PNPLA8 - Wikipedia
"Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner ... Calcium-independent phospholipase A2-gamma is an enzyme that in humans is encoded by the PNPLA8 gene. GRCh38: Ensembl release ... Tanaka H, Takeya R, Sumimoto H (Jul 2000). "A novel intracellular membrane-bound calcium-independent phospholipase A(2)". ... "Entrez Gene: PNPLA8 patatin-like phospholipase domain containing 8". Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning ...https://en.wikipedia.org/wiki/PNPLA8
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators | JEM
Group VIB Ca2+-independent phospholipase A2γ promotes cellular membrane hydrolysis and prostaglandin production in a manner ... prostaglandin D2. PGE2. prostaglandin E2. PLA2. phospholipase A2. PLA2G2D. group IID sPLA2. PUFA. polyunsaturated fatty acid. ... Biosynthesis of PUFA-derived lipid mediators is initiated by hydrolysis of phospholipids by phospholipase A2 (PLA2; Murakami et ... 15-deoxy-Δ12,14-prostaglandin J2. AA. arachidonic acid. BMDC. BM-derived DC. CHS. contact hypersensitivity. cPLA2. Ca2+- ...http://jem.rupress.org/content/early/2013/05/14/jem.20121887
KAKEN - Research Projects | Research for the anti-thrombus and anti-inflammation of annexin-V (KAKENHI-PROJECT-04671359)
Annexin-V also inhibits the hydrolysis of phospholipid by phospholipase A2. This inhibition is thought to suppress ... prostaglandin synthesis leading to antiinflammatory action.. The peptides, SHLRKV and DHTLIR, corresponding to annexin-V ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04671359/
Eicosanoid Synthesis - Molecular Biochemistry II Eicosanoid Synthesis Copyright 1999-2008 by Joyce J Diwan All rights reserved...
Arachidonate is released from phospholipids by hydrolysis catalyzed by Phospholipase A2 . This enzyme hydrolyzes the ester ... PGE2 (prostaglandin E2). Prostaglandins all have a cyclopentane ring . w A letter code is based on ring modifications (e.g., ... Arachidonic acid COOH PGE2 (prostaglandin E2) is an example of a prostaglandin, produced from arachidonic acid . COOH O HO OH ... w Prostaglandin receptors are specified by the same letter code. E.g., receptors for E-class prostaglandins are EP . ...https://www.coursehero.com/file/5960368/Eicosanoid-Synthesis/
Phospholipase | definition of phospholipase by Medical dictionary
... phospholipase explanation free. What is phospholipase? Meaning of phospholipase medical term. What does phospholipase mean? ... Looking for online definition of phospholipase in the Medical Dictionary? ... Phospholipase B. phospholipase. [fos″fo-lip´ās] any of four enzymes (phospholipase A to D) that catalyze the hydrolysis of a ... Various phospholipases digest cell membranes, aid in the synthesis of prostaglandins, and help produce arachidonic acid, one of ...https://medical-dictionary.thefreedictionary.com/phospholipase
Stimulation of Phospholipase D via α1-Adrenergic Receptors in Madin-Darby Canine Kidney Cells is Independent of PKCα and -ε...
1987) α1-Adrenergic receptor-mediated phosphoinositide hydrolysis and prostaglandin E2 formation in Madin-Darby canine kidney ... 1992) Norepinephrine-induced phosphatidylcholine hydrolysis by phospholipase D and C in rat tail artery. Am J Physiol 262:C1376 ... 1994) Signal-activated phospholipase D. in Signal-Activated Phospholipases, ed Liscovitch M (R. G. Landes, Austin, TX), pp 31- ... We know that stimulation of α1-adrenergic receptors increases phospholipase C-mediated phosphoinositide hydrolysis in different ...http://molpharm.aspetjournals.org/content/53/2/221
Recombinant Human phospholipase A2, group IID, His-tagged PLA2G2D-68H - Creative BioMart
sPLA2-IID His-Tagged Fusion protein is 16.4 kDa containing 125 amino acid residues of the human secreted phospholipase A2-IID ... Recombinant Human Secreted Phospholipase A2-IIDexpressed inE.Coliwas produced with N-terminal His-Tag. ... Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membraneglycerophospholipids to liberate arachidonic ... acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces ...https://www.creativebiomart.net/description_4129_12.htm
Expression of PLA2G4A in cancer - Summary - The Human Protein Atlas
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane ... Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, ... GO:0004620 [phospholipase activity]. GO:0004622 [lysophospholipase activity]. GO:0004623 [phospholipase A2 activity]. GO: ... Phospholipase A2 group IVA. Protein classi. Protein class the gene product belongs to according to selected gene lists. List of ...http://www.proteinatlas.org/ENSG00000116711-PLA2G4A/pathology
PLA2G5 Human | ProSpec
sPLA2-VHis-Tagged Fusion protein is 15.5 kDa containing 118 amino acid residues of the human secreted phospholipase A2-V and 16 ... Secreted Phospholipase A2-V Human Recombinant was produced with N-terminal His-Tag. ... Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic ... acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces ...https://www.prospecbio.com/PLA2G5_Human
Recombinant Human Phospholipase A2, Group IIE, His-tagged PLA2G2E-69H - Creative BioMart
sPLA2-IIE His-Tagged Fusion Protein is 15.8 kDa protein containing 123 amino acid residues of the human secreted phospholipase ... Recombinant Human Secreted Phospholipase A2-IIEproduced inE.Coliis manufactured with N-terminal His-Tag. ... Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic ... acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces ...https://www.creativebiomart.net/description_4130_12.htm
Eicosanoids are inflammatory mediators primarily generated by hydrolysis of membrane phospholipids by phospholipase A2 to ω-3 ... Patients with colorectal cancer (CRC) have been shown to have elevated levels of circulating prostaglandin E2 (PGE2) which ... potentially mediated by elevated levels of prostaglandin E2, which suppress HIV-specific T cell responses. ... ... in peripheral T cells from colorectal cancer patients are affected by high concentrations of circulating prostaglandin E2 ...https://www.duo.uio.no/handle/10852/233/discover?rpp=100&sort_by=dc.date.issued_dt&order=DESC
Recombinant Human PLA2G4A, His-tagged PLA2G4A-557H - Creative BioMart
sPLA2-X His-Tagged Fusion Protein, is 15.5 kDa containing 123 amino acid residues of the human secreted phospholipase A2. It is ... Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic ... acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces ... PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) [ Homo sapiens ]. Synonyms:. PLA2G4A; phospholipase A2, ...https://www.creativebiomart.net/description_6981_8.htm
BPAI Board of Patent Appeals and Interferences Patent and Trademark Office (P.T.O.) EX PARTE JOHN L. KNOPE AND JAMES CLARK - IP...
Phospholipase A2 (PLA2) is responsible for the hydrolysis of arachidonic acid-containing phospholipids, thereby providing ... The products of the arachidonic cascade are varied and include prostaglandins, thromboxanes, leukotrienes, and other ... and a phospholipase A2 enzyme and observing whether said phospholipase A2 enzyme cleaves said phospholipid and releases fatty ... said phospholipase A2 enzyme being characterized by an amino acid sequence selected from the group consisting of:. (a) an amino ...http://ipmall.info/content/bpai-board-patent-appeals-and-interferences-patent-and-trademark-office-pto-ex-parte-john-l
Guanine Nucleotide Regulatory Protein Couples Angiotensin II Receptors to Phospholipase C in Mesangial Cells | SpringerLink
... caused a rapid hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) in rat... ... which accounted for this degradation of PIP2 further leads to an increased synthesis of prostaglandins (PG). The present study ... Mesangial Cell Pertussis Toxin Inositol Phosphate PGE2 Synthesis Rapid Hydrolysis These keywords were added by machine and not ... Pfeilschifter J. (1987) Guanine Nucleotide Regulatory Protein Couples Angiotensin II Receptors to Phospholipase C in Mesangial ...https://link.springer.com/chapter/10.1007/978-1-4757-0166-1_39
Role of phospholipases A2 in lung inflammation. Lhousseine Touqui (PI). In this part of our project we investigate the role of ... AA is also converted by cyclooxygenases (COXs) into anti-inflammatory prostaglandins such as PGE2. AMPs are ubiquitous, gene- ... The latter is a ubiquitous enzyme present in host cells where it hydrolyses phospholipids at the sn-2 position resulting in the ... Movert E, Wu Y, Lambeau G, Kahn F, Touqui L, Areschoug T, Secreted group IIA phospholipase A2 protects humans against the group ...https://research.pasteur.fr/en/team/mucoviscidose-et-bronchopathies-chroniques-biopathologie-et-phenotype-cliniques/
PLA2G4A - Wikipedia
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane ... interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production". Molecular ... "Entrez Gene: PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)". Sheridan AM, Force T, Yoon HJ, O'Leary E, ... The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is ...https://en.wikipedia.org/wiki/PLA2G4A
Phospholipids are hydrolyzed by phospholipase A2 libera | Open-i
Phospholipids are hydrolyzed by phospholipase A2 liberating arachidonic acid and Lyso-PAF, regulators of insect's immune system ... Lyso-PAF is acetylated by PAF-acetyl transferase releasing PAF that can be degraded by PAF-acetyl hydrolase that hydrolyses PAF ... Arachidonic acid is the substrate for eicosanoid production, prostaglandins via cyclooxygenase and leukotrienes via ... Lyso-PAF is acetylated by PAF-acetyl transferase releasing PAF that can be degraded by PAF-acetyl hydrolase that hydrolyses PAF ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2719633_1756-3305-2-33-3&req=4
Physiology Kanani Flashcards by Sukhpreet Dubb | Brainscape
IP2: this is also generated by hydrolysis of IP3 by activated phospholipase C. IP2 has the effect of causing Ca2 release from ... DAG: this is produced when activated phospholipase C (generated from Gq-protein linked receptor stimulation) hydrolyses ... Arachidonic acid and eicosanoids: these are produced by G-protein linked receptors that activate phospholipase A2. These have ... or it may stimulate the enzyme phospholipase C. ... Gq: binding produces activation of phospholipase C, e.g. 1- ...https://www.brainscape.com/flashcards/physiology-kanani-2034844/packs/1974042
Phospholipase C beta 4 in mouse hepatocytes: Rhythmic expression and cellular distribution | Comparative Hepatology | Full Text
Prostaglandins Other Lipid Mediat. 2001, 65 (4): 159-166. 10.1016/S0090-6980(01)00124-1.View ArticlePubMedGoogle Scholar. ... Miguel BG, Calcerrada MC, Martin L, Catalan RE, Martinez AM: Increase of phosphoinositide hydrolysis and diacylglycerol ... The phospholipase C β4 (PLCβ4) enzyme is of particular interest as it has been linked to circadian clock function. In general, ... Kim D, Jun KS, Lee SB, Kang NG, Min DS, Kim YH, Ryu SH, Suh PG, Shin HS: Phospholipase C isozymes selectively couple to ...https://comparative-hepatology.biomedcentral.com/articles/10.1186/1476-5926-7-8
Frontiers | TNF-α-Induced cPLA2 Expression via NADPH Oxidase/Reactive Oxygen Species-Dependent NF-κB Cascade on Human Pulmonary...
... and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-alpha ... and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-alpha ... Phospholipase A2 (PLA2) enzymes catalyze the hydrolysis of membrane phospholipids resulting in the release of AA (Borsch- ... 1994). Interleukin-1β induces cytosolic phospholipase A2 and prostaglandin H synthase in rheumatoid synovial fibroblasts. ...https://www.frontiersin.org/articles/10.3389/fphar.2016.00447/full
A comparative study of endothelin- and platelet-activating-factor-mediated signal transduction and prostaglandin synthesis in...
ET-3-induced hydrolysis of phosphoinositides was characterized by the production of various inositol phosphates and of ... Treatment of Kupffer cells with pertussis toxin resulted in an inhibition of ET-3-induced phospholipase C activation; in ... In contrast to the increased production of prostaglandins E2 and D2 observed upon stimulation of Kupffer cells with PAF, ET-3 ... The mechanism of ET-3-stimulated metabolism of phosphoinositides and synthesis of prostaglandins appeared to be distinct from ...http://www.biochemj.org/content/281/2/485
Interplay between ultrastructural findings and atherothrombotic complications in type 2 diabetes mellitus | Cardiovascular...
During platelet aggregation and activation, mechanisms like phospholipase C-induced hydrolysis of inositol phospholipids and ... of prostacyclin and nitric oxide on aggregation and to diminish the proaggregatory properties of agonists such as prostaglandin ...https://cardiab.biomedcentral.com/articles/10.1186/s12933-015-0261-9
Oxidants, antioxidants and the ischemic brain | Journal of Experimental Biology
Ca2+-activated phospholipases C and A2 result in phospholipid hydrolysis, while resynthesis of phospholipids requires ATP. As a ... thromboxanes and prostaglandins) (Gaudet et al., 1980), free radical generation and lipid peroxidation-mediated chain reactions ...http://jeb.biologists.org/content/207/18/3221.full
Cerebrospinal fluid secretory [Ca.sup.2+]-dependent phospholipase [A.sub.2] activity is increased in alzheimer disease. - Free...
... dependent phospholipase [A.sub.2] activity is increased in alzheimer disease.(Proteomics and Protein Markers) by 'Clinical ... Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology 1999;53:1495-8. (39.) Montine TJ, Beal MF, ... Despite their differences, PLA2s share the ability to catalyze the hydrolysis of the sn-2 ester bonds of glycerophospholipids, ... Phospholipase A(2) Biochemistry. Cardiovasc Drugs Ther 2009;23:49-59. (2.) Farooqui AA, Horrocks LA. Phospholipase A2generated ...https://www.thefreelibrary.com/Cerebrospinal+fluid+secretory+%5BCa.sup.2%2B%5D-dependent+phospholipase+...-a0324398243
Inhibitors of Cytosolic Phospholipase A2α as Potential Anti-...: Ingenta Connect
The rate limiting step in the generation of prostaglandins, leukotrienes and the PAF, respectively, is the cleavage of the sn-2 ... appears to be the most likely candidate to catalyze this hydrolysis, since the enzyme is highly selective for arachidonoyl- ... ester of membrane phospholipids by phospholipase A2. To date four main groups of phospholipases are known, which comprise the ... Arachidonic acid derivatives, like prostaglandins and leukotrienes, and the platelet-activating factor (PAF) are highly active ...http://www.ingentaconnect.com/content/ben/aiaamc/2006/00000005/00000002/art00008