*  Maturational differences in lung NF-κB activation and their ro...
Neonatal rodents are more tolerant to hyperoxia than adults. We dete ... Maturational differences in lung NF-κB activation and their role in tolerance to hyperoxia: ... Maturational differences in lung NF-κB activation and their role in tolerance to hyperoxia. Authors * Guang Yang ... Neonatal rodents are more tolerant to hyperoxia than adults. We determined whether maturational differences in lung NF-κB ...
  https://www.mysciencework.com/publication/show/maturational-differences-in-lung-nf-kb-activation-and-their-role-in-tolerance-to-hyperoxia
*  "Acute Hyperoxia Increases Lipid Peroxidation and Induces Plasma Membra" by Dominic P. D'Agostino, James E. Olson et al.
U87 cells were exposed to 0.20 atmospheres absolute (ATA) O2, normobaric hyperoxia (0.95 ATA O2) or hyperbaric hyperoxia (HBO2 ... significantly reduced membrane Ra and MDA levels during hyperoxia. Hyperoxia-induced H2O2 production increased 189%±5% (0.95 ... Similarly, levels of MDA were significantly elevated in cultures treated with hyperoxia and H2O2 and correlated with O2-induced ... We hypothesize that membrane blebbing is an ultrastructural correlate of MLP resulting from hyperoxia. Furthermore, AFM is a ...
  https://corescholar.libraries.wright.edu/ncbp/212/
*  Ocular haemodynamic responses to induced hypercapnia and hyperoxia in glaucoma | British Journal of Ophthalmology
Vascular response to hyperoxia. Several previous studies have shown that when the partial pressure of oxygen in the blood ... Hyperoxia was induced by breathing 100% oxygen for 5 minutes. Both induced conditions were continued long enough for all ... Hyperoxia resulted in reduced IOP in both normal subjects and glaucoma patients. This is consistent with previous reported ... Baseline, hypercapnia, and hyperoxia conditions. All measurements were recorded with the patient breathing through a mouthpiece ...
  http://bjo.bmj.com/content/88/3/406
*  Foxm1 regulates resolution of hyperoxic lung injury in newborns. | Sigma-Aldrich
After hyperoxia, deletion of Foxm1 from the myeloid cell lineage decreased numbers of interstitial macrophages (CD45(+)CD11b(+) ... Immunohistochemistry and RNA analysis were used to assess Foxm1 in lung tissue from hyperoxia-treated mice and patients with ... Increased Foxm1 expression was observed in pulmonary macrophages of hyperoxia-exposed mice and in lung tissue from patients ... The exaggerated BPD-like phenotype observed in hyperoxia-exposed LysM-Cre/Foxm1(-/-) mice was associated with increased ...
  https://www.sigmaaldrich.com/catalog/papers/25275225
*  Hyperoxia- not just for divers anymore!
Looks like divers aren't the only ones who need to be aware of hyperoxia: NASA Decodes Trouble With F-22 Issue has actually ... Hyperoxia- not just for divers anymore! Looks like divers aren't the only ones who need to be aware of hyperoxia:. NASA Decodes ... Re: Hyperoxia- not just for divers anymore! Maybe they need a BOV just in case they get any symptoms? ... Re: Hyperoxia- not just for divers anymore! "absorption atelectasis, in which too much oxygen can wash away necessary nitrogen ...
  http://www.rebreatherworld.com/showthread.php?43908-Hyperoxia-not-just-for-divers-anymore
*  YUHSpace: Involvement of the MAPK and PI3K pathways in chitinase 3-like 1-regulated hyperoxia-induced airway epithelial cell...
BACKGROUND: Exposure to 100% oxygen causes hyperoxic acute lung injury characterized by cell death and injury of alveolar epithelial cells. Recently, the role of chitinase 3-like 1 (CHI3L1), a member of the glycosyl hydrolase 18 family that lacks chitinase activity, in oxidative stress was demonstrated in murine models. High levels of serum CHI3L1 have been associated with various diseases of the lung, such as asthma, chronic obstructive pulmonary disease, and cancer. However, the role of CHI3L1 in human airway epithelial cells undergoing oxidative stress remains unknown. In addition, the signaling pathways associated with CHI3L1 in this process are poorly understood. PURPOSE: In this study, we demonstrate the role of CHI3L1, along with the MAPK and PI3K signaling pathways, in hyperoxia-exposed airway epithelial cells. METHOD: The human airway epithelial cell line, BEAS-2B, was exposed to ,95% oxygen (hyperoxia) for up to 72h. Hyperoxia-induced cell death ...
  https://ir.ymlib.yonsei.ac.kr/handle/22282913/89694
*  Silencing hyperoxia-induced C/EBPα in neonatal mice improves lung architecture via enhanced proliferation of alveolar...
We demonstrated that hyperoxia increases C/EBPα mRNA and protein expression in the newborn lung and thereby impacts the development of epithelial type II cells, a major target for hyperoxic injury in the developing lung (24). We showed that increased C/EBPα expression in hyperoxia parallels the disrupted lung architecture and decreased radial alveolar counts and that these changes persist and even worsen after 2 wk of recovery in room air. Inhibition of the induced C/EBPα in hyperoxia improved lung architecture and partially rescued RAC loss after recovery, indicating that C/EBPα plays a crucial role in the regulation of alveolar formation in the neonate. Additionally, C/EBPα siRNA enhanced type II cell numbers and dampened type II cell hyperproliferation in recovery, which suggests that C/EBPα controls type II cell differentiation in hyperoxia and during recovery.. Postnatal lung development involves a series of coordinated events, ...
  http://ajplung.physiology.org/content/301/2/L187.long
*  The Inflammasome Mediates Hyperoxia-Induced Alveolar Cell Permeability | The Journal of Immunology
The results presented in this study show that inflammasome formation and IL-1β processing is induced by hyperoxia in vivo and in vitro and is associated with increased alveolar epithelial protein permeability. Hyperoxia-stimulated K+ efflux, inflammasome formation, proinflammatory cytokine release, and marked induction of caspase-1 and IL-1β cleavage. The P2X7 agonist ATP enhanced hyperoxia-induced inflammasome activation, whereas the P2X7 antagonist, oxATP, inhibited hyperoxia-induced inflammasome activation. However, when ATP was scavenged with apyrase, hyperoxia-induced inflammasome activation was significantly decreased, indicating the possible involvement of the P2X7 receptor. Furthermore, shRNA silencing of inflammasome component expression abrogated hyperoxia-induced secretion of proinflammatory cytokines in vitro. These results suggest that hyperoxia induces K+ efflux through the ...
  http://www.jimmunol.org/content/184/10/5819.long
*  Quantitative fMRI using hyperoxia calibration: reproducibility during a cognitive Stroop task. - Radcliffe Department of...
Arterial spin labelling allows simultaneous measurement of both the blood-oxygenation-level-dependent (BOLD) and the cerebral blood flow (CBF) response to changes in neural activity. The addition of a hypercapnia or hyperoxia calibration allows additional quantification of changes in the cerebral metabolic rate of oxygen (CMRO(2)). In this study we test the reproducibility of measurements derived using the hyperoxia approach, during a cognitive Stroop task. A QUIPSSII sequence is used at 3 T to collect simultaneous CBF and BOLD signal during two 3 min periods of hyperoxia and an 8 min Stroop task. Hyperoxia was administered via an open system and end-tidal values were sampled via a nasal cannula; average end-tidal values of 60% were reached. This procedure is repeated to allow the reproducibility of the estimated parameters to be tested. The use of a cognitive Stroop task allows testing of the measurements in frontal and parietal regions as ...
  https://www.rdm.ox.ac.uk/publications/241026
*  Application of normobaric hyperoxia therapy for amelioration of haemorrhagic shock-induced acute renal failure* : Nephrology...
Background. Hypoxia resultant from haemorrhagic shock is the primary cause of kidney damage. Application of normobaric hyperoxia therapy (NHT) is an acceptable treatment for acute haemorrhagic shock. We investigated the effect of NHT on amelioration of haemorrhagic shock-induced rat renal failure.. Methods. Twenty-four Sprague-Dawley rats were subjected to gradual blood withdrawal/reperfusion, followed by 12-h, 24-h or 48-h NHT. Verification/monitoring of intrarenal hypoxia was performed using Hypoxyprobe-TM-1. Subsequently, cystatin C, urea and creatinine were assessed in serum by a Hitachi autoanalyser, and NO, 3-nitro-tyrosine, STAT-8-isoprostane and NF-kB in renal medullae and cortices by specific ELISAs.. Results. In rats subjected to haemorrhagic shock, 12- to 48-h NHT significantly reduced intrarenal Hypoxyprobe-TM-1 stained areas and attenuated augmentation of urea, creatinine and cystatin C. Haemorrhagic shock resulted in a 10-fold drop of intrarenal NO availability. 12-h and 24-h, ...
  http://oxfordindex.oup.com/view/10.1093/ndt/gfn093?print
*  Identification of fast and slow ventilatory responses to carbon dioxide under hypoxic and hyperoxic conditions in humans. -...
1. Under conditions of both euoxia and hypoxia, it is generally accepted that the ventilatory response to CO2 has both rapid (peripheral chemoreflex) and slow (central chemoreflex) components. However, under conditions of hyperoxia, it is unclear in humans whether the fast component is completely abolished or merely attenuated in magnitude. 2. The present study develops a technique to determine whether or not a two-compartment model fits the ventilatory response to CO2 significantly better than a one-compartment model. Data were collected under both hypoxic (end-tidal PO2 = 50 Torr) conditions, when two components would be expected, and under hyperoxic (end-tidal PO2 = 200 Torr) conditions, when the presence of the fast compartment is under question. 3. Ten subjects were recruited, of whom nine completed the study. The end-tidal PCO2 of each subject was varied according to a multi-frequency binary sequence that involved 13 steps into and 13 steps out of hypercapnia lasting altogether 1408 s. ...
  https://www.dpag.ox.ac.uk/publications/114263
*  Effect of vitamin C on hyperoxia-induced vasoconstriction in exercising skeletal muscle | Physiology
atom:contributor xmlns:atom='http://www.w3.org/2005/Atom' xmlns:nlm='http://schema.highwire.org/NLM/Journal' xmlns:hwp='http://schema.highwire.org/Journal' nlm:contrib-type='author',,atom:name,Darren P. Casey,/atom:name,,nlm:aff,,nlm:sup,2,/nlm:sup,Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, Iowa,/nlm:aff,,nlm:name name-style='western' hwp:sortable='Casey Darren P.', ,nlm:surname,Casey,/nlm:surname, ,nlm:given-names,Darren P.,/nlm:given-names,,/nlm:name,,/atom:contributor ...
  http://www.physiology.org/content/117/10/1207
*  Plus it
We demonstrated that hyperoxia-induced NF-κB activation occurs in neonatal WT mice and that IκBβ overexpression is associated with sustained NF-κB nuclear translocation. This in turn was associated with improved survival and enhanced lung development in neonatal mice exposed to hyperoxia for 14 days. Importantly, attenuation of lung injury and preservation of lung development, as assessed by RAC and MLI, could be detected early (3 days) and persisted after a prolonged (14 days) hyperoxic exposure. Enhanced expression of known NF-κB target genes, including VEGFR2 and antiapoptotic factors, may explain these findings and are associated with preserved pulmonary vascular growth following 14 days of hyperoxic exposure. Although previous studies have demonstrated that NF-κB activity mediates neonatal resistance to hyperoxia, before this report, the effect sustained NF-κB activity on lung development and ongoing lung injury had not been investigated. These results ...
  http://ajplung.physiology.org/content/306/12/L1078
*  Episode 11: Hyperoxia
This comment is a little late; I just heard the podcast. As a practicing anesthesiologist, I'm mostly interested in perioperative medicine, rather than ICU. However, a couple comments. You discussed a number of observational studies that indicate patients with hyperoxia (PaO2 , 200) and worse outcomes with STMI, COPD, and TBI. These are intriguing, but without RCTs to back up this data, I am quite skeptical of these results because it is likely that sicker patients were given more oxygen in these situations. So patients with hyperoxia appear to have worse outcomes because of the oxygen, not because they were sicker to begin with. You don't mention any control for comorbidity or severity of illness in any of these studies, and it would really take large RCTs to really tease this factor out.. Also, as pertains to perioperative use of oxygen, the data are in conflict with those from the ICU. A recent meta-analysis showed hyperoxia is associated with REDUCTIONS ...
  http://accrac.com/episode-11-hyperoxia/
*  A novel NADH kinase is the mitochondrial source of NADPH in Saccharomyces cerevisiae | The EMBO Journal
As a consequence of oxidative metabolism, aerobic organisms are continuously bombarded with reactive oxygen species (ROS), such as superoxide (·O2−), hydrogen peroxide (H2O2) and hydroxyl radicals (·OH), which can damage DNA, proteins and lipids. Most of these highly reactive molecules are generated in the mitochondria as by‐products from the reduction of O2 to H2O during oxidative phosphorylation (Boveris and Cadenas, 1982). Cells can also be exposed to exogenous sources of oxidative stress such as hyperoxia.. Hyperoxia is a state in which individual cells or organisms are exposed to oxygen concentrations well above that of atmospheric oxygen. In laboratory animals, hyperoxia exposure (,90% O2) leads to death within 3-7 days (O'Reilly, 2001). Specific hyperoxia‐induced disorders in humans include bronchopulmonary dysplasia (Northway et al., 1967) and adult respiratory distress syndrome (Halliwell et al., 1992). In spite of the importance of ...
  http://emboj.embopress.org/content/22/9/2015
*  Notes from Dr. RW: Detrimental effect of hyperoxia post-arrest
Fourteen studies were identified from 2982 references. Odds ratio (OR) was used as effect estimate. OR was reconstructed if not provided in original articles. Hyperoxia was defined as a PaO2 greater than 300 mmHg. Meta-analysis indicated that hyperoxia appeared to be correlated with increased in-hospital mortality (OR, 1.40; 95% CI, 1.02-1.93; I2, 69.27%; 8 studies) but not worsened neurological outcome (OR, 1.62; 95% CI, 0.87-3.02; I2, 55.61%; 2 studies). However, the results were inconsistent in subgroup and sensitivity analyses. ...
  http://doctorrw.blogspot.com/2015/04/detrimental-effect-of-hyperoxia-post.html
*  Steve Kleeberger, Ph.D. | Principal Investigators | NIH Intramural Research Program
Project 1. Ozone (O3) is a major component of air pollution and it has important detrimental health effects on humans. Moreover, as much as 40% of the U.S. population is estimated to be exposed to potentially harmful levels of O3. We previously identified significant linkage of O3-induced lung hyperpermeability and inflammation QTLs to chromosomes 4 and 17 (Inf2), respectively. Ongoing research in the EGG has addressed the hypotheses that gene(s) within the chromosome 4 QTL [e.g. toll-like receptor 4 (Tlr4)] and Inf2 [e.g. tumor necrosis factor alpha (Tnf)] modulate differential susceptibility to O3-induced injury and inflammation.. Project 2. Reactive oxygen species (ROS) have been implicated in the pathogenesis of many acute and chronic clinical disorders such as acute lung injury, bronchopulmonary dysplasia (BPD), and cancer. The transcription factor NF-E2, related factor 2 (Nrf2) was identified as a candidate susceptibility gene for hyperoxia-induced lung injury and inflammation in adult ...
  https://irp.nih.gov/pi/steven-kleeberger
*  Plus it
Treatment of rat pups with hyperoxia-induced lung injury, an in vivo model for experimental BPD (41), with metformin prolongs survival; reduces lung injury by attenuating lung inflammation, coagulation, septal thickness, and collagen III expression; and stimulates vascularization. Metformin had no beneficial effects on alveolarization, capillary alveolar leakage, arterial medial wall thickness (PAH), and RVH, and no adverse effects on normal lung and heart development. These data demonstrate that metformin may be a suitable candidate to reduce lung inflammation, coagulation, and fibrosis in preterm infants with severe BPD.. Metformin is a potent antidiabetic drug that is commonly used in type 2 diabetic patients to lower glucose levels in the circulation. Compared with other treatment modalities for type 2 diabetes, patients treated with metformin were protected against mortality in cardiac disease and had less cancer, suggesting that metformin has various biological functions other than its ...
  http://ajplung.physiology.org/content/309/3/L262
*  Risk factors for immersion pulmonary edema: hyperoxia does not attenuate pulmonary hypertension associated with cold water...
atom:author xmlns:atom='http://www.w3.org/2005/Atom' xmlns:nlm='http://schema.highwire.org/NLM/Journal' xmlns:hwp='http://schema.highwire.org/Journal' nlm:contrib-type='author',,atom:name,J. A. V. Fraser,/atom:name,,nlm:name name-style='western' hwp:sortable='Fraser J. A. V.',,nlm:surname,Fraser,/nlm:surname,,nlm:given-names,J. A. V.,/nlm:given-names,,/nlm:name,,/atom:author ...
  http://www.physiology.org/content/110/3/610
*  Plus it
Current therapeutic strategies, while offering some symptomatic relief, fail to produce a significant survival rate in infants with PPHN. The data presented by Farrow et al. (3) ascertains a necessity to reduce oxidative stress to restore eNOS coupling as an alternative and more effective adjunctive treatment of PPHN. The authors convincingly demonstrated a hyperoxia-associated increase in oxidative stress in PPHN, a likely common side effect and drawback of oxygen therapy for PPHN. While the ups and downs of ROS stirring a debate in the pathogenesis of pulmonary arterial hypertension, a pertinent role for hyperoxia-induced increases in ROS in PPHN is seemingly assured. Previous work in animal models of PPHN from Steinhorn et al. (12) showed that rhSOD decreased pulmonary vascular resistance by facilitating the actions of inhaled NO. Although interesting, this initial study failed to determine a mechanistic rationale for such beneficial effects. Before the publication of the ...
  http://ajplung.physiology.org/content/295/6/L976
*  Surfactant proteins and lipids are regulated independently during hyperoxia. - Semantic Scholar
Adult hamsters were exposed to 100% oxygen for up to 8 days. At time of death lung tissue was analyzed for the expression of surfactant protein (SP) genes, and surfactant was isolated from alveolar lavage fluid. Surfactant was analyzed for the composition of proteins and phospholipids and for its surface properties. We found, over the 8 days of exposure, that an alveolitis composed of polymorphonuclear leukocytes (PMNs) and alveolar macrophages, accompanied by exudation of edema fluid, appeared in the alveolar spaces. The steady-state levels of SP mRNAs declined after 8 days of exposure to 100% oxygen, but the patterns indicated individual genetic control. SP-A was elevated early in the course of the hyperoxic exposure but decreased significantly by day 8; SP-B decreased continuously; SP-C was unchanged (or slightly elevated) through day 2 and then declined. The amounts of recoverable lavage surfactant increased by greater than threefold, and the phospholipid composition showed increasing percentages of
  https://www.semanticscholar.org/paper/Surfactant-proteins-and-lipids-are-regulated-indep-Minoo-King/8219e3430b4a79e59578b7f0bf6003668b9cd520
*  Moderate hyperoxic versus near-physiological oxygen targets during and after coronary artery bypass surgery: a randomised...
In the present RCT in patients undergoing scheduled isolated CABG surgery, we found no difference in markers of myocardial damage between a conventional moderate hyperoxic and a near-physiological oxygen strategy during and after surgery. The conservative oxygenation strategy did not improve haemodynamics in comparison to moderate hyperoxia. However, lower oxygen targets during CPB and ICU admission could be applied safely without risk of hypoxia.. With respect to myocardial damage, these findings are in apparent contrast to results from earlier clinical trials where the reduction of oxygen tension during CPB or reperfusion resulted in lower CK (672 ± 130 vs. 293 ± 21 U/l; P = 0.002) [1] or lower Troponin-T levels (~2.1 vs. ~0.8 μg/L; P , 0.05) [2]. However, the high PaO2 investigated in the latter two studies are no longer applied today. The first study compared a PaO2 of ~400 mmHg during CPB in the control group to ~140 mmHg in the conservative group [2]. The second study compared ...
  https://ccforum.biomedcentral.com/articles/10.1186/s13054-016-1240-6
*  "Hyperoxia induced pulmonary damage increases the metastatic potential " by J A. Stewart, S Krauss et al.
Stewart, J A.; Krauss, S; Hacker, M P.; Newman, R A.; and Jr, H J., "Hyperoxia induced pulmonary damage increases the metastatic potential of intravenous b16 melanoma in mice. Abstr." (1983). Subject Strain Bibliography 1983. 1092 ...
  http://mouseion.jax.org/ssbb1983/1092/
*  Varice în glezna
Proteze externe de san. Articole de compresie pt. Costume de baie speciale. PRODUSE PENTRU TRATAMENTUL ARSURILOR.. DISPOZITIVE PENTRU PROTEZARE STOMII. DISPOZITIVE SI MIJLOACE AJUTATOARE DE MERS. DETALII SI COMANDA ONLINE. SUTIEN SPORT Air Control Delta Pad - Suntem extrem de onorati si fericiti sa va anuntam lansarea celui mai inovativ sutien sport din lume. Air Control DeltaPad varice în glezna are un design revolutionar incorporand materiale de cea mai buna calitate si noul patent Anita, singura cupa dublata-intarita, aerata din lume. Designerii s-au intrecut pe sine in realizarea acestui sutien sport abordand cu totul diferit crearea acestuia.. Au schimbat total forma cupei, incluzand in aceasta un triunghi special, dintr-o spuma speciala. Aceasta forma triunghiulara permite fluxul de aer sub piept, prin zona decolteului, dar si in partile laterale ale sanilor. Deoarece nu varice în glezna nicio compresie realizata de materialele din care este realizata, noua cupa nu permite doar aerisirea ...
  http://jgrn.co/varice-n-glezna.php