*  A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic...
Wotton D, Prosser HM and Owen MJ (1993) Regulation of human T cell receptor beta gene expression by Ets‐1. Leukemia, 7, S55-60. ... specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP‐ ... John S, Reeves RB, Lin JX, Child R, Leiden JM, Thompson CB and Leonard WJ (1995) Regulation of cell‐type‐specific interleukin‐2 ... 1993) Expression of platelet‐derived growth factor beta receptor on human monocyte‐derived macrophages and effects of platelet‐ ...
  http://emboj.embopress.org/content/16/1/69
*  Extracellular HSP27 acts as a signaling molecule to activate NF-κB in macrophages - Semantic Scholar
... nuclear translocation of the NF-κB p65 subunit, and increased NF-κB transcriptional activity. Treatment of THP-1 macrophages ... However, rHSP27 also increased the expression of the anti-inflammatory factors IL-10 and GM-CSF both at the mRNA and protein ... shows attenuated expression in human coronary arteries as the extent of atherosclerosis progresses. In mice, overexpression of ... Attenuation of atherogenesis via the anti-inflammatory effects of the selective estrogen receptor beta modulator 8β-VE2.. * ...
  https://www.semanticscholar.org/paper/Extracellular-HSP27-acts-as-a-signaling-molecule-to-Salari-Seibert/167c2156941d06ee96d769384fe8cb5d04329d10
*  Interleukin - Wikipedia
Interleukin 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit and a 40kDa beta subunit. It is ... "Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA". The Journal of ... Interleukin 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune ... The receptors can both bind all three forms of IL-1 (IL-1 alpha, IL-1 beta and IL-1 receptor antagonist). The crystal ...
  https://en.wikipedia.org/wiki/Interleukin
*  Alveolar macrophage - Wikipedia
Integrins are dimeric cell-surface receptors composed of alpha and beta subunits, which activates TGF-β. TGF-β is a ... "Interleukin-4 Production by Human Alveolar Macrophages." Clinical & Experimental Allergy 35.6 (2005): 804-10. Paul, W. E. " ... and in humans it inhibits the TNF-alpha-mediated maturation of human dendritic cells, through cyclic GMP-dependent mechanisms. ... complement receptors, DC-SIGN, Toll-like receptors(TLRs), the scavenger receptor, CD14, and Mac-1. PRRs can be divided into ...
  https://en.wikipedia.org/wiki/Alveolar_macrophage
*  Anti-Mouse (Murine) CD25 antibody for Flow Cytometry (FACS)
IL2R alpha, IL-2R subunit alpha, IL-2Ra, IL2RA, IL-2-RA, IL2-RA, interleukin 2 receptor, alpha, interleukin-2 receptor subunit ... In direct ELISAs, no cross-reactivity with recombinant mouse (rm) gamma c, recombinant human CD25/IL-2 R alpha , rmIL-2 R beta ... Alternative Names: CD25, CD25 antigen, IDDM10, IL-2 R alpha, IL-2 receptor subunit alpha, IL2R, ... Interleukin 2 Receptor, alpha (IL2RA) Antibodies show synonyms for this antigen * CD25 ...
  http://www.antibodies-online.com/jak-stat-signaling-pathway-6/cd25-antibody-2504/mouse-facs-11614/
*  Correlation of NF-κB signal pathway with tumor metastasis of human head and neck squamous cell carcinoma | Springer for...
Jiang X, Takahashi N, Matsui N, Tetsuka T, Okamoto T: The NF-kappa B activation in lymphotoxin beta receptor signaling depends ... McNulty SE, Tohidian NB, Meyskens FL: RelA, p50 and inhibitor of kappa B alpha are elevated in human metastatic melanoma cells ... Buss H, Dorrie A, Schmitz ML, Hoffmann E, Resch K, Kracht M: Constitutive and interleukin-1-inducible phosphorylation of p65 NF ... Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression. Proc Natl Acad Sci USA ...
  https://rd.springer.com/article/10.1186/1471-2407-10-437
*  Genetic and Immunologic Biomarkers in Type 1 Diabetes
20 cells [ 53, 5860 ] The IL 2 receptor is composed of three subunits, an alpha chain (referenced as IL2r or CD25), a beta ... Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro J Immunol 1985, 135 (5):31723177. 158 ... Use of an antibody against the soluble interleukin 2 receptor alpha subunit can modulate the stability and biodistribution of ... Serum levels of soluble interleukin 2 receptor alpha (sIL 2R alpha) as a predictor of outcome in brucellosis J Infect 2005, 51( ...
  http://ufdc.ufl.edu/UFE0045760/00001
*  Oncostatin M - Wikipedia
All beta receptor subunits of the gp130 system also possess a box 3 region. This region corresponds to the C-terminal amino ... specific receptor but not leukemia inhibitory factor/OM receptor or interleukin-6 receptor. Complete block of OM-induced KS ... The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR. The human form of OSM ... "Distinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transduction". J. ...
  https://en.wikipedia.org/wiki/Oncostatin_M
*  Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation | Journal of Neuroinflammation | Full...
In bEnd3 cells, morphine did not affect the mRNA expression of interleukin-1β (IL-1β), but increased IL-6 and tumor necrosis ... and Toll-like receptor-4 (TLR-4) mRNA expression, which was inhibited by metformin. Metformin suppressed morphine-induced BV-2 ... Metabotropic glutamate mGlu5 receptor-mediated serine phosphorylation of NMDA receptor subunit NR1 in hippocampal CA1 region ... The inhibitory effect of IL-1 beta on IL-6-induced alpha 2-macroglobulin expression is due to activation of NF-kappa B. J ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0754-9
*  3hyn - TOPSAN
... it adopts a three layered alpha/beta fold, with a central beta-strands, but it contains additional structural elements as ... 3: 1t3g-A 8.5 3.6 124 152 9 PDB MOLECULE: X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY 4: 1dar 8.4 3.0 124 615 7 PDB MOLECULE: ... suppressing human innate immunity response. It is therefore intriguing to find such protein in a dominant human symbiont. ... SULFATE ADENYLYLTRANSFERASE SUBUNIT 2; 7: 1f60-A 8.2 3.3 126 440 12 PDB MOLECULE: ELONGATION FACTOR EEF1A; 8: 1f8x-A 8.2 3.0 ...
  http://proteins.burnham.org/Proteins/JCSG/3hyn
*  5-oxo-eicosatetraenoic acid - Wikipedia
... and found it coupled with and activated the G protein complex composed of the Gi alpha subunit (Gαi) and G beta-gamma complex ( ... it stimulates human neutrophils apparently by acting on one or more LTB4 receptors rather than OXER1. Human neutrophils, ... The interactions of 5-oxo-ETE with these mediators of allergy (e.g. platelet-activating factor, interleukin 5) in eosinophils ... site which reversibly bound 5-oxo-ETE and had the attributes of a Gi alpha subunit-linked G protein-coupled receptor based on ...
  https://en.wikipedia.org/wiki/5-oxo-eicosatetraenoic_acid
*  SMART: Secondary literature for IL7 domain
... and interleukin (IL)-7 receptor alpha (IL-7Ralpha)-deficient mice. These mutations block mainstream alpha/beta T cell ontogeny ... Rescue of human T cells by interleukin-9 (IL-9) from IL-2 deprivation-induced apoptosis: correlation with alpha subunit ... Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in ... Molecular analysis of human interleukin-9 receptor transcripts in peripheral blood mononuclear cells. Identification of a ...
  http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=IL7
*  Hugo Lagercrantz | Profilsida | Karolinska Institutet
beta 2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered ... Neurotransmitters and neuromodulators during early human development. Herlenius E, Lagercrantz H. EARLY HUMAN DEVELOPMENT 2001; ... Effects of alpha(2)-adrenoceptor agonists on perinatal excitotoxic brain injury - Comparison of clonidine and dexmedetomidine. ... Reduced expression of microsomal prostaglandin synthase 1 attenuates ventilatory effects of interleukin-1A in neonatal DBA/ ...
  https://ki.se/people/huglag
*  ST2/IL-1 R4 Antibody [Unconjugated] (AF523): Novus Biologicals
Fujiyama Y Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human ... a shared signaling subunit that also associates with IL-1 RI and IL-1 R rp2 (1, 10, 11). In macrophages, ST2 interferes with ... is an Interleukin-1 receptor family glycoprotein that contributes to Th2 immune responses (1, 2). Human ST2 consists of a 310 ... Human. Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H A novel IL-1 family cytokine, IL-33, potently activates human ...
  https://www.novusbio.com/products/st2-il-1-r4-antibody_af523
*  Similar articles for PubMed (Select 8648694) - PubMed - NCBI
The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and ... Subunit structure of the high and low affinity human interleukin-15 receptors. ... Generation of monoclonal antibodies to the rabbit interleukin-2 receptor alpha chain (CD25) and its distribution in HTLV-1- ... Induction of human T cell leukemia virus type I receptors on quiescent naive T lymphocytes by TGF-beta. ...
  https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=8648694
*  Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes | Journal of Neuroinflammation | Full Text
Identification of the IL-22 receptor subunit, IL-22R1, was performed by immunohistochemistry and immunofluorescence in human ... The role of IL-22 on human primary astrocytes was evaluated using 7-AAD and annexin V, markers of cell viability and apoptosis ... Using immunohistochemistry and confocal microscopy, we found that IL-22 and its receptor were detected on astrocytes of brain ... Cytometry-based functional assays revealed that addition of IL-22 improved the survival of human primary astrocytes. ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-015-0335-3
*  SIGIRR - Single Ig IL-1-related receptor - Homo sapiens (Human) - SIGIRR gene & protein
Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain ... Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. ... It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel ... "SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.". Wald D., Qin J., Zhao Z., Qian Y., ...
  http://www.uniprot.org/uniprot/Q6IA17
*  Interleukin 5 - Wikipedia
"A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the ... Interleukin 5 has been shown to interact with Interleukin 5 receptor alpha subunit. The IL-5 receptor is composed of an α and a ... "Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional ... is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin ...
  https://en.wikipedia.org/wiki/Interleukin_5
*  EXBIO Antibodies Product Data Sheet
CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit ... The interleukin-2 receptor in human monocytes and macrophages: regulation of expression and release of the alpha and beta ... Lai KN, Leung JC, Lai FM: Soluble interleukin 2 receptor release, interleukin 2 production, and interleukin 2 receptor ... The antibody MEM-181 reacts with CD25 (Interleukin-2 receptor alpha chain), a 55 kDa type I transmembrane glycoprotein ...
  http://www.exbio.cz/pdf/data_sheet_new.py/CLO000000000000028/26/6/datasheet-PB-218-T100.html?format=html
*  Hyaluronic acid in the treatment of cancer - Bioniche Life Sciences Inc.
Human prostate cancer. TGF-beta 1 receptor-negative; androgen-dependent. Du-145. Human prostate cancer. Fas-resistant; Rb- ... Yamamoto, S. et al., "In-Vitro Augmentation of Natural Killer Cell Activity and Production of Inerferon-Alpha Beta and Gamma ... Use of interleukin-2 in the immunostimulation of weakened immune reaction.. WO1987002679A1. 1987-05-07. IMMUNOTHERAPEUTIC ... As used herein, "hvaluronic acid (HA)" refers to hyaluronan, hyaluronate, subunits of HA that have been tested and found ...
  http://www.freepatentsonline.com/7125858.html
*  Anti-Mouse (Murine) IL15RA antibody for Immunofluorescence (Paraffin-embedded Sections) (IF (p))
Interleukin 15 receptor subunit alpha, Soluble interleukin 15 receptor subunit alpha, I15RA_HUMAN. ... It shares two subunits with the receptor of IL2, the IL2R beta and IL2R gamma chains. This forms the basis of many overlapping ... Synonyms: Interleukin-15 receptor subunit alpha, IL 15R alpha, IL15RA, Interleukin 15 receptor alpha, ... Interleukin 15 Receptor, alpha (IL15RA) Antibodies show synonyms for this antigen * IL15RA ...
  https://www.antibodies-online.com/jak-stat-signaling-pathway-6/il15ra-antibody-7543/mouse-if-p-29501/
*  Tyk2 - Non-receptor tyrosine-protein kinase TYK2 - Mus musculus (Mouse) - Tyk2 gene & protein
Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses ... Human and mouse protein kinases. Human and mouse protein kinases: classification and index ... help/subunit_structure' target='_top'>More...,/a>,/p>Subunit structurei. Interacts with JAKMIP1.By similarity ... interleukin-12-mediated signaling pathway Source: Reactome. *intracellular signal transduction Source: InterPro ...
  http://www.uniprot.org/uniprot/Q9R117
*  Apoptosis and survival APRIL and BAFF signaling
IKK-alpha, Bcl-XL, Calcineurin A (catalytic), TRAF3, IKK-gamma, CAML, TRAF5, NF-kB p50/p65, IKK-beta, BFL1, NF-kB1, IKK (cat), ... NF-kappaB regulates the expression of the human complement receptor 2 gene. Journal of immunology (Baltimore, Md. : 1950) 2002 ... MIP-1 beta ), Interleukin 10 ( IL-10 ) [9] and Prostaglandin-endoperoxide synthase 2 ( COX-2 ) in TACI -dependent manner [10], ... subunit isoforms of calcineurin ( Calcineurin A (catalytic)) cascade [15], [16]. NF-AT1(NFATC2) and NF-AT2(NFATC1) may activate ...
  http://pathwaymaps.com/maps/2375
*  Ubiquitin C - Wikipedia
"Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB ... "Agonist-promoted Lys63-linked polyubiquitination of the human kappa-opioid receptor is involved in receptor down-regulation". ... "Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for ... Nine to ten Ub units were in the UBC gene. In polyubiquitin-C, the C-terminus of a given ubiquitin molecule is covalently ...
  https://en.wikipedia.org/wiki/Ubiquitin_C
*  Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment | SpringerLink
Platelet-derived growth factor subunit B. PDGFR-B. Platelet-derived growth factor subunit B receptor ... Hypoxia-inducible factor 1 alpha. HUVEC. Human umbilical vein endothelial cells. HYD. Hydralazine ... Skurk C, Maatz H, Rocnik E, Bialik A, Force T, Walsh K (2005) Glycogen-synthase kinase3beta/beta-catenin axis promotes ... Synergistic in vivo antitumor effect of the histone deacetylase inhibitor MS-275 in combination with interleukin 2 in a murine ...
  https://link.springer.com/article/10.1007/s10456-017-9551-z?no-access=true