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*  Frontiers | NET Confusion | Immunology
These leukocytes are produced in high numbers on a daily basis in humans and are recruited rapidly to injured/infected tissues ... These leukocytes are produced in high numbers on a daily basis in humans and are recruited rapidly to injured/infected tissues ... human deoxyribonuclease therapy improves airway resistance and reduces DNA extracellular traps in a murine acute asthma model. ... Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment. Br J ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00259/full
*  Saccharomyces cerevisiae-Derived Mannan Does Not Alter Immune Responses to Aspergillus Allergens
Figure 4: Airways resistance was unaffected by MN treatment. While naïve and nonallergic mice that received MN had no airway ... with close similarity to humans with severe asthma. In this study, we showed that mannan treatment does not affect most ... Airways Inflammation Was Reduced in Mice Treated with Mannan. Inflammation in the airways is a feature of asthma that is ... Mannan Treatment Had No Effect on Airway Resistance in Mice with SAFS. Airway hyperresponsiveness is a hallmark of allergic ...
  https://www.hindawi.com/journals/bmri/2018/3298378/
*  Requirement for the Chemokine Receptor Ccr6 in Allergic Pulmonary Inflammation | JEM
As airway hyperreactivity is the feature considered most relevant to human asthma, we measured this parameter in the lungs of ... Values shown represent the change in airway resistance (cm/H2O/ml/s), defined as peak airway resistance minus the background ... In both sets of mice, airway resistance peaked at ∼8 h after challenge. However, the resistance in CCR6−/− mice was two- to ... challenged CCR6-deficient mice had reduced airway resistance, fewer eosinophils around the airway, lower levels of interleukin ...
  http://jem.rupress.org/content/194/4/551.full
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... with each mimicking the major features of human asthma.5 The major features of acute asthma include an exaggerated airway ... airway resistance, plethysmography, flexiVent, bronchoalveolar lavage, physiology ... These techniques provide powerful tools for studying asthma in ways that would not be possible in humans. ... of the US population has asthma, with the prevalence increasing.2 As with other diseases, animal models of allergic airway ...
  https://www.jove.com/visualize/abstract/23185289/a-global-analysis-tandem-3utrs-eosinophilic-chronic-rhinosinusitis
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... with each mimicking the major features of human asthma.5 The major features of acute asthma include an exaggerated airway ... First, determination of the role of jasmonic acid (JA - a plant hormone often indicated in resistance to insects) in resistance ... Modeling of the human disease alleles occurs through microinjection of zebrafish embryos with MO and/or human mRNA at the 1-4 ... These techniques provide powerful tools for studying asthma in ways that would not be possible in humans. ...
  https://www.jove.com/visualize/abstract/25101850/a-yersinia-pestis-tat-mutant-is-attenuated-bubonic-small-aerosol
*  Transcriptome Profiling of Human Airway Smooth Muscle Cells Stimulated with Dexamethasone Identifies <i>CRISPLD2</i> as a...
Asthma is a chronic inflammatory airway disease that affects over 300 million people around the world. Glucocorticoids are ... Previously conducted GWAS of two glucocorticoid- and HASM-related phenotypes, inhaled corticosteroid resistance and ... Transcriptome Profiling of Human Airway Smooth Muscle Cells Stimulated with Dexamethasone Identifies CRISPLD2 as a Regulator of ... We used RNA-Seq to characterize changes in the human airway smooth muscle (HASM) transcriptome in response to treatment with a ...
  http://www.ashg.org/2013meeting/abstracts/fulltext/f130120986.htm
*  NexBio and Weill Cornell Medical College Publish Preclinical Study Showing DAS181 (Fludase) Anti-Influenza Drug Inhibits...
DAS181 works by inactivating the human receptors ("host target") to which viruses bind; thus, drug resistance may be less ... In addition, NexBio has recently presented data from three independent studies in animal models of asthma, done with academic ... and patients with underlying airway disease," commented Dr. Anne Moscona, Professor of Pediatrics and of Microbiology and ... DAS181 is currently being studied for influenza in a human phase II clinical trial funded by the National Institute of Allergy ...
  https://www.drugs.com/clinical_trials/nexbio-weill-cornell-medical-college-publish-preclinical-study-showing-das181-fludase-anti-9662.html
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... with each mimicking the major features of human asthma.5 The major features of acute asthma include an exaggerated airway ... airway resistance, plethysmography, flexiVent, bronchoalveolar lavage, physiology ... Reducing airway smooth muscle decreases the ability of the airways to constrict, thereby reducing the frequency of asthma ... moving from distal to proximal along the length of the airway, and systematically from airway to airway as described previously ...
  https://www.jove.com/visualize/abstract/23251336/multiple-vitro-vivo-regulatory-effects-budesonide-cd4-t-lymphocyte
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... with each mimicking the major features of human asthma.5 The major features of acute asthma include an exaggerated airway ... The transendothelial electrical resistance (TEER) of brain endothelial monolayers, indicating the tightness of TJs reached 300 ... Ovalbumin-induced allergic asthma is a widely used model to reproduce the airway eosinophilia, pulmonary inflammation and ... These techniques provide powerful tools for studying asthma in ways that would not be possible in humans. ...
  https://www.jove.com/visualize/abstract/20552026/the-effects-overexpression-histamine-releasing-factor-hrf-transgenic
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... with each mimicking the major features of human asthma.5 The major features of acute asthma include an exaggerated airway ... Oropharyngeal Candidiasis (OPC) disease is caused not only due to the lack of host immune resistance, but also the absence of ... This biologically relevant in vitro model of the human upper airway can be used in a number of ways; the overall goal of this ... Ovalbumin-induced allergic asthma is a widely used model to reproduce the airway eosinophilia, pulmonary inflammation and ...
  https://www.jove.com/visualize/abstract/26066058/high-pulmonary-levels-il-6-il-1-children-with-chronic-suppurative
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... with each mimicking the major features of human asthma.5 The major features of acute asthma include an exaggerated airway ... airway resistance, plethysmography, flexiVent, bronchoalveolar lavage, physiology ... Ovalbumin-induced allergic asthma is a widely used model to reproduce the airway eosinophilia, pulmonary inflammation and ... Modeling of the human disease alleles occurs through microinjection of zebrafish embryos with MO and/or human mRNA at the 1-4 ...
  https://www.jove.com/visualize/abstract/25760038/prediction-chemical-respiratory-sensitizers-using-gard-novel-vitro
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... with each mimicking the major features of human asthma.5 The major features of acute asthma include an exaggerated airway ... Polarization is monitored by evaluating trans-epithelial electrical resistance (TEER) and is verified by evaluating the passive ... Ovalbumin-induced allergic asthma is a widely used model to reproduce the airway eosinophilia, pulmonary inflammation and ... We have the unique ability to model well differentiated human airway epithelium and heart muscle cells. This could be an ...
  https://www.jove.com/visualize/abstract/24759736/brd4-is-essential-for-il-1-induced-inflammation-human-airway
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... with each mimicking the major features of human asthma.5 The major features of acute asthma include an exaggerated airway ... A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice ... Airway hyperreactivity (AHR) measurements and bronchoalveolar lavage (BAL) fluid sampling are essential to experimental asthma ... These techniques provide powerful tools for studying asthma in ways that would not be possible in humans. ...
  https://www.jove.com/visualize/abstract/21479225/rnai-based-screening-identifies-kinases-interfering-with-dioxin
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... with each mimicking the major features of human asthma.5 The major features of acute asthma include an exaggerated airway ... Also PKR shows a virus-induced partial resistance to trypsin digestion, which coincides with its hallmark phosphorylation at ... Ovalbumin-induced allergic asthma is a widely used model to reproduce the airway eosinophilia, pulmonary inflammation and ... These techniques provide powerful tools for studying asthma in ways that would not be possible in humans. ...
  https://www.jove.com/visualize/abstract/23861971/unlipidated-outer-membrane-protein-omp16-u-omp16-from-brucella-spp-as
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... with each mimicking the major features of human asthma.5 The major features of acute asthma include an exaggerated airway ... airway resistance, plethysmography, flexiVent, bronchoalveolar lavage, physiology ... Ovalbumin-induced allergic asthma is a widely used model to reproduce the airway eosinophilia, pulmonary inflammation and ... These techniques provide powerful tools for studying asthma in ways that would not be possible in humans. ...
  https://www.jove.com/visualize/abstract/20041190/chylomicrons-promote-intestinal-absorption-systemic-dissemination
*  Most recent papers with the keyword Probiotic and Asthma | Read by QxMD
Ozone causes greater increases in pulmonary resistance, in bronchoalveolar lavage neutrophils, and in airway ... In humans, L. salivarius has been used to prevent and treat a variety of chronic diseases, including asthma, cancer, atopic ... Obesity is a risk factor for asthma, especially nonallergic asthma. Ozone, a common air pollutant, is a nonallergic asthma ... Soluble Fibre Meal Challenge Reduces Airway Inflammation and Expression of GPR43 and GPR41 in Asthma. ...
  https://www.readbyqxmd.com/keyword/84972
*  Asthma
... is a chronic, episodic disease of the airways, which is best viewed as a syndrome. ... Bronchial Asthma Online Medical Reference - including diagnostic evaluation and experimental therapies. Authored by Mani S. ... polymorphisms of the human steroid receptor have not been established. Two discrete types of relative steroid resistance have ... Most studies of airway inflammation in human asthma have been conducted in adults because of safety and convenience. However, ...
  http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/allergy/bronchial-asthma/
*  Airway resistance - Wikipedia
... in asthma during an attack the airways constrict causing an increase in airway resistance. Airway resistance can also vary ... Essentials of Human Physiology "Reynolds Number". "US EPA Glossary of Terms". Kirkby, J.; et al. (2010). "Reference equations ... airway resistance is the resistance of the respiratory tract to airflow during inhalation and expiration. Airway resistance can ... these airways may collapse causing increased airway resistance. This is simply the mathematical inverse of airway resistance. G ...
  https://en.wikipedia.org/wiki/Airway_resistance
*  Lebrikizumab in the personalized management of asthma
Unfortunately, these findings do not translate consistently in human asthma.9,10 This variable response in human asthma will no ... Asthma is a chronic inflammatory condition of the airways characterized by airway hyperresponsiveness, inflammatory infiltrates ... IL-13 is considered one of the potential inflammatory mediators involved in corticosteroid resistance.17 IL-13 acts on many of ... IL-13 in asthma: the successful integration of lessons from mice and humans. Am J Respir Crit Care Med. 2011;183(8):957-958. [ ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3459551/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... with each mimicking the major features of human asthma.5 The major features of acute asthma include an exaggerated airway ... This syndrome of decreased reserve and resistance to stressors increases in incidence with increasing age. In the elderly, ... Reducing airway smooth muscle decreases the ability of the airways to constrict, thereby reducing the frequency of asthma ... moving from distal to proximal along the length of the airway, and systematically from airway to airway as described previously ...
  https://www.jove.com/visualize/abstract/24204876/sex-differences-relationship-between-asthma-overweight-dutch-children
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... with each mimicking the major features of human asthma.5 The major features of acute asthma include an exaggerated airway ... The transendothelial electrical resistance (TEER) of brain endothelial monolayers, indicating the tightness of TJs reached 300 ... Reducing airway smooth muscle decreases the ability of the airways to constrict, thereby reducing the frequency of asthma ... However, small airway fibrosis also contributes significantly to airflow obstruction in human COPD patients(6), but much less ...
  https://www.jove.com/visualize/abstract/26030615/differential-expression-release-activin-follistatin-chronic
*  A-level Biology/Human Health and Disease/immunity - Wikibooks, open books for an open world
This forces the muscles to contract, narrowing the airways and increasing air flow resistance. This makes breathing very ... Asthma is a condition that is currently getting worse, 1/7 children in the UK have asthma. It has been linked to increased air ... Fluid leaks from the blood into the airways and the goblet cells secrete large amounts of mucus, blocking the smaller airways ... If pathogens reach the airway, the epithelial layer that covers the airways should prevent their entry, as should the mucus ...
  https://en.wikibooks.org/wiki/A-level_Biology/Human_Health_and_Disease/immunity
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... with each mimicking the major features of human asthma.5 The major features of acute asthma include an exaggerated airway ... Bioengineering, Issue 87, air-liquid interface, chlorine exposure, toxic inhaled chemicals, Transepithelial Electrical Resistance ... Reducing airway smooth muscle decreases the ability of the airways to constrict, thereby reducing the frequency of asthma ... This biologically relevant in vitro model of the human upper airway can be used in a number of ways; the overall goal of this ...
  https://www.jove.com/visualize/abstract/23741370/human-neutrophil-elastase-degrades-splunc1-impairs-airway-epithelial
*  Frontiers | Functional effects of KCNQ K+ channels in airway smooth muscle | Physiology
... the clinically approved KCNQ agonist retigabine caused a transient reduction in indexes of airway resistance in both wild type ... Studies have indicated expression of KCNQ channels in airway smooth muscle (ASM), a tissue that is predominantly regulated by ... Studies have indicated expression of KCNQ channels in airway smooth muscle (ASM), a tissue that is predominantly regulated by ... Previously, others have shown that KCNQ channel antagonists constrict airways in human lung slices (Brueggemann et al., 2012). ...
  https://www.frontiersin.org/articles/10.3389/fphys.2013.00277/full
*  Developing a non-animal model system to investigate bitter tastants as new treatments for asthma | NC3Rs
In these studies we will employ both primary human airway smooth muscle cells and human bronchi and vessels. Both known and ... These mutants will also be rescued by expression of the endogenous gene and by expression of the human homologue. Resistance ... and subsequently using human cells to confirm discoveries are relevant to asthma treatment. ... Developing a non-animal model system to investigate bitter tastants as new treatments for asthma ...
  https://www.nc3rs.org.uk/developing-non-animal-model-system-investigate-bitter-tastants-new-treatments-asthma