*  The Effects of Leukocyte-Type 12/15-Lipoxygenase on Id3-Mediated Vascular Smooth Muscle Cell Growth | Arteriosclerosis,...
Convincing evidence exists implicating leukocyte-type 12/15-LO as a key player in the development of atherosclerosis and restenosis. KO of the 12/15-LO gene in apolipoprotein E- and LDL receptor-deficient mice, 2 models of robust atherosclerosis, resulted in a marked decrease in atherosclerosis development in vivo.5,7 Marked upregulation of 12/15-LO occurred in VSMCs after balloon carotid injury in rats, and restenosis was significantly blocked with a pharmacological 12/15-LO inhibitor as well as a specific ribozyme targeted to cleave 12/15-LO.4,27 Many events and pathways involving 12/15-LO have been proposed to contribute to atherosclerosis and restenosis. Much is understood concerning the ability of 12/15-LO within macrophages to participate in the oxidation of LDL, an early event in vascular lesion formation.2,7-9,28 However, 12/15-LO ...
*  LOX-DB - LipOXygenases DataBase - General Information about Lipoxygenases
A LOX definition according to enzyme classification is linoleate: oxygen oxidoreductase (for plant LOX) and arachidonate: oxygen oxidoreductase (for mammalian LOX). Historically LOX are classified according to their positional specificity of the dioxygenation of their most common substrates linoleate (C-18) in plants, and arachidonic acid (C-20) in mammals. Accordingly, a LOX reacting at the ω-6 position of the substrate (as counted from the tail end of the fatty acid) in plants is referred to as a 13-LOX (alternate: linoleate ω6-LOX) and in mammals as a 15-LOX (alternate: arachidonate ω6-LOX). In plants 9-, and 13-LOX and in mammals, 5-, 8-, 12- and 15-LOX are known. When necessary, the stereoconfiguration is specified (e.g. 12S-LOX and 12R-LOX). In mammals, isoenzymes that exhibit the same position-specificity are named additionally after the prototypical tissue of their occurrence (e.g. platelet-type, ...
*  Recombinant Human 5 Lipoxygenase protein (ab114310) References
References for Abcam's Recombinant Human 5 Lipoxygenase protein (ab114310). Please let us know if you have used this product in your publication
*  Recombinant Human 5 Lipoxygenase protein (ab114310) Protocols
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*  Linoleate 13S-lipoxygenase elisa and antibody
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*  GFIT result for T01044
sp:LIDS_GAEGR] linoleate 8R-lipoxygenase / 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase (EC:; K17864 linoleate 8R-lipoxygenase / 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase [EC:] ...
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Deschamps, J. D., Gautschi, J. T., Whitman, S., Johnson, T. A., Gassner, N. C., Crews, P., & Holman, T. R. (2007). Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg ...
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