*  Fentanyl Ultra Low Doses Effects on the Nociceptive Threshold - Full Text View - ClinicalTrials.gov
Exaggerated pain and hyperalgesia are major issues after surgery and can lead to chronic pain. Opioid are parts of pain ... Postoperative Hyperalgesia. Human volunteer. Fentanyl. Randomized Controlled Trial. Pain chronicisation. Predictive test. ... Célèrier E, Laulin JP, Corcuff JB, Le Moal M, Simonnet G. Progressive enhancement of delayed hyperalgesia induced by repeated ... Hyperalgesia. Pain. Neurologic Manifestations. Nervous System Diseases. Postoperative Complications. Pathologic Processes. ...
  https://clinicaltrials.gov/ct2/show/NCT00454259
*  Plus it
... suggesting the presence of mechanical hyperalgesia and allodynia. B, Time course of mechanical hyperalgesia and allodynia as ... The behavioral hyperalgesia and allodynia develops and lasts for 4 h after microinjection of rTNF-α (120 fmol) as indicated by ... Mechanical hyperalgesia/allodynia and time course-dependent hyperactivation of astrocytes in the RVM after CCI-ION. A, Examples ... 8B,C). A single dose of rTNF-α (120 fmol) in the RVM produced behavioral hyperalgesia and allodynia, as indicated by a ...
  http://www.jneurosci.org/content/28/42/10482
*  The Protein Kinase IKKε Is a Potential Target for the Treatment of Inflammatory Hyperalgesia | The Journal of Immunology
Inflammatory hyperalgesia. A, Time course of mechanical hyperalgesia in WT and IKKε−/− mice after injection of 10 mg/ml (20 μl ... Intraplantar zymosan as a reliable, quantifiable model of thermal and mechanical hyperalgesia in the rat. Eur. J. Pain 1: 43-52 ... The Protein Kinase IKKε Is a Potential Target for the Treatment of Inflammatory Hyperalgesia. Christine V. Möser, Katharina ... 3, 28). On the one hand, our data indicated that IRF-3 is not activated during inflammatory hyperalgesia and, therefore, is ...
  http://www.jimmunol.org/content/187/5/2617
*  Insights into components governing image resolution of inflammatory pain happen to
Adoptive copy of IL-10? /? cuboid marrow-derived monocytes failed to stabilize the life long IL-1β-induced hyperalgesia in LysM ... In addition intrathecal IL-10 treatment attenuated IL-1β-induced hyperalgesia in LysM-GRK2+/? rats whereas zero effect was had ... Just lately we exhibited that IL-1β- and carrageenan-induced hyperalgesia is certainly significantly long term in LysM-GRK2+/? ... Each of our data find out a key position for monocytes/macrophages in promoting image resolution of inflammatory hyperalgesia ...
  http://researchhunt.com/2016/02/24/insights-into-components-governing-image-resolution-of-inflammatory-pain-happen-to/
*  Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil - Full Text View - ClinicalTrials.gov
Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil (0813). The safety and scientific ... Hyperalgesia. Somatosensory Disorders. Sensation Disorders. Neurologic Manifestations. Nervous System Diseases. Signs and ... This study investigated the time-course of opioid-induced hyperalgesia development in healthy normal volunteers (N=12 ... A Pilot Study of Prolonged, Intermittent Exposure to Alfentanil on Opioid-Induced Hyperalgesia in Healthy Volunteers. ...
  https://clinicaltrials.gov/ct2/show/NCT00991809
*  Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral Nerve Excitability - Full Text View -...
Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral Nerve Excitability. The safety and scientific ... Hyperalgesia. Somatosensory Disorders. Sensation Disorders. Neurologic Manifestations. Nervous System Diseases. Signs and ... Aera of flare reaction (cm2), area of primary and secondary hyperalgesia (cm2) [ Time Frame: 1 year ]. ...
  https://clinicaltrials.gov/ct2/show/NCT00900913
*  JOINT MANIPULATION REDUCES HYPERALGESIA BY ACTIVATION OF MONOAMINE RECEPTORS BUT NOT OPIOID OR GABA RECEPTORS IN THE SPINAL CORD
This page contains the abstract Joint Manipulation Reduces Hyperalgesia By Activation of Monoamine Receptors But Not Opioid or ... GABA Receptors in the Spinal Cord http://www.chiro.org/LINKS/ABSTRACTS/Joint_Manipulation_Reduces_Hyperalgesia.shtml ... Joint Manipulation Reduces Hyperalgesia By Activation of Monoamine Receptors But Not Opioid or GABA Receptors in the Spinal ... Joint manipulation reverses mechanical hyperalgesia Two hours after injection of capsaicin into the ankle joint, there was a ...
  http://www.chiro.org/LINKS/ABSTRACTS/Joint_Manipulation_Reduces_Hyperalgesia.shtml
*  Mechanisms of Hyperalgesia
... 16 May Inflammation causes an increased synthesis of COX-2-dependent prostaglan- dins, which ... tified PGE2 receptors of the EP2 receptor subtype as key signaling elements in spinal inflammatory hyperalgesia (Reinold et al. ... Experimental data suggest that both acidic and nonacidic COX inhibitors antagonize central hy- peralgesia in the dorsal horn of ... 3a, b Molecular mechanisms underlying peripheral and central hyperalgesia elicited by prostaglandin E2 (adapted from Brune and ...
  http://fx.damasgate.com/mechanisms-of-hyperalgesia/
*  Hyperalgesia - Wikipedia
Secondary hyperalgesia describes pain sensitivity that occurs in surrounding undamaged tissues. Opioid-induced hyperalgesia may ... Where hyperalgesia has been produced by chronic high doses of opioids, reducing the dose may result in improved pain management ... Hyperalgesia can be experienced in focal, discrete areas, or as a more diffuse, body-wide form. Conditioning studies have ... Hyperalgesia is induced by platelet-activating factor (PAF) which comes about in an inflammatory or an allergic response. This ...
  https://en.wikipedia.org/wiki/Hyperalgesia
*  Hyperalgesia (album) - Wikipedia
"Victorian Halls released Hyperalgesia @ Bottom Lounge". The Deli Magazine. 19 May 2015. Retrieved 30 June 2017. "Hyperalgesia ... Hyperalgesia is the second full-length studio album by American alternative rock band Victorian Halls from Chicago, Illinois, ...
  https://en.wikipedia.org/wiki/Hyperalgesia_(album)
*  Opioid-induced hyperalgesia - Wikipedia
Opioid-induced hyperalgesia or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia is a phenomenon ... Opioid-induced hyperalgesia has also been criticized as overdiagnosed among chronic pain patients, due to poor differential ... Ketamine, a NMDA antagonist, has been shown to prevent the extended use of opioid in post-operative hyperalgesia when it is ... "Opioid-Induced Hyperalgesia (OIH)". Revista Brasileira de Anestesiologia. 60: 639-647. DuPen, Anna; Shen, Danny; Ersek, Mary ( ...
  https://en.wikipedia.org/wiki/Opioid-induced_hyperalgesia
*  Neuropathic Pain:HyperAlgesia&Trigeminal Neuro | DailyStrength
Erythromelalgia(heat hyperalgesia) is in part due to mutations in TTX sensitivity of channel Na 1.7 (Sodium 1.7). Trigeminal ... Knockout IL-1 receptor and reduce hyperalgesia Sodium Channel Dysfunction can contribute to pain. Channel Na 1.3 (Sodium 1.3) ...
  https://www.dailystrength.org/group/neuropathy/discussion/neuropathic-pain-hyperalgesia-amp-trigeminal-neu_1
*  Prolonged Differential Wound Hyperalgesia After an Interval... : Anesthesia & Analgesia
We assessed postoperative pain at rest and with movement along with wound hyperalgesia in a patient ... Wound hyperalgesia was also determined on each side of the horizontal incision with an algometer (8,9). These data are shown in ... Pain and wound hyperalgesia were consistently greater on the "unblocked" side for the 3-wk period of observation. Thus, even ... Prolonged Differential Wound Hyperalgesia After an Interval of Unilateral Epidural Blockade During Lower Abdominal Surgery. ...
  http://journals.lww.com/anesthesia-analgesia/Fulltext/2005/05000/Prolonged_Differential_Wound_Hyperalgesia_After_an.39.aspx
*  Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia - Full Text View - ClinicalTrials.gov
Pericicatricial hyperalgesia area [ Time Frame: 72 hours after surgery ]. Secondary Outcome Measures: *Pain intensity (rest/ ... Hyperalgesia, postoperative. Local anesthetic, ropivacaine, lidocaine. Colorectal laparoscopic surgery. Pain management after ... Besides hyperalgesia assessment, immediate postoperative and long-term pain, morphine consumption, and endocrin-metabolic ... Hyperalgesia. Pain. Neurologic Manifestations. Nervous System Diseases. Postoperative Complications. Pathologic Processes. ...
  https://clinicaltrials.gov/ct2/show/NCT01077752
*  Medial Prefrontal Cortex, Secondary Hyperalgesia, and the Default Mode Network | Journal of Neuroscience
... showed a robust response during the perception of secondary hyperalgesia but not primary hyperalgesia (i.e., no mPFC responses ... Secondary hyperalgesia is generally defined as the development of a heightened sensitivity to normal mechanical stimulation in ... Because secondary hyperalgesia pain thresholds were not matched across participants, the pin-prick stimulation used to evoke ... Medial Prefrontal Cortex, Secondary Hyperalgesia, and the Default Mode Network Message Subject (Your Name) has forwarded a page ...
  http://www.jneurosci.org/content/29/37/11424
*  Fenobam on Heat/Capsaicin Induced Hyperalgesia in Healthy Volunteers - Full Text View - ClinicalTrials.gov
Fenobam on Heat/Capsaicin Induced Hyperalgesia in Healthy Volunteers. The safety and scientific validity of this study is the ... Hyperalgesia. Somatosensory Disorders. Sensation Disorders. Neurologic Manifestations. Nervous System Diseases. Signs and ... size of the area of hyperalgesia and allodynia around the area sensitized by heat/capsaicin as quantified by cutaneous ... Suppression of the development of cutaneous hyperalgesia and allodynia around the area treated with heat/capsaicin. [ Time ...
  https://clinicaltrials.gov/ct2/show/NCT01981395
*  Effects of Lidocaine Patch on Intradermal Capsaicin Induced Pain and Hyperalgesia - Tabular View - ClinicalTrials.gov
Allodynia and Hyperalgesia. *At the completion of the stimulation, areas of cutaneous allodynia and hyperalgesia will be mapped ... The region of hyperalgesia will be established with a 5.18 von Frey hair, and the area of allodynia with a foam brush gently ... Effects of Lidocaine Patch on Intradermal Capsaicin Induced Pain and Hyperalgesia. The safety and scientific validity of this ... Effects of Lidocaine Patch on Intradermal Capsaicin Induced Pain and Hyperalgesia. Official Title ICMJE Effects of Lidocaine ...
  https://clinicaltrials.gov/ct2/show/record/NCT00373893
*  Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats. - PubMed - NCBI
Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats.. Bradesi S1, ... These data support a major role for V(3) receptors in repeated psychological stress-induced visceral hyperalgesia and suggest ... Repeated administration of SSR149415 at 1 or 3 mg/kg completely prevented stress-induced visceral hyperalgesia. Similarly, a ... signaling system in the development of stress-induced visceral hyperalgesia in rats. Rats were exposed to a daily 1-h session ...
  https://www.ncbi.nlm.nih.gov/pubmed/19033533
*  Abstract: Quantitative and Qualitative Perceptual Analysis of Cold Dysesthesia and Hyperalgesia in Fibromyalgia
... * ... The combination of cold hyperesthesia, cold dysesthesia, and multimodal hyperalgesia suggests a selective pathophysiology at a ...
  http://www.prohealth.com/library/showarticle.cfm?libid=8352
*  Deficits in Visceral Pain and Referred Hyperalgesia in Nav1.8 (SNS/PN3)-Null Mice | Journal of Neuroscience
Referred visceral hyperalgesia in wild-type (+/+) and Nav1.8-null (−/−) mice. Referred visceral hyperalgesia was measured as ... Nav1.8-null mutants show no referred hyperalgesia after intracolonic capsaicin and weak hyperalgesia after intracolonic mustard ... evidence of referred hyperalgesia. Significant referred hyperalgesia was seen in both the abdomen (data not shown) and the ... Referred hyperalgesia was measured by testing the frequency of withdrawal responses to the application of von Frey hairs to the ...
  http://www.jneurosci.org/content/22/19/8352
*  A NEW MODEL OF VISCERAL HYPERALGESIA IN NEONATAL RATS: 197 : Journal of Pediatric Gastroenterology and Nutrition
A NEW MODEL OF VISCERAL HYPERALGESIA IN NEONATAL RATS: 197. Miranda, Adrian; Peles, Shachar; Rudolph, Colin; Hodzic, Enisa; ... Home , October 2005 - Volume 41 - Issue 4 , A NEW MODEL OF VISCERAL HYPERALGESIA IN NEONATAL RATS: 197 ... A NEW MODEL OF VISCERAL HYPERALGESIA IN NEONATAL RATS: 197 Journal of Pediatric Gastroenterology and Nutrition41(4):554, ... Rats that received pH 4.0 injections as neonates developed visceral hyperalgesia with a significant increase in the ...
  http://journals.lww.com/jpgn/Fulltext/2005/10000/A_New_Model_of_Visceral_Hyperalgesia_in_Neonatal.220.aspx
*  New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice | RTI
Furthermore, varenicline (0.1 and 0.5 mg/kg) reversed nicotine withdrawal signs such as hyperalgesia and somatic signs and ... Moreover, the effects of varenicline on nicotine withdrawal-induced hyperalgesia and aversion are unknown. We also examined the ... New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice. ... withdrawal and hyperalgesia in mice. Neuropharmacology, 138, 72-79. DOI: 10.1016/j.neuropharm.2018.05.025 ...
  https://www.rti.org/publication/new-insights-effects-varenicline-nicotine-reward-withdrawal-and-hyperalgesia-mice
*  The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers - Full Text View - ClinicalTrials.gov
Area of pin prick hyperalgesia [ Time Frame: 0-6 hours ]. Secondary Outcome Measures : *Stimulus-response (SR) function to a ... The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (RemiSun 1). The safety and ... Hyperalgesia. Sunburn. Somatosensory Disorders. Sensation Disorders. Neurologic Manifestations. Nervous System Diseases. Signs ... The investigators want to test the influence of remifentanil, an ultra-short acting opioid, on hyperalgesia observed after UV-B ...
  https://clinicaltrials.gov/ct2/show/NCT00811837