Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators | JEM
Group VIB Ca2+-independent phospholipase A2γ promotes cellular membrane hydrolysis and prostaglandin production in a manner ... prostaglandin D2. PGE2. prostaglandin E2. PLA2. phospholipase A2. PLA2G2D. group IID sPLA2. PUFA. polyunsaturated fatty acid. ... Biosynthesis of PUFA-derived lipid mediators is initiated by hydrolysis of phospholipids by phospholipase A2 (PLA2; Murakami et ... 15-deoxy-Δ12,14-prostaglandin J2. AA. arachidonic acid. BMDC. BM-derived DC. CHS. contact hypersensitivity. cPLA2. Ca2+- ...http://jem.rupress.org/content/early/2013/05/14/jem.20121887
PNPLA8 - Wikipedia
"Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner ... Calcium-independent phospholipase A2-gamma is an enzyme that in humans is encoded by the PNPLA8 gene. GRCh38: Ensembl release ... Tanaka H, Takeya R, Sumimoto H (Jul 2000). "A novel intracellular membrane-bound calcium-independent phospholipase A(2)". ... "Entrez Gene: PNPLA8 patatin-like phospholipase domain containing 8". Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning ...https://en.wikipedia.org/wiki/PNPLA8
Eicosanoid Synthesis - Molecular Biochemistry II Eicosanoid Synthesis Copyright 1999-2008 by Joyce J Diwan All rights reserved...
Arachidonate is released from phospholipids by hydrolysis catalyzed by Phospholipase A2 . This enzyme hydrolyzes the ester ... PGE2 (prostaglandin E2). Prostaglandins all have a cyclopentane ring . w A letter code is based on ring modifications (e.g., ... Arachidonic acid COOH PGE2 (prostaglandin E2) is an example of a prostaglandin, produced from arachidonic acid . COOH O HO OH ... w Prostaglandin receptors are specified by the same letter code. E.g., receptors for E-class prostaglandins are EP . ...https://www.coursehero.com/file/5960368/Eicosanoid-Synthesis/
KAKEN - Research Projects | Research for the anti-thrombus and anti-inflammation of annexin-V (KAKENHI-PROJECT-04671359)
Annexin-V also inhibits the hydrolysis of phospholipid by phospholipase A2. This inhibition is thought to suppress ... prostaglandin synthesis leading to antiinflammatory action.. The peptides, SHLRKV and DHTLIR, corresponding to annexin-V ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04671359/
Stimulation of Phospholipase D via α1-Adrenergic Receptors in Madin-Darby Canine Kidney Cells is Independent of PKCα and -ε...
1987) α1-Adrenergic receptor-mediated phosphoinositide hydrolysis and prostaglandin E2 formation in Madin-Darby canine kidney ... 1992) Norepinephrine-induced phosphatidylcholine hydrolysis by phospholipase D and C in rat tail artery. Am J Physiol 262:C1376 ... 1994) Signal-activated phospholipase D. in Signal-Activated Phospholipases, ed Liscovitch M (R. G. Landes, Austin, TX), pp 31- ... We know that stimulation of α1-adrenergic receptors increases phospholipase C-mediated phosphoinositide hydrolysis in different ...http://molpharm.aspetjournals.org/content/53/2/221
Phospholipases | definition of Phospholipases by Medical dictionary
Phospholipases explanation free. What is Phospholipases? Meaning of Phospholipases medical term. What does Phospholipases mean? ... Looking for online definition of Phospholipases in the Medical Dictionary? ... Phospholipase B phospholipase. [fos″fo-lip´ās] any of four enzymes (phospholipase A to D) that catalyze the hydrolysis of a ... Various phospholipases digest cell membranes, aid in the synthesis of prostaglandins, and help produce arachidonic acid, one of ...https://medical-dictionary.thefreedictionary.com/Phospholipases
Phospholipids are hydrolyzed by phospholipase A2 libera | Open-i
Phospholipids are hydrolyzed by phospholipase A2 liberating arachidonic acid and Lyso-PAF, regulators of insect's immune system ... Lyso-PAF is acetylated by PAF-acetyl transferase releasing PAF that can be degraded by PAF-acetyl hydrolase that hydrolyses PAF ... Arachidonic acid is the substrate for eicosanoid production, prostaglandins via cyclooxygenase and leukotrienes via ... Lyso-PAF is acetylated by PAF-acetyl transferase releasing PAF that can be degraded by PAF-acetyl hydrolase that hydrolyses PAF ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2719633_1756-3305-2-33-3&req=4
PLA2G4A - Wikipedia
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane ... interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production". Molecular ... "Entrez Gene: PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)". Sheridan AM, Force T, Yoon HJ, O'Leary E, ... The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is ...https://en.wikipedia.org/wiki/PLA2G4A
Phospholipase C beta 4 in mouse hepatocytes: Rhythmic expression and cellular distribution | Comparative Hepatology | Full Text
Prostaglandins Other Lipid Mediat. 2001, 65 (4): 159-166. 10.1016/S0090-6980(01)00124-1.View ArticlePubMedGoogle Scholar. ... Miguel BG, Calcerrada MC, Martin L, Catalan RE, Martinez AM: Increase of phosphoinositide hydrolysis and diacylglycerol ... The phospholipase C β4 (PLCβ4) enzyme is of particular interest as it has been linked to circadian clock function. In general, ... Kim D, Jun KS, Lee SB, Kang NG, Min DS, Kim YH, Ryu SH, Suh PG, Shin HS: Phospholipase C isozymes selectively couple to ...https://comparative-hepatology.biomedcentral.com/articles/10.1186/1476-5926-7-8
Frontiers | TNF-α-Induced cPLA2 Expression via NADPH Oxidase/Reactive Oxygen Species-Dependent NF-κB Cascade on Human Pulmonary...
... and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-alpha ... and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-alpha ... Phospholipase A2 (PLA2) enzymes catalyze the hydrolysis of membrane phospholipids resulting in the release of AA (Borsch- ... 1994). Interleukin-1β induces cytosolic phospholipase A2 and prostaglandin H synthase in rheumatoid synovial fibroblasts. ...https://www.frontiersin.org/articles/10.3389/fphar.2016.00447/full
A comparative study of endothelin- and platelet-activating-factor-mediated signal transduction and prostaglandin synthesis in...
ET-3-induced hydrolysis of phosphoinositides was characterized by the production of various inositol phosphates and of ... Treatment of Kupffer cells with pertussis toxin resulted in an inhibition of ET-3-induced phospholipase C activation; in ... In contrast to the increased production of prostaglandins E2 and D2 observed upon stimulation of Kupffer cells with PAF, ET-3 ... The mechanism of ET-3-stimulated metabolism of phosphoinositides and synthesis of prostaglandins appeared to be distinct from ...http://www.biochemj.org/content/281/2/485
Interplay between ultrastructural findings and atherothrombotic complications in type 2 diabetes mellitus | Cardiovascular...
During platelet aggregation and activation, mechanisms like phospholipase C-induced hydrolysis of inositol phospholipids and ... of prostacyclin and nitric oxide on aggregation and to diminish the proaggregatory properties of agonists such as prostaglandin ...https://cardiab.biomedcentral.com/articles/10.1186/s12933-015-0261-9
Oxidants, antioxidants and the ischemic brain | Journal of Experimental Biology
Ca2+-activated phospholipases C and A2 result in phospholipid hydrolysis, while resynthesis of phospholipids requires ATP. As a ... thromboxanes and prostaglandins) (Gaudet et al., 1980), free radical generation and lipid peroxidation-mediated chain reactions ...http://jeb.biologists.org/content/207/18/3221.long
Cerebrospinal fluid secretory [Ca.sup.2+]-dependent phospholipase [A.sub.2] activity is increased in alzheimer disease. - Free...
... dependent phospholipase [A.sub.2] activity is increased in alzheimer disease.(Proteomics and Protein Markers) by 'Clinical ... Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology 1999;53:1495-8. (39.) Montine TJ, Beal MF, ... Despite their differences, PLA2s share the ability to catalyze the hydrolysis of the sn-2 ester bonds of glycerophospholipids, ... Phospholipase A(2) Biochemistry. Cardiovasc Drugs Ther 2009;23:49-59. (2.) Farooqui AA, Horrocks LA. Phospholipase A2generated ...https://www.thefreelibrary.com/Cerebrospinal+fluid+secretory+%5BCa.sup.2%2B%5D-dependent+phospholipase+...-a0324398243
Inhibitors of Cytosolic Phospholipase A2α as Potential Anti-...: Ingenta Connect
The rate limiting step in the generation of prostaglandins, leukotrienes and the PAF, respectively, is the cleavage of the sn-2 ... appears to be the most likely candidate to catalyze this hydrolysis, since the enzyme is highly selective for arachidonoyl- ... ester of membrane phospholipids by phospholipase A2. To date four main groups of phospholipases are known, which comprise the ... Arachidonic acid derivatives, like prostaglandins and leukotrienes, and the platelet-activating factor (PAF) are highly active ...http://www.ingentaconnect.com/content/ben/aiaamc/2006/00000005/00000002/art00008
Src and Rac Mediate Endothelin-1 and Lysophosphatidic Acid Stimulation of the Human Brain Natriuretic Peptide Promoter |...
In addition to phospholipase C, phospholipase A2 (PLA2) is involved in signal transduction.21 Hydrolysis of the ester bond at ... whereas the ETB receptor may induce vasodilatation by releasing nitric oxide or prostaglandins.8 The ETA receptor is the ... Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells. Biochem Biophys Res Commun. 1989;158:279 ... Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J. 1991;5:2068-2077. ...http://hyper.ahajournals.org/content/37/2/478
IJMS | Free Full-Text | Understanding Resolvin Signaling Pathways to Improve Oral Health | HTML
Complete discrimination of docosahexaenoate from arachidonate by 85 kDa cytosolic phospholipase A2 during the hydrolysis of ... Zurier, R.B. Role of prostaglandins E in inflammation and immune responses. Adv. Prostaglandin Thromboxane Leukot. Res 1991, ... Prostaglandins Other Lipid Mediat 2004, 73, 155-172. [Google Scholar]. *Sun, Y.P.; Oh, S.F.; Uddin, J.; Yang, R.; Gotlinger, K ... Prostaglandins Other Lipid Mediat 2012, 97, 73-82. [Google Scholar]. *Zhang, M.J.; Spite, M. Resolvins: Anti-inflammatory and ...http://www.mdpi.com/1422-0067/14/3/5501/htm
Trypanosoma rangeli: a new perspective for studying the modulation of immune reactions of Rhodnius prolixus | Parasites &...
Lyso-PAF is acetylated by PAF-acetyl transferase releasing PAF that can be degraded by PAF-acetyl hydrolase that hydrolyses PAF ... Stanley DW: Prostaglandins and other eicosanoids in insects: biological significance. Ann Rev Entomol. 2006, 51: 25-44. 10.1146 ... Phospholipids are hydrolyzed by phospholipase A 2 liberating arachidonic acid and Lyso-PAF, regulators of insect's immune ... In the presence of dexamethasone the immune responses are inhibited due to the suppression of phospholipase A2 activity with ...https://parasitesandvectors.biomedcentral.com/articles/10.1186/1756-3305-2-33
... phospholipase A2 (PLA2)-catalyzed hydrolysis from phospholipids, and 3) hydration to form the corresponding diol by soluble ... 5,6-EET is converted to a prostaglandin analog, 5,6-epoxy-prostaglandin (PG) E1, which functions as a renal vasodilator (12). 8 ... Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the ... Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM. A prostaglandin J2 metabolite binds peroxisome proliferator ...http://ajpcell.physiology.org/content/292/3/C996
Scripps Research Scientists Discover Inflammation Is Controlled Differently in Brain and Other Tissues - Healthcanal.com :...
In addition to Cravatt, Nomura, and Morrison, authors of the paper "Endocannabinoid hydrolysis generates brain prostaglandins ... Phospholipase A2 enzymes have long been considered the dominant producers of arachidonic acid, and thus a major element in ... MAGL also regulated arachidonic acid and prostaglandins in liver and lungs.. "Biological pathways that we think we understand ... However, in the brain, the MAGL enzyme was the principal regulator, with phospholipase A2 enzymes making a more limited ...https://www.healthcanal.com/brain-nerves/22208-scripps-research-scientists-discover-inflammation-is-controlled-differently-in-brain-and-other-tissues.html
Brain Sciences | Free Full-Text | Ethanol Neurotoxicity in the Developing Cerebellum: Underlying Mechanisms and Implications |...
In prostaglandin synthesis, the enzyme phospholipase A2 (PLA2) catalyzes the formation of arachidonic acid from membrane-bound ... PDEs mediate cAMP and cGMP hydrolysis. Erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA), a PDE2 specific inhibitor, reduces the ... 9. Ethanol Increases Prostaglandin Production. Prostaglandins (PGs), especially prostaglandin E2 (PGE2), regulate CNS ... Prostaglandins 1988, 36, 835-846. [Google Scholar]. *Luo, J.; Lindstrom, C.L.; Donahue, A.; Miller, M.W. Differential effects ...http://mdpi.com/2076-3425/3/2/941/htm
Role of Group II Secretory Phospholipase A2 in Atherosclerosis | Arteriosclerosis, Thrombosis, and Vascular Biology
Phospholipase A2 (PLA2) enzymes catalyze the hydrolysis of the sn-2 fatty acyl ester bonds of phospholipids to produce a free ... including prostaglandins, thromboxanes, and leukotrienes.4 5 The secreted group IIa PLA2 (sPLA2) has been shown to stimulate ... Role of Group II Secretory Phospholipase A2 in Atherosclerosis Boris Ivandic, Lawrence W. Castellani, Xu-Ping Wang, Jian-Hua ... Role of Group II Secretory Phospholipase A2 in Atherosclerosis Boris Ivandic, Lawrence W. Castellani, Xu-Ping Wang, Jian-Hua ...http://atvb.ahajournals.org/content/19/5/1284.long
HRASLS3 - Wikipedia
Group XVI phospholipase A2 also commonly known as adipocyte phospholipase A2 (AdPLA) is an enzyme that in humans is encoded by ... "Release and effects of prostaglandins in adipose tissue". Prostaglandins Leukot. Essent. Fatty Acids. 47 (3): 171-82. doi: ... to facilitate formation of a histidine-water complex and subsequent fatty acid hydrolysis. Studies on AdPLA have shown ... It belongs to a superfamily of phospholipase A2 (PLA2) enzymes and is found primarily in adipose tissue. AdPLA regulates ...https://en.wikipedia.org/wiki/HRASLS3
Free Radicals and Biomarkers Related to the Diagnosis of Cardiorenal Syndrome | IntechOpen
AT1 signaling through phospholipids involves phospholipase C (PLC), phospholipase D (PLD), and phospholipase A2 (PLA2). ... F2-isoprostanes are a series of active compounds like prostaglandin F2. They are produced regardless of the route of the COX in ... PLD signaling is related to the phosphatidylcholine hydrolysis. The AT1 receptors mediating PLD activation involve Gβ-γ, Gα12, ... In VSMC, AT1 receptor stimulation by Ang II interconnects all phospholipases (PLA2, PLD, and PKC) activation to initiate NADPH ...https://www.intechopen.com/books/free-radicals-and-diseases/free-radicals-and-biomarkers-related-to-the-diagnosis-of-cardiorenal-syndrome/
Reactome | Effects of PIP2 hydrolysis
Hydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol ... DAG is also a precursor for the biosynthesis of prostaglandins, the endocannabinoid 2-arachidonoylglycerol and an activator of ...http://www.reactome.org/content/detail/114508
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