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*  In Vitro Systems for the Study of Hepatitis C Virus Infection
"Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus ... HCV and lack of small animal models have necessitated the development of in vitro model systems for the study of the full virus ... "Efficient replication of primary or culture hepatitis C virus isolates in human liver slices: a relevant ex vivo model of liver ... "Going towards more relevant cell culture models to study the in vitro replication of serum-derived hepatitis C virus and virus/ ...
  https://www.hindawi.com/journals/ijh/2012/292591/
*  MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis | Journal...
The direction toward therapeutic application has been set in animal models to suppress liver cancer (Hébert and De Strooper, ... or chronic hepatitis C virus infection (Kota et al., 2009). Importantly, our current data point to a significant and novel role ... supplemented with human EGF, hydrocortisone, GA-1000, FBS, VEGF, human fibroblast growth factor-B, R3-IGF-1, ascorbic acid, and ... 2009) MicroRNA profiling in human medulloblastoma. Int J Cancer 124:568-577, doi:10.1002/ijc.23948, pmid:18973228. ...
  http://www.jneurosci.org/content/33/16/6857
*  Lorne Tyrrell
Chimeric animal model susceptible to human hepatitis C virus infection. Kneteman; N. M.; Tyrrell; D. L.; Mercer; D. F. Issue ... The research in my laboratory is focused on the study of hepatitis B virus (HBV) and hepatitis C virus (HCV). We have a major ... in mice with chimeric human livers, and in humans infected with hepatitis C virus. Hepatology. Accepted 2008 ... 2007) Hepatitis B Virus-binding Polypeptides and Methods of Use Thereof. U.S. Patent Application 60/972,644. ...
  http://www.mmi.med.ualberta.ca/staff_students/lorne_tyrrell.php
*  912. Aflatoxins (WHO Food Additives Series 40)
... persistent hepatitis virus infection and exposure to dietary aflatoxins, has been hampered by lack of an animal model, and ... hepatitis virus (WHV), which is closely related to the human hepatitis B virus (Bannasch et al., 1995). When the woodchucks ... from the wild and experimentally infected with human hepatitis B virus. In animals exposed to AFB1 and infected with HBV, the ... DNA-damaging products that occur in animal models. A well-established major risk factor for liver cancer is hepatitis B virus; ...
  http://www.inchem.org/documents/jecfa/jecmono/v040je16.htm
*  Binding of the Hepatitis C Virus Envelope Protein E2 to CD81 Inhibits Natural Killer Cell Functions
... in host defense against various viral infections has been extensively investigated in humans and in different animal models (10 ... Suppression of host immune response by the core protein of hepatitis C virus: possible implications for hepatitis C virus ... Abbreviations used in this paper: HBV, hepatitis B virus; HCV, hepatitis C virus; TM4SF, tetraspan superfamily. ... In humans, low NK cell function has been linked with increased human susceptibility to HSV, Epstein-Barr virus, human ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2196015/?lang=en-ca
*  Duck hepatitis B virus - Wikipedia
The virus has also provided as a useful animal model in the absence of one from the HBV. Jilbert AR, Kotlarski I (March-April ... virus has provided a basis for the use of vaccines and prophylactic treatments for individuals at high risk of human Hepatitis ... Duck Hepatitis B virus, abbreviated DHBV, is part of the Avihepadnavirus genus of the Hepadnaviridae, and is the causal agent ... Cooper A, Paran N, Shaul Y (2003-07-11). "The earliest steps in hepatitis B virus infection". Biochimica et Biophysica Acta. ...
  https://en.wikipedia.org/wiki/Duck_hepatitis_B_virus
*  Groundhog - Wikipedia
The only other animal model for hepatitis B virus studies is the chimpanzee, an endangered species. Groundhog burrows have been ... similar to human hepatitis B virus. Humans do not receive hepatitis from woodchucks with WHV but the virus and its effects on ... the liver make the woodchuck the best available animal for the study of viral hepatitis in humans. ... In aiding these animals, the woodchuck indirectly helps the farmer. In addition to providing homes for itself and other animals ...
  https://en.wikipedia.org/wiki/Groundhog
*  Molecular Pathways: Hepatitis C Virus, CXCL10, and the Inflammatory Road to Liver Cancer | Clinical Cancer Research
... and TGF-β in animal models, although limited success has been seen in human clinical trials for alcohol-related liver disease ... cytokine response in hepatitis C virus-infected hepatocytes depends on Toll-like receptor 3 sensing of hepatitis C virus double ... Molecular Pathways: Hepatitis C Virus, CXCL10, and the Inflammatory Road to Liver Cancer. Jessica Brownell and Stephen J. ... Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc ...
  http://clincancerres.aacrjournals.org/content/19/6/1347
*  Cocarcinogenic effects of alcohol in hepatocarcinogenesis | Gut
... of investigated human HCCs.73 However, genetic alterations in animal models and human hepatocarcinogenesis differ substantially ... Effect of alcohol consumption on serum hepatitis C virus RNA and histological lesions in chronic hepatitis C. Hepatology1998;27 ... namely hepatitis B (HBV) and especially hepatitis C (HCV). Epidemiological studies have incriminated both viruses in ... Evidence that hepatitis B virus has a role in liver-cell carcinoma in alcoholic liver disease. N Engl J Med1982;306:1384-7. ...
  http://gut.bmj.com/content/51/1/132
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Hepatitis B virus (HBV) infection lacks IFN? induction in animal models and patients and chronic HBV patients display impaired ... Hepatitis C virus (HCV) is a hepatotropic virus with a host-range restricted to humans and chimpanzees. Although HCV RNA ... An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus ... Infectious Diseases, Issue 88, Hepatitis C Virus, HCV, Tumor-virus, Hepatitis C, Cirrhosis, Liver Cancer, Hepatocellular ...
  https://www.jove.com/visualize/abstract/21246041/hepatitis-b-virus-lacks-immune-activating-capacity-but-actively
*  HCV-Induced Immune Responses Influence the Development of Operational Tolerance After Liver Transplantation in Humans | Science...
The development of operational tolerance in liver transplant recipients with chronic hepatitis C virus (HCV) infection allows ... Pathogen-induced immune responses prevent the establishment of transplantation tolerance in experimental animal models. Whether ... Our data suggest that in humans, persistent viral infections exert immunoregulatory effects that could contribute to the ... HCV-Induced Immune Responses Influence the Development of Operational Tolerance After Liver Transplantation in Humans ...
  http://stm.sciencemag.org/content/6/242/242ra81.short?rss=1
*  Scientists create humanized mouse model for hepatitis C
... some of these previously identified human genes into mice would allow them to infect the animals with the hepatitis C virus. ... Further reports about: , CD81 , HCV , HCV infection , Rockefeller , hepatitis C virus , mouse model , scavenger receptor ... CD81 »HCV »HCV infection »Rockefeller »hepatitis C virus »mouse model »scavenger receptor ... While the hepatitis C virus can infect chimpanzees and humans, scientists have been unable to study the progression of the ...
  http://www.innovations-report.com/html/reports/life-sciences/scientists-create-humanized-mouse-model-hepatitis-c-176745.html
*  Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration | PNAS
In an animal model of HBV, the woodchuck hepatitis virus, viral DNA found integrated in HCC commonly activates members of the ... The family prototype, human hepatitis B virus (HBV), can cause chronic hepatitis and hepatocellular carcinomas (HCCs). HBV- ... Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate ... Abbreviations: HBV, hepatitis B virus; HCC, hepatocellular carcinoma; NHEJ, nonhomologous end joining; DHBV, duck HBV; EGFP, ...
  http://www.pnas.org/content/101/30/11135
*  UPENN Biomedical Graduate Studies | Susan R. Weiss
... virus-induced hepatitis. We have the important tools of a well-developed animal model system and two reverse genetic systems ... Human coronaviruses are primarily respiratory viruses, and include the common cold viruses OC43 and 229E as well as the ... We use murine coronavirus, mouse hepatitis virus (MHV) infection of mice as a model system for the study of: 1) acute viral ... Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses. Proceedings of the National ...
  http://www.med.upenn.edu/apps/faculty/index.php/g20000320/p11346
*  Frontiers | Technical Improvement and Application of Hydrodynamic Gene Delivery in Study of Liver Diseases | Pharmacology
... synthetic small compounds and even viruses in vivo. Given its ability to robustly mimic in vivo hepatitis B virus (HBV) ... synthetic small compounds and even viruses in vivo. Given its ability to robustly mimic in vivo hepatitis B virus (HBV) ... gives a transient but high in vivo gene expression especially in the liver of small animals. In addition to DNA, it has also ... gives a transient but high in vivo gene expression especially in the liver of small animals. In addition to DNA, it has also ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00591/full
*  Shoshana Levy | Stanford Medicine Profiles
Recognition of native hepatitis C virus E1E2 heterodimers by a human monoclonal antibody JOURNAL OF VIROLOGY Cocquerel, L., ... We have developed several generations of idiotype vaccines that were tested in an animal model, the 38C13 mouse B cell lymphoma ... Hepatitis C virus (HCV) is the major cause for non-A, non-B hepatitis. Most HCV-infected individuals do not clear the virus ... CD81 and hepatitis C virus (HCV) infection. Viruses Fénéant, L., Levy, S., Cocquerel, L. 2014; 6 (2): 535-572 Abstract. ...
  https://med.stanford.edu/profiles/shoshana-levy?tab=teaching
*  Aldabe Arregui, Rafael. CV. Nuestros investigadores. Investigación. Universidad de Navarra
Título: Animal models of chronic hepatitis delta virus infection host virus immunologic interactions ... CONCLUSION: The animal model described here reproduces important characteristics of human HDV infection and provides a valuable ... Hepatitis delta virus (HDV) is a defective RNA virus that has an absolute requirement for a virus belonging to the ... Recently, more practical animal models in which to perform a deeper study of host virus interactions and to evaluate new ...
  https://www.unav.edu/web/investigacion/nuestros-investigadores/detalle-investigadores-cv?investigadorId=123973&investigador=Aldabe%20Arregui,%20Rafael
*  Oldstone, Michael B. A. [WorldCat Identities]
Animal models Virus diseases--Genetic aspects Virus diseases--Immunological aspects Virus diseases--Pathogenesis Viruses ... In this volume, these approaches for study of human immunodeficiency virus, hepatitis virus, viruses causing tumors and chronic ... laboratory animal model. By this process, murine models of human infections can be developed and studied; effects of cytokines ... Measles virus, one of the most contagious of all human viruses, has been largely contained by the development and use of a ...
  http://worldcat.org/identities/lccn-n83-328776/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... there are numerous attempts to employ tree shrews as models for a variety of human disorders: depression, myopia, hepatitis B ... Animal models are indispensible in biomedical research and have made tremendous contributions to answer fundamental questions ... We studied the relationships among Cx43, CD105, and VEGF in specimens of hepatitis B virus (HBV)-related hepatocellular ... Tree shrews under the spot light: emerging model of human diseases].. Lin Xu, Yun Zhang, Bin Liang, Long-Bao Lü, Ce-Shi Chen, ...
  https://www.jove.com/visualize?author=Yong-Gang%20Yao%20
*  Highlights from the Inaugural International Cancer Microbiome Consortium Meeting (ICMC), 5-6 September 2017, London, UK....
Experimental work in cell lines and animal models certainly provide plausible mechanisms but current human data, although ... There was overwhelming evidence for the role of specific pathogens, such as HPV, H. pylori and Hepatitis B virus, but the ... Are these models generalisable to other cancers or do we need other models? Is there a unifying model to describe how dysbiosis ... of colorectal cancer was discussed and debated in detail with experts highlighting the latest data in animal models and humans ...
  http://ecancer.org/journal/11/full/791-highlights-from-the-inaugural-international-cancer-microbiome-consortium-meeting-icmc-5-6-september-2017-london-uk.php
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... there are numerous attempts to employ tree shrews as models for a variety of human disorders: depression, myopia, hepatitis B ... Several animal models of persistent inflammatory and neuropathic pain (tail-flick test, hot plate test, acetic acid-induced ... Bacteriophages, the viruses of eubacteria, have developed unique mechanisms to interact with their host bacteria. They have ... It promotes wound healing in a murine model with a full-thickness dermal wound in both normal and diabetic animals. In addition ...
  https://www.jove.com/visualize?author=Ren-Hau+Lai
*  Natural killer cells in hepatitis B virus infection | The Brazilian Journal of Infectious Diseases
However, most of these studies were carried out in animal models, which may not fully represent the reality in humans. On the ... An immunocompetent mouse model for the tolerance of human chronic hepatitis B virus infection ... providing insufficient animal models for its study. Although woodchuck infected with the woodchuck hepatitis virus (WHV) offers ... Hepatitis B virus (HBV) infection is one of the most common chronic viral infections in humans. HBV is not cytopathic, i.e. ...
  http://www.bjid.org.br/en-natural-killer-cells-in-hepatitis-articulo-S1413867015001075
*  Targeting glycosylation as a therapeutic approach. - Department of Pharmacology
... such as hepatitis B, and glucosphingolipid storage disorders, such as Gaucher disease. ... Disease Models, Animal, Gaucher Disease, Glycoproteins, Glycosphingolipids, Glycosylation, HIV, Hepatitis B virus, Humans, Mice ... Animals, Antiviral Agents, Diarrhea Viruses, Bovine Viral, ... such as hepatitis B, and glucosphingolipid storage disorders, ...
  https://pharm.ox.ac.uk/publications/100316
*  Protocols and Video Articles Authored by Ben Doron
Lymphocytes from naïve/fibrotic WT animals and healthy/cirrhotic hepatitis C virus were preincubated in vitro with or without ... In vitro activation of human hepatic stellate cells cocultured with hepatitis C virus-derived peripheral blood lymphocytes ... In an animal model of hepatic fibrosis, GA has an antifibrotic effect associated with decreased CD8 cells and reduced serum IL- ... Hepatitis B virus (HBV) and hepatitis C virus (HCV) are important pathogens in the SOT population as indications for ...
  https://www.jove.com/author/Ben_Doron
*  Research Areas - Shoshana Levy, Ph.D., Stanford Division of Oncology - Faculty Research Laboratories - Stanford University...
CD81 has been implicated in the pathogenesis of two major human diseases: hepatitis C virus (HCV) and malaria. CD81 is the ... humans and chimpanzees and cannot be propagated in small animal models. Moreover, HCV cannot be readily grown in tissue culture ... CD81 is a putative receptor for hepatitis C virus (HCV) Hepatitis C virus (HCV) infection affects an estimated 160 million ... Cloning of the virus enabled the production of the recombinant envelope glycoprotein E2, which in turn, was shown to bind to ...
  http://med.stanford.edu/labs/shoshana_levy/research.html