ... Chiti F and Dobson CM (2006) Protein misfolding, functional amyloid, and human disease. Annual Review of Biochemistry 75: 333- ... Potter H (2001) The inflammation‐induced pathological chaperones ACT and apo‐E are necessary catalysts of Alzheimer amyloid ... 2004) Beta‐sheet breaker peptide prevents A beta‐induced spatial memory impairments with partial reduction of amyloid deposits ...http://www.els.net/WileyCDA/ElsArticle/refId-a0021868.html
Metabolism | JEM
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism Abhisek Mukherjee, Diego ...http://jem.rupress.org/collection/metabolism
Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells. -...
IAPP, islet amyloid polypeptide; iPSC, cells before differentiation.. Reversal of hyperglycemia in diabetic mouse models using ...https://www.ncbi.nlm.nih.gov/pubmed/20616080
Amyloid Plaques. Amyloid plaques, which characterize islets in T2D, consist mainly of islet amyloid polypeptide (IAPP). In ... Metabolic stress, IAPP and islet amyloid. Diabetes Obes Metab 2012;14(Suppl. 3):68-77. ... Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. ... For example, early hyperglycemia may activate multiple pathophysiologic processes, including inflammation, amyloid accumulation ...http://care.diabetesjournals.org/content/37/6/1751
Frontiers | Biophysical Insights into How Surfaces, Including Lipid Membranes, Modulate Protein Aggregation Related to...
These diseases are commonly classified as protein misfolding or amyloid diseases. The interaction of these proteins with liquid ... These diseases are commonly classified as protein misfolding or amyloid diseases. The interaction of these proteins with liquid ... islet amyloid polypeptide (IAPP; Knight and Miranker, 2004), and β-amyloid (Aβ; McLaurin and Chakrabartty, 1996, 1997; Choo- ... 2004). Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers. FEBS Lett. 577, ...https://www.frontiersin.org/articles/10.3389/fneur.2013.00017/full
Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology
R. L. Hull, S. Zraika, J. Udayasankar, K. Aston-Mourney, S. L. Subramanian, and S. E. Kahn, "Amyloid formation in human IAPP ... L. E. Buchanan, E. B. Dunkelberger, H. Q. Tran et al., "Mechanism of IAPP amyloid fibril formation involves an intermediate ... A. Abedini and D. P. Raleigh, "Destabilization of human IAPP amyloid fibrils by proline mutations outside of the putative ... M. Stridsberg, S. Sandler, and E. Wilander, "Cosecretion of islet amyloid polypeptide (IAPP) and insulin from isolated rat ...https://www.hindawi.com/journals/jdr/2016/2798269/ref/
Abbreviations: FAP, familial amyloidotic polyneuropathy; SAA, serum amyloid A; IAPP, islet amyloid polypeptide; Aβ, amyloid β; ... Amyloid and autoimmunity 5.1. Amyloid-β vaccine for the treatment of AD 5.2. Amyloid and immune homeostasis AD is the most ... Therapeutic clearance of amyloid by antibodies to serum amyloid P component. N. Engl. J. Med. 373, 1106-1114. Saibil, H.R., ... 2. Amyloid and inﬂammation 2.1. Amyloidosis and amyloid-related disease The amyloidosis consists of a variety of heterogeneous ...https://www.docme.ru/doc/2192837/j.imbio.2017.10.038
BRICHOS domains efficiently delay fibrillation of amyloid β-peptide. - Semantic Scholar
Electron microscopy shows that although the process is delayed, typical amyloid fibrils are eventually formed also when BRICHOS ... We find that recombinant BRICHOS domains from Bri2 and pro-SP-C prevent fibril formation of amyloid β-peptides (Aβ(40) and Aβ( ... Amyloid diseases such as Alzheimer, Parkinson, and prion diseases are associated with a specific form of protein misfolding and ... Islet amyloid polypeptide ( IAPP ) in Type 2 diabetes and Alzheimer disease. *Marie E. Oskarsson ...https://www.semanticscholar.org/paper/BRICHOS-domains-efficiently-delay-fibrillation-of-Willander-Presto/53d3d265f145bbbdb70125cc51a001fe90bcd901
Natural tri- to hexapeptides self-assemble in water to amyloid β-type fiber aggregates by unexpected α-helical intermediate...
1999) Conformational transitions of islet amyloid polypeptide (IAPP) in amyloid formation in vitro. J Mol Biol 287:781-796. ... 2009) Amyloids as natural storage of peptide hormones in pituitary secretory granules. Science 325:328-332. ... Amyloid fiber aggregates are further examples of self-assembly. They are found in microorganisms (such as bacteria and fungi) ... 2010) Identifying the amylome, proteins capable of forming amyloid-like fibrils. Proc Natl Acad Sci USA 107:3487-3492. ...http://www.pnas.org/content/108/4/1361
ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice | SpringerLink
... forms from the aggregation of islet amyloid polypeptide (IAPP), a beta cell peptide that is produced and co-secreted with... ... Aims/hypothesis Islet amyloid, a pathological feature of type 2 diabetes, ... hIAPP Tg/o; black bars: hIAPP Tg/o Abca1 βKO) from hIAPP Tg/o and hIAPP Tg/o Abca1 βKO mice. (e) Thioflavin S (ThioS) staining ... hIAPP Tg/o Abca1 βKO islets had an amyloid area twofold greater than that of islets from hIAPP Tg/o mice, as determined by ...https://link.springer.com/article/10.1007/s00125-016-3907-6
LiU Electronic Press
Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP. ... Artikel i tidskrift: Effects of free fatty acid on polymerization of islet amyloid polypeptide (IAPP) in vitro and on amyloid ... Artikel i tidskrift: Altered immunoreactivity of islet amyloid polypeptide (IAPP) may reflect major modifications of the IAPP ... Konferensbidrag: Effects of free fatty acids (FFAs) on polymerization of islet amyloid polypeptide (IAPP). Gunilla Westermark, ...http://www.ep.liu.se/m/default.sv.aspx?uid=gunwe13
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism. Mukherjee, A, Morales- ...http://www.houstonmethodist.org/faculty/aosama-gaber/
Conformational characterization of oligomeric intermediates and aggregates in β-lactoglobulin heat aggregation - Carrotta -...
Conformational transitions of Islet amyloid polypeptide (IAPP) in amyloid formation in vitro. J. Mol. Biol. 287: 781-796. * ... Thioflavine T interaction with amyloid β-sheet structures. Amyloid: Int. J. Exp. Clin. Invest. 2: 1-6. *CAS ... Amyloid β-protein fibrillogenesis. Detection of a protofibrillar intermediate. J. Biol. Chem. 272: 22364-22372. *CrossRef , ... 2000). These amyloid fibrils are usually detected by using staining molecules such as thioflavin T or congo red, which change ...http://onlinelibrary.wiley.com/doi/10.1110/ps.42501/full
DiVA - Search result
Amyloid deposits were always IAPP immunoreactive. In conclusion, increased circulating levels of IAPP occurred in 12% of 102 ... Islet amyloid polypeptide (IAPP) in patients with neuroendocrine tumours1995In: Regulatory Peptides, ISSN 0167-0115, E-ISSN ... Although IAPP was first discovered and isolated from amyloid deposits in an endocrine pancreatic tumour (EPT), surprisingly few ... Nature of os labrum-associated amyloid deposits: 2011In: Amyloid : the international journal of experimental and clinical ...http://uu.diva-portal.org/smash/resultList.jsf?searchType=ORGANISATION&language=en&onlyFullText=false&af=%5B%5D&aq=%5B%5B%7B%22organisationId%22%3A%223215%22%7D%5D%5D
Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus
R. Kayed, J. Bernhagen, N. Greenfield et al., "Conformational transitions of islet amyloid polypeptide (IAPP) in amyloid ... and finally islet amyloid polypeptide (IAPP)  or amylin . The presence of these amyloid deposits in T2DM has been linked ... There is a correlation between the sequence of IAPP and its propensity to form amyloid fibrils. For example, rat or mouse IAPP ... "Suppression of IAPP fibrillation at anionic lipid membranes via IAPP-derived amyloid inhibitors and insulin," Biophysical ...https://www.hindawi.com/journals/jdr/2016/5639875/
Modular Design in Natural and Biomimetic Soft Materials.
Ser20 of the IAPP (amylin) amyloid forming et al. used a d-Pro-d-Pro artificial turn for the pH-triggered assembly of b-sheet ... Amyloid Fibrils "Amyloid" is the name most commonly associated with the plaques of long, stiff fibers found in Alzheimers and ... compression behavior of single amyloid protofibrils reveal that the assembly of a protein polymer into an amyloid or amyloid- ... the adventitious use of long-range functional amyloid fibers in biology was reported. Amyloid-based biological materials ...https://www.docme.ru/doc/1938148/modular-design-in-natural-and-biomimetic-soft-materials