CD30-positive malignant lymphomas: time for a change of management? | Haematologica
Phase I/II study of an anti-CD30 monoclonal antibody (MDX-060) in Hodgkin's lymphoma and anaplastic large-cell lymphoma. J Clin ... human or humanized monoclonal antibodies against CD30 also gave disappointing clinical results.14,15 ... 4 the CD30 antigen has attracted substantial scientific interest. Initially termed Ki-1, this antigen was clustered as CD30 ... Treatment of refractory Hodgkin's lymphoma patients with an iodine-131-labeled murine anti-CD30 monoclonal antibody. J Clin ...http://www.haematologica.org/content/98/8/1165
The data in this manuscript highlight the activity of MDX-1401, a fully human anti-CD30 monoclonal antibody currently in phase ... Antibodies and cell lines. MDX-060 and MDX-1401 are fully human IgG1 (κ) isotype mAbs specific for human CD30 antigen. MDX-060 ... Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, ... Anti-CD30 antibody MDX-060, also known as 5F11, is a fully human IgG1 mAb that was generated in mice transgenic for human ...http://clincancerres.aacrjournals.org/content/15/10/3376
EXBIO Antibodies Product Data Sheet
Franke AC, Jung D, Ellis TM: Characterization of the CD30L binding domain on the human CD30 molecule using anti-CD30 antibodies ... CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. ... The mouse monoclonal antibody Ber-H8 recognizes extracellular part of CD30 (Ki-1 antigen), a 105 kDa single chain glycoprotein ... Extremely rapid and intense induction of apoptosis in human eosinophils by anti-CD30 antibody treatment in vitro. J Immunol. ...http://www.exbio.cz/pdf/data_sheet_new.py/CLO000000000000641/7/6/datasheet-1P-153-T100.html?format=html
Lymphocyte activation antigen CD30 Immunogen: Human CD30.. Specificity: The antibody binds to CD30.. Application Notes: The ... Anti-CD30 [Ki-3]. Clone Number: Ki-3. Description: Recombinant monoclonal antibody to CD30. Manufactured using AbAb's ... Targeting the CD30 antigen with specific monoclonal antibodies is a possible therapy for Hodgkin's lymphoma.. Antibody First ... Incubation of CD30 positive L540 cells with Ki-3 antibody weakly enhances release of soluble CD30 (in contrast to Ki-4, Ab00475 ...http://absoluteantibody.com/ab/Anti-CD30-Ki-3/
Fc-Epsilon Receptor (CD23) Expressing Follicular Dendritic Cells as a Main Prognostic Factor in Follicular Lymphoma
... common leukocyte antigen CD45 and Ki-1 (CD30) molecule. CD23 detection used standard monoclonal antibodies for by enzyme ... Most of these cells die by apoptosis because the anti-apoptotic gene bcl-2 does not work in centroblasts. ... FL morphological diagnosis was made at the Human Tumor Pathology Department, Clinical Oncology Research Institute, N. N. ... Three-color and multi-color fluorescent staining was made with monoclonal antibodies used to assess antigen coexpression on ...http://www.scirp.org/Journal/PaperInformation.aspx?paperID=75607
Anti-Human CD52 Antibody, clone YTH34.5 - Rat Anti-Human Monoclonal Antibody WB, IHC-P, IHC-F, FC, E, IP, CHIP, IH - Buy Now! ...
Rat Anti-Human Monoclonal Antibody validated in WB, IHC-P, IHC-F, FC, E, IP, CHIP, IH (ABD12091), Abgent ... Rat anti-Human CD52 antibody, clone YTH34.5 reacts with the human CD52 antigen, also known as CAMPATH-1. The CD52 antigen is a ... Bisig, B. et al. (2013) Molecular and phenotypic features are shared by CD30-positive peripheral T-cell lymphomas. ... home , Products , Primary Antibodies , Immunology , Anti-Human CD52 Antibody, clone YTH34.5 (RPE) ...http://www.abgent.com/products/ABD12091-Anti-Human-CD52-Antibody-clone-YTH345-RPE
Anti-TNFRSF8 Mouse Monoclonal Antibody [clone: 200] | VWR
Antigen Synonyms. cytokine receptor CD30, CD30 antigen, Ki-1 antigen, CD30, CD30L receptor, lymphocyte activation antigen CD30 ... Clonality: Monoclonal. Clone: 200. Conjugation: Unconjugated. Epitope: Host: Mouse. Isotype: Reactivity: Human. ... Antibodies. , Anti-TNFRSF8 Mouse Monoclonal Antibody [clone: 200]. Anti-TNFRSF8 Mouse Monoclonal Antibody [clone: 200]. ...https://us.vwr.com/store/product/16494962/anti-tnfrsf8-mouse-monoclonal-antibody-clone-200
Lymphocyte Activation Antigen CD70 Expressed by Renal Cell Carcinoma Is a Potential Therapeutic Target for Anti-CD70 Antibody...
The specificity of human liver membrane lipoprotein: studies with monoclonal antibodies. Hepatology 1984; 4: 192-8. ... cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood 2003; 102: ... We also show that antibody-drug conjugates (ADC) consisting of an anti-CD70 monoclonal antibody (mAb) conjugated to novel ... Lymphocyte Activation Antigen CD70 Expressed by Renal Cell Carcinoma Is a Potential Therapeutic Target for Anti-CD70 Antibody- ...http://cancerres.aacrjournals.org/content/66/4/2328
CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) Antibody - Mouse Monoclonal Antibody [Clone SPM121 ] IHC, IF, FC - Buy...
Antibody, Mouse Monoclonal Antibody [Clone SPM121 ] validated in IHC, IF, FC (AH12690-7), Abgent ... Lymphocyte activation antigen CD30, CD30, TNFRSF8, CD30, D1S166E. Storage. Store at 2 to 8°C.Antibody is stable for 24 months. ... Schwarting R, Gerdes J, Durkop H, Falini B, Pileri S, Stein H. Ber-H2: A new anti-Ki-1 (CD30) monoclonal antibody directed at a ... Formalin-fixed, paraffin-embedded human Hodgkin's Lymphoma stained with CD30 Monoclonal Antibody (SPM121). ...http://www.abgent.com/products/AH12690-CD30--TNFRSF8-Hodgkin-Reed-Sternberg-Cell-Marker-Antibody
Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function -...
... the humanized anti-human 17-1A antigen monoclonal antibody 3622W94, the humanized anti-human colorectal tumor antibody A33, the ... an anti-human PSMA antibody, an anti-human PSCA antibody, an anti-human CD22 antibody, an anti-human CD30 antibody, an anti- ... an anti-human CD40 antibody, an anti-human CD45 antibody, an anti-human CD52 antibody, an anti-human CD 138 antibody, an anti- ... human HLA-DR variant antibody, an anti-human EpCAM antibody, an anti-human CEA antibody, an anti-human MUC1 antibody, an anti- ...http://www.freepatentsonline.com/8859234.html
Stem cell marker - Wikipedia
June 2001). "Expression of anti-OV6 antibody and anti-N-CAM antibody along the biliary line of normal and diseased human livers ... ALDH alkaline phosphatase alpha6-integrin Anti-WNT2B monoclonal antibody antithrombin III (AT) asialo GM1 Bcl-2 Beta- ... PSCs pSV2gpt PTPRC purified LRC Rat liver fatty acid-binding protein/human growth hormone transgenes (Fabpl/hGH) RC1 antigen ... CD30) PECAM-1 (CD31) Siglec-3 (CD33) CD34 CD44 NCAM (CD56) CD73 CD9 CD90 CDCP1 Circulating anticoagulants protein C (PC) CK19 ...https://en.wikipedia.org/wiki/Stem_cell_marker
Chemically linked Fab - Wikipedia
"Anti-CD3-based bispecific antibody designed for therapy of human B-cell malignancy can induce T-cell activation by antigen- ... They are fragments antigen-binding (Fab or Fab') of two different monoclonal antibodies and are linked by chemical means like a ... Typically, one of the Fabs binds to a tumour antigen (such as CD30) and the other to a protein on the surface of an immune cell ... Two chemically linked fragments antigen-binding form an artificial antibody that binds to two different antigens, making it a ...https://en.wikipedia.org/wiki/Chemically_linked_Fab
Competitive binding assay. Clone R24.1 and clone R23.1 | Open-i
Clone R24.1 and clone R23.1 mabs did not block the binding of anti-CD30 (BerH2 antibody) to KMH2 cells. ... Antibodies, Monoclonal/immunology. *Antibody Specificity. *Antigens, CD30/analysis. *Antigens, Neoplasm/immunology. *Cell Line ... Mentions: Neither clone R24.1 mab nor clone anti-R23.1 mab blocked the ability of three different anti-CD30 antibodies specific ... Health and Human Services • 8600 Rockville Pike,Bethesda,MD 20894 Privacy • Accessibility • Freedom of Information Act • ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2267462_1476-4598-7-12-5&req=4
JoVE Search Results: CD30 Antigens
Antigen, Cd30 Antigen, Hodgkins Lymphoma, Lymphoma, Chemotherapy, History, Hodgkin Lymphoma, Natural History, Apoptosis, Cell, ... Susceptibility of human T-cell leukemia virus type I-infected cells to humanized anti-CD30 monoclonal antibodies in vitro and ... CD30-targeted antibody therapy. Abstract Hermine, Olivier. Université et Centre National de la Recherche Scientifique (CNRS). ... Human microtubule-associated protein tau mediates targeted killing of CD30(+) lymphoma cells in vitro and inhibits tumour ...http://labindex.jove.com/group/CD30-Antigens
MONOCLONAL ANTIBODIES AGAINST HEPATITIS C VIRUS CORE PROTEIN - Patent application
0115] Humanized antibodies are antibody molecules from non-human species antibody that binds the desired antigen having one or ... an anti-CTLA4 antibody being developed by Medarex, MDX-060, an anti-CD30 antibody being developed by Medarex, MDX-070 being ... anti-C5, anti-CBL, anti-CD147, anti-gp120, anti-VLA4, anti-CD11a, anti-CD18, anti-VEGF, anti-CD40L, anti-Id, anti-ICAM-1, anti- ... anti-Fact VII, anti-Her2/neu, anti-F gp, anti-CD11/18, anti-CD14, anti-ICAM-3, anti-CD80, anti-CD4, anti-CD3, anti-CD23, anti- ...http://www.patentsencyclopedia.com/app/20120009196
Anti-Human CD30 F(ab) Stable Cell Line-CHO CSC-P0126 - Creative BioMart
... which has been transfected with an anti-human CD30 F(ab) gene to allow expression of the F(ab). It is an example of a cell line ... CHO-Anti-Human CD30 F(ab) stable cell line is clonally-derived from a CHO cell line, ... Tested positive against native human antigen.. Product Storage:. It should be stored at -20 °C. Reconstituted antibody aliquots ... This is a human monoclonal antibody fragment designed for the treatment of hypercholesterolemia. ...https://www.creativebiomart.net/description_145166_309.htm
Antibody-drug conjugate - Wikipedia
However, the combination of MMAE linked to an anti-CD30 monoclonal antibody (cAC10, a cell membrane protein of the tumor ... The biochemical reaction between the antibody and the target protein (antigen) triggers a signal in the tumor cell, which then ... to human specific CD30-positive malignant cells. Because of its high toxicity MMAE, which inhibits cell division by blocking ... As a result, the entire antibody, linker and cytotoxic (anti-cancer) agent enter the targeted cancer cell where the antibody is ...https://en.wikipedia.org/wiki/Antibody-drug_conjugate
Anti Human CD30 Antibody, clone C03-8D3 | Bio-Rad Antibodies (formerly AbD Serotec)
... recognizes the human CD30 cell surface antigen also known as TNFRSF8. CD30 is a 120 kDa, type I tran ... Product Types Monoclonal and Polyclonal Antibodies Negative Isotype Controls PrecisionAb™ Antibodies Secondary Antibodies ... Anti-idiotypic Antibodies Anti-Adalimumab Antibodies Anti-Alemtuzumab Antibodies Anti-Bevacizumab Antibodies Anti-Cetuximab ... Anti-Panitumumab Antibodies Anti-Rituximab Antibodies Anti-Tocilizumab Antibodies Anti-Trastuzumab Antibodies Anti-Ustekinumab ...https://www.bio-rad-antibodies.com/human-cd30-antibody-c03-8d3-mca5968ga.html
Linker Technology and Impact of Linker Design on ADC Properties | SpringerLink
... the antibody. In this chapter, we review various... ... The function of a linker in an antibody-drug conjugate is to ... a potent anti-CD30 antibody-drug conjugate. Clin Cancer Res 16:888-897PubMedCrossRefGoogle Scholar ... Greiner JW (1986) Modulation of antigen expression in human tumor cell populations. Cancer Invest 4:239-256PubMedCrossRefGoogle ... Jain RK, Baxter LT (1988) Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors ...https://link.springer.com/chapter/10.1007/978-1-4614-5456-4_7
Clinical Pharmacology Study of Brentuximab Vedotin (SGN-35) - Full Text View - ClinicalTrials.gov
Antibody-Drug Conjugate. Antigens, CD30. Disease, Hodgkin. Lymphoma, Large-Cell, Anaplastic. Lymphoma, Non-Hodgkin. monomethyl ... Antibodies. Antibodies, Monoclonal. Midazolam. Ketoconazole. Rifampin. Immunologic Factors. Physiological Effects of Drugs. ... Anti-Anxiety Agents. Tranquilizing Agents. Psychotropic Drugs. Anesthetics, Intravenous. Anesthetics, General. Anesthetics. ... U.S. Department of Health and Human Services. ... an antibody-drug conjugate, in patients with CD30-positive ...https://clinicaltrials.gov/ct2/show/NCT01026415
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4 P1 antigen and anti-P1 4.. 3-4136 Estradioli benzoas. 15) the monodromy matrix for the nth iterate of the map is Mn(x0) 1 ... Monoclonal antibody drug conjugates in the treatment of cancer. He left instructions for his tomb to be marked with a sphere ... Whereas green tea extract forex 100 deposit bonus have limited activity on human cancer, EGCG sensitization of human cancer ... CD30-regulated apoptosis in murine CD8 Bonue cells after cessation of TCR signals. ...http://forex-time.com/forex-100-deposit-bonus.html
Method of reversibly staining a target cell - IBA GmbH
Kwong et al., Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual ... example it is referred to the determination of the koff rate of anti-CD30 Fab fragments for the recombinant CD30A antigen ... 1 for the Fab fragment of anti-human NKG2D monoclonal antibody and antibodies as IgG1 (see Table 1 of Kwong et al., supra). ... Noguchi et al., Preparation and Properties of the Immunoconjugate Composed of Anti-Human Colon Cancer Monoclonal Antibody and ...http://www.freepatentsonline.com/9023604.html
MUC1 (EMA) is preferentially expressed by ALK positive anaplastic large cell lymphoma, in the normally glycosylated or only...
Production of monoclonal antibodies against human epithelial membrane antigen for use in diagnostic immunocytochemistry. Br J ... MUC1 MONOCLONAL ANTIBODIES. The five anti-MUC1 monoclonal antibodies selected are all directed at the immunodominant tandem ... and classic HD were all CD30 positive. Two cases of DLBCL showed CD30 expression in a subset of the tumour cells. ALK ... 17 and the first monoclonal antibodies designated HMFG1 and HMFG225 were described, many anti-MUC1 monoclonal antibodies have ...http://jcp.bmj.com/content/54/12/933
WikiGenes - TNFRSF8 - tumor necrosis factor receptor superfamily...
... antigen CD30 were cloned from expression libraries of the human HUT-102 cell line using the monoclonal antibodies Ki-1 and Ber- ... of RA patients expressed surface CD30 when stimulated with anti-CD3 antibody (Ab) and anti-CD28 Ab, but their CD30 induction ... Cure of xenografted human tumors by bispecific monoclonal antibodies and human T cells. Renner, C., Jung, W., Sahin, U., ... Bispecific monoclonal antibodies (Bi-mAbs) were designed that bound to a Hodgkin's tumor-associated antigen (CD30) on the tumor ...https://www.wikigenes.org/e/gene/e/943.html
Olivia Martinez | Stanford Medicine Profiles
... as well as anti-CD3 plus anti-CD28 mAb stimulation, to further characterize human CD30(+) T cells with respect to function and ... Apoptosis of SLCLs was induced with an anti-Fas agonist monoclonal antibody in the presence or absence of CsA and TAC and ... The percentage of Leu-M3+ monocytes bearing the HLA Class II antigens and the density of antigen on the monocytes, however, was ... population than did stimulation with plate-bound anti-CD3 plus anti-CD28 mAb or stimulation with soluble anti-CD3 plus anti- ...https://med.stanford.edu/profiles/olivia-martinez