*  Background Astrocytomas are the most aggressive and common human brain tumors - Suppression of KRas-mutant cancer through the...
Components and strategies Cell Ethnicities and Individual Cells Rat C6 astrocytoma cells and human being U87-MG astrocytoma ... Background Astrocytomas are the most aggressive and common human brain tumors Tags. a member of the integrin a chain family ... Background Astrocytomas are the most aggressive and common human brain tumors. December 1, 2017. Felix Stevens ... Background Astrocytomas are the most aggressive and common human brain tumors characterized by their highly invasive ...
  http://complextraitgenomics.com/background-astrocytomas-are-the-most-aggressive-and-common-human-brain-tumors/
*  Array Comparative Genomic Hybridization Identifies Genetic Subgroups in Grade 4 Human Astrocytoma | Clinical Cancer Research
Tumor DNA. Fifty tumor samples (GBM, grade 4 astrocytoma) were obtained from the tissue bank at the Brain Tumor Research Center ... Previous reports identified EGFR amplification in 35% to 40% of grade 4 astrocytomas (26-29). The differences in amplification ... Alterations of DNA copy number are believed to be important indicators of tumor progression in human astrocytoma. We used an ... Primary human brain tumors.Figures 3 and 4 show 9p loss and chromosome 7 gain/epidermal growth factor receptor (EGFR) ...
  http://clincancerres.aacrjournals.org/content/11/8/2907
*  Membrane alterations in human glioblastoma | SpringerLink
Plasma membrane-enriched fractions were isolated from human gliomas and brain white matter. These membrane fractions were ... Coakham H, Lakshin MS (1975) Tumor-associated surface antigen(s) in human astrocytomas. Oncology 31:233-243Google Scholar ... Coakham H (1974) Surface antigen(s) common to human astrocytoma cells. Nature 250:328-330Google Scholar ... Day ED, Lassiter S, Woodhall B, Mahaley JL, Mahaley MS (1965) The localization of radioantibodies in human brain tumors. I. ...
  https://link.springer.com/article/10.1007/BF00688756
*  Mouse Models of Human Cancers Consortium Workshop on Nervous System Tumors | Cancer Research
Nervous system tumors can be divided into those tumors that arise from glial lineage cells (glioma, astrocytoma, and ... Cell of origin. Although it is often presumed that astrocytomas (gliomas) arise from astrocytes, it is not known whether these ... several groups have begun to develop human orthotopic brain tumor models in which surgically resected human brain tumors are ... In addition, isolated human brain tumor stem cells have been used to generate gliomas and medulloblastoma tumors in mice. ...
  http://cancerres.aacrjournals.org/content/66/1/10
*  CTSB | Cancer Genetics Web
... overexpression may be associated with aggressive tumor progression and poor prognosis in human astrocytoma. The aim of this ... We further evaluated the clinical value of the miRNA-EZH2 mRNA axis in astrocytomas. As a result, we identified EZH2 as a ... The lysosomal cysteine protease Cathepsin B has been implicated in the progression of various human tumors. In the present ... Finally, β-galactosidase, a known lysosomal enzyme and biomarker of senescence, was localized to the tumor stroma in human ...
  http://www.cancerindex.org/geneweb/CTSB.htm
*  Pediatric tumors - Humpath.com - Human pathology
pilocytic astrocytoma 12 July 2010 Digital cases HPC:246 : Pilocytic astrocytoma Definition: Juvenile pilocytic astrocytomas ( ... 1996 - 2018 Humpath.com - Human pathology Site Map , Log in , Contact , RSS 2.0 ... JPA), a subgroup of low-grade astrocytomas (LGA), are common, heterogeneous and poorly understood subset of brain tumours in ...
  http://www.humpath.com/spip.php?mot210&debut_articles=10
*  The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas
17] showed that rate of survival for p-AKT positive tumor patients was lower than that of p-AKT negative tumors, whereas ... They then examined the prognostic significance of p-AKT only in patients diagnosed with a grade IV astrocytoma treated by ... A. A. Saetta, G. Levidou, E. A. El-Habr et al., "Expression of pERK and pAKT in human astrocytomas: correlation with IDH1-R132H ... AKT Protein: A Basic "AKTor" in Human Astrocytomas. AKT (also known as protein kinase B, PKB) is a serine/threonine kinase with ...
  https://www.hindawi.com/journals/nri/2012/454957/
*  Plus it
Because BrdUrd is not used to measure proliferation in human tumors, we quantified the number of proliferating tumor cells ... including pilocytic astrocytoma, in which continued rapamycin administration resulted in tumor shrinkage ( 40). ... astrocytomas; this is in fact similar to a subset of the astrocytomas encountered in children with NF1 ( 5). These lesions are ... and optimizing tumor suppression during the periods of maximal tumor growth. Unlike high-grade gliomas, where significant tumor ...
  http://cancerres.aacrjournals.org/content/68/5/1520
*  ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis. | Sigma-Aldrich
Grade IV astrocytoma or glioblastoma multiforme (GBM) is one of the most aggressive and lethal tumors affecting humans. ADAR2- ... Here, we show that ADAR2 editing rescue in astrocytomas prevents tumor growth in vivo and modulates an important cell cycle ... is impaired in GBMs and astrocytoma cell lines. However, the role of ADAR2 editing in astrocytomas remains to be defined. ... We demonstrate that ADAR2 deaminase activity is essential to inhibit tumor growth. Indeed, we identify the phosphatase CDC14B, ...
  https://www.sigmaaldrich.com/catalog/papers/22525274
*  Treatment for Low-Grade Level II Astrocytoma | Cancer Survivors Network
... have been detected in human astrocytomas; however, the expression pattern of PR isoforms in these brain tumors is unknown. ... Re: Treatment for Low-Grade Level II Astrocytoma. Here's the latest information on hormone receptor status of astrocytomas. ... These data suggest that PR-B is the predominant isoform expressed in human astrocytomas grades III and IV, and that estrogen ... Estrogen receptor-á protein was only observed in 33% of astrocytomas grade III, whereas no astrocytomas grade IV expressed it. ...
  https://csn.cancer.org/node/155122
*  Frontiers | Emerging Insights into Barriers to Effective Brain Tumor Therapeutics | Oncology
... combined with rapidly expanding knowledge of brain tumor patho-biology will provide new, more effective therapies. Brain tumors ... Brain tumors that form from brain cells, as opposed to those that come from other parts of the body, rarely metastasize outside ... Instead, the tumor cells invade deep into the brain itself, causing disruption in brain circuits, blood vessel and blood flow ... Instead, the tumor cells invade deep into the brain itself, causing disruption in brain circuits, blood vessel and blood flow ...
  https://www.frontiersin.org/articles/10.3389/fonc.2014.00126/full
*  Connexin and pannexin channels in cancer | Springer for Research & Development
Among 131 cases of human astrocytic tumors, Cx43 was observed in 76.9 % of diffuse astrocytoma and in all cases of anaplastic ... particularly in astrocytomas, glioblastoma multiforme (GBM), and oligodendro-gliomas [183]. Additionally, in Kaplan-Meier ... Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is ... tumor cells were loaded with Lucifer yellow (LY) and implanted into tumor in situ. By irradiation with blue light, only tumor ...
  https://rd.springer.com/article/10.1186/s12860-016-0094-8
*  Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas
Normal human brain showed faint positive signals for both isoforms. All astrocytoma tumor samples except for one grade II ... We chose diffuse astrocytomas, because they are the most common highly malignant glial cell-derived brain tumors. They are ... CA12 Variant mRNA Is Expressed in Astrocytic Tumors. All astrocytoma samples except for one grade II tumor were positive for CA ... Only one astrocytoma tumor sample and two glioblastoma cell lines contained the longer isoform in addition to the shorter one, ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2613815/
*  Astrocytoma - Wikipedia
Low Grade Astrocytomas in Children, Tumor Types, Treatment, FAQs, Research Cancer.Net: Astrocytoma, Childhood Astro Fund - UK ... Despite the low incidence of astrocytomas compared to other human cancers, mortality is significant, as the higher grades (III ... Intracranial pressure Brain tumor Notes Astrocytoma at eMedicine mdguidelines.com > Astrocytoma Retrieved on Mars 26, 2010 ... A pathological specimen of a gemistocytic astrocytoma MRI scans of an astrocytoma patient, showing tumor progression over the ...
  https://en.wikipedia.org/wiki/Astrocytoma
*  Neurooncology - Wikipedia
1. Malignant Astrocytomas Malignant astrocytomas are the most common primary brain tumors in adults. Malignant astrocytomas ... astrocytoma, glioma, glioblastoma multiforme, ependymoma, pontine glioma, and brain stem tumors are among the many examples of ... Human and animal studies have suggested that perturbations in neurovascular integrity and breakdown of the BBB lead to neuronal ... Germ Cell and Pineal Region Tumors Most tumors of the pineal region are either germinomas or pineal cell tumors, and are tumors ...
  https://en.wikipedia.org/wiki/Neurooncology
*  Grading of the tumors of the central nervous system - Wikipedia
Grade 1 tumors are benign astrocytomas. Grade 2 tumors are low-grade astrocytomas. Grade 3 tumors are anaplastic astrocytomas. ... Atlanta, Georgia: Department of Health and Human Services, Centers for Disease Control and Prevention. Kernohan JW, Mabon RF, ... IARC, Lyon ISBN 92-832-2430-2. AFIP Course Syllabus - Astrocytoma WHO Grading Lecture Handout. ... Grade III tumors are malignant and often recur as higher grade tumors. Grade IV tumors reproduce rapidly and are very ...
  https://en.wikipedia.org/wiki/Grading_of_the_tumors_of_the_central_nervous_system
*  Brain tumor - Wikipedia
Choroid plexus tumor, Dysembryoplastic neuroepithelial tumour, Ependymal tumor, Fibrillary astrocytoma, Giant-cell glioblastoma ... Tumors of the meninges are meningiomas and are often benign. The brains of humans and other vertebrates are composed of very ... The most common types of primary tumors in adults are meningiomas (usually benign), and astrocytomas such as glioblastomas. In ... There are two main types of tumors: malignant or cancerous tumors and benign tumors. Cancerous tumors can be divided into ...
  https://en.wikipedia.org/wiki/Brain_tumor
*  IDH1 - Wikipedia
Liu X, Ling ZQ (Oct 2015). "Role of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors". Histology and ... including diffuse astrocytoma, anaplastic astrocytoma, oligodendroglioma, anaplastic oligodendroglioma, oligoastrocytoma, ... Watanabe T, Nobusawa S, Kleihues P, Ohgaki H (Apr 2009). "IDH1 mutations are early events in the development of astrocytomas ... occur frequently in high-grade gliomas but not in other solid tumors". Human Mutation. 30 (1): 7-11. doi:10.1002/humu.20937. ...
  https://en.wikipedia.org/wiki/IDH1
*  DNA mismatch repair - Wikipedia
In contrast, the gene-poor, late-replicating heterochromatic genome regions exhibit high mutation rates in many human tumors. ... Jiang Z, Hu J, Li X, Jiang Y, Zhou W, Lu D (2006). "Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low- ... were significantly down-regulated in lower grade as well as in higher grade astrocytomas, in contrast to normal brain tissue. ... some of which could produce a tumor. In humans, seven DNA mismatch repair (MMR) proteins (MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 ...
  https://en.wikipedia.org/wiki/DNA_mismatch_repair
*  Luis F. Parada - Wikipedia
"Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model." Cancer Cell, ... "Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma." Cancer Cell 2005 Aug; ... "Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene." Nature 297 (1982): 474-478. Parada, Luis F ... In 2015, he became Director of the Brain Tumor Center at Memorial Sloan Kettering Cancer Center in New York City, NY. where he ...
  https://en.wikipedia.org/wiki/Luis_F._Parada
*  LAMP1 - Wikipedia
"Expression of Lamp-1 and Lamp-2 and their interactions with galectin-3 in human tumor cells". International Journal of Cancer. ... and Astrocytoma. Cluster of differentiation GRCh38: Ensembl release 89: ENSG00000185896 - Ensembl, May 2017 GRCm38: Ensembl ... in astrocytomas". International Journal of Clinical and Experimental Pathology. 6 (7): 1294-1305. PMC 3693194 . PMID 23826410. ... "LAMP1". The Human Protein Atlas. Carlsson SR, Fukuda M (Dec 1989). "Structure of human lysosomal membrane glycoprotein 1. ...
  https://en.wikipedia.org/wiki/LAMP1
*  O-6-methylguanine-DNA methyltransferase - Wikipedia
Yet there is evidence that more than 80% of the somatic mutations found in mutator phenotype human colorectal tumors occur ... as well as in higher grade astrocytomas suggested that they may be important in early as well as in later stages of astrocytoma ... human tumor cell line". Mutat. Res. 314 (2): 99-113. doi:10.1016/0921-8777(94)90074-4. PMID 7510369. Bernstein C, Prasad AR, ... As pointed out by Rubin, "The vast majority of studies in cancer research has been done on well-defined tumors in vivo, or on ...
  https://en.wikipedia.org/wiki/O-6-methylguanine-DNA_methyltransferase
*  Pathology High Yield (FA) Flashcards - Cram.com
tumor suppresor gene:. p53. - chromosome. - associated tumor (specific) 17p. most human cancers. Li-Fraumeni syndrome ... astrocytoma. cardiac rhabdomyoma associated neoplasm:. Plummer-Vinson syndrome. - atrophic glossitis. - esophageal webs - ... primary tumors that metastazie to the bone - lytic, blastic, or both (if applicable). - most common (2) ... paraneoplastic effects of tumors:. small cell lung carcinoma (in addition to ACTH and ADH) ...
  http://www.cram.com/flashcards/pathology-high-yield-fa-478727
*  Cancer Stem Cells
ADAM12 is upregulated in human breast cancers and is a predictor of chemoresistance in estrogen receptor-negative tumors. ... Pilocytic astrocytomas (PAs) are the most common pediatric central nervous system neoplasms. In the majority of cases these ... Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged ... Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells More than 80% of ...
  https://www.biomedcentral.com/collections/cancerstemcells
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... that recapitulated the histopathological hallmarks of human astrocytomas, including diffuse invasion of normal brain parenchyma ... Current astrocytoma models are limited in their ability to define the roles of oncogenic mutations in specific brain cell types ... resulting in expression of mutated oncogenes and deletion of tumor suppressor genes. The phenotypic consequences of these ... Differentiation of human neural progenitors into neuronal and glial cell types offers a model to study and compare molecular ...
  https://www.jove.com/visualize/abstract/23626774/blood-levels-glial-fibrillary-acidic-protein-gfap-patients-with