*  PTPRC - Wikipedia
"Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II". J. ... Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. ... Ishikawa H, Tsuyama N, Abroun S, Liu S, Li FJ, Otsuyama K, Zheng X, Kawano MM (2004). "Interleukin-6, CD45 and the src-kinases ... "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases ...
  https://en.wikipedia.org/wiki/PTPRC
*  HMGA1 - Wikipedia
"Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions ... and HMGI-Y controls human insulin receptor gene transcription". Molecular and Cellular Biology. 23 (8): 2720-32. doi:10.1128/ ... Currie RA (Dec 1997). "Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high ... Foti D, Iuliano R, Chiefari E, Brunetti A (Apr 2003). "A nucleoprotein complex containing Sp1, C/EBP beta, ...
  https://en.wikipedia.org/wiki/HMGA1
*  Targeted integration into stem cells - Patent application
Human Rex-1 (hRex-1), importin alpha 1, Interleukin-2 receptors, Interleukin-3 receptor alpha chain, KDR, Keratin 19, c-kit, ... Alpha and beta subunits of inhibin/activin, Alpha-smooth muscle actin Stem cells 4G10.3, AA4, AC133, Bcrp/ABCG2, c-Mpl, CD9, ... IL-4 Receptors, beta 1, beta 2, and beta 7 integrins, Interleukin-4 (IL-4), MBP (Major Basic Protein), MMCP-8, NCA, PSGL-1 ( ... human chorionic gonadotropin), hCG-beta (Human chorionic gonadotrophin beta), HLA-A/HLA-B/HLA-C/HLA-G, hPL (human placental ...
  http://www.patentsencyclopedia.com/app/20110027235
*  ADCY2 - Wikipedia
This enzyme is insensitive to Ca2+/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. Therefore, ... Patke CL, Shearer WT (May 2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP ... In human embryonic kidney cells, ADCY2 is stimulated by activation of Gq-coupled muscarinic receptors through protein kinase C ... ADCY2 is one of ten different mammalian isoforms of adenylyl cyclases. ADCY2 can be found on chromosome 5 and the "MIR2113- ...
  https://en.wikipedia.org/wiki/ADCY2
*  Actin - Wikipedia
"Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal ... Different recognition sub-units are used for actin or tubulin although there is some overlap. In actin the subunits that bind ... Within Arabidopsis thaliana, a dicotyledon used as a model organism, there are ten types of actin, nine types of α-tubulins, ... Stüven T, Hartmann E, Görlich D (Nov 2003). "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin ...
  https://en.wikipedia.org/wiki/Actin
*  C3B6-Tg(APP695)3Dbo/Mmjax
These transgenic mice express the human amyloid precursor protein bearing the Swedish (K670N/M671L) mutation and develop ... Amyloid-beta effects on synapses and memory require AMPA receptor subunit GluA3. Proc Natl Acad Sci U S A 113(42):E6526-E6534. ... Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-alpha: ... Interleukin-19 acts as a negative autocrine regulator of activated microglia. PLoS One 10(3):e0118640. PubMed: 25794104MGI: J: ...
  https://www.jax.org/strain/003375
*  Anti-Mouse (Murine) CD25 antibody for Flow Cytometry (FACS)
IL2R alpha, IL-2R subunit alpha, IL-2Ra, IL2RA, IL-2-RA, IL2-RA, interleukin 2 receptor, alpha, interleukin-2 receptor subunit ... In direct ELISAs, no cross-reactivity with recombinant mouse (rm) gamma c, recombinant human CD25/IL-2 R alpha , rmIL-2 R beta ... Alternative Names: CD25, CD25 antigen, IDDM10, IL-2 R alpha, IL-2 receptor subunit alpha, IL2R, ... Interleukin 2 Receptor, alpha (IL2RA) Antibodies show synonyms for this antigen * CD25 ...
  http://www.antibodies-online.com/jak-stat-signaling-pathway-6/cd25-antibody-2504/mouse-facs-11614/
*  3hyn - TOPSAN
... it adopts a three layered alpha/beta fold, with a central beta-strands, but it contains additional structural elements as ... 3: 1t3g-A 8.5 3.6 124 152 9 PDB MOLECULE: X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY 4: 1dar 8.4 3.0 124 615 7 PDB MOLECULE: ... suppressing human innate immunity response. It is therefore intriguing to find such protein in a dominant human symbiont. ... SULFATE ADENYLYLTRANSFERASE SUBUNIT 2; 7: 1f60-A 8.2 3.3 126 440 12 PDB MOLECULE: ELONGATION FACTOR EEF1A; 8: 1f8x-A 8.2 3.0 ...
  http://proteins.burnham.org/Proteins/JCSG/3hyn
*  PRKACG - Wikipedia
1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via ... gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit ... PRKACG has been shown to interact with Ryanodine receptor 2. GRCh38: Ensembl release 89: ENSG00000165059 - Ensembl, May 2017 " ... beta)". J. Biol. Chem. 277 (49): 47080-7. doi:10.1074/jbc.M208329200. PMID 12361948. Strausberg RL, Feingold EA, Grouse LH, et ...
  https://en.wikipedia.org/wiki/PRKACG
*  Heat shock protein 90kDa alpha (cytosolic), member A1 - Wikipedia
"The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and ... "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". The ... Metz K, Ezernieks J, Sebald W, Duschl A (Apr 1996). "Interleukin-4 upregulates the heat shock protein Hsp90alpha and enhances ... "Evidence that the beta-isoform of the human glucocorticoid receptor does not act as a physiologically significant repressor". ...
  https://en.wikipedia.org/wiki/Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1
*  Introduction to the genetics and biology of interleukin-28B - Urban - 2012 - Hepatology - Wiley Online Library
... from type I IFNs by their binding to a unique heterodimeric receptor complex formed by the IFN-λ-specific alpha subunit (IL28RA ... GWAS, genome-wide association study; HCV, hepatitis C virus; HLA-C, human leukocyte antigen C; IL28B, interleukin-28B; IFN, ... Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with ... Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following ...
  http://onlinelibrary.wiley.com/doi/10.1002/hep.25794/full?globalMessage=0&systemMessage=Wiley+Online+Library+usage+report+download+page+will+be+unavailable+on+Friday+24th+November+2017+at+21%3A00+EST+%2F+02.00+GMT+%2F+10%3A00+SGT+%28Saturday+25th+Nov+for+SGT+
*  ST2/IL-1 R4 Antibody [Unconjugated] (AF523): Novus Biologicals
Fujiyama Y Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human ... a shared signaling subunit that also associates with IL-1 RI and IL-1 R rp2 (1, 10, 11). In macrophages, ST2 interferes with ... is an Interleukin-1 receptor family glycoprotein that contributes to Th2 immune responses (1, 2). Human ST2 consists of a 310 ... Human. Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H A novel IL-1 family cytokine, IL-33, potently activates human ...
  https://www.novusbio.com/products/st2-il-1-r4-antibody_af523
*  Ion channels in inflammation | SpringerLink
Interleukin-1 beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 ... of proteinase-activated receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human ... Madsen KL, Tavernini MM, Mosmann TR, Fedorak RN (1996) Interleukin10 modulates ion transport in rat small intestine. ... IL-1 beta and TNF alpha but not IFN-alpha, interferon-gamma, IL-6 or IL-8, are secretory mediators in human distal colon. ...
  https://link.springer.com/article/10.1007%2Fs00424-010-0917-y
*  Frontiers | Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines | Immunology
Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 ... of beta2-adrenergic receptor-mediated alveolar epithelial fluid transport by interleukin-8 and transforming growth factor-beta ... Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J ... The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00766/full
*  Housekeeping gene - Wikipedia
... alpha subunit FARSB NM_005687 phenylalanyl-tRNA synthetase, beta subunit GARS (gene)GARS NM_002047 glycyl-tRNA synthetase HARS ... 001105 similar to ACVRL1 TGF Beta receptor family Rendu-Osler-Weber syndrome ACVR1B NM_004302 CD23 FCER2 low affinity IgE ... Regulated by MITF) HMGB1 High mobility group box binds DNA ILF2 Homo sapiens interleukin enhancer binding factor 2, 45kDa (ILF2 ... 2008). "On the nature of human housekeeping genes". Trends in Genetics. 24 (10): 481-484. doi:10.1016/j.tig.2008.08.004. PMID ...
  https://en.wikipedia.org/wiki/Housekeeping_gene
*  The Renin-Angiotensin-Aldosterone System in Vascular Inflammation and Remodeling
plays a central role in regulating the expression of vascular inflammatory mediators interleukin-1 beta (IL-1. ), interleukin-6 ... K. Takahashi, H. Yamamoto, T. Hirose et al., "Expression of (pro)renin receptor in human kidneys with end-stage kidney disease ... Tumor necrosis factor alpha (TNF. ) is a key proinflammatory cytokine regulating the expression of many genes of inflammation, ... Total genetic deletion of NADPH oxidase subunit, Nox2, in mice results in significant decrease of aortic atherosclerosis [57]. ...
  https://www.hindawi.com/journals/iji/2014/689360/
*  Hugo Lagercrantz | Profilsida | Karolinska Institutet
beta 2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered ... Neurotransmitters and neuromodulators during early human development. Herlenius E, Lagercrantz H. EARLY HUMAN DEVELOPMENT 2001; ... Effects of alpha(2)-adrenoceptor agonists on perinatal excitotoxic brain injury - Comparison of clonidine and dexmedetomidine. ... Reduced expression of microsomal prostaglandin synthase 1 attenuates ventilatory effects of interleukin-1A in neonatal DBA/ ...
  https://ki.se/people/huglag
*  T-cell surface glycoprotein CD3 epsilon chain - Wikipedia
... and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an ... "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29)". Immunology Letters. 44 ( ... "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". European Journal of Immunology ... a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". The Journal of ...
  https://en.wikipedia.org/wiki/T-cell_surface_glycoprotein_CD3_epsilon_chain
*  EXBIO Antibodies Product Data Sheet
CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit ... The interleukin-2 receptor in human monocytes and macrophages: regulation of expression and release of the alpha and beta ... Lai KN, Leung JC, Lai FM: Soluble interleukin 2 receptor release, interleukin 2 production, and interleukin 2 receptor ... The antibody MEM-181 reacts with CD25 (Interleukin-2 receptor alpha chain), a 55 kDa type I transmembrane glycoprotein ...
  http://www.exbio.cz/pdf/data_sheet_new.py/CLO000000000000028/26/6/datasheet-PB-218-T100.html?format=html
*  CHUK - Wikipedia
Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous ... lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602-6. doi:10.1074/jbc.C100103200. PMID 11278268. Ninomiya- ... and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells". J. Biol. ... Windheim M, Stafford M, Peggie M, Cohen P (March 2008). "Interleukin-1 (IL-1) Induces the Lys63-Linked Polyubiquitination of IL ...
  https://en.wikipedia.org/wiki/CHUK
*  Gemfibrozil, a Lipid Lowering Drug, Inhibits the Activation of Primary Human Microglia Via Peroxisome Proliferator-Activated...
Increased peroxisomal fatty acid beta-oxidation and enhanced expression of peroxisome proliferator-activated receptor-alpha in ... Jana M, Pahan K (2009) Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive ... BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit. J Immunol 174:205-214PubMedGoogle Scholar ... Xu J, Chavis JA, Racke MK, Drew PD (2006) Peroxisome proliferator-activated receptor-alpha and retinoid × receptor agonists ...
  https://link.springer.com/article/10.1007%2Fs11064-012-0781-6
*  STAT1 - Wikipedia
ISGF3G Interleukin 27 receptor, alpha subunit, MCM5, Mammalian target of rapamycin, PIAS1, PRKCD, PTK2, Protein kinase R, STAT2 ... "STAT1 - Signal transducer and activator of transcription 1-alpha/beta - Homo sapiens (Human) - STAT1 gene & protein". www. ... These processes are dependent on cytokines like interferon alpha or beta, interferon gamma or interleukin 27. As mentioned ... "Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency". Nature Genetics. 33 (3): 388-91 ...
  https://en.wikipedia.org/wiki/STAT1
*  Psoriasis - Wikipedia
Two major immune system genes under investigation are interleukin-12 subunit beta (IL12B) on chromosome 5q, which expresses ... which expresses the interleukin-23 receptor, and is involved in T cell differentiation. Interleukin-23 receptor and IL12B have ... October 2010). "Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis ... When infliximab no longer binds tumor necrosis factor alpha, it no longer decreases inflammation, and psoriasis may worsen. ...
  https://en.wikipedia.org/wiki/Psoriasis
*  Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment | SpringerLink
Platelet-derived growth factor subunit B. PDGFR-B. Platelet-derived growth factor subunit B receptor ... Hypoxia-inducible factor 1 alpha. HUVEC. Human umbilical vein endothelial cells. HYD. Hydralazine ... Skurk C, Maatz H, Rocnik E, Bialik A, Force T, Walsh K (2005) Glycogen-synthase kinase3beta/beta-catenin axis promotes ... Synergistic in vivo antitumor effect of the histone deacetylase inhibitor MS-275 in combination with interleukin 2 in a murine ...
  https://link.springer.com/article/10.1007/s10456-017-9551-z?no-access=true
*  Interleuchina 3 - Wikipedia
Stomski FC, Sun Q, Bagley CJ, et al., Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain ... Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors., in ... Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required ... Klein BK, Feng Y, McWherter CA, et al., The receptor binding site of human interleukin-3 defined by mutagenesis and molecular ...
  https://it.wikipedia.org/wiki/Interleuchina_3