*  The Human Connectome Project: Deciphering the Brain's Wiring | ALZFORUM
This finding illustrates the power of the new machine to provide a more detailed anatomical understanding of the brain. ... The Human Connectome data will link to other Internet resources such as the Allen Human Brain Atlas, which records patterns of ... The Human Connectome Project: Deciphering the Brain's Wiring. Go to another part. Series - Society for Neuroscience Annual ... The five-year "Human Connectome Project" began in autumn 2010, and its leaders provided a progress update in a symposium at the ...
  http://www.alzforum.org/news/conference-coverage/human-connectome-project-deciphering-brains-wiring
*  Gibbs distribution for statistical analysis of graphical data with a sample application to fcMRI brain images. - PubMed - NCBI
... statistical methods that are novel and complementary to existing methods of analysis of human brain scan connectomes, defined ... as graphs representing brain anatomical or functional connectivity. OODA is an emerging field where classical statistical ... By providing statistical tools that analyze sets of connectomes without loss of information, new insights into neurology and ... and apply them to connectomes from fMRI brain scans collected during a serial reaction time task study. Software for fitting ...
  https://www.ncbi.nlm.nih.gov/pubmed/26608238
*  Optimality of the Human Connectome | Philosophical Transactions of the Royal Society B: Biological Sciences
2009 Mapping anatomical connectivity patterns of human cerebral cortex using in vivo diffusion tensor imaging tractography. ... 2011 Brain graphs: graphical models of the human brain connectome. Annu. Rev. Clin. Psychol. 7, 113-140. (doi:10.1146/annurev- ... 2013 The WU-Minn human connectome project: an overview. Neuroimage 80, 62-79. (doi:10.1016/j.neuroimage.2013.05.041). ... 2011 Rich club organization of the human connectome. J. Neurosci. 31, 15775-15786. (doi:10.1523/JNEUROSCI.3539-11.2011). ...
  http://rstb.royalsocietypublishing.org/content/369/1653/20130530
*  Human multitasking - Wikipedia
have computed structural (i.e., anatomical) connectomes of 96 subjects of the data of the NIH-funded large project, the Human ... "Sex differences in the structural connectome of the human brain". Proceedings of the National Academy of Sciences. 16 April ... "Human Factors: The Journal of the Human Factors and Ergonomics Society. 48 (2): 381-391. doi:10.1518/001872006777724471. ... Human multitasking is an apparent human ability to perform more than one task, or activity, at the same time. An example of ...
  https://en.wikipedia.org/wiki/Human_multitasking
*  Frontiers | Alterations in interhemispheric functional and anatomical connectivity are associated with tobacco smoking in...
Taken together, our results implicate changes in interhemispheric functional and anatomical connectivity in current cigarette ... Taken together, our results implicate changes in interhemispheric functional and anatomical connectivity in current cigarette ... hypothesis of neuronal interconnectivity as a function of brain size-a general organization principle of the human connectome. ... Alterations in interhemispheric functional and anatomical connectivity are associated with tobacco smoking in humans. Humsini ...
  https://www.frontiersin.org/articles/10.3389/fnhum.2015.00116/full
*  Impact of Alcohol and Drug Use on the Development of Neural Connections During Adolescence and Young Adulthood | Minnesota...
... which relates directly to the goals of the Human Connectome Project. For example, using high-resolution anatomical MRI scans, ... high resolution anatomical scans, several types of diffusion scans, spectroscopy, resting functional scans), and ...
  https://www.msi.umn.edu/content/disrupted-development-neural-connections-alcohol-initiation-adolescence
*  A predictive model of the cat cortical connectome based on cytoarchitecture and distance | SpringerLink
Information processing in the brain is strongly constrained by anatomical connectivity. However, the principles governing the ... Evidence accumulated from detailed quantitative studies of the connectome of cat, monkey and human cerebral cortex (Young 1992 ... For each anatomical variable, the absolute number of present projections is shown for each of its values (bars, left axis). ... For each anatomical variable, the cumulative percentage at each of its values was calculated as the sum of the number of ...
  https://link.springer.com/article/10.1007%2Fs00429-014-0849-y
*  Frontiers | Microstructural Analysis of Human White Matter Architecture Using Polarized Light Imaging: Views from Neuroanatomy ...
The microstructure of the anterior human cingulum bundle was analyzed in serial sections of 6 human brains. PLI can generate ... The microstructure of the anterior human cingulum bundle was analyzed in serial sections of 6 human brains. PLI ... ... We describe the principles of PLI and present several studies of fiber anatomy in the human brain: 6 brainstems were serially ... We describe the principles of PLI and present several studies of fiber anatomy in the human brain: 6 brainstems were serially ...
  https://www.frontiersin.org/articles/10.3389/fninf.2011.00028/full
*  Budapest Reference Connectome - Wikipedia
"Parameterizable consensus connectomes from the Human Connectome Project: the Budapest Reference Connectome Server v3.0". ... The Budapest Reference Connectome server computes the frequently appearing anatomical brain connections of 418 healthy subjects ... The Budapest Reference Connectome has led the researchers to the discovery of the Consensus Connectome Dynamics of the human ... It has been prepared from diffusion MRI datasets of the Human Connectome Project into a reference connectome (or brain graph), ...
  https://en.wikipedia.org/wiki/Budapest_Reference_Connectome
*  Outline of brain mapping - Wikipedia
Human Connectome Project - 2009 NIH $30 million project to build a network map of the human brain, including structural ( ... manually delineate anatomical regions of interest, and perform automatic image segmentation. Its most frequently used to work ... human or non-human) brain resulting in maps. Brain mapping is further defined as the study of the anatomy and function of the ... Human Brain Project (EU) - 1 billion euro, 10-year project to simulate the human brain with supercomputers. BigBrain A high- ...
  https://en.wikipedia.org/wiki/Outline_of_brain_mapping
*  Resting state fMRI - Wikipedia
... as the Human Connectome Project try to build a connectome or a neural connectivity map that will shed light on the anatomical ... link) Van Essen, D. C.; Ugurbil, K. (2012). "The future of the human connectome. [Review]". NeuroImage. 62 (2): 1299-1310. doi: ... "Resting-state fMRI in the Human Connectome Project". NeuroImage. 80: 144-168. doi:10.1016/j.neuroimage.2013.05.039. ISSN 1053- ... Fox, M. D.; Snyder, A. Z.; Vincent, J. L.; Corbetta, M.; Van Essen, D. C.; Raichle, M. E. (2005). "The human brain is ...
  https://en.wikipedia.org/wiki/Resting_state_fMRI
*  Forschungszentrum Jülich - Institute of Neuroscience and Medicine (INM)
Neuronal activity, brain function and finally behavior emerge from the multi-scale organization of the human connectome. ... Bridging the scales and relating anatomical and activity data is the major challenge addressed using electron microscopy, 3D ... The Institute of Neuroscience and Medicine addresses under the program "Decoding the Human Brain" human brain organization on ... Human Brain Project. SPM Anatomy Toolbox. NEST Simulator. JARA HPC. JARA BRAIN. Virtual Reality, RWTH Aachen University. ...
  http://www.fz-juelich.de/inm/EN/Home/home_node.html
*  Single neuron consciousness in the binocular brain
However, short of having a whole matter connectome, these crude anatomical statements don't offer us much. Smell itself is ... In the human visual system, each eye projects to both hemispheres, while for smell, the major cortical projection from each ... Human single neuron activity precedes emergence of conscious perception, Nature Communications (2018). DOI: 10.1038/s41467-018- ... Ultimately, it does not seem that we will be able to advance much in this arena, even with complete connectomes in hand, unless ...
  https://medicalxpress.com/news/2018-06-neuron-consciousness-binocular-brain.html
*  Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome
We conclude that normative human brain maturation involves a genetically patterned process of consolidating anatomical network ... Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome ... Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome. Proceedings of ... How does human brain structure mature during adolescence? We used MRI to measure cortical thickness and intracortical ...
  http://www.open-access.bcu.ac.uk/5269/
*  Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell...
Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding *. Rapid stimulation of ... 2004) Atlas of Human Central Nervous System Development, Volume 2: The Human Brain During the Third Trimester (CRC Press, Boca ... 2005) Atlas of Human Central Nervous System Development, Volume 3: The Human Brain During the Second Trimester (CRC Press, Boca ... Using 3D culture of human ES cells, we show new self-organizing aspects of human corticogenesis: spontaneous development of ...
  http://www.pnas.org/content/110/50/20284
*  Expander graph - Wikipedia
... data of the NIH-funded large Human Connectome Project, it was shown by Szalkai et al. that the graph, describing the anatomical ... "Brain size bias compensated graph-theoretical parameters are also better in women's structural connectomes". Brain Imaging and ...
  https://en.wikipedia.org/wiki/Expander_graph
*  Abnormal rich club organization and impaired correlation between structural and functional connectivity in migraine sufferers |...
Sporns, O., Tononi, G., & Kötter, R. (2005). The human connectome: a structural description of the human brain. PLoS ... 2009a). Mapping anatomical connectivity patterns of human cerebral cortex using in vivo diffusion tensor imaging tractography. ... 2014). The hubs of the human connectome are generally implicated in the anatomy of brain disorders. Brain, 137(8), 2382-2395. ... van den Heuvel, M. P., & Sporns, O. (2011). Rich-club organization of the human connectome. Journal of Neuroscience, 31(44), ...
  https://rd.springer.com/article/10.1007/s11682-016-9533-6
*  The Human Connectome Project (HCP) - Bruce Rosen
2016) Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral ... The Human Connectome Project (HCP) Rosen, Bruce R. Massachusetts General Hospital, Boston, MA, United States ... This work will be integral part of the collaborative HCP effort to construct a map of the human connectome that represents the ... The Human Connectome Project (HCP). Rosen, Bruce R. / Massachusetts General Hospital. $1,996,356. ...
  http://grantome.com/grant/NIH/U01-MH093765-04
*  FASTA alternatives
The Budapest Reference Connectome server computes the frequently appearing anatomical brain connections of 418 healthy subjects ... It has played an integral role in the Human Genome.... Latest version of BioPerl. is 1.6.924. and it was released on 2014-07-10 ... It has been prepared from diffusion MRI datasets of the Human.... Tags: Computational Neuroscience, Neuroscience, ... Budapest Reference Connectome. by Balázs Szalkai, Csaba Kerepesi, Bálint Varga, Vince Grolmusz. ...
  http://getalternative.net/software/fasta
*  Phylogenetic Analysis Using Parsimony *and other methods alternatives
The Budapest Reference Connectome server computes the frequently appearing anatomical brain connections of 418 healthy subjects ... It has played an integral role in the Human Genome.... Latest version of BioPerl. is 1.6.924. and it was released on 2014-07-10 ... It has been prepared from diffusion MRI datasets of the Human.... Tags: Computational Neuroscience, Neuroscience, ... Budapest Reference Connectome. by Balázs Szalkai, Csaba Kerepesi, Bálint Varga, Vince Grolmusz. ...
  http://getalternative.net/software/phylogenetic-analysis-using-parsimony-and-other-methods
*  The Brain Activity Map Project | The Kavli Foundation
The Human Connectome Project, for example, has begun to map the pathways of neurons in the human brain - that is, the bundles ... In combination, the two mapping efforts would provide both the anatomical and the functional dimensions of the brain. ... the Human Genome Project (HGP), a 12-year, $3 billion race to sequence the complete human genome completed a decade ago. When ... can be used to examine more complex functions or perfect novel approaches for use in humans. Meanwhile, human studies are ...
  http://www.kavlifoundation.org/brain-activity-map-project
*  Diffusion MRI - Wikipedia
... www.popsci.com/science/article/2010-09/introducing-human-connectome-project-first-its-kind-map-brains-circuitry Le Bihan, D. ( ... The ability to visualize anatomical connections between different parts of the brain, noninvasively and on an individual basis ... has emerged as a major breakthrough for neuroscience's Human Connectome Project. More recently, a new field has emerged, ... "The Human Connectome Project Is a First-of-its-Kind Map of the Brain's Circuitry." Popular Science. Sept 2010. http:// ...
  https://en.wikipedia.org/wiki/Diffusion_MRI
*  Connectome - Workbench Commands
CRHD Human Connectomes for Low Vision, Blindness, and Sight Restoration * CRHD Mapping Connectomes for Disordered Mental States ... surface-inflation SURFACE INFLATION wb_command -surface-inflation ,anatomical-surface-in, - the anatomical surface ,surface-in ... The Human Connectome Project and Connectome Coordination Facility are funded by the National Institutes of Health, and all ... Privacy Statement for the Human Connectome Project and Connectome Coordination Facility. Privacy Statement. The member ...
  https://www.humanconnectome.org/software/workbench-command/-all-commands-help
*  RFA-MH-17-220: BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific...
Several efforts are currently underway to study large-scale, long-range connections, such as the NIH Human Connectome Project, ... Development of novel tools that will delineate anatomical connections between cells and expand our knowledge of circuit ... Protections for Human Subjects. For research that involves human subjects but does not involve one of the six categories of ... Protection of Human Subjects: The NIMH has published updated policies and guidance for investigators regarding human research ...
  https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-17-220.html
*  Frontiers | Memory-Efficient Analysis of Dense Functional Connectomes | Frontiers in Neuroinformatics
The functioning of the human brain relies on the interplay and integration of numerous individual units within a complex network. To identify network configurations characteristic of specific cognitive tasks or mental illnesses, functional connectomes can be constructed based on the assessment of synchronous fMRI activity at separate brain sites, and then analyzed using graph-theoretical concepts. In most previous studies, relatively coarse parcellations of the brain were used to define regions as graphical nodes. Such parcellated connectomes are highly dependent on parcellation quality because regional and functional boundaries need to be relatively consistent for the results to be interpretable. In contrast, dense connectomes are not subject to this limitation, since the parcellation inherent to the data is used to define graphical nodes, also allowing for a more detailed spatial mapping ...
  https://www.frontiersin.org/articles/10.3389/fninf.2016.00050/full
*  Connectome | Affective Neuroscience & Development Lab | Leah Somerville
What is the Human Connectome Project?. The Human Connectome Project in Development is a ground-breaking multi-site study funded by the National Institutes of Health that seeks to investigate how different parts of the brains are connected to each other, and how these connections change from childhood through adulthood. The Harvard branch of the Human Connectome Project in Development is being led by Dr. Leah Somerville at the Affective Neuroscience and Development Lab.. Who can participate? We are currently recruiting participants ages 8 to 21 years old. For participants that are minors (i.e. ages 8-17), their participation also involves the presence and active participation of one of their parents during the study visits.. What will happen during the study visits?. Participation is this study involves coming to our lab in Cambridge for two separate ...
  http://andl.wjh.harvard.edu/connectome
*  Human Connectome Project informatics: Quality control, database services, and data visualization - Nuffield Department of...
The Human Connectome Project (HCP) has developed protocols, standard operating and quality control procedures, and a suite of informatics tools to enable high throughput data collection, data sharing, automated data processing and analysis, and data mining and visualization. Quality control procedures include methods to maintain data collection consistency over time, to measure head motion, and to establish quantitative modality-specific overall quality assessments. Database services developed as customizations of the XNAT imaging informatics platform support both internal daily operations and open access data sharing. The Connectome Workbench visualization environment enables user interaction with HCP data and is increasingly integrated with the HCP's database services. Here we describe the current state of these procedures and tools and their application in the ongoing HCP study. © 2013 Elsevier Inc.
  https://www.ndcn.ox.ac.uk/publications/415332
*  NITRC: 1000 Functional Connectomes Project: Forums for 1000 Functional Connectomes Project
The following forums are available for 1000 Functional Connectomes Project. Click on a forum to post or view posts to that forum. ...
  https://www.nitrc.org/forum/?group_id=296
*  The comprehensive connectome of a neural substrate for 'ON' motion detection in Drosophila. | Janelia Research Campus
Analysing computations in neural circuits often uses simplified models because the actual neuronal implementation is not known. For example, a problem in vision, how the eye detects image motion, has long been analysed using Hassenstein-Reichardt (HR) detector or Barlow-Levick (BL) models. These both simulate motion detection well, but the exact neuronal circuits undertaking these tasks remain elusive. We reconstructed a comprehensive connectome of the circuits of Drosophila's motion-sensing T4 cells using a novel EM technique. We uncover complex T4 inputs and reveal that putative excitatory inputs cluster at T4's dendrite shafts, while inhibitory inputs localize to the bases. Consistent with our previous study, we reveal that Mi1 and Tm3 cells provide most synaptic contacts onto T4. We are, however, unable to reproduce the spatial offset between these cells reported previously. Our comprehensive connectome reveals complex circuits that ...
  https://www.janelia.org/publication/comprehensive-connectome-neural-substrate-motion-detection-drosophila
*  阿唐的繆想: 嘗試的力量 The Power of Trying @ Connectome
前一陣子受一群熱血的學弟妹邀請3去做給生技生科相關學弟妹的分享》他們組成了一個團體叫做Connectome3想協助懵懂尋找未來的生科學生們一個平台3藉由我們出社會"稍微"久一點的學長姐來分享》Connectome除了有神經連結體的意義外3還有一個意思"Connect-to-me"3期望的就是把生科領域的老壯青少可以連結在一起》果然是長江後浪3讓我對台灣的未來看到了希望( ...
  http://mingtangyang.blogspot.com/2012/08/power-of-trying-connectome.html
*  Integral Options Cafe: Sebastian Seung and the Human Connectome Project
It was clear from the opening statements at Monday's debate that Movshon and Seung represent two different schools of thought, but their conversation ended up being less a "brain brawl" and more a respectful airing of differences. Seung believes neuroscience is stuck in a traditional mode of research, where the necessity to publish the next paper and get the next grant corrals scientists into overly-specific, limited fields of view of the whole system they're studying. As a result, Seung argued, "neuroscientists can be very short-sighted." Seung's own plan of attack is one he's elaborated in his popular TED talk and documented thoroughly (and very accessibly) in his new book, Connectome: How the Brain's Wiring Makes Us Who We Are. On Monday, he reiterated this philosophy: the best way to understand perception, memory, and the basis of psychiatric disorders like schizophrenia and autism, Seung believes, is to study the brain at the level of the synapse-to trace all the ...
  http://integral-options.blogspot.com/2012/04/sebastian-seung-and-human-connectome.html
*  PLOS Computational Biology: Brain Anatomical Network and Intelligence
Author Summary Networks of interconnected brain regions coordinate brain activities. Information is processed in the grey matter (cortex and subcortical structures) and passed along the network via whitish, fatty-coated fiber bundles, the white matter. Using maps of these white matter tracks, we provided evidence that higher intelligence may result from more efficient information transfer. Specifically, we hypothesized that higher IQ derives from higher global efficiency of the brain anatomical network. Seventy-nine healthy young adults were divided into general and high IQ groups. We used diffusion tensor tractography, which maps brain white matter fibers, to construct anatomical brain networks for each subject and calculated the network properties using both binary and weighted networks. We consistently found that the high intelligence group's brain network was significantly more efficient than was the general intelligence group's. Moreover, IQ scores were significantly ...
  http://journals.plos.org/ploscompbiol/article/authors?id=10.1371/journal.pcbi.1000395&imageURI=info:doi/10.1371/journal.pcbi.1000395.t005
*  Royal Ballet's Connectome - The Mind Mapped Through Dance | Crane.tv Contemporary Culture Video Magazine
We interview Alastair Marriott with his work and life partner Jonathan Howells to talk choreography and neuroscience. The pair met as students at the Royal Ballet School but only began working together on professional projects recently. As choreographer, Marriott takes the lead while a work is initially developed. He explores ideas on his own before sharing them with dancers in a studio where their reactions influence the work. Once the principal shape of the choreography is determined Howells takes over and directs rehearsals. He must learn all the dancers movements and communicate Marriott's desired nuances and aesthetic. This allows to Marriott take some distance during rehearsals; keeping his eye sharp for fine-tuning.. Marriott's ballet, Connectome, explores the theory that every individual has a unique mental map that is shaped and coloured by events in their life. As a project of neuroscience, mental mapping remains largely underdeveloped so as creative stimulus it ...
  http://www.crane.tv/mapping-the-brain-through-ballet-the-story-behind-the-royal-ballet-s-connectome?locale=en
*  Theatre review: Raven Girl / Connectome at Royal Opera House
Theatre review of Raven Girl / Connectome (Choreography Wayne McGregor / Alastair Marriott) from Royal Ballet at Royal Opera House, reviewer: Vera Liber
  http://www.britishtheatreguide.info/reviews/raven-girl-co-royal-opera-hou-12128
*  DT-MRI Brain: Human Connectome
White Matter Fiber Tracking from Human Brain DT-MRI Data In this paper we develop a new technique for tracing anatomical white mater fibers from 3D diffusion
  http://www.leonidzhukov.net/research/visualization/dt-mri-brain
*  NEW SAVANNA: Mapping the Brain: The Human Connectome Project
Navigate the brain in a way that was never before possible; fly through major brain pathways, compare essential circuits, zoom into a region to explore the cells that comprise it, and the functions that depend on it ...
  http://new-savanna.blogspot.com/2013/06/mapping-brain-human-connectome-project.html
*  Recent Articles | Human Connectome Project And Immunology | The Scientist Magazine®| Page 12
Much of the CD4+ T-cell death that occurs during HIV infection may be caused by direct delivery of the virus from neighboring cells, a study shows.. 0 Comments. ...
  https://www.the-scientist.com/?articles.list/tagNo/3065,12/tags/Human-Connectome-Project,immunology/pageNo/12/
*  NeuroDojo: March 2012
I would like to propose a metaphor for the relationship between neural activity and connectivity. Neural activity is constantly changing. It's like the water of the stream; it never sits still. The connections of the brain's neural network determines the pathways along which neural activity flows. And so the connectome is like bed of the stream; but the metaphor is richer than that, because it's true that the stream bed guides the flow of the water, but over long timescales, the water also reshapes the bed of the stream. And as I told you just now, neural activity can change the connectome. And if you'll allow me to ascend to metaphorical heights, I will remind you that neural activity is the physical basis - or so neuroscientists think - of thoughts, feelings and perceptions. And so we might even speak of the stream of consciousness. Neural activity is its water, and the connectome is its bed ...
  http://neurodojo.blogspot.co.il/2012/03/
*  Plus it
Despite recent advances, the tissue clearing technologies have a fundamental limitation: the working distance of optical microscopy. Without physical sectioning, an objective lens with high numerical aperture (≥1.2) for resolving submicron-resolution details does not have enough working distance (≥0.28 mm) to visualize cellular structures that are more than several millimeters deep. This limitation can be partially addressed by shrinkage-mediated imaging, which reduces the tissue volume after clearing (Pan et al., 2016). However, serial sectioning is still required for 3D imaging and reconstruction of large tissues.. Serial sectioning has been used with transmission EM to reconstruct the whole-body connectome of Caenorhabditis elegans (White et al., 1986; Xu et al., 2013) and larval Drosophila (Ohyama et al., 2015) as well as the partial optic medulla connectome in Drosophila (Takemura et al., 2013). However, the use of transmission EM in ...
  http://www.jneurosci.org/content/36/45/11375
*  Welcome to the brain: ID access only - Harvard Neuro Blog
For example, one discipline that has been quickly expanding and receiving much attention from the media is connectomics. The aim of this field is to create detailed maps, or connectomes, of all synaptic connections among neurons. This stands in contrast to other more conventional approaches that interrogate specific pathways and networks of connections among a restricted group of neurons. The generation of these connectomes has been strongly pursued through the development of techniques for high-resolution, high-throughput reconstruction of small volumes of nervous tissue. For example, recent work by Kasthuri et al (2015) shows the potential of new electron microscopy (EM) techniques for expanding our understanding of the connections and structure of the brain. Unlike other forms of histology that rely on fluorescence to visualize cells, EM generates high-resolution images that reveal all membranous structures. Kasthuri and colleagues have ...
  https://www.harvardneuroblog.com/blog/2015/10/15/welcome-to-the-brain-id-access-only
*  A Very Big Map
Neurons and their processes, color-coded to distinguish one from another. Credit: Lichtman Lab / Harvard University. The scale of the problem. Since the end of that project, Lichtman's lab has improved further the automation of imaging and analysis, and now, Lichtman says, could reconstruct the same-sized volume of brain tissue (0.0000015 cubic millimeters, or roughly one cell-width across) in a matter of months, not years.. Still, that is only a very tiny volume, on the order of a billionth of a whole mouse brain-or less than a trillionth of a human brain.. The enormity of the connectomics challenge is also apparent when one looks at the data storage requirements. The annotated imagery generated in Lichtman's project required about 3 trillion bytes (terabytes) of storage. According to Kasthuri, mapping a full human brain connectome would require more than 1021 bytes (one zettabyte), which represents a large fraction of the total storage ...
  http://dana.org/Briefing_Papers/A_Very_Big_Map_/
*  functional networks - The Connectome
New data is enabling neuroscientists to make accurate predictions about a young connectome's future development. By comparing the resting-state functional networks in pre-adolescent brains with connectivity' patterns found in adult brains, neuroscientists have developed a brain maturity growth curve that charts functional connectivity changes as the brain matures. A report published in the journal Science explains that nodes in these networks are a bit like high-schoolers, because they join, branch, and and rejoin in a series of predictable "cliques" as an individual ages. Many of these cliques involve brain areas that influence a person's ability to sustain attention, and to quickly come up … Continue reading Measuring Maturity. ...
  https://theconnectome.wordpress.com/tag/functional-networks/
*  Clubs/Organizations / Clubs/Organizations Directory
Green Hope High School currently has over 100 different clubs and organizations to choose from. It is our hope that every student will find a group that interests them and gets involved! For further information, please email the Club Advisor listed.. All email addresses are "@wcpss.net" unless otherwise noted.. ...
  https://www.wcpss.net/Page/16486
*  Neural Circuits, Ensembles + Connectomes - The Solomon H Snyder Department of Neuroscience
Early studies in brain science, including breakthroughs from pioneering Johns Hopkins researcher and professor Dr. Vernon Mountcastle, were designed to disentangle the network complexity of the brain by exploiting the relative accessibility of sensory receptive fields. Pioneering work at Hopkins on these sensory fields would reveal network principles such as the columnar organization of the cerebral cortex. More recently, the advent of modern molecular, viral, and optogenetic approaches has allowed neuroscientists to discover new principles of ensemble organization. Experimental tools used widely in the department include in vivo and ex vivo electrophysiology; calcium imaging; anatomical mapping; molecular targeting of synapses and circuits with viral and optogenetic strategies; as well as behavioral analysis to determine the functional properties of identified circuits. These tools are being used to dissect neural circuits controlling reward and motivation, social interactions, complex ...
  http://neuroscience.jhu.edu/research/area/5
*  Our results on brain development in the "Mindentudás" television magazine | PIT Bioinformatics Group
On July 29, 2016, in the "Mindentudás" ("Omniscience") magazine, Hungarian Television Channel 1 (M1) aired a news block on our research: How to Direct the Edges of the Connectomes: Dynamics of the Consensus Connectomes and the Development of the Connections in the Human Brain ...
  https://pitgroup.org/result-brain-development-mindentudas-televison-magazine/
*  Recent publications of our group | PIT Bioinformatics Group
Csaba Kerepesi, Balázs Szalkai, Bálint Varga, Vince Grolmusz: How to Direct the Edges of the Connectomes: Dynamics of the Consensus Connectomes and the Development of the Connections in the Human Brain, PLoS One 11(6): e0158680. http://dx.doi.org/10.1371/journal.pone.0158680, June 30, 2016 [impact factor: 3.057 ...
  https://pitgroup.org/publications-group/
*  Do glial connectomes and activity maps make any sense?
(Medical Xpress)-'If all you have is a hammer, everything looks like a nail.' This so-called 'law of the instrument' has shaped neuroscience to core. It can be rephrased as, if all you have a fancy voltmeter, everything ...
  https://medicalxpress.com/news/2013-09-glial-connectomes.html
*  Towards Baby Brain Connectome: a Study of Newborn Brain Networks - Xu Duan
The growing incidence of preterm birth (|500,000/year in the US) and birth injuries (|25,000/year in the US) have had a profound impact on society, with million...
  http://grantome.com/grant/NIH/R01-HD072074-02