*  CD30-positive malignant lymphomas: time for a change of management? | Haematologica
Phase I/II study of an anti-CD30 monoclonal antibody (MDX-060) in Hodgkin's lymphoma and anaplastic large-cell lymphoma. J Clin ... human or humanized monoclonal antibodies against CD30 also gave disappointing clinical results.14,15 ... 4 the CD30 antigen has attracted substantial scientific interest. Initially termed Ki-1, this antigen was clustered as CD30 ... Treatment of refractory Hodgkin's lymphoma patients with an iodine-131-labeled murine anti-CD30 monoclonal antibody. J Clin ...
  http://www.haematologica.org/content/98/8/1165
*  Plus it
The data in this manuscript highlight the activity of MDX-1401, a fully human anti-CD30 monoclonal antibody currently in phase ... Antibodies and cell lines. MDX-060 and MDX-1401 are fully human IgG1 (κ) isotype mAbs specific for human CD30 antigen. MDX-060 ... Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, ... Anti-CD30 antibody MDX-060, also known as 5F11, is a fully human IgG1 mAb that was generated in mice transgenic for human ...
  http://clincancerres.aacrjournals.org/content/15/10/3376
*  EXBIO Antibodies Product Data Sheet
Franke AC, Jung D, Ellis TM: Characterization of the CD30L binding domain on the human CD30 molecule using anti-CD30 antibodies ... CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. ... The mouse monoclonal antibody Ber-H8 recognizes extracellular part of CD30 (Ki-1 antigen), a 105 kDa single chain glycoprotein ... Extremely rapid and intense induction of apoptosis in human eosinophils by anti-CD30 antibody treatment in vitro. J Immunol. ...
  http://www.exbio.cz/pdf/data_sheet_new.py/CLO000000000000641/7/6/datasheet-1P-153-T100.html?format=html
*  Anti-CD30 [Ki-3]
Lymphocyte activation antigen CD30 Immunogen: Human CD30.. Specificity: The antibody binds to CD30.. Application Notes: The ... Anti-CD30 [Ki-3]. Clone Number: Ki-3. Description: Recombinant monoclonal antibody to CD30. Manufactured using AbAb's ... Targeting the CD30 antigen with specific monoclonal antibodies is a possible therapy for Hodgkin's lymphoma.. Antibody First ... Incubation of CD30 positive L540 cells with Ki-3 antibody weakly enhances release of soluble CD30 (in contrast to Ki-4, Ab00475 ...
  http://absoluteantibody.com/ab/Anti-CD30-Ki-3/
*  CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) Antibody - Mouse Monoclonal Antibody [Clone SPM121 ] IHC, IF, FC - Buy...
Antibody, Mouse Monoclonal Antibody [Clone SPM121 ] validated in IHC, IF, FC (AH12690-7), Abgent ... Lymphocyte activation antigen CD30, CD30, TNFRSF8, CD30, D1S166E. Storage. Store at 2 to 8°C.Antibody is stable for 24 months. ... Schwarting R, Gerdes J, Durkop H, Falini B, Pileri S, Stein H. Ber-H2: A new anti-Ki-1 (CD30) monoclonal antibody directed at a ... Formalin-fixed, paraffin-embedded human Hodgkin's Lymphoma stained with CD30 Monoclonal Antibody (SPM121). ...
  http://www.abgent.com/products/AH12690-CD30--TNFRSF8-Hodgkin-Reed-Sternberg-Cell-Marker-Antibody
*  Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function -...
... the humanized anti-human 17-1A antigen monoclonal antibody 3622W94, the humanized anti-human colorectal tumor antibody A33, the ... an anti-human PSMA antibody, an anti-human PSCA antibody, an anti-human CD22 antibody, an anti-human CD30 antibody, an anti- ... an anti-human CD40 antibody, an anti-human CD45 antibody, an anti-human CD52 antibody, an anti-human CD 138 antibody, an anti- ... human HLA-DR variant antibody, an anti-human EpCAM antibody, an anti-human CEA antibody, an anti-human MUC1 antibody, an anti- ...
  http://www.freepatentsonline.com/8859234.html
*  Stem cell marker - Wikipedia
June 2001). "Expression of anti-OV6 antibody and anti-N-CAM antibody along the biliary line of normal and diseased human livers ... ALDH alkaline phosphatase alpha6-integrin Anti-WNT2B monoclonal antibody antithrombin III (AT) asialo GM1 Bcl-2 Beta- ... PSCs pSV2gpt PTPRC purified LRC Rat liver fatty acid-binding protein/human growth hormone transgenes (Fabpl/hGH) RC1 antigen ... CD30) PECAM-1 (CD31) Siglec-3 (CD33) CD34 CD44 NCAM (CD56) CD73 CD9 CD90 CDCP1 Circulating anticoagulants protein C (PC) CK19 ...
  https://en.wikipedia.org/wiki/Stem_cell_marker
*  Chemically linked Fab - Wikipedia
"Anti-CD3-based bispecific antibody designed for therapy of human B-cell malignancy can induce T-cell activation by antigen- ... They are fragments antigen-binding (Fab or Fab') of two different monoclonal antibodies and are linked by chemical means like a ... Typically, one of the Fabs binds to a tumour antigen (such as CD30) and the other to a protein on the surface of an immune cell ... Two chemically linked fragments antigen-binding form an artificial antibody that binds to two different antigens, making it a ...
  https://en.wikipedia.org/wiki/Chemically_linked_Fab
*  Anti-TNFRSF8 Mouse Monoclonal Antibody [clone: 4C9] | VWR
Antigen Synonyms. lymphocyte activation antigen CD30, cytokine receptor CD30, CD30L receptor, CD30 antigen, Ki-1 antigen, tumor ... Clonality: Monoclonal. Clone: 4C9. Conjugation: Unconjugated. Epitope: Host: Mouse. Isotype: Reactivity: Human. ... Antibodies. , Anti-TNFRSF8 Mouse Monoclonal Antibody [clone: 4C9]. Anti-TNFRSF8 Mouse Monoclonal Antibody [clone: 4C9]. ...
  https://us.vwr.com/store/product/16494961/anti-tnfrsf8-mouse-monoclonal-antibody-clone-4c9
*  Competitive binding assay. Clone R24.1 and clone R23.1 | Open-i
Clone R24.1 and clone R23.1 mabs did not block the binding of anti-CD30 (BerH2 antibody) to KMH2 cells. ... Antibodies, Monoclonal/immunology. *Antibody Specificity. *Antigens, CD30/analysis. *Antigens, Neoplasm/immunology. *Cell Line ... Mentions: Neither clone R24.1 mab nor clone anti-R23.1 mab blocked the ability of three different anti-CD30 antibodies specific ... Health and Human Services • 8600 Rockville Pike,Bethesda,MD 20894 Privacy • Accessibility • Freedom of Information Act • ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2267462_1476-4598-7-12-5&req=4
*  JoVE Search Results: CD30 Antigens
Antigen, Cd30 Antigen, Hodgkins Lymphoma, Lymphoma, Chemotherapy, History, Hodgkin Lymphoma, Natural History, Apoptosis, Cell, ... Susceptibility of human T-cell leukemia virus type I-infected cells to humanized anti-CD30 monoclonal antibodies in vitro and ... CD30-targeted antibody therapy. Abstract Hermine, Olivier. Université et Centre National de la Recherche Scientifique (CNRS). ... Human microtubule-associated protein tau mediates targeted killing of CD30(+) lymphoma cells in vitro and inhibits tumour ...
  http://labindex.jove.com/group/CD30-Antigens
*  MONOCLONAL ANTIBODIES AGAINST HEPATITIS C VIRUS CORE PROTEIN - Patent application
0115] Humanized antibodies are antibody molecules from non-human species antibody that binds the desired antigen having one or ... an anti-CTLA4 antibody being developed by Medarex, MDX-060, an anti-CD30 antibody being developed by Medarex, MDX-070 being ... anti-C5, anti-CBL, anti-CD147, anti-gp120, anti-VLA4, anti-CD11a, anti-CD18, anti-VEGF, anti-CD40L, anti-Id, anti-ICAM-1, anti- ... anti-Fact VII, anti-Her2/neu, anti-F gp, anti-CD11/18, anti-CD14, anti-ICAM-3, anti-CD80, anti-CD4, anti-CD3, anti-CD23, anti- ...
  http://www.patentsencyclopedia.com/app/20120009196
*  Anti-Human CD30 F(ab) Stable Cell Line-CHO CSC-P0126 - Creative BioMart
... which has been transfected with an anti-human CD30 F(ab) gene to allow expression of the F(ab). It is an example of a cell line ... CHO-Anti-Human CD30 F(ab) stable cell line is clonally-derived from a CHO cell line, ... Tested positive against native human antigen.. Product Storage:. It should be stored at -20 °C. Reconstituted antibody aliquots ... This is a human monoclonal antibody fragment designed for the treatment of hypercholesterolemia. ...
  https://www.creativebiomart.net/description_145166_309.htm
*  Anti Human CD30 Antibody, clone C03-8D3 | Bio-Rad Antibodies (formerly AbD Serotec)
... recognizes the human CD30 cell surface antigen also known as TNFRSF8. CD30 is a 120 kDa, type I tran ... Product Types Monoclonal and Polyclonal Antibodies Negative Isotype Controls PrecisionAb™ Antibodies Secondary Antibodies ... Anti-idiotypic Antibodies Anti-Adalimumab Antibodies Anti-Alemtuzumab Antibodies Anti-Bevacizumab Antibodies Anti-Cetuximab ... Anti-Panitumumab Antibodies Anti-Rituximab Antibodies Anti-Tocilizumab Antibodies Anti-Trastuzumab Antibodies Anti-Ustekinumab ...
  https://www.bio-rad-antibodies.com/human-cd30-antibody-c03-8d3-mca5968ga.html
*  Antibody-drug conjugate - Wikipedia
However, the combination of MMAE linked to an anti-CD30 monoclonal antibody (cAC10, a cell membrane protein of the tumor ... The biochemical reaction between the antibody and the target protein (antigen) triggers a signal in the tumor cell, which then ... to human specific CD30-positive malignant cells. Because of its high toxicity MMAE, which inhibits cell division by blocking ... As a result, the entire antibody, linker and cytotoxic (anti-cancer) agent enter the targeted cancer cell where the antibody is ...
  https://en.wikipedia.org/wiki/Antibody-drug_conjugate
*  Linker Technology and Impact of Linker Design on ADC Properties | SpringerLink
... the antibody. In this chapter, we review various... ... The function of a linker in an antibody-drug conjugate is to ... a potent anti-CD30 antibody-drug conjugate. Clin Cancer Res 16:888-897PubMedCrossRefGoogle Scholar ... Greiner JW (1986) Modulation of antigen expression in human tumor cell populations. Cancer Invest 4:239-256PubMedCrossRefGoogle ... Jain RK, Baxter LT (1988) Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors ...
  https://link.springer.com/chapter/10.1007/978-1-4614-5456-4_7
*  Clinical Pharmacology Study of Brentuximab Vedotin (SGN-35) - Full Text View - ClinicalTrials.gov
Antibody-Drug Conjugate. Antigens, CD30. Disease, Hodgkin. Lymphoma, Large-Cell, Anaplastic. Lymphoma, Non-Hodgkin. monomethyl ... Antibodies. Antibodies, Monoclonal. Midazolam. Ketoconazole. Rifampin. Immunologic Factors. Physiological Effects of Drugs. ... Anti-Anxiety Agents. Tranquilizing Agents. Psychotropic Drugs. Anesthetics, Intravenous. Anesthetics, General. Anesthetics. ... U.S. Department of Health and Human Services. ... an antibody-drug conjugate, in patients with CD30-positive ...
  https://clinicaltrials.gov/ct2/show/NCT01026415
*  1 - Forex 100 deposit bonus
4 P1 antigen and anti-P1 4.. 3-4136 Estradioli benzoas. 15) the monodromy matrix for the nth iterate of the map is Mn(x0) 1 ... Monoclonal antibody drug conjugates in the treatment of cancer. He left instructions for his tomb to be marked with a sphere ... Whereas green tea extract forex 100 deposit bonus have limited activity on human cancer, EGCG sensitization of human cancer ... CD30-regulated apoptosis in murine CD8 Bonue cells after cessation of TCR signals. ...
  http://forex-time.com/forex-100-deposit-bonus.html
*  Method of reversibly staining a target cell - IBA GmbH
Kwong et al., Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual ... example it is referred to the determination of the koff rate of anti-CD30 Fab fragments for the recombinant CD30A antigen ... 1 for the Fab fragment of anti-human NKG2D monoclonal antibody and antibodies as IgG1 (see Table 1 of Kwong et al., supra). ... Noguchi et al., Preparation and Properties of the Immunoconjugate Composed of Anti-Human Colon Cancer Monoclonal Antibody and ...
  http://www.freepatentsonline.com/9023604.html
*  MUC1 (EMA) is preferentially expressed by ALK positive anaplastic large cell lymphoma, in the normally glycosylated or only...
Production of monoclonal antibodies against human epithelial membrane antigen for use in diagnostic immunocytochemistry. Br J ... MUC1 MONOCLONAL ANTIBODIES. The five anti-MUC1 monoclonal antibodies selected are all directed at the immunodominant tandem ... and classic HD were all CD30 positive. Two cases of DLBCL showed CD30 expression in a subset of the tumour cells. ALK ... 17 and the first monoclonal antibodies designated HMFG1 and HMFG225 were described, many anti-MUC1 monoclonal antibodies have ...
  http://jcp.bmj.com/content/54/12/933
*  WikiGenes - TNFRSF8 - tumor necrosis factor receptor superfamily...
... antigen CD30 were cloned from expression libraries of the human HUT-102 cell line using the monoclonal antibodies Ki-1 and Ber- ... of RA patients expressed surface CD30 when stimulated with anti-CD3 antibody (Ab) and anti-CD28 Ab, but their CD30 induction ... Cure of xenografted human tumors by bispecific monoclonal antibodies and human T cells. Renner, C., Jung, W., Sahin, U., ... Bispecific monoclonal antibodies (Bi-mAbs) were designed that bound to a Hodgkin's tumor-associated antigen (CD30) on the tumor ...
  https://www.wikigenes.org/e/gene/e/943.html
*  Olivia Martinez | Stanford Medicine Profiles
... as well as anti-CD3 plus anti-CD28 mAb stimulation, to further characterize human CD30(+) T cells with respect to function and ... Apoptosis of SLCLs was induced with an anti-Fas agonist monoclonal antibody in the presence or absence of CsA and TAC and ... The percentage of Leu-M3+ monocytes bearing the HLA Class II antigens and the density of antigen on the monocytes, however, was ... population than did stimulation with plate-bound anti-CD3 plus anti-CD28 mAb or stimulation with soluble anti-CD3 plus anti- ...
  https://med.stanford.edu/profiles/olivia-martinez
*  T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications
After binding to CD30+ HL cells, anti-CD30-IL-2 or anti-CD30-IL-12, antibody-cytokine fusion proteins were able to induce ... "Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells," Journal of Experimental Medicine, vol ... For instance, the inhibition of CCR4 by using a chimeric anti-CCR4 monoclonal antibody was shown to deplete CCR4+ T cells and ... C. Heuser, V. Diehl, H. Abken, and A. Hombach, "Anti-CD30-IL-12 antibody-cytokine fusion protein that induces IFN-γ secretion ...
  https://www.hindawi.com/journals/ah/2011/501659/
*  WikiGenes - Diabetes Mellitus, Type 1
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese ... Certain class II determinants of the human histocompatibility locus antigens (HLA) have been implicated in the aetiology of ... Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells. Kurts, C., Carbone, F.R., Krummel, M.F., ... Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Vafiadis, P., Bennett, S.T., Todd, J.A ...
  https://www.wikigenes.org/e/mesh/e/23325.html
*  Frontiers | Evolving Strategies for Cancer and Autoimmunity: Back to the Future | Immunology
Paradoxically, it appears that such a detuned and deregulated immune system is much better equipped to mount anti-tumor immune ... Studies of immune function in mammals shows that high affinity antibodies and CD4 memory, along with its regulation, co-evolved ... It is our view that human susceptibility to autoimmunity and cancer are the evolutionarily acceptable side effects of the ... Paradoxically, it appears that such a detuned and deregulated immune system is much better equipped to mount anti-tumor immune ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2014.00154/full