*  "Generation of cross-reactive cytotoxic t lymphocytes following immuniz" by M H. Jeggo and R C. Wardley
Jeggo, M H. and Wardley, R C., "Generation of cross-reactive cytotoxic t lymphocytes following immunization of mice with various bluetongue virus types." (1982). Subject Strain Bibliography 1982. 3115 ...
  https://mouseion.jax.org/ssbb1982/3115/
*  Bi-specific MHC heterodimers for the characterization of cross-reactive T cells (67.13) | The Journal of Immunology
T cell cross-reactivity describes the phenomenon whereby a single T cell can recognize two or more different peptide antigens presented in complex withMHCproteins. Cross-reactive T cells have previously been characterized at the population level by cytokine secretion and MHC tetramer staining assays, but single-cell analysis is difficult or impossible using these methods. In this study, we describe development of a novel peptide-MHC heterodimer specific for cross-reactive T cells. MHC-peptide monomers were independently conjugated to hydrazide or aldehyde-containing cross-linkers using thiol-maleimide coupling at cysteine residues introduced into recombinant MHC heavy chain proteins. Hydrazone formation provided bi-specific MHC heterodimers carrying two different peptides. Using this approach we prepared heterodimers of the murine class I MHC protein H-2Kb carrying peptides from lymphocytic choriomeningitis virus and vaccinia virus, and used ...
  http://www.jimmunol.org/content/186/1_Supplement/67.13
*  Investigation of cross reactions in serology of Toxoplasma gondii
Klc, H.; Sahin, I.; Altntas, K.; Fazl, S.A.; Ozbel, Y.; Dalklc, E., 1991: Investigation of cross reactions in serology of Toxoplasma gondii
  https://eurekamag.com/research/002/416/002416783.php
*  Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8(+) cytotoxic T lymphocyte...
Heterosubtypic immunity, defined as cross-reactive immune responses to influenza virus of a different serotype than the virus initially encountered, was investigated in association with virus-specific cytotoxic T lymphocyte (CTL) responses induced in systemic and mucosa-associated lymph nodes after immunization via different routes. Mice immunized by the pulmonary route with live nonpathogenic influenza virus, strain Udorn (H3N2), survived challenge with mouse-adapted pathogenic influenza virus, strain PR/8/34 (H1N1). These mice developed strong heterosubtypic CTL responses in spleen, cervical lymph nodes (CLN), and mediastinal lymph nodes (MLN). Alternately, only 20% of mice immunized intravenously, intraperitoneally, or intranasally survived the challenge; all of these developed CTL responses in spleen and CLN, but not in MLN. Direct correlation between short-term and long-term memory heterosubtypic CTL responses induced in MLN and host recovery after lethal infection indicates that these ...
  https://www.semanticscholar.org/paper/Heterosubtypic-immunity-to-lethal-influenza-A-viru-Nguyen-Moldoveanu/c27c2d20ba720254cece0d64f22598baa9ed8fc6
*  T Cell Cross-Reactivity and Conformational Changes during TCR Engagement | JEM
Our results make two important and related points. First, the data show the exquisite functional specificity of CD8+ T cells, with different receptors from chronically HIV-infected patients, to variants of this immunodominant epitope. Second, we provide evidence in support of an induced fit mechanism of TCR binding, whereby large conformational changes in the peptide follow initial TCR engagement.. Whether CD8+ T cells cross-react with virus variants is a very important issue in infection with HIV and other variable viruses. Failure of T cells to recognize variants gives the chronically replicating virus multiple chances to escape from immune control. Here, we show that for a clinically relevant epitope, two thirds of random mutations are not recognized. Although much has been made of cross-reactive T cells in the arena of vaccine design, our data are in line with earlier studies on peptide variants of influenza matrix peptide presented by HLA-A2, HTLV-1 tax peptide ...
  http://jem.rupress.org/content/200/11/1455
*  Infection with an avirulent phoP mutant of Neisseria meningitidis confers broad cross-reactive immunity - Surrey Research...
Newcombe, J, Eales-Reynolds, L, Wootton, L, Gorringe, AR, Funnell, SGP, Taylor, SC and McFadden, JJ (2004) Infection with an avirulent phoP mutant of Neisseria meningitidis confers broad cross-reactive immunity ...
  http://epubs.surrey.ac.uk/835549/
*  Arabidopsis] Rubisco crossreactivity
On Jul 2, 2007, at 11:59 AM, Michael Sullivan wrote: , I've prepared a rabbit polyclonal antiserum against a protein of , interest. From immunoblots, it appears that the antiserum is , crossreacting with the large subunit of Rubisco to make a big fat , band. Since the antigen was protein that was produced in bacteria, , I think any cross reactivity must just be coincidental. Also, the , pre-immune serum, did not have any problem with rubisco , crossreactivity. I haven't found any obvious stretches of sequence , similarity between rubisco and my protein of interest to account , for the crossreactivity, but I think it can be hard to make , predictions about antibody cross-reactivity based on sequence , alone. Unfortunately, the protein I would like to detect with the , antiserum is very similar in size to Rubisco. I'm worried I won't , be able to detect 'real' signal from my protein of interest because , of the big fat Rubisco ...
  http://www.bio.net/bionet/mm/arab-gen/2007-July/011245.html
*  Snail allergy cross reaction with dust mite allergy
The talkhealth blogs are one of the leading health blog sites - bringing together the widest range of health subjects from a diverse set of bloggers.
  http://www.talkhealthpartnership.com/blog/2013/10/snail-allergy-cross-reaction-with-dust-mite-allergy/
*  QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION | JEM
1. Antisera to R-salt-azo-benzidine-azo-crystalline egg albumin give precipitates with crystalline egg albumin by virtue of their antidye content.. 2. The quantitative course of the reactions with increasing amounts of antigen is very similar for the dye-antidye and egg albumin-anti-egg albumin systems, but differs markedly for the cross reaction between egg albumin and antidye.. 3. A possible explanation for the occurrence of this one-sided crossreaction is given in terms of reactive groupings on the antigen and antibody.. 4. A qualitative expression of the course of the cross-reaction is given in terms of the laws of classical chemistry.. ...
  http://jem.rupress.org/content/59/4/519
*  JCI - Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy...
Heterosubtypic T cell-mediated immunity to influenza A viruses in humans has been widely reported (24-26, 36). While cross-reactive T cells cannot prevent establishment of infection, they can enhance recovery by promoting virus clearance and reduce the severity of illness (15). It has also been demonstrated that in vitro T cell cultures derived from healthy individuals can lyse target cells infected with swine or avian influenza viruses (28, 29). Together with a large number of studies in mice that demonstrated cross-protection conferred by influenza A-specific T cells during subsequent challenges (reviewed in ref. 11), these studies suggest that vaccines stimulating cross-reactive T cell populations, potentially used in conjunction with the current antibody-based strategy, may confer broader and more effective protection against a potential pandemic strain. However, most studies using T cell cultures expanded in vitro were unable to assess accurately the ...
  https://www.jci.org/articles/view/32460
*  JCI Insight - Delineating antibody recognition against Zika virus during natural infection
Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that shares a considerable degree of homology with dengue virus (DENV). Here, we examined longitudinal antibody response against ZIKV during natural infection in 2 convalescent individuals. By decomposing the antibody recognition into DI/DII and DIII of the E glycoprotein, we showed their development in humans followed a spatiotemporal hierarchy. Plasma binding to DI/DII appeared to peak and wane during early infection with extensive cross-reactivity with DI/DII of DENV. Binding to DIII, however, peaked early but persisted months into the infection without detectable cross-reactivity with DIII of DENV. A clear trend of increase in DIII-specific neutralizing activity was observed over the course of infection. mAbs isolated during early infection are largely DI/DII specific, weakly neutralizing, and highly cross-reactive with DENV, while those from later infection are more diverse in recognition, ...
  https://insight.jci.org/articles/view/93042/pdf
*  SWINE FLU: 2010
Control of swine influenza by vaccination has become more difficult in recent decades, as the evolution of the virus has resulted in inconsistent responses to traditional vaccines. Standard commercial swine flu vaccines are effective in controlling the infection when the virus strains match enough to have significant cross-protection, and custom (autogenous) vaccines made from the specific viruses isolated are created and used in the more difficult cases.[80][81] Present vaccination strategies for SIV control and prevention in swine farms typically include the use of one of several bivalent SIV vaccines commercially available in the United States. Of the 97 recent H3N2 isolates examined, only 41 isolates had strong serologic cross-reactions with antiserum to three commercial SIV vaccines. Since the protective ability of influenza vaccines depends primarily on the closeness of the match between the vaccine virus and the epidemic virus, the ...
  http://swineflucares.blogspot.com/2010/
*  SWINE FLU: January 2010
Control of swine influenza by vaccination has become more difficult in recent decades, as the evolution of the virus has resulted in inconsistent responses to traditional vaccines. Standard commercial swine flu vaccines are effective in controlling the infection when the virus strains match enough to have significant cross-protection, and custom (autogenous) vaccines made from the specific viruses isolated are created and used in the more difficult cases.[80][81] Present vaccination strategies for SIV control and prevention in swine farms typically include the use of one of several bivalent SIV vaccines commercially available in the United States. Of the 97 recent H3N2 isolates examined, only 41 isolates had strong serologic cross-reactions with antiserum to three commercial SIV vaccines. Since the protective ability of influenza vaccines depends primarily on the closeness of the match between the vaccine virus and the epidemic virus, the ...
  http://swineflucares.blogspot.com/2010/01/
*  Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop. - Semantic Scholar
Self-reactive CD4 T cells are thought to have a central role in the pathogenesis of many chronic inflammatory human diseases. Microbial peptides can activate self-reactive T cells, but the structural basis for such crossreactivity is not well understood. The Hy.1B11 T cell receptor (TCR) originates from a patient with multiple sclerosis and recognizes the self-antigen myelin basic protein. Here we report the structural mechanism of TCR crossreactivity with two distinct peptides from human pathogens. The structures show that a single TCR residue (CDR3α F95) makes the majority of contacts with the self-peptide and both microbial peptides (66.7-80.6%) due to a highly tilted TCR-binding topology on the peptide-MHC surface. Further, a neighbouring residue located on the same TCR loop (CDR3α E98) forms an energetically critical interaction with the MHC molecule. These data show how binding by a self-reactive TCR favors crossreactivity between self and microbial ...
  https://www.semanticscholar.org/paper/Crossreactivity-of-a-human-autoimmune-TCR-is-domin-Sethi-Gordo/7494e7263cff8b0489efcefaaca93a077278efd3
*  FDA Tissue Panel
Full FDA Tissue Panel of high quality normal tissues for antibody cross-reactivity studies. Multiple organs from a range of age and gender-specific donors.
  http://www.proteogenex.com/biorepository/human-tissue-specimens/fda-tissue-panel/
*  Abbkine announces new release of the EliKine™ Human TNF-alpha ELISA Kit | Pristine Report
Human TNF-α ELISA Kit is the latest product from Abbkine Scientific Research Company. As part of the company's plans to ease the research process and ensure that better results are gotten in record time, the company made the announcement to official launch the Human TNF alpha ELISA Kit on the market.. The ELISA Kit is particularly designed to allow for the easy detection of Human TNF-α. Consequently, investigators, researchers and other such users of the product can easily get their desired results in record time. This also ensures that better results are gotten.. EliKine™ Human TNF-α ELISA Kit employs a two-site sandwich ELISA to quantitate TNF-α in samples, it has high sensitivity and excellent specificity for detection of Human TNF-α. No significant cross-reactivity or interference between Human TNF-α and analogues was observed.. The recent launch of the Human TNF-α ELISA Kit has been described by many as a revolutionary introduction to the industry. With a high sensitivity and ...
  http://www.pristinereport.com/story/169959/abbkine-announces-new-release-of-the-elikine-human-tnfalpha-elisa-kit.html
*  Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins - MIMS EPrints
Centralized" (ancestral and consensus) HIV-1 envelope immunogens induce broadly cross-reactive T cell responses in laboratory animals; however, their potential to elicit cross-reactive neutralizing antibodies has not been fully explored. Here, we report the construction of a panel of consensus subtype B (ConB) envelopes and compare their biologic, antigenic, and immunogenic properties to those of two wild-type Env controls from individuals with early and acute HIV-1 infection. Glycoprotein expressed from full-length (gp160), uncleaved (gp160-UNC), truncated (gp145), and N-linked glycosylation site deleted (gp160-201N/S) versions of the ConB env gene were packaged into virions and, except for the fusion defective gp160-UNC, mediated infection via the CCR5 co-receptor. Pseudovirions containing ConB Envs were sensitive to neutralization by patient plasma and monoclonal antibodies, indicating the preservation of neutralizing epitopes found in contemporary subtype B viruses. When ...
  http://eprints.ma.man.ac.uk/697/
*  WEIL-FELIX TEST - Healthy Life Live
An agglutination test used in the laboratory to diagnose rickettsial diseases. It depends on a nonspecific cross reaction between antibodies produced by the rickettsial infection with the OX-2, OX-19 and OXK antigens of the Gram negative rod, Proteus.. ...
  http://www.healthylifelive.org/weil-felix-test/
*  If preimmune sera and immune sera are both reacting to recombinat antigen in wes - SDS-PAGE and Western Blotting
The secondary antibody is specific for the primary antibody but there can be cross reactivity. Cross reactivity is more probable when the other protein is an antibody of another species (say the goat anti-rabbit polyclonal produces some cross reactivity with mouse antibody) but it is possible that it can also cross react with a non-IgG protein. I think it is more of a reach but it does happen and so is a reasonable and quick thing to rule out.. ...
  http://www.protocol-online.org/biology-forums-2/posts/29756.html
*  Publications PUBLICATIONS - PDF
Publications 164 Publications PUBLICATIONS 1. Heemskerk B, Veltrop-Duits LA, van Vreeswijk T, ten Dam MM, Heidt S, Toes RE, van Tol MJ, Schilham MW. Extensive cross-reactivity of CD4 + adenovirus-specific
  http://docplayer.nl/7832644-Publications-publications.html
*  Protein profiling
Biomarker studies which were previously limited by poor assay sensitivity, low throughput systems and insufficient sample amount are now feasible in a simple and efficient way.. For the first time it is possible to do high capacity quantification of 92 protein biomarkers in 96 samples. Conventional immunoassays have been unable to scale due to increasing antibody cross-reactivity but TATAA Biocenter offers a solution using the Multiplex platform from Olink Proteomics. It generates high quality data even in highly multiplexed formats and the opportunities are enormous for powerful analysis of multivariate biomarker patterns.. ...
  http://www.tataa.com/services/descriptions/protein-profiling/
*  Fetal-Maternal Immunological Relationships
Despite inheriting half of its genetic material from its father, the fetoplacental unit is not rejected by the maternal immune system because of a unique immunological relationship with the mother
  http://www.els.net/WileyCDA/ElsArticle/refId-a0000516.html
*  Immunochemical metods - Psykiatri och neurokemi, Göteborgs universitet
The properties of high affinity and specificity of antibodies are successfully employed in assays used for quantification of specific analytes in complex mixtures. The method is indirect in the sense that it is the antibody-analyte complex that is detected rather than the analyte per se. However, if the quality of the antibody is good, i.e., low cross reactivity with other molecules, there is a strong relationship between the measured signal from the complex and the concentration of the analyte. This relationship can be determined by the use of calibrators with known concentrations, which allow for a standard curve to be constructed and the concentration in a sample to be calculated.. ...
  https://neurophys.gu.se/sektioner/psykiatri_och_neurokemi/neurokem/TheAlzAssQCProgram/immunochemical-metods
*  Rat Serum - 50mL | GeneTex
, Rat Serum - 50mL, GTX73216, Applications: Blocking, ELISA, ICC/IF, IHC, WB; Blocking, ELISA, Immunocytochemistry/ Immunofluorescence (ICC/IF), Immunohistochemistry (IHC), Western Blot (WB); CrossReactivity:
  http://www.genetex.com/Rat-Serum-50mL-GTX73216.html
*  Rat Plasma - 500mL | GeneTex
, Rat Plasma - 500mL, GTX73283, Applications: Blocking, ELISA, ICC/IF, IHC, WB; Blocking, ELISA, Immunocytochemistry/ Immunofluorescence (ICC/IF), Immunohistochemistry (IHC), Western Blot (WB); CrossReactivity:
  http://www.genetex.com/Rat-Plasma-500mL-GTX73283.html