Brain glucose sensing and body energy homeostasis: role in obesity and diabetes | Regulatory, Integrative and Comparative...
1991) Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia 21:2-21. ... and hyperglycemia (3, 36,81). Relatively large intravenous or intracarotid glucose infusions produce generalized sympathetic ... It is highly likely that there are many other types of such integrator neurons throughout the brain that can monitor multiple ... 1991) Brain uptake of glucose in diabetes mellitus: the role of glucose transporters. Am. J. Med. Sci. 301:173-177. ...http://ajpregu.physiology.org/content/276/5/R1223
Dapagliflozin (Forxiga) and canagliflozin (Invokana) sodium-glucose co-transporter-2 inhibitors for add-on therapy in type 2...
The new SGLT-2 inhibitors have been PBS listed as dual oral therapy in combination with either metformin or a sulfonylurea in ... even when hyperglycaemia occurs, filtered glucose continues to be reabsorbed, leading to persistently elevated blood glucose ... A new drug class for lowering blood glucose in type 2 diabetes, as dual combination therapy with metformin or a sulfonylurea. ... Sodium-glucose co-transporter-2 (SGLT2) inhibitors block glucose reabsortion in the kidneys, so efficacy is dependent on kidney ...https://www.nps.org.au/radar/articles/dapagliflozin-forxiga-and-canagliflozin-invokana-sodium-glucose-co-transporter-2-inhibitors-for-add-on-therapy-in-type-2-diabetes-mellitus
Modulation of Glucose Transporter Protein by Dietary Flavonoids in Type 2 Diabetes Mellitus [Abstract]
Diabetes mellitus (DM) is a metabolic diseases characterized by hyperglycemia due to insufficient or inefficient insulin ... Modulation of Glucose Transporter Protein by Dietary Flavonoids in Type 2 Diabetes Mellitus Fatemeh Hajiaghaalipour1*✉, ... Keywords: Glucose transporter protein, insulin, type 2 diabetes mellitus, flavonoids, glucose uptake. ... Hajiaghaalipour F, Khalilpourfarshbafi M, Arya A. Modulation of Glucose Transporter Protein by Dietary Flavonoids in Type 2 ...http://www.ijbs.com/v11p0508
Sodium-glucose Co-transporter-2 Inhibitors in Type 1 Diabetes-a Dangerous Ally | touchENDOCRINOLOGY
There is a rising trend of overweight and obesity in individuals with type 1 diabetes (T1D). The prevalence of overweight and ... 2 This has been attributed to a general worldwide increase in prevalence of obesity and similar risk factors such as family ... obesity among newly diagnosed T1D subjects was 21-22% in the 2-19 year age group in the Pediatric Diabetes Consortium and the ... 5 There are periods of hyperglycemia and hypoglycemia with marked daily fluctuations in blood glucose. Weight gain associated ...http://www.touchendocrinology.com/articles/sodium-glucose-co-transporter-2-inhibitors-type-1-diabetes-dangerous-ally
Diabetes Drug Helps the Obese Shed Some Weight | Medpage Today
... was associated with modest weight loss in an early trial of heavy patients who didn't have hyperglycemia, researchers found. ... Canagliflozin is the first sodium glucose co-transporter 2 (SGLT2) inhibitor approved to treat type 2 diabetes in the U.S., and ... The type 2 diabetes drug canagliflozin was associated with modest weight loss in an early trial of obese and overweight ... patients who did not have hyperglycemia. *Point out that canagliflozin is the first sodium glucose co-transporter 2 (SGLT2) ...https://www.medpagetoday.com/endocrinology/obesity/43338
Sodium-Glucose Co-Transport Inhibition With Dapagliflozin in Type 2 Diabetes Mellitus | Diabetes Care
Objective: Dapagliflozin, a novel inhibitor of renal sodium-glucose co-transporter 2, allows an insulin-independent approach to ... Conclusions: Dapagliflozin improves hyperglycemia and facilitates weight loss in T2DM patients by inducing controlled ... Sodium-Glucose Co-Transport Inhibition With Dapagliflozin in Type 2 Diabetes Mellitus ... Sodium-Glucose Co-Transport Inhibition With Dapagliflozin in Type 2 Diabetes Mellitus ...http://care.diabetesjournals.org/content/early/2008/12/29/dc08-1863
Investigating the Use of Quercetin on Glucose Absorption in Obesity, and Obesity With Type 2 Diabetes - Tabular View -...
In vitro, quercetin is a potent and reversible inhibitor of glucose transport by the intestinal glucose transporter GLUT2. In ... We hypothesize that quercetin blunts intestinal glucose absorption in humans, and attenuates postprandial hyperglycemia. We ... Investigating the Use of Quercetin on Glucose Absorption in Obesity, and Obesity With Type 2 Diabetes. The safety and ... Inhibition of Intestinal Glucose Absorption by the Bioflavonoid Quercetin in the Obese and in Obese Type 2 Diabetics. ...https://clinicaltrials.gov/ct2/show/record/NCT00065676?show_rss=Y&sel_rss=mod14
Linagliptin as Add on Therapy to Empagliflozin 10 mg or 25 mg With Background Metformin in Patient With Type 2 Diabetes - Full...
Sodium Glucose Transporter 2) inhibitors ... Uncontrolled hyperglycemia during open label period and placebo ... Diabetes Mellitus, Type 2 Drug: BI 10773 Drug: BI 10773 Placebo Drug: BI 10773 / BI 1356 Drug: BI 10773 / BI 1356 Placebo Phase ... Linagliptin as Add on Therapy to Empagliflozin 10 mg or 25 mg With Background Metformin in Patient With Type 2 Diabetes. The ... Fasting Plasma Glucose (FPG) Change From Baseline at 24 Weeks. [ Time Frame: Baseline and 24 weeks ]. Change from baseline FPG ...https://clinicaltrials.gov/ct2/show/NCT01778049?term=%22Type+2+Diabetes%22&lup_s=02%2F03%2F2013&lup_d=14&show_rss=Y&sel_rss=mod14
Linagliptin as Add on Therapy to Empagliflozin 10 mg or 25 mg With Background Metformin in Patient With Type 2 Diabetes - Full...
Sodium Glucose Transporter 2) inhibitors ... Uncontrolled hyperglycemia during open label period and placebo ... Diabetes Mellitus, Type 2 Drug: BI 10773 Drug: BI 10773 Placebo Drug: BI 10773 / BI 1356 Drug: BI 10773 / BI 1356 Placebo Phase ... Study Type:. Interventional Study Design:. Allocation: Randomized. Intervention Model: Parallel Assignment. Masking: Double. ... Linagliptin as Add on Therapy to Empagliflozin 10 mg or 25 mg With Background Metformin in Patient With Type 2 Diabetes. This ...https://clinicaltrials.gov/ct2/show/study/NCT01778049?term=%22Type+2+Diabetes%22&lup_s=06%2F18%2F2013&lup_d=14&show_rss=Y&sel_rss=mod14&show_locs=Y
Effect of Self-Monitoring of Blood Glucose in Patients With Type 2 Diabetes Mellitus Not Using Insulin
... clinicaltrials.gov Self-monitoring of blood glucose (SMBG) is one of the important instruments in diabetes management. Most ... and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a ... A glucoside-derived SODIUM-GLUCOSE TRANSPORTER 2 inhibitor that stimulates urinary excretion of glucose by suppressing renal ... The two main types of diabetes are: type 1 diabetes type 2 diabetes In the UK, diabetes affects approximately 2.9 million ...https://www.bioportfolio.com/resources/trial/109612/Effect-of-Self-Monitoring-of-Blood-Glucose-in-Patients-With-Type-2.html
JCI table of contents: December 1, 2005 | EurekAlert! Science News
Glucose-sensing glial cells guard against low blood sugar; and others. ... TITLE: Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors AUTHOR ... This also proposes the participation of GLUT2 as a hypoglycemic sensor in addition to its more familiar role as a hyperglycemia ... Bernard Thorens and colleagues from the University of Lausanne demonstrate that expression of the glucose transporter type 2 ( ...https://www.eurekalert.org/pub_releases/2005-12/joci-jto112205.php
Effect of Empagliflozin on Liver Fat in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease: A Randomized...
A significant decrease in glucose and HbA1c was found in both the empagliflozin (glucose 173 to 124 mg/dL [P , 0.0001], HbA1c ... Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, ... By inhibiting this transporter, SGLT-2 inhibitors promote urinary glucose excretion, which, in turn, decreases blood levels of ... fasting glucose 80-130 mg/dL, postprandial glucose ,180 mg/dL, HbA1c ,7.0%). No significant differences were found between ...http://care.diabetesjournals.org/content/41/8/1801
My Site - Chapter 13: Pharmacologic Management of Type 2 Diabetes - Feb 2016 Interim Update
More recently, the first cardiovascular outcome trial of the sodium glucose linked transporter 2 (SGLT2) inhibitor classwas ... Management of hyperglycemia in type 2 diabetes.. CHF, congestive heart failure; CVD, cardiovascular disease; DPP, dipeptidyl ... The management of hyperglycemia in type 2 diabetes is summarized in Figure 1, which integrates the findings of EMPA-REG OUTCOME ... Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009;360:129-39. ...http://guidelines.diabetes.ca/browse/chapter13_feb-2016
Sodium-Glucose Cotransport Inhibition With Dapagliflozin in Type 2 Diabetes | Diabetes Care
... limiting renal glucose reabsorption through the inhibition of SGLT2 represents a new approach to treating hyperglycemia in type ... with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter ... Sodium-Glucose Cotransport Inhibition With Dapagliflozin in Type 2 Diabetes. James F. List, Vincent Woo, Enrique Morales, ... Sodium-Glucose Cotransport Inhibition With Dapagliflozin in Type 2 Diabetes. James F. List, Vincent Woo, Enrique Morales, ...http://care.diabetesjournals.org/content/32/4/650
Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice...
... of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes. ... with the glucocorticoid antagonist RU486 markedly reduced production of both H6PDH and 11β-HSD1 and improved hyperglycaemia and ... of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes. ... mediates intracellular NADPH availability for 11β-HSD1 and depends on the glucose-6-phosphate transporter (G6PT). Little is ...http://ad-astra.ro/2012/12/07/tissue-specific-dysregulation-of-hexose-6-phosphate-dehydrogenase-and-glucose-6-phosphate-transporter-production-in-db-db-mice-as-a-model-of-type-2-diabetes/
In Vitro Antidiabetic Effects of Isolated Triterpene Glycoside Fraction from Gymnema sylvestre
Glucose transporter 2.. Data Availability. All the data used to support the findings of this study are included in the ... Type II diabetes is one of the most widespread metabolic disorders in the world, characterized by hyperglycemia and ... TG also improved insulin secretion and glucose transporter protein levels in beta cells in vitro. (Supplementary Materials) ... GLUT2 is a facilitative glucose transporter located in the plasma membrane of pancreas, liver, intestinal, kidney cells, and ...https://www.hindawi.com/journals/ecam/2018/7154702/
Sodium-glucose transport proteins - Wikipedia
Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found ... hyperglycemia), glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose. Glucose is ... SGLT2 inhibitors, also called gliflozins, are used in the treatment of type 2 diabetes. Examples include dapagliflozin (Farxiga ... These co-transporters are an example of secondary active transport. Members of the GLUT family of glucose uniporters then ...https://en.wikipedia.org/wiki/Sodium-glucose_transport_proteins
Beneficial Role of Bitter Melon Supplementation in Obesity and Related Complications in Metabolic Syndrome
Glucose transporter type 4. HDL:. High-density lipoprotein. HDL-C:. High-density lipoprotein cholesterol. ... M. B. Krawinkel and G. B. Keding, "Bitter gourd (Momordica charantia): a dietary approach to hyperglycemia," Nutrition Reviews ... prevention of glucose absorption in the alimentary canal, (b) enhancing the glucose uptake by tissues, (c) increasing glucose ... cucurbitane type triterpenoids, cucurbitane type triterpene glycoside, oleanane type triterpene saponins, and insulin like ...https://www.hindawi.com/journals/jl/2015/496169/
Impact of empagliflozin on subclinical left ventricular dysfunctions and on the mechanisms involved in myocardial disease...
Follow-up of blood-pressure lowering and glucose control in type 2 diabetes. N Engl J Med. 2014;371:1392-406.View ArticlePubMed ... Sodium-glucose linked co-transporter 2 (SGLT2) inhibitors in cardiovascular disease. In the kidney, plasma glucose is freely ... If the patient requires additional treatment for the presence of hyperglycemia, either symptomatic or detected at self-glucose ... Rahmoune H, Thompson PW, Ward JM, Smith CD, Hong G, Brown J. Glucose transporters in human renal proximal tubular cells ...https://cardiab.biomedcentral.com/articles/10.1186/s12933-017-0615-6
Similar articles for PubMed (Select 22937169) - PubMed - NCBI
... regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic ... in the presence of hyperglycemia induced via peripheral glucose infusion, does not change whole body glucose utilization. ... Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions. ... Normalizing action of exendin-4 and GLP-1 in the glucose metabolism of extrapancreatic tissues in insulin-resistant and type 2 ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=22937169
The CANTATA-MSU Trial (CANagliflozin Treatment And Trial Analysis - Metformin and SUlphonylurea)
... clinicaltrials.gov The purpose of this study is to evaluate the efficacy and safety of 2 different doses of canagliflozin ... and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a ... A glucoside-derived SODIUM-GLUCOSE TRANSPORTER 2 inhibitor that stimulates urinary excretion of glucose by suppressing renal ... It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES. ...https://www.bioportfolio.com/resources/trial/65864/The-CANTATA-MSU-Trial-CANagliflozin-Treatment-And-Trial-Analysis-Metformin-and-SUlphonylurea.html
VLDL-triglyceride Kinetics in Type 2 Diabetes
... clinicaltrials.gov Type 2 diabetes is associated with diabetic dyslipidemia, which is a major risk factor for coronary heart ... and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a ... The impact of tofogliflozin, a sodium glucose transporter 2 inhibitor, on peripheral glucose uptake in patients with type 2 ... Glucose Clamp Technique. Maintenance of a constant blood glucose level by perfusion or infusion with glucose or insulin. It is ...https://www.bioportfolio.com/resources/trial/69570/VLDL-triglyceride-Kinetics-in-Type-2-Diabetes.html
Most recent papers with the keyword Proximal tubule | Read by QxMD
Interaction Between the Sodium-Glucose-Linked Transporter 2 Inhibitor Dapagliflozin and the Loop Diuretic Bumetanide in Normal ... thereby promoting glycosuria to reduce hyperglycemia in type 2 diabetes mellitus. Because these patients may require loop ... Even in the presence of excess glucose, the proximal renal tubules continue to resorb more glucose. Sodium glucose ... BACKGROUND: Dapagliflozin inhibits the sodium-glucose-linked transporter 2 in the renal proximal tubule, ...https://www.readbyqxmd.com/keyword/107291
Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity | PNAS
2009) Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 ... S961 caused hyperglycemia (∼600 mg/dL) in all treated animals, while the control animals kept normal-fed glucose levels (∼200 ... zinc transporter. SLC30A8 is a zinc transporter (ZnT8) located in the islet cells of the endocrine pancreas. In β-cells, ... For oral glucose tolerance tests (oGTT), mice were fasted overnight (16 h) followed by oral gavage of glucose (Sigma) at 2 g/kg ...http://www.pnas.org/content/115/32/E7642
Wilson's Disease Clinical Research Trials | CenterWatch
... mechanistic intervention trial to assess the effect of 12-week treatment with the sodium-glucose linked transporters (SGLT)-2 ... Type 2 Diabetes Mellitus with Moderate Renal Impairment This study evaluates an investigational oral tablet compared to placebo ... Diabetic nephropathy is a multifactorial progressive disease that occurs through various mechanisms such as hyperglycemia, ... Renoprotective Effects of Dapagliflozin in Type 2 Diabetes Study design A phase 4, monocenter, randomized, double-blind, ...https://www.centerwatch.com/clinical-trials/listings/condition/517/wilsons-disease/