TSRI - News & Views, In Memoriam: Norman R. Klinman
Klinman's work on immunoregulation, monoclonal antibody responses, humoral immunity, and B cell maturation and repertoire ... He was the first to show that tolerance was an active process involving metabolic activity in antigen specific B cells, and ... "Before hybridoma technology was invented, Norman developed the splenic focus assay, which allowed analysis of the antibody ... and remained active in this organization after his term as president ended. Klinman is survived by his wife and Scripps ...http://www.scripps.edu/newsandviews/e_20100510/klinman.html
Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved...
Combination of active specific immunotherapy or adoptive antibody or lymphocyte immunotherapy with chemotherapy in the ... and treatment with monoclonal antibodies such as anti-CTLA-4 [2, 9], anti-PD1 , CD40  and OX40 . Despite the varied ... a humoral response was induced by both the mRNA and protein vaccines; however, the levels of IgG2a antibodies (indicator of a ... Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly. Proc Natl Acad Sci USA 2010; 107: 12198-12203.. * ...http://onlinelibrary.wiley.com/doi/10.1002/jgm.2605/full
The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep
Immunity against murine Trichuris muris has been achieved through monoclonal IgA antibody infusion that resulted in the ... In mice, the humoral immune response has been reported to exert a direct effector role against gastrointestinal nematode ... IgA is not complement fixing and recently has been implicated in anti-inflammatory mechanisms . Evidence for an active role ... antigen recognition and transfer of immunity in mice by IgA monoclonal antibodies," Parasite Immunology, vol. 13, no. 1, pp. 1- ...https://www.hindawi.com/journals/jpr/2011/101848/
MedImmune Presents Data Highlighting its Progressive Inflammatory Disease Portfolio at the 72nd Annual Meeting of the American...
MEDI-545 is a monoclonal antibody (MAb) targeting ...,MedImmune,Presents,Data,Highlighting,its,Progressive,Inflammatory,Disease ... MEDI-545 - MEDI-545 is a monoclonal antibody (MAb) targeting. interferon-alpha, which regulates processes involved in ... that plays a central role in humoral immunity. Elevated levels of ICOS ... study in patients with active dermatomyositis and polymyositis. The. company has also conducted clinical trials in psoriasis ...http://www.bio-medicine.org/biology-technology-1/MedImmune-Presents-Data-Highlighting-its-Progressive-Inflammatory-Disease-Portfolio-at-the-72nd-Annual-Meeting-of-the-American-College-of-Rheumatology-8533-1/
USMLE Content Outline - PDF
... monoclonal antibodies, polyclonal antibodies including IVIG, VZIG, rabies immunoglobulin) Effect of age on the function of ... Prognosis Disorders associated with immunodeficiency deficiency primarily of humoral immunity: common variable immunodeficiency ... Principles of immunologic protection vaccine production and mechanisms of vaccine action biologically active antibodies (eg, ... monoclonal antibody drugs [eg, abciximab, adalimumab; bevacizumab, infliximab, omalizumab, rituximab]); vaccine adverse effects ...http://docplayer.net/422362-Usmle-content-outline.html
Cicatricial (Mucous Membrane) Pemphigoid Medication: Anti-inflammatory Agents, Immunosuppressants, Antineoplastics, Anti-CD20...
Antineoplastics, Anti-CD20 Monoclonal Antibodies. Class Summary. Antineoplastic agents act by inhibiting the key factors ... It is a cyclic polypeptide that suppresses some humoral immunity and, to a greater extent, cell-mediated immune reactions, such ... As an alkylating agent, the mechanism of action of the active metabolites may involve cross-linking of DNA, which may interfere ... Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the ...https://emedicine.medscape.com/article/1062534-medication
SC 122b Anatomy and Physiology II | College of Micronesia - FSM
... and the medical use of monoclonal antibodies. Describe the function of T cells involved in cell mediated immunity, clonal ... the differences between primary and secondary immune responses and the importance of active and passive humoral immunity in ... Describe the function of specific (adaptative) protective structures involved in specific immunity (antibody and cell mediated ... Explain the structure of different classes of antibodies (Ig. A, D, G, E, and M), the way antibodies destroy antigens ( ...http://www.comfsm.fm/?q=SC-122b-Anatomy-and-Physiology-II
Anti-FGFR3 antibody - C-terminal (ab180906) | Abcam
Rabbit polyclonal FGFR3 antibody validated for WB, IHC, ICC/IF and tested in Human, Mouse and Rat. Immunogen corresponding to ... The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. ... Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma ... typically originating from a dysplastic or premalignant lesion previously present at the active squamocolumnar junction. The ...http://www.abcam.com/fgfr3-antibody-c-terminal-ab180906.html
Principles of Vaccination - PDF
specific B cells Humoral immunity lymphocytes antibodies B cells bone marrow Cell-mediated immunity: T cells antibodies ... antibody) and cellular immunity. Unlike passive immunity, which is temporary, active immunity usually lasts for many years, ... which led to the development of monoclonal antibody products. Monoclonal antibody is produced from a single clone of B cells, ... Effector Mechanisms of Humoral Immunity Immunologie II für Naturwissenschaftler Effector Mechanisms of Humoral Immunity Beda M ...http://docplayer.net/13103284-Principles-of-vaccination.html
Recombinant human FGFR3 protein (ab60857) | Abcam
Ab60857 is an active protein fragment produced in Baculovirus infected Sf9 cells and has been validated in FuncS… ... The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. ... We offer world-leading antibody development platforms based on a proprietary RabMAb® rabbit monoclonal platform, a phage ... This product is an active protein and may elicit a biological response in vivo, handle with caution. ...http://www.abcam.com/recombinant-human-fgfr3-protein-ab60857.html
Monoclonal Antibodies. *Mechanisms of Immunization. *Active and Passive Immunity. *Acquired and Artificial Immunity ... Humoral-mediated immunity. *B-cells: Memory cells and Plasma cells. *Class switching =, the same plasma cell can produce a ... Antigens, Immunogens and Antibodies. *Immunogen =, Any substance that induces an immune response and specifically binds to the ... Antibodies for a particular immunogen are not present in the serum until an exposure has occurred ...http://www.angelfire.com/nt/classinfo/Micro/microchapter6.html
... this study shows that a single vaccination with TA-HPV can induce immunity to HPV proteins in patients with active malignancy. ... monoclonal antibody. ... Because a humoral response to HPV E6 and E7 proteins is not ... De novo antibodies to HPV-16 E7 or HPV-18 E7 developed in four patients each (Table 2)⇓ . Antibodies to both HPV-16 and HPV-18 ... Overall antibodies to HPV-16 E7 were detected in 11 of 29 patients, and overall antibodies to HPV-18 E7 were detected in 15 of ...http://clincancerres.aacrjournals.org/content/8/12/3676
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in...
Contributions of humoral and cellular immunity to vaccine-induced protection in humans. Virology. 411:206-215. doi:10.1016/j. ... Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization ... Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies. Immunity. 37:412-425. doi:10.1016/j. ... Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science. 329:856-861. doi: ...http://jem.rupress.org/content/211/10/2061
Protocols and Video Articles Authored by Gene S. Tan
Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies' ... Monoclonal antibody 1B2 binds to viruses of the Eurasian and North American H7 lineages and monoclonal antibody 1H5 reacts ... demonstrating that broad-spectrum humoral immunity to influenza viruses can be elicited in vivo. ... that the specific design of our immunogen is integral in the induction of broadly active anti-hemagglutinin antibodies. These ...https://www.jove.com/author/Gene+S._Tan
Are Anti-Oxidized Low-Density Lipoprotein Antibodies Pathogenic or Protective? | Circulation
41 Because antibodies may protect or neutralize pathogens and immunogens,42-44 humoral immunity to oxLDL can reduce the ... A monoclonal IgM anti-oxLDL antibody (EO6) derived from apoE-deficient mice, which binds intact oxLDL, blocked the macrophage ... These active molecules seem to contribute to the recruitment of leukocytes to the affected area.20 A vast number of T cells, ... Natural antibodies with the T15 idiotype may act on atherosclerosis, apoptotic clearance and protective immunity. J Clin Invest ...http://circ.ahajournals.org/content/110/17/2552
... mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: induction of humoral anti-HMW MAA immunity and prolongation of ... Patients with other active malignancies, active uncontrolled infection, active autoimmune disease, immune deficiency, or known ... This antibody functionally imitates the CA125 antigen and induces humoral as well as cellular anti-CA125 immunity in animals ( ... several studies have been performed with a monoclonal murine anti-Id called monoclonal antibody (mAb) ACA125. ...http://clincancerres.aacrjournals.org/content/10/5/1580
Induction of Active Immunity in Cancer Patients Undergoing Passive Immunotherapy with Antitumor Antibodies
... specific humoral immunity occurs commonly in Trastuzumab-treated patients and that the appearance of HER-2 humoral immunity ... Researchers have thought that the monoclonal antibody breast cancer treatment Trastuzumab works by interfering with processes ... Induction of Active Immunity in Cancer Patients Undergoing Passive Immunotherapy with Antitumor Antibodies Raphael Clynes, M.D ... Induction of Active Immunity in Cancer Patients Undergoing Passive Immunotherapy with Antitumor Antibodies. The therapeutic ...http://www.dana.org/Media/GrantsDetails.aspx?id=38715
Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model |...
Moreover, tumor protection was associated with humoral immune responses dominated by IgG2a and IgG3 tumor-reactive antibodies ... Autoreactive antibodies against the GD2 target antigen were not induced. Our data suggest that Surek revealed strong tumor ... The induction of tumor-associated and autoreactive antibodies was evaluated. Despite its low affinity of approximately 107 M-1 ... The results warrant further clinical development of the human therapeutic equivalent antibody Ektomab. ...https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-10-219
The examples of humoral and cellular immunity selectively activated by changes in carriers and adjuvants discussed earlier in ... Baral R., Sherrat A., Das R., Foon K. A., Bhattacharya-Chatterjee M. Murine monoclonal anti-idiotypic antibody as a surrogate ... MacLean G. D., Bowen-Yacyshyn M. B., Samuel J., Meikle A., Stuart G., Longenecker B. M. Active immunization of human ovarian ... as opposed to humoral) immunity to CEA and that rVV-CEA was more effective as a primer. The VAAA dose schedule was the more ...http://clincancerres.aacrjournals.org/content/9/9/3222
Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites - Immunomedics,...
Le Bon et al., "Type I Interferons Potently Enhance Humoral Immunity and Can Promote Isotype Switching by Stimulating Dendritic ... J. Cancer 46: 310 (1990). In another embodiment, an antibody may be a human monoclonal antibody. Such antibodies are obtained ... 1999; 6:222). Binding of cAMP to the R subunits leads to the release of active catalytic subunits for a broad spectrum of ... CEACAM5 antibodies, EGP-1 (e.g., RS-7)+ILGF antibodies, CEACAM5+EGFR antibodies. Such antibodies need not only be used in ...http://www.freepatentsonline.com/8889835.html
Polyclonal B cell response - Wikipedia
... involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to- ... Difficulty in producing monoclonal antibodies. Main article: Monoclonal antibodies. Monoclonal antibodies are ... "inoculation" is usually used in context of active immunization, i.e., deliberately introducing the antigenic substance into ... Any monoclonal antibody or group of monoclonal antibodies that does not react with known surface molecules of lymphocytes, but ...https://en.wikipedia.org/wiki/Polyclonal
State of play and clinical prospects of antibody gene transfer | Journal of Translational Medicine | Full Text
RNA presents another emerging platform for antibody gene transfer. Early reports in mice show that mRNA may be able to rival ... To address these issues, antibody gene transfer seeks to administer to patients the mAb-encoding nucleotide sequence, rather ... The current review outlines the state of play and clinical prospects of antibody gene transfer, thereby highlighting recent ... Overall, substantial progress has been made in the clinical translation of antibody gene transfer. While challenges persist, ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1234-4
Immunohistologic and cytochemical studies of temporal arteritis.
With the use of labeled monoclonal antibodies which were specific for human T cells, it was possible to demonstrate that the ... All 6 of these patients showed clinical manifestations of active disease at the time of biopsy. Histopathology. In all cases ... These findings are consistent with the hypothesis that cell-mediated immunity may be important in the pathogenesis of temporal ... have indicated the possible importance of humoral immune processes in the pathogenesis of this condition. With the recent ...https://www.docme.ru/doc/2175434/immunohistologic-and-cytochemical-studies-of-temporal-art..
Pharmacokinetics, Pharmacodynamics and Physiologically-Based Pharmacokinetic Modelling of Monoclonal Antibodies | SpringerLink
Development of monoclonal antibodies (mAbs) and their functional derivatives represents a growing segment of the development ... CD4 coating, but not CD4 depletion, is a predictor of efficacy with primatized monoclonal anti-CD4 treatment of active ... Humoral immune responses to adenovirus vectors in the brain. J Neuroimmunol. 2000;103(1):8-15.PubMedCrossRefGoogle Scholar ... Neonatal Fc receptor: from immunity to therapeutics. J Clin Immunol. 2010;30(6):777-89.PubMedCrossRefGoogle Scholar ...https://link.springer.com/article/10.1007%2Fs40262-012-0027-4
Immunity (medical) - Wikipedia
Humoral immunity is called active when the organism generates its own antibodies, and passive when antibodies are transferred ... and in the form of monoclonal antibodies (MAb). Passive transfer is used prophylactically in the case of immunodeficiency ... humoral immunity is the aspect of immunity that is mediated by secreted antibodies, whereas cell mediated immunity involves T- ... Active immunity often involves both the cell-mediated and humoral aspects of immunity as well as input from the innate immune ...https://en.wikipedia.org/wiki/Immunity_(medical)